Compile Data Set for Download or QSAR

Found 3271 hits with Last Name = 'woolford' and Initial = 'aj'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Platelet-activating factor acetylhydrolase (Homo sapiens (Human))	BDBM50125265 (CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...) Show SMILES CCN(CC)CCN(Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(=O)Cn1c2CCCc2c(=O)nc1SCc1ccc(F)cc1 Show InChI InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.0350	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of Lp-PLA2 in whole human plasma pre-incubated for 15 mins before 2-thio-PAF substrate addition				J Med Chem 59: 10738-10749 (2016) Article DOI: 10.1021/acs.jmedchem.6b01427 BindingDB Entry DOI: 10.7270/Q27946ND
					More data for this Ligand-Target Pair				3D Structure (crystal)
Platelet-activating factor acetylhydrolase (Homo sapiens (Human))	BDBM50125265 (CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...) Show SMILES CCN(CC)CCN(Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(=O)Cn1c2CCCc2c(=O)nc1SCc1ccc(F)cc1 Show InChI InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant human Lp-PLA2 pre-incubated for 30 mins before PED6 fluorogenic substrate				J Med Chem 59: 10738-10749 (2016) Article DOI: 10.1021/acs.jmedchem.6b01427 BindingDB Entry DOI: 10.7270/Q27946ND
					More data for this Ligand-Target Pair				3D Structure (crystal)
Platelet-activating factor acetylhydrolase (Homo sapiens (Human))	BDBM50125265 (CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...) Show SMILES CCN(CC)CCN(Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(=O)Cn1c2CCCc2c(=O)nc1SCc1ccc(F)cc1 Show InChI InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human recombinant Lp-PLA2 using 2-thio-PAF as substrate after 20 mins by CPM-based fluorescence assay				J Med Chem 59: 5356-67 (2016) Article DOI: 10.1021/acs.jmedchem.6b00212 BindingDB Entry DOI: 10.7270/Q2Z60R0G
					More data for this Ligand-Target Pair				3D Structure (crystal)
Platelet-activating factor acetylhydrolase (Homo sapiens (Human))	BDBM50125265 (CHEMBL204021 | N-(2-Diethylamino-ethyl)-2-[2-(4-fl...) Show SMILES CCN(CC)CCN(Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(=O)Cn1c2CCCc2c(=O)nc1SCc1ccc(F)cc1 Show InChI InChI=1S/C36H38F4N4O2S/c1-3-42(4-2)20-21-43(22-25-8-12-27(13-9-25)28-14-16-29(17-15-28)36(38,39)40)33(45)23-44-32-7-5-6-31(32)34(46)41-35(44)47-24-26-10-18-30(37)19-11-26/h8-19H,3-7,20-24H2,1-2H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	0.0490	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of recombinant human Lp-PLA2 incubated for 20 mins by Thio-PAF assay				J Med Chem 59: 10738-10749 (2016) Article DOI: 10.1021/acs.jmedchem.6b01427 BindingDB Entry DOI: 10.7270/Q27946ND
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418177 (2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES COc1cc(F)cc(c1)[C@@H](CO)NC(=O)CN1[C@H](C)c2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl |r| Show InChI InChI=1S/C29H31ClFN5O5/c1-16-22-4-3-17(27-24(30)13-32-29(35-27)33-20-5-7-41-8-6-20)11-23(22)28(39)36(16)14-26(38)34-25(15-37)18-9-19(31)12-21(10-18)40-2/h3-4,9-13,16,20,25,37H,5-8,14-15H2,1-2H3,(H,34,38)(H,32,33,35)/t16-,25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00905 BindingDB Entry DOI: 10.7270/Q2BP06M5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM50573875 (CHEMBL4869086) Show SMILES COc1cc(F)cc(c1)[C@@H](CO)NC(=O)CN1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00905 BindingDB Entry DOI: 10.7270/Q2BP06M5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418177 (2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES COc1cc(F)cc(c1)[C@@H](CO)NC(=O)CN1[C@H](C)c2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl |r| Show InChI InChI=1S/C29H31ClFN5O5/c1-16-22-4-3-17(27-24(30)13-32-29(35-27)33-20-5-7-41-8-6-20)11-23(22)28(39)36(16)14-26(38)34-25(15-37)18-9-19(31)12-21(10-18)40-2/h3-4,9-13,16,20,25,37H,5-8,14-15H2,1-2H3,(H,34,38)(H,32,33,35)/t16-,25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418177 (2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES COc1cc(F)cc(c1)[C@@H](CO)NC(=O)CN1[C@H](C)c2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl |r| Show InChI InChI=1S/C29H31ClFN5O5/c1-16-22-4-3-17(27-24(30)13-32-29(35-27)33-20-5-7-41-8-6-20)11-23(22)28(39)36(16)14-26(38)34-25(15-37)18-9-19(31)12-21(10-18)40-2/h3-4,9-13,16,20,25,37H,5-8,14-15H2,1-2H3,(H,34,38)(H,32,33,35)/t16-,25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418281 ((2R)-2-[6-(5-chloro-2-{[(2S)-1- hydroxypropan-2-yl...) Show SMILES COc1cc(F)cc(c1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(N[C@@H](C)CO)ncc1Cl |r| Show InChI InChI=1S/C27H29ClFN5O5/c1-14(12-35)31-27-30-10-22(28)24(33-27)16-4-5-17-11-34(26(38)21(17)8-16)15(2)25(37)32-23(13-36)18-6-19(29)9-20(7-18)39-3/h4-10,14-15,23,35-36H,11-13H2,1-3H3,(H,32,37)(H,30,31,33)/t14-,15+,23+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418281 ((2R)-2-[6-(5-chloro-2-{[(2S)-1- hydroxypropan-2-yl...) Show SMILES COc1cc(F)cc(c1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(N[C@@H](C)CO)ncc1Cl |r| Show InChI InChI=1S/C27H29ClFN5O5/c1-14(12-35)31-27-30-10-22(28)24(33-27)16-4-5-17-11-34(26(38)21(17)8-16)15(2)25(37)32-23(13-36)18-6-19(29)9-20(7-18)39-3/h4-10,14-15,23,35-36H,11-13H2,1-3H3,(H,32,37)(H,30,31,33)/t14-,15+,23+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM417999 (US10457669, Example 675 | US11001575, Example 675) Show SMILES COc1cccc(c1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl |r| Show InChI InChI=1S/C29H32ClN5O5/c1-17(27(37)33-25(16-36)18-4-3-5-22(12-18)39-2)35-15-20-7-6-19(13-23(20)28(35)38)26-24(30)14-31-29(34-26)32-21-8-10-40-11-9-21/h3-7,12-14,17,21,25,36H,8-11,15-16H2,1-2H3,(H,33,37)(H,31,32,34)/t17-,25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM417954 (US10457669, Example 615) Show SMILES COc1cccc(n1)[C@@H](CO)NC(=O)CN1[C@@H](C)c2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl |r| Show InChI InChI=1S/C28H31ClN6O5/c1-16-19-7-6-17(26-21(29)13-30-28(34-26)31-18-8-10-40-11-9-18)12-20(19)27(38)35(16)14-24(37)32-23(15-36)22-4-3-5-25(33-22)39-2/h3-7,12-13,16,18,23,36H,8-11,14-15H2,1-2H3,(H,32,37)(H,30,31,34)/t16-,23+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM417999 (US10457669, Example 675 | US11001575, Example 675) Show SMILES COc1cccc(c1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl |r| Show InChI InChI=1S/C29H32ClN5O5/c1-17(27(37)33-25(16-36)18-4-3-5-22(12-18)39-2)35-15-20-7-6-19(13-23(20)28(35)38)26-24(30)14-31-29(34-26)32-21-8-10-40-11-9-21/h3-7,12-14,17,21,25,36H,8-11,15-16H2,1-2H3,(H,33,37)(H,31,32,34)/t17-,25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of full-length human N-terminal MAHHHHHH tagged-ERK2 expressed in Escherichia coli BL21 (DE3) using ATF2-GFP as substrate incubated for 30...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c00905 BindingDB Entry DOI: 10.7270/Q2BP06M5
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM417999 (US10457669, Example 675 | US11001575, Example 675) Show SMILES COc1cccc(c1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl |r| Show InChI InChI=1S/C29H32ClN5O5/c1-17(27(37)33-25(16-36)18-4-3-5-22(12-18)39-2)35-15-20-7-6-19(13-23(20)28(35)38)26-24(30)14-31-29(34-26)32-21-8-10-40-11-9-21/h3-7,12-14,17,21,25,36H,8-11,15-16H2,1-2H3,(H,33,37)(H,31,32,34)/t17-,25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM417953 (US10457669, Example 614 | US11001575, Example 616) Show SMILES COc1cccc(n1)[C@@H](CO)NC(=O)CN1C(C)c2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl |r| Show InChI InChI=1S/C28H31ClN6O5/c1-16-19-7-6-17(26-21(29)13-30-28(34-26)31-18-8-10-40-11-9-18)12-20(19)27(38)35(16)14-24(37)32-23(15-36)22-4-3-5-25(33-22)39-2/h3-7,12-13,16,18,23,36H,8-11,14-15H2,1-2H3,(H,32,37)(H,30,31,34)/t16?,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418188 (2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES CO[C@H]1N(CC(=O)N[C@H](CO)c2cc(F)cc(OC)c2)C(=O)c2cc(ccc12)-c1nc(NC2CCOCC2)ncc1Cl |r| Show InChI InChI=1S/C29H31ClFN5O6/c1-40-20-10-17(9-18(31)12-20)24(15-37)34-25(38)14-36-27(39)22-11-16(3-4-21(22)28(36)41-2)26-23(30)13-32-29(35-26)33-19-5-7-42-8-6-19/h3-4,9-13,19,24,28,37H,5-8,14-15H2,1-2H3,(H,34,38)(H,32,33,35)/t24-,28-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418188 (2-[(1R)-5-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES CO[C@H]1N(CC(=O)N[C@H](CO)c2cc(F)cc(OC)c2)C(=O)c2cc(ccc12)-c1nc(NC2CCOCC2)ncc1Cl |r| Show InChI InChI=1S/C29H31ClFN5O6/c1-40-20-10-17(9-18(31)12-20)24(15-37)34-25(38)14-36-27(39)22-11-16(3-4-21(22)28(36)41-2)26-23(30)13-32-29(35-26)33-19-5-7-42-8-6-19/h3-4,9-13,19,24,28,37H,5-8,14-15H2,1-2H3,(H,34,38)(H,32,33,35)/t24-,28-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Platelet-activating factor acetylhydrolase (Homo sapiens (Human))	BDBM50182422 (CHEMBL3818650) Show SMILES COC(CO)Cn1ccc(Nc2cc(c(C)cc2OCCN)-c2ccccc2C)n1 Show InChI InChI=1S/C23H30N4O3/c1-16-6-4-5-7-19(16)20-13-21(22(12-17(20)2)30-11-9-24)25-23-8-10-27(26-23)14-18(15-28)29-3/h4-8,10,12-13,18,28H,9,11,14-15,24H2,1-3H3,(H,25,26)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
Astex Pharmaceuticals Curated by ChEMBL					Assay Description Inhibition of human recombinant Lp-PLA2 using 2-thio-PAF as substrate after 20 mins by CPM-based fluorescence assay				J Med Chem 59: 5356-67 (2016) Article DOI: 10.1021/acs.jmedchem.6b00212 BindingDB Entry DOI: 10.7270/Q2Z60R0G
					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418230 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1nc(ccc1Cl)N1CCN(C)CC1 |r| Show InChI InChI=1S/C32H38Cl2N8O4/c1-19(30(44)37-26(18-43)29-24(33)5-6-27(38-29)41-11-9-40(2)10-12-41)42-17-21-4-3-20(15-23(21)31(42)45)28-25(34)16-35-32(39-28)36-22-7-13-46-14-8-22/h3-6,15-16,19,22,26,43H,7-14,17-18H2,1-2H3,(H,37,44)(H,35,36,39)/t19-,26-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418223 ((2R)-2-(3-{5-chloro-2-[(2-methyl-2H- 1,2,3-triazol...) Show SMILES COc1cc(F)cc(c1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ncc(cc2C1=O)-c1nc(Nc2cnn(C)n2)ncc1Cl |r| Show InChI InChI=1S/C26H25ClFN9O4/c1-13(24(39)32-21(12-38)14-4-16(28)7-17(5-14)41-3)37-11-20-18(25(37)40)6-15(8-29-20)23-19(27)9-30-26(34-23)33-22-10-31-36(2)35-22/h4-10,13,21,38H,11-12H2,1-3H3,(H,32,39)(H,30,33,34,35)/t13-,21-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418223 ((2R)-2-(3-{5-chloro-2-[(2-methyl-2H- 1,2,3-triazol...) Show SMILES COc1cc(F)cc(c1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ncc(cc2C1=O)-c1nc(Nc2cnn(C)n2)ncc1Cl |r| Show InChI InChI=1S/C26H25ClFN9O4/c1-13(24(39)32-21(12-38)14-4-16(28)7-17(5-14)41-3)37-11-20-18(25(37)40)6-15(8-29-20)23-19(27)9-30-26(34-23)33-22-10-31-36(2)35-22/h4-10,13,21,38H,11-12H2,1-3H3,(H,32,39)(H,30,33,34,35)/t13-,21-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418230 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1nc(ccc1Cl)N1CCN(C)CC1 |r| Show InChI InChI=1S/C32H38Cl2N8O4/c1-19(30(44)37-26(18-43)29-24(33)5-6-27(38-29)41-11-9-40(2)10-12-41)42-17-21-4-3-20(15-23(21)31(42)45)28-25(34)16-35-32(39-28)36-22-7-13-46-14-8-22/h3-6,15-16,19,22,26,43H,7-14,17-18H2,1-2H3,(H,37,44)(H,35,36,39)/t19-,26-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418305 ((2R)-2-(6-{5-chloro-2-[(2- methylpyrimidin-4-yl)am...) Show SMILES CCNc1cccc(n1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(Nc2ccnc(C)n2)ncc1Cl |r| Show InChI InChI=1S/C29H30ClN9O3/c1-4-31-24-7-5-6-22(35-24)23(15-40)36-27(41)16(2)39-14-19-9-8-18(12-20(19)28(39)42)26-21(30)13-33-29(38-26)37-25-10-11-32-17(3)34-25/h5-13,16,23,40H,4,14-15H2,1-3H3,(H,31,35)(H,36,41)(H,32,33,34,37,38)/t16-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418307 ((2R)-2-(6-}5-chloro-2-[(oxetan-3- yl)amino]pyrimid...) Show SMILES C[C@@H](NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(NC2COC2)ncc1Cl)c1cc(F)cc(c1)N1CCN(C)CC1 |r| Show InChI InChI=1S/C31H35ClFN7O3/c1-18(22-10-23(33)13-25(11-22)39-8-6-38(3)7-9-39)35-29(41)19(2)40-15-21-5-4-20(12-26(21)30(40)42)28-27(32)14-34-31(37-28)36-24-16-43-17-24/h4-5,10-14,18-19,24H,6-9,15-17H2,1-3H3,(H,35,41)(H,34,36,37)/t18-,19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418229 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1cc(ncc1F)N1CCN(C)CC1 |r| Show InChI InChI=1S/C32H38ClFN8O4/c1-19(30(44)38-27(18-43)24-14-28(35-16-26(24)34)41-9-7-40(2)8-10-41)42-17-21-4-3-20(13-23(21)31(42)45)29-25(33)15-36-32(39-29)37-22-5-11-46-12-6-22/h3-4,13-16,19,22,27,43H,5-12,17-18H2,1-2H3,(H,38,44)(H,36,37,39)/t19-,27-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418266 ((2R)-2-(6-{5-chloro-2-[(1-methyl-1H- 1,2,3-triazol...) Show SMILES C[C@@H](NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(Nc2cnnn2C)ncc1Cl)c1cccc(n1)N1CCN(C)CC1 |r| Show InChI InChI=1S/C30H34ClN11O2/c1-18(24-6-5-7-25(35-24)41-12-10-39(3)11-13-41)34-28(43)19(2)42-17-21-9-8-20(14-22(21)29(42)44)27-23(31)15-32-30(37-27)36-26-16-33-38-40(26)4/h5-9,14-16,18-19H,10-13,17H2,1-4H3,(H,34,43)(H,32,36,37)/t18-,19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418305 ((2R)-2-(6-{5-chloro-2-[(2- methylpyrimidin-4-yl)am...) Show SMILES CCNc1cccc(n1)[C@@H](CO)NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(Nc2ccnc(C)n2)ncc1Cl |r| Show InChI InChI=1S/C29H30ClN9O3/c1-4-31-24-7-5-6-22(35-24)23(15-40)36-27(41)16(2)39-14-19-9-8-18(12-20(19)28(39)42)26-21(30)13-33-29(38-26)37-25-10-11-32-17(3)34-25/h5-13,16,23,40H,4,14-15H2,1-3H3,(H,31,35)(H,36,41)(H,32,33,34,37,38)/t16-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418307 ((2R)-2-(6-}5-chloro-2-[(oxetan-3- yl)amino]pyrimid...) Show SMILES C[C@@H](NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(NC2COC2)ncc1Cl)c1cc(F)cc(c1)N1CCN(C)CC1 |r| Show InChI InChI=1S/C31H35ClFN7O3/c1-18(22-10-23(33)13-25(11-22)39-8-6-38(3)7-9-39)35-29(41)19(2)40-15-21-5-4-20(12-26(21)30(40)42)28-27(32)14-34-31(37-28)36-24-16-43-17-24/h4-5,10-14,18-19,24H,6-9,15-17H2,1-3H3,(H,35,41)(H,34,36,37)/t18-,19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418266 ((2R)-2-(6-{5-chloro-2-[(1-methyl-1H- 1,2,3-triazol...) Show SMILES C[C@@H](NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(Nc2cnnn2C)ncc1Cl)c1cccc(n1)N1CCN(C)CC1 |r| Show InChI InChI=1S/C30H34ClN11O2/c1-18(24-6-5-7-25(35-24)41-12-10-39(3)11-13-41)34-28(43)19(2)42-17-21-9-8-20(14-22(21)29(42)44)27-23(31)15-32-30(37-27)36-26-16-33-38-40(26)4/h5-9,14-16,18-19H,10-13,17H2,1-4H3,(H,34,43)(H,32,36,37)/t18-,19-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418192 (2-{6-[5-chloro-2- (methylamino)pyrimidin-4-yl]-1-o...) Show SMILES CCC(O)C(NC(=O)CN1Cc2ccc(cc2C1=O)-c1nc(NC)ncc1Cl)c1cc(C)cc(F)c1 Show InChI InChI=1S/C26H27ClFN5O3/c1-4-21(34)24(17-7-14(2)8-18(28)9-17)31-22(35)13-33-12-16-6-5-15(10-19(16)25(33)36)23-20(27)11-30-26(29-3)32-23/h5-11,21,24,34H,4,12-13H2,1-3H3,(H,31,35)(H,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418192 (2-{6-[5-chloro-2- (methylamino)pyrimidin-4-yl]-1-o...) Show SMILES CCC(O)C(NC(=O)CN1Cc2ccc(cc2C1=O)-c1nc(NC)ncc1Cl)c1cc(C)cc(F)c1 Show InChI InChI=1S/C26H27ClFN5O3/c1-4-21(34)24(17-7-14(2)8-18(28)9-17)31-22(35)13-33-12-16-6-5-15(10-19(16)25(33)36)23-20(27)11-30-26(29-3)32-23/h5-11,21,24,34H,4,12-13H2,1-3H3,(H,31,35)(H,29,30,32)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418229 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1cc(ncc1F)N1CCN(C)CC1 |r| Show InChI InChI=1S/C32H38ClFN8O4/c1-19(30(44)38-27(18-43)24-14-28(35-16-26(24)34)41-9-7-40(2)8-10-41)42-17-21-4-3-20(13-23(21)31(42)45)29-25(33)15-36-32(39-29)37-22-5-11-46-12-6-22/h3-4,13-16,19,22,27,43H,5-12,17-18H2,1-2H3,(H,38,44)(H,36,37,39)/t19-,27-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM417812 (US10457669, Example 450) Show SMILES Cc1ccc(F)c(c1)[C@@H](CO)NC(=O)CN1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl |r| Show InChI InChI=1S/C28H29ClFN5O4/c1-16-2-5-23(30)21(10-16)24(15-36)33-25(37)14-35-13-18-4-3-17(11-20(18)27(35)38)26-22(29)12-31-28(34-26)32-19-6-8-39-9-7-19/h2-5,10-12,19,24,36H,6-9,13-15H2,1H3,(H,33,37)(H,31,32,34)/t24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM417711 (2-(6-{5-bromo-2- [(oxan-4- yl)amino]pyrimidiin-4- ...) Show SMILES C[C@H](O)[C@@H](NC(=O)CN1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Br)c1ccccc1 |r| Show InChI InChI=1S/C28H30BrN5O4/c1-17(35)25(18-5-3-2-4-6-18)32-24(36)16-34-15-20-8-7-19(13-22(20)27(34)37)26-23(29)14-30-28(33-26)31-21-9-11-38-12-10-21/h2-8,13-14,17,21,25,35H,9-12,15-16H2,1H3,(H,32,36)(H,30,31,33)/t17-,25+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418298 ((2R)-2-(6-{5-chloro-2-[(2- methylpyrimidin-4-yl)am...) Show SMILES CCNc1cccc(n1)[C@@H](C)NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(Nc2ccnc(C)n2)ncc1Cl |r| Show InChI InChI=1S/C29H30ClN9O2/c1-5-31-24-8-6-7-23(36-24)16(2)34-27(40)17(3)39-15-20-10-9-19(13-21(20)28(39)41)26-22(30)14-33-29(38-26)37-25-11-12-32-18(4)35-25/h6-14,16-17H,5,15H2,1-4H3,(H,31,36)(H,34,40)(H,32,33,35,37,38)/t16-,17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418300 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1cc(O)cc(F)c1 |r| Show InChI InChI=1S/C28H29ClFN5O5/c1-15(26(38)33-24(14-36)18-8-19(30)11-21(37)9-18)35-13-17-3-2-16(10-22(17)27(35)39)25-23(29)12-31-28(34-25)32-20-4-6-40-7-5-20/h2-3,8-12,15,20,24,36-37H,4-7,13-14H2,1H3,(H,33,38)(H,31,32,34)/t15-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418308 ((2R)-2-[6-(5-chloro-2-{[cis-3- methoxycyclobutyl]a...) Show SMILES CO[C@@H]1C[C@@H](C1)Nc1ncc(Cl)c(n1)-c1ccc2CN([C@H](C)C(=O)N[C@H](CO)c3cc(F)cc(OC)c3)C(=O)c2c1 |r,wU:4.6,25.26,2.1,wD:20.22,(7.51,-8.83,;6.18,-8.06,;4.85,-8.83,;3.36,-8.43,;2.96,-9.92,;4.45,-10.31,;1.63,-10.69,;.29,-9.92,;-1.04,-10.69,;-2.38,-9.92,;-2.38,-8.38,;-3.71,-7.61,;-1.04,-7.61,;.29,-8.38,;-1.04,-6.07,;.29,-5.3,;.29,-3.76,;-1.04,-2.99,;-1.36,-1.48,;-2.89,-1.32,;-3.66,.02,;-5.2,.02,;-2.89,1.35,;-1.35,1.35,;-3.66,2.68,;-2.89,4.02,;-1.35,4.02,;-.58,5.35,;-3.66,5.35,;-5.2,5.35,;-5.97,6.68,;-7.51,6.68,;-5.2,8.02,;-3.66,8.02,;-2.89,9.35,;-3.66,10.69,;-2.89,6.68,;-3.52,-2.72,;-5.01,-3.12,;-2.38,-3.76,;-2.38,-5.3,)| Show InChI InChI=1S/C29H31ClFN5O5/c1-15(27(38)34-25(14-37)18-6-19(31)9-21(7-18)40-2)36-13-17-5-4-16(8-23(17)28(36)39)26-24(30)12-32-29(35-26)33-20-10-22(11-20)41-3/h4-9,12,15,20,22,25,37H,10-11,13-14H2,1-3H3,(H,34,38)(H,32,33,35)/t15-,20-,22+,25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418276 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1nc(ccc1Cl)N1CCOCC1 |r| Show InChI InChI=1S/C31H35Cl2N7O5/c1-18(29(42)36-25(17-41)28-23(32)4-5-26(37-28)39-8-12-45-13-9-39)40-16-20-3-2-19(14-22(20)30(40)43)27-24(33)15-34-31(38-27)35-21-6-10-44-11-7-21/h2-5,14-15,18,21,25,41H,6-13,16-17H2,1H3,(H,36,42)(H,34,35,38)/t18-,25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM497509 (2-(6-{5-chloro-2-[(oxan- 4-yl)amino]pyrimidin-4- y...) Show SMILES COc1cccc(c1)[C@H](NC(=O)CN1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Br)[C@H](C)O |r| Show InChI InChI=1S/C29H32BrN5O5/c1-17(36)26(18-4-3-5-22(12-18)39-2)33-25(37)16-35-15-20-7-6-19(13-23(20)28(35)38)27-24(30)14-31-29(34-27)32-21-8-10-40-11-9-21/h3-7,12-14,17,21,26,36H,8-11,15-16H2,1-2H3,(H,33,37)(H,31,32,34)/t17-,26+/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418300 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1cc(O)cc(F)c1 |r| Show InChI InChI=1S/C28H29ClFN5O5/c1-15(26(38)33-24(14-36)18-8-19(30)11-21(37)9-18)35-13-17-3-2-16(10-22(17)27(35)39)25-23(29)12-31-28(34-25)32-20-4-6-40-7-5-20/h2-3,8-12,15,20,24,36-37H,4-7,13-14H2,1H3,(H,33,38)(H,31,32,34)/t15-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418276 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1nc(ccc1Cl)N1CCOCC1 |r| Show InChI InChI=1S/C31H35Cl2N7O5/c1-18(29(42)36-25(17-41)28-23(32)4-5-26(37-28)39-8-12-45-13-9-39)40-16-20-3-2-19(14-22(20)30(40)43)27-24(33)15-34-31(38-27)35-21-6-10-44-11-7-21/h2-5,14-15,18,21,25,41H,6-13,16-17H2,1H3,(H,36,42)(H,34,35,38)/t18-,25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418308 ((2R)-2-[6-(5-chloro-2-{[cis-3- methoxycyclobutyl]a...) Show SMILES CO[C@@H]1C[C@@H](C1)Nc1ncc(Cl)c(n1)-c1ccc2CN([C@H](C)C(=O)N[C@H](CO)c3cc(F)cc(OC)c3)C(=O)c2c1 |r,wU:4.6,25.26,2.1,wD:20.22,(7.51,-8.83,;6.18,-8.06,;4.85,-8.83,;3.36,-8.43,;2.96,-9.92,;4.45,-10.31,;1.63,-10.69,;.29,-9.92,;-1.04,-10.69,;-2.38,-9.92,;-2.38,-8.38,;-3.71,-7.61,;-1.04,-7.61,;.29,-8.38,;-1.04,-6.07,;.29,-5.3,;.29,-3.76,;-1.04,-2.99,;-1.36,-1.48,;-2.89,-1.32,;-3.66,.02,;-5.2,.02,;-2.89,1.35,;-1.35,1.35,;-3.66,2.68,;-2.89,4.02,;-1.35,4.02,;-.58,5.35,;-3.66,5.35,;-5.2,5.35,;-5.97,6.68,;-7.51,6.68,;-5.2,8.02,;-3.66,8.02,;-2.89,9.35,;-3.66,10.69,;-2.89,6.68,;-3.52,-2.72,;-5.01,-3.12,;-2.38,-3.76,;-2.38,-5.3,)| Show InChI InChI=1S/C29H31ClFN5O5/c1-15(27(38)34-25(14-37)18-6-19(31)9-21(7-18)40-2)36-13-17-5-4-16(8-23(17)28(36)39)26-24(30)12-32-29(35-26)33-20-10-22(11-20)41-3/h4-9,12,15,20,22,25,37H,10-11,13-14H2,1-3H3,(H,34,38)(H,32,33,35)/t15-,20-,22+,25-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418298 ((2R)-2-(6-{5-chloro-2-[(2- methylpyrimidin-4-yl)am...) Show SMILES CCNc1cccc(n1)[C@@H](C)NC(=O)[C@@H](C)N1Cc2ccc(cc2C1=O)-c1nc(Nc2ccnc(C)n2)ncc1Cl |r| Show InChI InChI=1S/C29H30ClN9O2/c1-5-31-24-8-6-7-23(36-24)16(2)34-27(40)17(3)39-15-20-10-9-19(13-21(20)28(39)41)26-22(30)14-33-29(38-26)37-25-11-12-32-18(4)35-25/h6-14,16-17H,5,15H2,1-4H3,(H,31,36)(H,34,40)(H,32,33,35,37,38)/t16-,17-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418200 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1ccn2ccnc2c1 |r| Show InChI InChI=1S/C29H30ClN7O4/c1-17(27(39)34-24(16-38)18-4-8-36-9-7-31-25(36)13-18)37-15-20-3-2-19(12-22(20)28(37)40)26-23(30)14-32-29(35-26)33-21-5-10-41-11-6-21/h2-4,7-9,12-14,17,21,24,38H,5-6,10-11,15-16H2,1H3,(H,34,39)(H,32,33,35)/t17-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418133 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1csc(C)c1 |r| Show InChI InChI=1S/C27H30ClN5O4S/c1-15-9-19(14-38-15)23(13-34)31-25(35)16(2)33-12-18-4-3-17(10-21(18)26(33)36)24-22(28)11-29-27(32-24)30-20-5-7-37-8-6-20/h3-4,9-11,14,16,20,23,34H,5-8,12-13H2,1-2H3,(H,31,35)(H,29,30,32)/t16-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US11001575 (2021) BindingDB Entry DOI: 10.7270/Q2TB1B01
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418200 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1ccn2ccnc2c1 |r| Show InChI InChI=1S/C29H30ClN7O4/c1-17(27(39)34-24(16-38)18-4-8-36-9-7-31-25(36)13-18)37-15-20-3-2-19(12-22(20)28(37)40)26-23(30)14-32-29(35-26)33-21-5-10-41-11-6-21/h2-4,7-9,12-14,17,21,24,38H,5-6,10-11,15-16H2,1H3,(H,34,39)(H,32,33,35)/t17-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418133 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1csc(C)c1 |r| Show InChI InChI=1S/C27H30ClN5O4S/c1-15-9-19(14-38-15)23(13-34)31-25(35)16(2)33-12-18-4-3-17(10-21(18)26(33)36)24-22(28)11-29-27(32-24)30-20-5-7-37-8-6-20/h3-4,9-11,14,16,20,23,34H,5-8,12-13H2,1-2H3,(H,31,35)(H,29,30,32)/t16-,23-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418089 ((2R)-2-{6-[5-chloro-2- (methylamino)pyrimidin-4-yl...) Show SMILES CNc1ncc(Cl)c(n1)-c1ccc2CN([C@H](C)C(=O)N[C@H](CO)c3cccc(n3)N(C)C)C(=O)c2c1 |r| Show InChI InChI=1S/C25H28ClN7O3/c1-14(23(35)30-20(13-34)19-6-5-7-21(29-19)32(3)4)33-12-16-9-8-15(10-17(16)24(33)36)22-18(26)11-28-25(27-2)31-22/h5-11,14,20,34H,12-13H2,1-4H3,(H,30,35)(H,27,28,31)/t14-,20-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM418105 ((2R)-2-(6-{5-chloro-2-[(oxan-4- yl)amino]pyrimidin...) Show SMILES C[C@@H](N1Cc2ccc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)C(=O)N[C@H](CO)c1ccnc(c1)N(C)C |r| Show InChI InChI=1S/C29H34ClN7O4/c1-17(27(39)34-24(16-38)18-6-9-31-25(13-18)36(2)3)37-15-20-5-4-19(12-22(20)28(37)40)26-23(30)14-32-29(35-26)33-21-7-10-41-11-8-21/h4-6,9,12-14,17,21,24,38H,7-8,10-11,15-16H2,1-3H3,(H,34,39)(H,32,33,35)/t17-,24-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Homo sapiens (Human))	BDBM417975 (US10457669, Example 642 | US11001575, Example 642) Show SMILES OC[C@@H](NC(=O)CN1Cc2ncc(cc2C1=O)-c1nc(NC2CCOCC2)ncc1Cl)c1cccc(OC(F)F)c1 |r| Show InChI InChI=1S/C27H27ClF2N6O5/c28-20-11-32-27(33-17-4-6-40-7-5-17)35-24(20)16-9-19-21(31-10-16)12-36(25(19)39)13-23(38)34-22(14-37)15-2-1-3-18(8-15)41-26(29)30/h1-3,8-11,17,22,26,37H,4-7,12-14H2,(H,34,38)(H,32,33,35)/t22-/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	n/a	n/a
OTSUKA PHARMACEUTICAL CO., LTD. US Patent					Assay Description Activity of ERK2 enzyme (Life Technologies) was determined using a time-resolved fluorescence format measuring the phosphorylation of a truncated ver...				US Patent US10457669 (2019) BindingDB Entry DOI: 10.7270/Q2B27XNR
					More data for this Ligand-Target Pair

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