Compile Data Set for Download or QSAR

Found 3222 hits with Last Name = 'xu' and Initial = 'd'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ITK/TSK (Homo sapiens (Human))	BDBM209866 (PF-06651600 | US11111242, Example 5 | US2023034848...) Show SMILES C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	0.0269	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Worldwide R&D					Assay Description Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...				ACS Chem Biol 11: 3442-3451 (2016) Article DOI: 10.1021/acschembio.6b00677 BindingDB Entry DOI: 10.7270/Q2PN94F8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335985 (CHEMBL1669013 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2ccc(C)cc2)cc1C Show InChI InChI=1S/C35H37N3O6S/c1-5-43-31-26-9-7-8-10-27(26)32(44-6-2)30-28(31)21-38(33(30)39)29-16-13-24(19-23(29)4)20-35(17-18-35)36-34(40)37-45(41,42)25-14-11-22(3)12-15-25/h7-16,19H,5-6,17-18,20-21H2,1-4H3,(H2,36,37,40)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372064 (CHEMBL256873) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2cccnc12)c1ccc(CS(=O)(=O)NC(=O)Cc2c(OC)cccc2C(C)=O)cc1C Show InChI InChI=1S/C34H35N3O8S/c1-6-44-32-24-11-9-15-35-31(24)33(45-7-2)26-18-37(34(40)30(26)32)27-14-13-22(16-20(27)3)19-46(41,42)36-29(39)17-25-23(21(4)38)10-8-12-28(25)43-5/h8-16H,6-7,17-19H2,1-5H3,(H,36,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Tyrosine-protein kinase TXK (Homo sapiens (Human))	BDBM209866 (PF-06651600 | US11111242, Example 5 | US2023034848...) Show SMILES C[C@H]1CC[C@H](CN1C(=O)C=C)Nc1ncnc2[nH]ccc12 |r| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	0.131	n/a	n/a	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Worldwide R&D					Assay Description Assay buffer was 20 mM HEPES, pH 7.5, 10 mM MgCl2, 0.01% BSA, 1 mM DTT, 0.0005% Tween 20, and 2% DMSO. Inactivation kinetic reactions were performed ...				ACS Chem Biol 11: 3442-3451 (2016) Article DOI: 10.1021/acschembio.6b00677 BindingDB Entry DOI: 10.7270/Q2PN94F8
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335986 (2-chloro-N-(1-(4-(4,9-diethoxy-1-oxo-1H-benzo[f]is...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2ccccc2Cl)cc1C Show InChI InChI=1S/C34H34ClN3O6S/c1-4-43-30-23-10-6-7-11-24(23)31(44-5-2)29-25(30)20-38(32(29)39)27-15-14-22(18-21(27)3)19-34(16-17-34)36-33(40)37-45(41,42)28-13-9-8-12-26(28)35/h6-15,18H,4-5,16-17,19-20H2,1-3H3,(H2,36,37,40)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335980 (CHEMBL1669017 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)Cc2ncccc2OC)cc1C Show InChI InChI=1S/C35H37N3O5/c1-5-42-32-24-10-7-8-11-25(24)33(43-6-2)31-26(32)21-38(34(31)40)28-14-13-23(18-22(28)3)20-35(15-16-35)37-30(39)19-27-29(41-4)12-9-17-36-27/h7-14,17-18H,5-6,15-16,19-21H2,1-4H3,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335989 (CHEMBL1669009 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2ccccc2OC)cc1C Show InChI InChI=1S/C35H37N3O7S/c1-5-44-31-24-11-7-8-12-25(24)32(45-6-2)30-26(31)21-38(33(30)39)27-16-15-23(19-22(27)3)20-35(17-18-35)36-34(40)37-46(41,42)29-14-10-9-13-28(29)43-4/h7-16,19H,5-6,17-18,20-21H2,1-4H3,(H2,36,37,40)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.170	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335981 (3-(2-(1-(4-(4,9-diethoxy-1-oxo-1H-benzo[f]isoindol...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)Cc2cc(ccc2OC)C(O)=O)cc1C Show InChI InChI=1S/C37H38N2O7/c1-5-45-33-26-9-7-8-10-27(26)34(46-6-2)32-28(33)21-39(35(32)41)29-13-11-23(17-22(29)3)20-37(15-16-37)38-31(40)19-25-18-24(36(42)43)12-14-30(25)44-4/h7-14,17-18H,5-6,15-16,19-21H2,1-4H3,(H,38,40)(H,42,43)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335984 (CHEMBL1669018 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)Cc2ccccc2OC)cc1C Show InChI InChI=1S/C36H38N2O5/c1-5-42-33-26-12-8-9-13-27(26)34(43-6-2)32-28(33)22-38(35(32)40)29-16-15-24(19-23(29)3)21-36(17-18-36)37-31(39)20-25-11-7-10-14-30(25)41-4/h7-16,19H,5-6,17-18,20-22H2,1-4H3,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372051 (CHEMBL269987) Show SMILES CCOc1c2C(=O)N(Cc2c(OCC)c2ncccc12)c1ccc(CS(=O)(=O)NC(=O)Cc2ccccc2OC(F)(F)F)cc1C Show InChI InChI=1S/C32H30F3N3O7S/c1-4-43-29-22-10-8-14-36-28(22)30(44-5-2)23-17-38(31(40)27(23)29)24-13-12-20(15-19(24)3)18-46(41,42)37-26(39)16-21-9-6-7-11-25(21)45-32(33,34)35/h6-15H,4-5,16-18H2,1-3H3,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50319837 (4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...) Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cccc2ccn(Cc3ccc(cc3)C(F)(F)F)c12 Show InChI InChI=1S/C27H21F3N2O3/c28-27(29,30)21-8-4-17(5-9-21)16-32-15-12-18-2-1-3-22(23(18)32)24(33)31-26(13-14-26)20-10-6-19(7-11-20)25(34)35/h1-12,15H,13-14,16H2,(H,31,33)(H,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Ltd Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 20: 3760-3 (2010) Article DOI: 10.1016/j.bmcl.2010.04.065 BindingDB Entry DOI: 10.7270/Q20P106K
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335988 (CHEMBL1669010 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2ccccc2C)cc1C Show InChI InChI=1S/C35H37N3O6S/c1-5-43-31-25-12-8-9-13-26(25)32(44-6-2)30-27(31)21-38(33(30)39)28-16-15-24(19-23(28)4)20-35(17-18-35)36-34(40)37-45(41,42)29-14-10-7-11-22(29)3/h7-16,19H,5-6,17-18,20-21H2,1-4H3,(H2,36,37,40)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372054 (CHEMBL255527) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CS(=O)(=O)NC(=O)Cc2ccccc2)cc1C Show InChI InChI=1S/C32H32N2O6S/c1-4-39-30-24-13-9-10-14-25(24)31(40-5-2)29-26(30)19-34(32(29)36)27-16-15-23(17-21(27)3)20-41(37,38)33-28(35)18-22-11-7-6-8-12-22/h6-17H,4-5,18-20H2,1-3H3,(H,33,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.25	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372050 (CHEMBL255906) Show SMILES CCOc1ccccc1CC(=O)NS(=O)(=O)Cc1ccc(N2Cc3c(C2=O)c(OCC)c2cccnc2c3OCC)c(C)c1 Show InChI InChI=1S/C33H35N3O7S/c1-5-41-27-13-9-8-11-23(27)18-28(37)35-44(39,40)20-22-14-15-26(21(4)17-22)36-19-25-29(33(36)38)31(42-6-2)24-12-10-16-34-30(24)32(25)43-7-3/h8-17H,5-7,18-20H2,1-4H3,(H,35,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372052 (CHEMBL218699) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2cccnc12)c1ccc(CS(=O)(=O)NC(=O)Cc2ccccc2Cl)cc1C Show InChI InChI=1S/C31H30ClN3O6S/c1-4-40-29-22-10-8-14-33-28(22)30(41-5-2)23-17-35(31(37)27(23)29)25-13-12-20(15-19(25)3)18-42(38,39)34-26(36)16-21-9-6-7-11-24(21)32/h6-15H,4-5,16-18H2,1-3H3,(H,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372065 (CHEMBL272363) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2cccnc12)c1ccc(CS(=O)(=O)NC(=O)Cc2c(Cl)cccc2Cl)cc1C Show InChI InChI=1S/C31H29Cl2N3O6S/c1-4-41-29-20-8-7-13-34-28(20)30(42-5-2)22-16-36(31(38)27(22)29)25-12-11-19(14-18(25)3)17-43(39,40)35-26(37)15-21-23(32)9-6-10-24(21)33/h6-14H,4-5,15-17H2,1-3H3,(H,35,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50334136 ((S)-4-(1-(1-(biphenyl-4-ylmethyl)indoline-7-carbox...) Show SMILES C[C@H](NC(=O)c1cccc2CCN(Cc3ccc(cc3)-c3ccccc3)c12)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C31H28N2O3/c1-21(23-14-16-27(17-15-23)31(35)36)32-30(34)28-9-5-8-26-18-19-33(29(26)28)20-22-10-12-25(13-11-22)24-6-3-2-4-7-24/h2-17,21H,18-20H2,1H3,(H,32,34)(H,35,36)/t21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 21: 484-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.106 BindingDB Entry DOI: 10.7270/Q2BZ6695
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335990 (2,6-dichloro-N-(1-(4-(4,9-diethoxy-1-oxo-1H-benzo[...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2c(Cl)cccc2Cl)cc1C Show InChI InChI=1S/C34H33Cl2N3O6S/c1-4-44-29-22-9-6-7-10-23(22)30(45-5-2)28-24(29)19-39(32(28)40)27-14-13-21(17-20(27)3)18-34(15-16-34)37-33(41)38-46(42,43)31-25(35)11-8-12-26(31)36/h6-14,17H,4-5,15-16,18-19H2,1-3H3,(H2,37,38,41)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372056 (CHEMBL255422) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CS(=O)(=O)NC(=O)Cc2ccccc2)cc1 Show InChI InChI=1S/C31H30N2O6S/c1-3-38-29-24-12-8-9-13-25(24)30(39-4-2)28-26(29)19-33(31(28)35)23-16-14-22(15-17-23)20-40(36,37)32-27(34)18-21-10-6-5-7-11-21/h5-17H,3-4,18-20H2,1-2H3,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50319836 (4-(1-(5-chloro-1-(4-(trifluoromethyl)benzyl)-1H-in...) Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cc(Cl)cc2ccn(Cc3ccc(cc3)C(F)(F)F)c12 Show InChI InChI=1S/C27H20ClF3N2O3/c28-21-13-18-9-12-33(15-16-1-5-20(6-2-16)27(29,30)31)23(18)22(14-21)24(34)32-26(10-11-26)19-7-3-17(4-8-19)25(35)36/h1-9,12-14H,10-11,15H2,(H,32,34)(H,35,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Ltd Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 20: 3760-3 (2010) Article DOI: 10.1016/j.bmcl.2010.04.065 BindingDB Entry DOI: 10.7270/Q20P106K
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372049 (CHEMBL257255) Show SMILES CCOc1c2C(=O)N(Cc2c(OCC)c2ncccc12)c1ccc(CS(=O)(=O)NC(=O)Cc2ccccc2OC(F)F)cc1C Show InChI InChI=1S/C32H31F2N3O7S/c1-4-42-29-22-10-8-14-35-28(22)30(43-5-2)23-17-37(31(39)27(23)29)24-13-12-20(15-19(24)3)18-45(40,41)36-26(38)16-21-9-6-7-11-25(21)44-32(33)34/h6-15,32H,4-5,16-18H2,1-3H3,(H,36,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50336003 (CHEMBL1669023 | N-(4-(4,9-diethoxy-1-oxo-1H-benzo[...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CCNC(=O)Cc2ccccc2OC)cc1C Show InChI InChI=1S/C34H36N2O5/c1-5-40-32-25-12-8-9-13-26(25)33(41-6-2)31-27(32)21-36(34(31)38)28-16-15-23(19-22(28)3)17-18-35-30(37)20-24-11-7-10-14-29(24)39-4/h7-16,19H,5-6,17-18,20-21H2,1-4H3,(H,35,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335982 (2-(2-chlorophenyl)-N-(1-(4-(4,9-diethoxy-1-oxo-1H-...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)Cc2ccccc2Cl)cc1C Show InChI InChI=1S/C35H35ClN2O4/c1-4-41-32-25-11-7-8-12-26(25)33(42-5-2)31-27(32)21-38(34(31)40)29-15-14-23(18-22(29)3)20-35(16-17-35)37-30(39)19-24-10-6-9-13-28(24)36/h6-15,18H,4-5,16-17,19-21H2,1-3H3,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50334129 ((S)-4-(1-(1-(3,5-dibromobenzyl)indoline-7-carboxam...) Show SMILES C[C@H](NC(=O)c1cccc2CCN(Cc3cc(Br)cc(Br)c3)c12)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H22Br2N2O3/c1-15(17-5-7-19(8-6-17)25(31)32)28-24(30)22-4-2-3-18-9-10-29(23(18)22)14-16-11-20(26)13-21(27)12-16/h2-8,11-13,15H,9-10,14H2,1H3,(H,28,30)(H,31,32)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.330	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 21: 484-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.106 BindingDB Entry DOI: 10.7270/Q2BZ6695
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50334130 ((S)-4-(1-(1-(3,4-dichlorobenzyl)indoline-7-carboxa...) Show SMILES C[C@H](NC(=O)c1cccc2CCN(Cc3ccc(Cl)c(Cl)c3)c12)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H22Cl2N2O3/c1-15(17-6-8-19(9-7-17)25(31)32)28-24(30)20-4-2-3-18-11-12-29(23(18)20)14-16-5-10-21(26)22(27)13-16/h2-10,13,15H,11-12,14H2,1H3,(H,28,30)(H,31,32)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 21: 484-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.106 BindingDB Entry DOI: 10.7270/Q2BZ6695
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50319837 (4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...) Show SMILES OC(=O)c1ccc(cc1)C1(CC1)NC(=O)c1cccc2ccn(Cc3ccc(cc3)C(F)(F)F)c12 Show InChI InChI=1S/C27H21F3N2O3/c28-27(29,30)21-8-4-17(5-9-21)16-32-15-12-18-2-1-3-22(23(18)32)24(33)31-26(13-14-26)20-10-6-19(7-11-20)25(34)35/h1-12,15H,13-14,16H2,(H,31,33)(H,34,35)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	0.340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Ltd Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting in presence of 10%...				Bioorg Med Chem Lett 20: 3760-3 (2010) Article DOI: 10.1016/j.bmcl.2010.04.065 BindingDB Entry DOI: 10.7270/Q20P106K
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335983 (2-(2,4-dichlorophenyl)-N-(1-(4-(4,9-diethoxy-1-oxo...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)Cc2ccc(Cl)cc2Cl)cc1C Show InChI InChI=1S/C35H34Cl2N2O4/c1-4-42-32-25-8-6-7-9-26(25)33(43-5-2)31-27(32)20-39(34(31)41)29-13-10-22(16-21(29)3)19-35(14-15-35)38-30(40)17-23-11-12-24(36)18-28(23)37/h6-13,16,18H,4-5,14-15,17,19-20H2,1-3H3,(H,38,40)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335993 (CHEMBL1669005 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2c(OC)cccc2OC)cc1C Show InChI InChI=1S/C36H39N3O8S/c1-6-46-31-24-11-8-9-12-25(24)32(47-7-2)30-26(31)21-39(34(30)40)27-16-15-23(19-22(27)3)20-36(17-18-36)37-35(41)38-48(42,43)33-28(44-4)13-10-14-29(33)45-5/h8-16,19H,6-7,17-18,20-21H2,1-5H3,(H2,37,38,41)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372062 (CHEMBL272498) Show SMILES COc1ccccc1CC(=O)NS(=O)(=O)Cc1ccc(N2Cc3c(C2=O)c(OC(C)C)c2cccnc2c3OC(C)C)c(C)c1 Show InChI InChI=1S/C34H37N3O7S/c1-20(2)43-32-25-11-9-15-35-31(25)33(44-21(3)4)26-18-37(34(39)30(26)32)27-14-13-23(16-22(27)5)19-45(40,41)36-29(38)17-24-10-7-8-12-28(24)42-6/h7-16,20-21H,17-19H2,1-6H3,(H,36,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.360	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50334149 ((S)-4-(1-(5-fluoro-1-(4-(trifluoromethyl)benzyl)in...) Show SMILES C[C@H](NC(=O)c1cc(F)cc2CCN(Cc3ccc(cc3)C(F)(F)F)c12)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C26H22F4N2O3/c1-15(17-4-6-18(7-5-17)25(34)35)31-24(33)22-13-21(27)12-19-10-11-32(23(19)22)14-16-2-8-20(9-3-16)26(28,29)30/h2-9,12-13,15H,10-11,14H2,1H3,(H,31,33)(H,34,35)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.370	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 21: 484-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.106 BindingDB Entry DOI: 10.7270/Q2BZ6695
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372073 (CHEMBL256220) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CS(=O)(=O)NC(=O)Cc2cc(OC)ccc2OC)cc1 Show InChI InChI=1S/C33H34N2O8S/c1-5-42-31-25-9-7-8-10-26(25)32(43-6-2)30-27(31)19-35(33(30)37)23-13-11-21(12-14-23)20-44(38,39)34-29(36)18-22-17-24(40-3)15-16-28(22)41-4/h7-17H,5-6,18-20H2,1-4H3,(H,34,36)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.370	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50334133 ((S)-4-(1-(1-(4-(trifluoromethyl)benzyl)indoline-7-...) Show SMILES C[C@H](NC(=O)c1cccc2CCN(Cc3ccc(cc3)C(F)(F)F)c12)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C26H23F3N2O3/c1-16(18-7-9-20(10-8-18)25(33)34)30-24(32)22-4-2-3-19-13-14-31(23(19)22)15-17-5-11-21(12-6-17)26(27,28)29/h2-12,16H,13-15H2,1H3,(H,30,32)(H,33,34)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.370	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 21: 484-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.106 BindingDB Entry DOI: 10.7270/Q2BZ6695
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372075 (CHEMBL256183) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CS(=O)(=O)NC(=O)COc2ccccc2)cc1 Show InChI InChI=1S/C31H30N2O7S/c1-3-38-29-24-12-8-9-13-25(24)30(39-4-2)28-26(29)18-33(31(28)35)22-16-14-21(15-17-22)20-41(36,37)32-27(34)19-40-23-10-6-5-7-11-23/h5-17H,3-4,18-20H2,1-2H3,(H,32,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50319840 ((S)-4-(1-(1-(3-chloro-5-(trifluoromethoxy)benzyl)-...) Show SMILES C[C@H](NC(=O)c1cccc2ccn(Cc3cc(Cl)cc(OC(F)(F)F)c3)c12)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C26H20ClF3N2O4/c1-15(17-5-7-19(8-6-17)25(34)35)31-24(33)22-4-2-3-18-9-10-32(23(18)22)14-16-11-20(27)13-21(12-16)36-26(28,29)30/h2-13,15H,14H2,1H3,(H,31,33)(H,34,35)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Ltd Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 20: 3760-3 (2010) Article DOI: 10.1016/j.bmcl.2010.04.065 BindingDB Entry DOI: 10.7270/Q20P106K
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372063 (CHEMBL271095) Show SMILES COc1ccccc1CC(=O)NS(=O)(=O)Cc1ccc(N2Cc3c(C2=O)c(OCC(F)(F)F)c2cccnc2c3OCC(F)(F)F)c(C)c1 Show InChI InChI=1S/C32H27F6N3O7S/c1-18-12-19(15-49(44,45)40-25(42)13-20-6-3-4-8-24(20)46-2)9-10-23(18)41-14-22-26(30(41)43)28(47-16-31(33,34)35)21-7-5-11-39-27(21)29(22)48-17-32(36,37)38/h3-12H,13-17H2,1-2H3,(H,40,42)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Sigma intracellular receptor 2 (Rattus norvegicus (Rat))	BDBM50562182 (CHEMBL4744466) Show SMILES COc1cc2CCN(CCCCCC(=O)c3c(C)c(OC)c(OC)c(OC)c3OC)Cc2cc1OC Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.380	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of [125I]-RHM-4 from sigma 2 receptor in rat liver membranes after 120 mins by microbeta scintillation counting method				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112906 BindingDB Entry DOI: 10.7270/Q23T9MXS
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335992 (CHEMBL1669006 | N-(1-(4-(4,9-diethoxy-1-oxo-1H-ben...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2ccccc2C(F)(F)F)cc1C Show InChI InChI=1S/C35H34F3N3O6S/c1-4-46-30-23-10-6-7-11-24(23)31(47-5-2)29-25(30)20-41(32(29)42)27-15-14-22(18-21(27)3)19-34(16-17-34)39-33(43)40-48(44,45)28-13-9-8-12-26(28)35(36,37)38/h6-15,18H,4-5,16-17,19-20H2,1-3H3,(H2,39,40,43)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.390	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50334147 ((S)-4-(1-(5-chloro-1-(4-(trifluoromethyl)benzyl)in...) Show SMILES C[C@H](NC(=O)c1cc(Cl)cc2CCN(Cc3ccc(cc3)C(F)(F)F)c12)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C26H22ClF3N2O3/c1-15(17-4-6-18(7-5-17)25(34)35)31-24(33)22-13-21(27)12-19-10-11-32(23(19)22)14-16-2-8-20(9-3-16)26(28,29)30/h2-9,12-13,15H,10-11,14H2,1H3,(H,31,33)(H,34,35)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 21: 484-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.106 BindingDB Entry DOI: 10.7270/Q2BZ6695
					More data for this Ligand-Target Pair
Mu-type opioid receptor (Homo sapiens (Human))	BDBM50463297 (CHEMBL4246433) Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@](C)(C1)C(O)c1ccc(OC)cc1)ccc3OC |r,THB:10:9:17:5.6.4| Show InChI InChI=1S/C33H41NO5/c1-30(28(35)21-7-10-23(36-2)11-8-21)19-31-13-14-33(30,38-4)29-32(31)15-16-34(18-20-5-6-20)25(31)17-22-9-12-24(37-3)27(39-29)26(22)32/h7-12,20,25,28-29,35H,5-6,13-19H2,1-4H3/t25-,28?,29-,30-,31-,32+,33+/m1/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Displacement of [3H]DAMGO from human MOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysis				Bioorg Med Chem 26: 4254-4263 (2018) Article DOI: 10.1016/j.bmc.2018.07.020 BindingDB Entry DOI: 10.7270/Q28W3GZJ
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50463294 (CHEMBL4249256) Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@]51C[C@H](C(=O)c4ccccc4)[C@]2(OC)C=C1)ccc3OC |r,wU:16.16,1.0,wD:17.38,28.36,7.7,19.23,c:37,THB:10:9:17:5.6.4,(9.78,-11.07,;9.03,-9.74,;7.65,-10.81,;5.94,-9.74,;6.72,-8.4,;5.95,-7.07,;6.71,-5.74,;8.25,-5.74,;9.79,-5.74,;9.03,-4.41,;9.78,-3.07,;11.32,-3.05,;12.66,-3.81,;12.64,-2.27,;7.47,-5.14,;7.41,-7.18,;8.25,-8.41,;9.02,-7.07,;10.56,-7.06,;11.34,-8.4,;12.88,-8.4,;13.65,-7.07,;13.65,-9.73,;12.87,-11.06,;13.64,-12.4,;15.18,-12.4,;15.95,-11.05,;15.18,-9.72,;10.59,-9.7,;11.34,-11.07,;10.57,-12.41,;9.25,-8.93,;10.35,-7.84,;4.41,-7.06,;3.64,-8.38,;4.4,-9.72,;3.62,-11.05,;2.08,-11.04,)| Show InChI InChI=1S/C31H33NO4/c1-34-23-11-10-21-16-24-29-12-13-31(35-2,22(17-29)26(33)20-6-4-3-5-7-20)28-30(29,25(21)27(23)36-28)14-15-32(24)18-19-8-9-19/h3-7,10-13,19,22,24,28H,8-9,14-18H2,1-2H3/t22-,24-,28-,29-,30+,31-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Displacement of [3H]U69,593 from human KOR expressed in CHO cell membranes after 30 mins by liquid scintillation counting analysis				Bioorg Med Chem 26: 4254-4263 (2018) Article DOI: 10.1016/j.bmc.2018.07.020 BindingDB Entry DOI: 10.7270/Q28W3GZJ
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335999 (2,6-dimethyl-N-(1-(4-(4,9-diethoxy-1-oxo-1H-benzo[...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2c(C)cccc2C)cc1C Show InChI InChI=1S/C36H39N3O6S/c1-6-44-31-26-13-8-9-14-27(26)32(45-7-2)30-28(31)21-39(34(30)40)29-16-15-25(19-24(29)5)20-36(17-18-36)37-35(41)38-46(42,43)33-22(3)11-10-12-23(33)4/h8-16,19H,6-7,17-18,20-21H2,1-5H3,(H2,37,38,41)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50334128 ((S)-4-(1-(1-(3-(trifluoromethyl)benzyl)indoline-7-...) Show SMILES C[C@H](NC(=O)c1cccc2CCN(Cc3cccc(c3)C(F)(F)F)c12)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C26H23F3N2O3/c1-16(18-8-10-20(11-9-18)25(33)34)30-24(32)22-7-3-5-19-12-13-31(23(19)22)15-17-4-2-6-21(14-17)26(27,28)29/h2-11,14,16H,12-13,15H2,1H3,(H,30,32)(H,33,34)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 21: 484-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.106 BindingDB Entry DOI: 10.7270/Q2BZ6695
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50335998 (2,3-dichloro-N-(1-(4-(4,9-diethoxy-1-oxo-1H-benzo[...) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CC2(CC2)NC(=O)NS(=O)(=O)c2cccc(Cl)c2Cl)cc1C Show InChI InChI=1S/C34H33Cl2N3O6S/c1-4-44-30-22-9-6-7-10-23(22)31(45-5-2)28-24(30)19-39(32(28)40)26-14-13-21(17-20(26)3)18-34(15-16-34)37-33(41)38-46(42,43)27-12-8-11-25(35)29(27)36/h6-14,17H,4-5,15-16,18-19H2,1-3H3,(H2,37,38,41)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as PGE2-induced cAMP accumulation by scintillation proximity assay				Bioorg Med Chem Lett 21: 1041-6 (2011) Article DOI: 10.1016/j.bmcl.2010.12.014 BindingDB Entry DOI: 10.7270/Q2VH5P4H
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372077 (CHEMBL271070) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CS(=O)(=O)NC(=O)Cc2c(C)cc(C)cc2C)cc1 Show InChI InChI=1S/C34H36N2O6S/c1-6-41-32-26-10-8-9-11-27(26)33(42-7-2)31-29(32)19-36(34(31)38)25-14-12-24(13-15-25)20-43(39,40)35-30(37)18-28-22(4)16-21(3)17-23(28)5/h8-17H,6-7,18-20H2,1-5H3,(H,35,37)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372067 (CHEMBL270397) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2cccnc12)c1ccc(CS(=O)(=O)NC(=O)Cc2ccccc2C(F)(F)F)cc1C Show InChI InChI=1S/C32H30F3N3O6S/c1-4-43-29-22-10-8-14-36-28(22)30(44-5-2)23-17-38(31(40)27(23)29)25-13-12-20(15-19(25)3)18-45(41,42)37-26(39)16-21-9-6-7-11-24(21)32(33,34)35/h6-15H,4-5,16-18H2,1-3H3,(H,37,39)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50372071 (CHEMBL255529) Show SMILES CCOc1c2CN(C(=O)c2c(OCC)c2ccccc12)c1ccc(CS(=O)(=O)NC(=O)Cc2cccc3ccccc23)cc1 Show InChI InChI=1S/C35H32N2O6S/c1-3-42-33-28-14-7-8-15-29(28)34(43-4-2)32-30(33)21-37(35(32)39)26-18-16-23(17-19-26)22-44(40,41)36-31(38)20-25-12-9-11-24-10-5-6-13-27(24)25/h5-19H,3-4,20-22H2,1-2H3,(H,36,38)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.430	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Binding affinity to human EP4 receptor expressed in HEK293 cells				Bioorg Med Chem Lett 18: 2048-54 (2008) Article DOI: 10.1016/j.bmcl.2008.01.103 BindingDB Entry DOI: 10.7270/Q2J96770
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50334131 ((S)-4-(1-(1-(4-chlorobenzyl)indoline-7-carboxamido...) Show SMILES C[C@H](NC(=O)c1cccc2CCN(Cc3ccc(Cl)cc3)c12)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H23ClN2O3/c1-16(18-7-9-20(10-8-18)25(30)31)27-24(29)22-4-2-3-19-13-14-28(23(19)22)15-17-5-11-21(26)12-6-17/h2-12,16H,13-15H2,1H3,(H,27,29)(H,30,31)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.440	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 21: 484-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.106 BindingDB Entry DOI: 10.7270/Q2BZ6695
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50319838 ((S)-4-(1-(5-chloro-1-(4-(trifluoromethyl)benzyl)-1...) Show SMILES C[C@H](NC(=O)c1cc(Cl)cc2ccn(Cc3ccc(cc3)C(F)(F)F)c12)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C26H20ClF3N2O3/c1-15(17-4-6-18(7-5-17)25(34)35)31-24(33)22-13-21(27)12-19-10-11-32(23(19)22)14-16-2-8-20(9-3-16)26(28,29)30/h2-13,15H,14H2,1H3,(H,31,33)(H,34,35)/t15-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.440	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Ltd Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 20: 3760-3 (2010) Article DOI: 10.1016/j.bmcl.2010.04.065 BindingDB Entry DOI: 10.7270/Q20P106K
					More data for this Ligand-Target Pair
Prostaglandin E2 receptor EP4 subtype (Homo sapiens (Human))	BDBM50334127 ((S)-4-(1-(1-(3-chlorobenzyl)indoline-7-carboxamido...) Show SMILES C[C@H](NC(=O)c1cccc2CCN(Cc3cccc(Cl)c3)c12)c1ccc(cc1)C(O)=O |r| Show InChI InChI=1S/C25H23ClN2O3/c1-16(18-8-10-20(11-9-18)25(30)31)27-24(29)22-7-3-5-19-12-13-28(23(19)22)15-17-4-2-6-21(26)14-17/h2-11,14,16H,12-13,15H2,1H3,(H,27,29)(H,30,31)/t16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	0.440	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Canada Inc. Curated by ChEMBL					Assay Description Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting				Bioorg Med Chem Lett 21: 484-7 (2010) Article DOI: 10.1016/j.bmcl.2010.10.106 BindingDB Entry DOI: 10.7270/Q2BZ6695
					More data for this Ligand-Target Pair
Kappa-type opioid receptor (Homo sapiens (Human))	BDBM50506108 (CHEMBL4449252) Show SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@H](C1)c1ccc(NC(=O)c2ccccc2)cc1)ccc3OC |r,THB:10:9:17:4.5.6| Show InChI InChI=1S/C37H40N2O4/c1-41-29-15-12-26-20-30-35-16-17-37(42-2,34-36(35,31(26)32(29)43-34)18-19-39(30)22-23-8-9-23)28(21-35)24-10-13-27(14-11-24)38-33(40)25-6-4-3-5-7-25/h3-7,10-15,23,28,30,34H,8-9,16-22H2,1-2H3,(H,38,40)/t28-,30-,34-,35-,36+,37-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Fudan University Curated by ChEMBL					Assay Description Displacement of [3H]U69593 from human KOR expressed in CHO cell membranes incubated for 30 mins by liquid scintillation counting				J Med Chem 62: 11054-11070 (2019) Article DOI: 10.1021/acs.jmedchem.9b00857 BindingDB Entry DOI: 10.7270/Q2VD72RV
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 3222 total )  |  Next  |  Last  >>

Jump to: