Found 87 hits with Last Name = 'yamaguchi' and Initial = 'a' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305129
(6-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)Show SMILES NCCOc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H25N5O3/c27-13-15-33-21-11-6-17-12-14-31-26(29-22(17)16-21)23(25(28)32)24(30-31)18-7-9-20(10-8-18)34-19-4-2-1-3-5-19/h1-11,16,29H,12-15,27H2,(H2,28,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.300 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305140
(7-(2-aminoethoxy)-2-(4-phenoxyphenyl)-9,10-dihydro...)Show SMILES NCCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H25N5O3/c27-13-15-33-21-10-11-22-18(16-21)12-14-31-26(29-22)23(25(28)32)24(30-31)17-6-8-20(9-7-17)34-19-4-2-1-3-5-19/h1-11,16,29H,12-15,27H2,(H2,28,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.410 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305119
(7-(2-(dimethylamino)ethoxy)-2-(4-hydroxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(O)cc1 Show InChI InChI=1S/C22H25N5O3/c1-26(2)11-12-30-17-7-8-18-15(13-17)9-10-27-22(24-18)19(21(23)29)20(25-27)14-3-5-16(28)6-4-14/h3-8,13,24,28H,9-12H2,1-2H3,(H2,23,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.440 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305131
(6-(3-(dimethylamino)propoxy)-2-(4-phenoxyphenyl)-9...)Show SMILES CN(C)CCCOc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C29H31N5O3/c1-33(2)16-6-18-36-24-14-9-20-15-17-34-29(31-25(20)19-24)26(28(30)35)27(32-34)21-10-12-23(13-11-21)37-22-7-4-3-5-8-22/h3-5,7-14,19,31H,6,15-18H2,1-2H3,(H2,30,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.510 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305139
(6-(2-(4-methylpiperazin-1-yl)ethoxy)-2-(4-phenoxyp...)Show SMILES CN1CCN(CCOc2ccc3CCn4nc(c(C(N)=O)c4Nc3c2)-c2ccc(Oc3ccccc3)cc2)CC1 Show InChI InChI=1S/C31H34N6O3/c1-35-15-17-36(18-16-35)19-20-39-26-12-7-22-13-14-37-31(33-27(22)21-26)28(30(32)38)29(34-37)23-8-10-25(11-9-23)40-24-5-3-2-4-6-24/h2-12,21,33H,13-20H2,1H3,(H2,32,38) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.550 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305117
(7-(2-morpholinoethoxy)-2-(4-phenoxyphenyl)-9,10-di...)Show SMILES NC(=O)c1c2Nc3ccc(OCCN4CCOCC4)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H31N5O4/c31-29(36)27-28(21-6-8-24(9-7-21)39-23-4-2-1-3-5-23)33-35-13-12-22-20-25(10-11-26(22)32-30(27)35)38-19-16-34-14-17-37-18-15-34/h1-11,20,32H,12-19H2,(H2,31,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.560 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of SRC |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.720 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305142
(7-(2-hydroxyethoxy)-2-(4-phenoxyphenyl)-9,10-dihyd...)Show SMILES NC(=O)c1c2Nc3ccc(OCCO)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H24N4O4/c27-25(32)23-24(17-6-8-20(9-7-17)34-19-4-2-1-3-5-19)29-30-13-12-18-16-21(33-15-14-31)10-11-22(18)28-26(23)30/h1-11,16,28,31H,12-15H2,(H2,27,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.75 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305138
(6-(2-morpholinoethoxy)-2-(4-phenoxyphenyl)-9,10-di...)Show SMILES NC(=O)c1c2Nc3cc(OCCN4CCOCC4)ccc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H31N5O4/c31-29(36)27-28(22-7-9-24(10-8-22)39-23-4-2-1-3-5-23)33-35-13-12-21-6-11-25(20-26(21)32-30(27)35)38-19-16-34-14-17-37-18-15-34/h1-11,20,32H,12-19H2,(H2,31,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.770 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305121
(7-(2-(dimethylamino)ethoxy)-2-(4-(phenylamino)phen...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Nc2ccccc2)cc1 Show InChI InChI=1S/C28H30N6O2/c1-33(2)16-17-36-23-12-13-24-20(18-23)14-15-34-28(31-24)25(27(29)35)26(32-34)19-8-10-22(11-9-19)30-21-6-4-3-5-7-21/h3-13,18,30-31H,14-17H2,1-2H3,(H2,29,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305125
(2-(4-(3-(2,6-dichlorophenyl)ureido)phenyl)-7-(2-(d...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(NC(=O)Nc2c(Cl)cccc2Cl)cc1 Show InChI InChI=1S/C29H29Cl2N7O3/c1-37(2)14-15-41-20-10-11-23-18(16-20)12-13-38-28(34-23)24(27(32)39)25(36-38)17-6-8-19(9-7-17)33-29(40)35-26-21(30)4-3-5-22(26)31/h3-11,16,34H,12-15H2,1-2H3,(H2,32,39)(H2,33,35,40) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.940 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305141
(7-(3-(dimethylamino)propoxy)-2-(4-phenoxyphenyl)-9...)Show SMILES CN(C)CCCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C29H31N5O3/c1-33(2)16-6-18-36-24-13-14-25-21(19-24)15-17-34-29(31-25)26(28(30)35)27(32-34)20-9-11-23(12-10-20)37-22-7-4-3-5-8-22/h3-5,7-14,19,31H,6,15-18H2,1-2H3,(H2,30,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305135
(2-(3-carbamoyl-2-(4-phenoxyphenyl)-9,10-dihydro-4H...)Show SMILES NC(=O)c1c2Nc3cc(OCC(O)=O)ccc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H22N4O5/c27-25(33)23-24(17-7-9-19(10-8-17)35-18-4-2-1-3-5-18)29-30-13-12-16-6-11-20(34-15-22(31)32)14-21(16)28-26(23)30/h1-11,14,28H,12-13,15H2,(H2,27,33)(H,31,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305122
(2-(4-(2,6-dichlorobenzylamino)phenyl)-7-(2-(dimeth...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(NCc2c(Cl)cccc2Cl)cc1 Show InChI InChI=1S/C29H30Cl2N6O2/c1-36(2)14-15-39-21-10-11-25-19(16-21)12-13-37-29(34-25)26(28(32)38)27(35-37)18-6-8-20(9-7-18)33-17-22-23(30)4-3-5-24(22)31/h3-11,16,33-34H,12-15,17H2,1-2H3,(H2,32,38) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305118
(7-(2-(4-methylpiperazin-1-yl)ethoxy)-2-(4-phenoxyp...)Show SMILES CN1CCN(CCOc2ccc3Nc4c(C(N)=O)c(nn4CCc3c2)-c2ccc(Oc3ccccc3)cc2)CC1 Show InChI InChI=1S/C31H34N6O3/c1-35-15-17-36(18-16-35)19-20-39-26-11-12-27-23(21-26)13-14-37-31(33-27)28(30(32)38)29(34-37)22-7-9-25(10-8-22)40-24-5-3-2-4-6-24/h2-12,21,33H,13-20H2,1H3,(H2,32,38) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305143
(7-(2-amino-2-oxoethoxy)-2-(4-phenoxyphenyl)-9,10-d...)Show SMILES NC(=O)COc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H23N5O4/c27-22(32)15-34-20-10-11-21-17(14-20)12-13-31-26(29-21)23(25(28)33)24(30-31)16-6-8-19(9-7-16)35-18-4-2-1-3-5-18/h1-11,14,29H,12-13,15H2,(H2,27,32)(H2,28,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305130
(6-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-13-8-19-14-15-33-28(30-24(19)18-23)25(27(29)34)26(31-33)20-9-11-22(12-10-20)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305132
(6-(2-hydroxyethoxy)-2-(4-phenoxyphenyl)-9,10-dihyd...)Show SMILES NC(=O)c1c2Nc3cc(OCCO)ccc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H24N4O4/c27-25(32)23-24(18-7-9-20(10-8-18)34-19-4-2-1-3-5-19)29-30-13-12-17-6-11-21(33-15-14-31)16-22(17)28-26(23)30/h1-11,16,28,31H,12-15H2,(H2,27,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305134
(6-(2-amino-2-oxoethoxy)-2-(4-phenoxyphenyl)-9,10-d...)Show SMILES NC(=O)COc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C26H23N5O4/c27-22(32)15-34-20-11-6-16-12-13-31-26(29-21(16)14-20)23(25(28)33)24(30-31)17-7-9-19(10-8-17)35-18-4-2-1-3-5-18/h1-11,14,29H,12-13,15H2,(H2,27,32)(H2,28,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase CSK
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of Csk |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305123
(CHEMBL595625 | benzyl 4-(3-carbamoyl-7-(2-(dimethy...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(NC(=O)OCc2ccccc2)cc1 Show InChI InChI=1S/C30H32N6O4/c1-35(2)16-17-39-24-12-13-25-22(18-24)14-15-36-29(33-25)26(28(31)37)27(34-36)21-8-10-23(11-9-21)32-30(38)40-19-20-6-4-3-5-7-20/h3-13,18,33H,14-17,19H2,1-2H3,(H2,31,37)(H,32,38) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305128
(7-methoxy-2-(4-phenoxyphenyl)-9,10-dihydro-4H-benz...)Show SMILES COc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C25H22N4O3/c1-31-20-11-12-21-17(15-20)13-14-29-25(27-21)22(24(26)30)23(28-29)16-7-9-19(10-8-16)32-18-5-3-2-4-6-18/h2-12,15,27H,13-14H2,1H3,(H2,26,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305124
(7-(2-(dimethylamino)ethoxy)-2-(4-(3-phenylureido)p...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(NC(=O)Nc2ccccc2)cc1 Show InChI InChI=1S/C29H31N7O3/c1-35(2)16-17-39-23-12-13-24-20(18-23)14-15-36-28(33-24)25(27(30)37)26(34-36)19-8-10-22(11-9-19)32-29(38)31-21-6-4-3-5-7-21/h3-13,18,33H,14-17H2,1-2H3,(H2,30,37)(H2,31,32,38) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305145
(2-(4-phenoxyphenyl)-7-(pyridin-3-ylmethoxy)-9,10-d...)Show SMILES NC(=O)c1c2Nc3ccc(OCc4cccnc4)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H25N5O3/c31-29(36)27-28(21-8-10-24(11-9-21)38-23-6-2-1-3-7-23)34-35-16-14-22-17-25(12-13-26(22)33-30(27)35)37-19-20-5-4-15-32-18-20/h1-13,15,17-18,33H,14,16,19H2,(H2,31,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305136
(6-(2-oxopropoxy)-2-(4-phenoxyphenyl)-9,10-dihydro-...)Show SMILES CC(=O)COc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C27H24N4O4/c1-17(32)16-34-22-12-7-18-13-14-31-27(29-23(18)15-22)24(26(28)33)25(30-31)19-8-10-21(11-9-19)35-20-5-3-2-4-6-20/h2-12,15,29H,13-14,16H2,1H3,(H2,28,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305120
(2-(4-aminophenyl)-7-(2-(dimethylamino)ethoxy)-9,10...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(N)cc1 Show InChI InChI=1S/C22H26N6O2/c1-27(2)11-12-30-17-7-8-18-15(13-17)9-10-28-22(25-18)19(21(24)29)20(26-28)14-3-5-16(23)6-4-14/h3-8,13,25H,9-12,23H2,1-2H3,(H2,24,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase CSK
(Homo sapiens (Human)) | BDBM50305146
(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)Show SMILES NC(=O)c1c(N)c([nH]c1-c1ccc(Oc2ccccc2)cc1)C(=O)c1c(F)cccc1F Show InChI InChI=1S/C24H17F2N3O3/c25-16-7-4-8-17(26)18(16)23(30)22-20(27)19(24(28)31)21(29-22)13-9-11-15(12-10-13)32-14-5-2-1-3-6-14/h1-12,29H,27H2,(H2,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of Csk |
Bioorg Med Chem Lett 20: 108-11 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.014 BindingDB Entry DOI: 10.7270/Q2Z60P5W |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305127
(6-methoxy-2-(4-phenoxyphenyl)-9,10-dihydro-4H-benz...)Show SMILES COc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C25H22N4O3/c1-31-20-12-7-16-13-14-29-25(27-21(16)15-20)22(24(26)30)23(28-29)17-8-10-19(11-9-17)32-18-5-3-2-4-6-18/h2-12,15,27H,13-14H2,1H3,(H2,26,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305144
(2-(4-phenoxyphenyl)-7-(pyridin-2-ylmethoxy)-9,10-d...)Show SMILES NC(=O)c1c2Nc3ccc(OCc4ccccn4)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H25N5O3/c31-29(36)27-28(20-9-11-24(12-10-20)38-23-7-2-1-3-8-23)34-35-17-15-21-18-25(13-14-26(21)33-30(27)35)37-19-22-6-4-5-16-32-22/h1-14,16,18,33H,15,17,19H2,(H2,31,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305137
(2-(4-phenoxyphenyl)-6-(pyridin-3-ylmethoxy)-9,10-d...)Show SMILES NC(=O)c1c2Nc3cc(OCc4cccnc4)ccc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H25N5O3/c31-29(36)27-28(22-9-11-24(12-10-22)38-23-6-2-1-3-7-23)34-35-16-14-21-8-13-25(17-26(21)33-30(27)35)37-19-20-5-4-15-32-18-20/h1-13,15,17-18,33H,14,16,19H2,(H2,31,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305116
(2-(4-phenoxyphenyl)-7-(pyridin-4-ylmethoxy)-9,10-d...)Show SMILES NC(=O)c1c2Nc3ccc(OCc4ccncc4)cc3CCn2nc1-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H25N5O3/c31-29(36)27-28(21-6-8-24(9-7-21)38-23-4-2-1-3-5-23)34-35-17-14-22-18-25(10-11-26(22)33-30(27)35)37-19-20-12-15-32-16-13-20/h1-13,15-16,18,33H,14,17,19H2,(H2,31,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Homo sapiens (Human)) | BDBM50305146
(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)Show SMILES NC(=O)c1c(N)c([nH]c1-c1ccc(Oc2ccccc2)cc1)C(=O)c1c(F)cccc1F Show InChI InChI=1S/C24H17F2N3O3/c25-16-7-4-8-17(26)18(16)23(30)22-20(27)19(24(28)31)21(29-22)13-9-11-15(12-10-13)32-14-5-2-1-3-6-14/h1-12,29H,27H2,(H2,28,31) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of Src |
Bioorg Med Chem Lett 20: 108-11 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.014 BindingDB Entry DOI: 10.7270/Q2Z60P5W |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase Lck
(Homo sapiens (Human)) | BDBM50305133
(6-(4-methylpentyloxy)-2-(4-phenoxyphenyl)-9,10-dih...)Show SMILES CC(C)CCCOc1ccc2CCn3nc(c(C(N)=O)c3Nc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C30H32N4O3/c1-20(2)7-6-18-36-25-15-10-21-16-17-34-30(32-26(21)19-25)27(29(31)35)28(33-34)22-11-13-24(14-12-22)37-23-8-4-3-5-9-23/h3-5,8-15,19-20,32H,6-7,16-18H2,1-2H3,(H2,31,35) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >100 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of GST-tagged human LCK by scintillation counting |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
fMet-Leu-Phe receptor
(Homo sapiens (Human)) | BDBM50051610
(CHEMBL3311300)Show SMILES CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(cc1)C(=O)c1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r,t:10| Show InChI InChI=1S/C51H67N5O9/c1-32(2)27-39(53-48(61)42(56-50(64)65-51(5,6)7)30-36-23-25-38(26-24-36)44(57)37-21-15-10-16-22-37)45(58)54-41(29-34-17-11-8-12-18-34)47(60)52-40(28-33(3)4)46(59)55-43(49(62)63)31-35-19-13-9-14-20-35/h9-10,13-17,19-26,32-33,39-43H,8,11-12,18,27-31H2,1-7H3,(H,52,60)(H,53,61)(H,54,58)(H,55,59)(H,56,64)(H,62,63)/t39-,40-,41+,42+,43+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Saga University
Curated by ChEMBL
| Assay Description Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins p... |
Bioorg Med Chem 22: 3824-8 (2014)
Article DOI: 10.1016/j.bmc.2014.06.048 BindingDB Entry DOI: 10.7270/Q28S4RK8 |
More data for this Ligand-Target Pair | |
fMet-Leu-Phe receptor
(Homo sapiens (Human)) | BDBM50051690
(CHEMBL3311137)Show SMILES CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(cc1)C(=O)c1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C51H63N5O9/c1-32(2)27-39(53-48(61)42(56-50(64)65-51(5,6)7)30-36-23-25-38(26-24-36)44(57)37-21-15-10-16-22-37)45(58)54-41(29-34-17-11-8-12-18-34)47(60)52-40(28-33(3)4)46(59)55-43(49(62)63)31-35-19-13-9-14-20-35/h8-26,32-33,39-43H,27-31H2,1-7H3,(H,52,60)(H,53,61)(H,54,58)(H,55,59)(H,56,64)(H,62,63)/t39-,40-,41+,42+,43+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Saga University
Curated by ChEMBL
| Assay Description Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins p... |
Bioorg Med Chem 22: 3824-8 (2014)
Article DOI: 10.1016/j.bmc.2014.06.048 BindingDB Entry DOI: 10.7270/Q28S4RK8 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of Zap70 |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
fMet-Leu-Phe receptor
(Homo sapiens (Human)) | BDBM50051608
(CHEMBL3311030)Show SMILES CC(C)C[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C44H59N5O8/c1-28(2)23-33(46-41(53)36(26-31-19-13-9-14-20-31)49-43(56)57-44(5,6)7)38(50)47-35(25-30-17-11-8-12-18-30)40(52)45-34(24-29(3)4)39(51)48-37(42(54)55)27-32-21-15-10-16-22-32/h8-22,28-29,33-37H,23-27H2,1-7H3,(H,45,52)(H,46,53)(H,47,50)(H,48,51)(H,49,56)(H,54,55)/t33-,34-,35+,36+,37+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Saga University
Curated by ChEMBL
| Assay Description Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of fMLP-induced calcium mobilization incubated for 5 mins p... |
Bioorg Med Chem 22: 3824-8 (2014)
Article DOI: 10.1016/j.bmc.2014.06.048 BindingDB Entry DOI: 10.7270/Q28S4RK8 |
More data for this Ligand-Target Pair | |
Protein kinase C alpha type
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of PKCalpha |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of MEK1 |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of PKBalpha |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Calcium/calmodulin-dependent protein kinase type IV
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of CamK4 |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Homo sapiens (Human)) | BDBM50305126
(7-(2-(dimethylamino)ethoxy)-2-(4-phenoxyphenyl)-9,...)Show SMILES CN(C)CCOc1ccc2Nc3c(C(N)=O)c(nn3CCc2c1)-c1ccc(Oc2ccccc2)cc1 Show InChI InChI=1S/C28H29N5O3/c1-32(2)16-17-35-23-12-13-24-20(18-23)14-15-33-28(30-24)25(27(29)34)26(31-33)19-8-10-22(11-9-19)36-21-6-4-3-5-7-21/h3-13,18,30H,14-17H2,1-2H3,(H2,29,34) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of MAPK1 |
Bioorg Med Chem Lett 20: 112-6 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.013 BindingDB Entry DOI: 10.7270/Q22Z15NV |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ZAP-70
(Homo sapiens (Human)) | BDBM50305146
(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)Show SMILES NC(=O)c1c(N)c([nH]c1-c1ccc(Oc2ccccc2)cc1)C(=O)c1c(F)cccc1F Show InChI InChI=1S/C24H17F2N3O3/c25-16-7-4-8-17(26)18(16)23(30)22-20(27)19(24(28)31)21(29-22)13-9-11-15(12-10-13)32-14-5-2-1-3-6-14/h1-12,29H,27H2,(H2,28,31) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ZAP70 |
Bioorg Med Chem Lett 20: 108-11 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.014 BindingDB Entry DOI: 10.7270/Q2Z60P5W |
More data for this Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 1
(Homo sapiens (Human)) | BDBM50305146
(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)Show SMILES NC(=O)c1c(N)c([nH]c1-c1ccc(Oc2ccccc2)cc1)C(=O)c1c(F)cccc1F Show InChI InChI=1S/C24H17F2N3O3/c25-16-7-4-8-17(26)18(16)23(30)22-20(27)19(24(28)31)21(29-22)13-9-11-15(12-10-13)32-14-5-2-1-3-6-14/h1-12,29H,27H2,(H2,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of MEK1 |
Bioorg Med Chem Lett 20: 108-11 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.014 BindingDB Entry DOI: 10.7270/Q2Z60P5W |
More data for this Ligand-Target Pair | |
RAC-alpha serine/threonine-protein kinase
(Homo sapiens (Human)) | BDBM50305146
(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)Show SMILES NC(=O)c1c(N)c([nH]c1-c1ccc(Oc2ccccc2)cc1)C(=O)c1c(F)cccc1F Show InChI InChI=1S/C24H17F2N3O3/c25-16-7-4-8-17(26)18(16)23(30)22-20(27)19(24(28)31)21(29-22)13-9-11-15(12-10-13)32-14-5-2-1-3-6-14/h1-12,29H,27H2,(H2,28,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of PKB |
Bioorg Med Chem Lett 20: 108-11 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.014 BindingDB Entry DOI: 10.7270/Q2Z60P5W |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Homo sapiens (Human)) | BDBM50305146
(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)Show SMILES NC(=O)c1c(N)c([nH]c1-c1ccc(Oc2ccccc2)cc1)C(=O)c1c(F)cccc1F Show InChI InChI=1S/C24H17F2N3O3/c25-16-7-4-8-17(26)18(16)23(30)22-20(27)19(24(28)31)21(29-22)13-9-11-15(12-10-13)32-14-5-2-1-3-6-14/h1-12,29H,27H2,(H2,28,31) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of Abl |
Bioorg Med Chem Lett 20: 108-11 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.014 BindingDB Entry DOI: 10.7270/Q2Z60P5W |
More data for this Ligand-Target Pair | |
Cyclin-dependent kinase 1
(Homo sapiens (Human)) | BDBM50305146
(4-amino-5-(2,6-difluorobenzoyl)-2-(4-phenoxyphenyl...)Show SMILES NC(=O)c1c(N)c([nH]c1-c1ccc(Oc2ccccc2)cc1)C(=O)c1c(F)cccc1F Show InChI InChI=1S/C24H17F2N3O3/c25-16-7-4-8-17(26)18(16)23(30)22-20(27)19(24(28)31)21(29-22)13-9-11-15(12-10-13)32-14-5-2-1-3-6-14/h1-12,29H,27H2,(H2,28,31) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Taisho Pharmaceutical Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of CDK1 |
Bioorg Med Chem Lett 20: 108-11 (2010)
Article DOI: 10.1016/j.bmcl.2009.11.014 BindingDB Entry DOI: 10.7270/Q2Z60P5W |
More data for this Ligand-Target Pair | |
fMet-Leu-Phe receptor
(Homo sapiens (Human)) | BDBM50051609
(CHEMBL3311301)Show SMILES CC(C)C[C@@H](NC(=O)[C@H](CC1=CCCCC1)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(cc1)C(=O)c1ccccc1)NC(=O)OC(C)(C)C)C(=O)N[C@@H](CC1CCCCC1)C(O)=O |r,t:10| Show InChI InChI=1S/C51H73N5O9/c1-32(2)27-39(53-48(61)42(56-50(64)65-51(5,6)7)30-36-23-25-38(26-24-36)44(57)37-21-15-10-16-22-37)45(58)54-41(29-34-17-11-8-12-18-34)47(60)52-40(28-33(3)4)46(59)55-43(49(62)63)31-35-19-13-9-14-20-35/h10,15-17,21-26,32-33,35,39-43H,8-9,11-14,18-20,27-31H2,1-7H3,(H,52,60)(H,53,61)(H,54,58)(H,55,59)(H,56,64)(H,62,63)/t39-,40-,41+,42+,43+/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | 6.90 | n/a | n/a | n/a | n/a | n/a |
Saga University
Curated by ChEMBL
| Assay Description Antagonist activity at formyl peptide receptor in human HL60 cells assessed as inhibition of intracellular calcium mobilization incubated for 5 mins ... |
Bioorg Med Chem 22: 3824-8 (2014)
Article DOI: 10.1016/j.bmc.2014.06.048 BindingDB Entry DOI: 10.7270/Q28S4RK8 |
More data for this Ligand-Target Pair | |