Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258546 (CHEMBL4087727) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Non-competitive inhibition of recombinant human N-terminal GST-tagged WNK1 (1 to 491 residues) expressed in baculovirus expression system using fluor... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [166-489] (Homo sapiens (Human)) | BDBM203827 (N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | 7.3 | 25 |
Novartis Institutes | Assay Description Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ... | Nat Chem Biol 12: 896-898 (2016) Article DOI: 10.1038/nchembio.2168 BindingDB Entry DOI: 10.7270/Q2ZK5FH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50344367 (1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(7-hydrox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd Curated by ChEMBL | Assay Description Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... | Bioorg Med Chem Lett 22: 3408-11 (2012) Article DOI: 10.1016/j.bmcl.2012.03.108 BindingDB Entry DOI: 10.7270/Q2C24XF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50382237 (CHEMBL2024668) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd Curated by ChEMBL | Assay Description Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... | Bioorg Med Chem Lett 22: 3408-11 (2012) Article DOI: 10.1016/j.bmcl.2012.03.108 BindingDB Entry DOI: 10.7270/Q2C24XF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50382237 (CHEMBL2024668) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd Curated by ChEMBL | Assay Description Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... | Bioorg Med Chem Lett 22: 3408-11 (2012) Article DOI: 10.1016/j.bmcl.2012.03.108 BindingDB Entry DOI: 10.7270/Q2C24XF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50160523 (1-Benzyl-2-[2-(3-tert-butyl-ureido)-ethyl]-1H-benz...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration of the compound towards rat leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 805-7 (2005) Article DOI: 10.1016/j.bmcl.2004.10.090 BindingDB Entry DOI: 10.7270/Q27M07D8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258566 (CHEMBL4088706) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of recombinant human N-terminal GST-tagged WNK1 catalytic domain (1 to 491 residues) expressed in baculovirus expression system... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50160523 (1-Benzyl-2-[2-(3-tert-butyl-ureido)-ethyl]-1H-benz...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration of the compound towards human leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 805-7 (2005) Article DOI: 10.1016/j.bmcl.2004.10.090 BindingDB Entry DOI: 10.7270/Q27M07D8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [1-491] (Homo sapiens (Human)) | BDBM203827 (N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 5 | n/a | n/a | n/a | n/a | 7.3 | 25 |
Novartis Institutes | Assay Description Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ... | Nat Chem Biol 12: 896-898 (2016) Article DOI: 10.1038/nchembio.2168 BindingDB Entry DOI: 10.7270/Q2ZK5FH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 (Homo sapiens (Human)) | BDBM50258547 (CHEMBL4098876) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. , Cambridge, Massachusetts 02139-4133, United States. Curated by ChEMBL | Assay Description Allosteric inhibition of WNK1 (unknown origin) expressed in HEK293 cells co-expressing flag-OSR1 assessed as reduction in sorbitol-stimulated OSR1 ph... | J Med Chem 60: 7099-7107 (2017) Article DOI: 10.1021/acs.jmedchem.7b00708 BindingDB Entry DOI: 10.7270/Q29W0HXP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585716 (8-chloro-1-(2,6-dichlorophenyl)-5- ((2-(2-(2-(2- h...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [1-434] (Homo sapiens (Human)) | BDBM203827 (N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.3 | 25 |
Novartis Institutes | Assay Description Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ... | Nat Chem Biol 12: 896-898 (2016) Article DOI: 10.1038/nchembio.2168 BindingDB Entry DOI: 10.7270/Q2ZK5FH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585717 (8-chloro-1-(2,6-dichlorophenyl)-5- (2,3-dihydroxyp...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585715 (N-(2-((8-chloro-1-(2,6- dichlorophenyl)-2-methyl-4...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585727 (8-chloro-1-(2,6-dichlorophenyl)-5- (2-hydroxyethox...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase WNK1 [1-444] (Homo sapiens (Human)) | BDBM203827 (N-(tert-butyl)-1-(1-(5-(5-(trifluoromethyl)-1,3,4-...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.3 | 25 |
Novartis Institutes | Assay Description Each well of the MBP-coated ScintiPlates held 100 ul of a solution containing 20 mM HEPES pH 7.3, 5 mM MnCl2 (WNK1 and WNK4) or 3 mM MnCl2 (WNK2 and ... | Nat Chem Biol 12: 896-898 (2016) Article DOI: 10.1038/nchembio.2168 BindingDB Entry DOI: 10.7270/Q2ZK5FH5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50382245 (CHEMBL2024494) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd Curated by ChEMBL | Assay Description Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... | Bioorg Med Chem Lett 22: 3408-11 (2012) Article DOI: 10.1016/j.bmcl.2012.03.108 BindingDB Entry DOI: 10.7270/Q2C24XF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585729 (8-chloro-1-(2,6-dichlorophenyl)-2- methyl-5-(oxeta...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50160511 (1-Benzyl-2-[2-(3-tert-butyl-ureido)-ethyl]-1H-benz...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration of the compound towards rat leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 805-7 (2005) Article DOI: 10.1016/j.bmcl.2004.10.090 BindingDB Entry DOI: 10.7270/Q27M07D8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585719 (8-chloro-1-(2,6-chlorophenyl)-5- (2,3-dihydroxy-3-...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585741 (US11530213, Example 62) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585738 (US11530213, Example 59) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50160515 (1-Benzyl-2-[2-(3-tert-butyl-ureido)-ethyl]-1H-benz...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration of the compound towards rat leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 805-7 (2005) Article DOI: 10.1016/j.bmcl.2004.10.090 BindingDB Entry DOI: 10.7270/Q27M07D8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585718 ((S)-8-chloro-1-(2,6- dichlorophenyl)-5-((2,3- dihy...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585721 (8-chloro-1-(2,6-dichlorophenyl)-5- (2-hydroxy-2-me...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585742 (US11530213, Example 63) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50382240 (CHEMBL2024667) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd Curated by ChEMBL | Assay Description Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... | Bioorg Med Chem Lett 22: 3408-11 (2012) Article DOI: 10.1016/j.bmcl.2012.03.108 BindingDB Entry DOI: 10.7270/Q2C24XF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585737 (US11530213, Example 58) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Transient receptor potential cation channel subfamily V member 1 (Homo sapiens (Human)) | BDBM50382243 (CHEMBL2024492) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Bayer Yakuhin, Ltd Curated by ChEMBL | Assay Description Antagonist activity at human TRPV1 expressed in CHOluc9aeq cells assessed as inhibition of capsaicin-stimulated response by aequorin and CRE-lucifear... | Bioorg Med Chem Lett 22: 3408-11 (2012) Article DOI: 10.1016/j.bmcl.2012.03.108 BindingDB Entry DOI: 10.7270/Q2C24XF7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesteryl ester transfer protein (Homo sapiens (Human)) | BDBM50312718 (CHEMBL479527 | torcetrapib) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. Curated by ChEMBL | Assay Description Inhibition of CETP in human plasma measured every 30 mins for 120 mins by fluorescence method | J Med Chem 60: 8466-8481 (2017) Article DOI: 10.1021/acs.jmedchem.7b00900 BindingDB Entry DOI: 10.7270/Q27083WQ | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Cholesteryl ester transfer protein (Homo sapiens (Human)) | BDBM50348228 (CHEMBL1800807) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research, Inc. Curated by ChEMBL | Assay Description Inhibition of CETP in human plasma measured every 30 mins for 120 mins by fluorescence method | J Med Chem 60: 8466-8481 (2017) Article DOI: 10.1021/acs.jmedchem.7b00900 BindingDB Entry DOI: 10.7270/Q27083WQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50165518 (1-tert-Butyl-3-[2-(2-methoxy-5-nitro-benzylsulfany...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration against human leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 2265-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.030 BindingDB Entry DOI: 10.7270/Q2GB23K1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585764 (US11530213, Example 85) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50165530 (6-(3-tert-Butyl-ureido)-2-(2-methoxy-5-nitro-benzy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration against rat leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 2265-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.030 BindingDB Entry DOI: 10.7270/Q2GB23K1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50160511 (1-Benzyl-2-[2-(3-tert-butyl-ureido)-ethyl]-1H-benz...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration of the compound towards human leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 805-7 (2005) Article DOI: 10.1016/j.bmcl.2004.10.090 BindingDB Entry DOI: 10.7270/Q27M07D8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesteryl ester transfer protein (Homo sapiens (Human)) | BDBM124871 (US8759365, 9-4 | US8759365, 9-5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 21 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Novartis AG US Patent | Assay Description CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #... | US Patent US8759365 (2014) BindingDB Entry DOI: 10.7270/Q2NG4P95 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50165538 (6-(3-tert-Butyl-ureido)-2-(2-methoxy-5-nitro-benzy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration against human leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 2265-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.030 BindingDB Entry DOI: 10.7270/Q2GB23K1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50165553 (6-(3-tert-Butyl-ureido)-2-(2-methoxy-5-nitro-benzy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration against rat leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 2265-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.030 BindingDB Entry DOI: 10.7270/Q2GB23K1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50160515 (1-Benzyl-2-[2-(3-tert-butyl-ureido)-ethyl]-1H-benz...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration of the compound towards human leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 805-7 (2005) Article DOI: 10.1016/j.bmcl.2004.10.090 BindingDB Entry DOI: 10.7270/Q27M07D8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585760 (US11530213, Example 81) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesteryl ester transfer protein (Homo sapiens (Human)) | BDBM124882 (US8759365, 6) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Novartis AG US Patent | Assay Description CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #... | US Patent US8759365 (2014) BindingDB Entry DOI: 10.7270/Q2NG4P95 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50165539 (1-tert-Butyl-3-[1-butyl-2-(2-methoxy-5-nitro-benzy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration against human leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 2265-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.030 BindingDB Entry DOI: 10.7270/Q2GB23K1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50165528 (6-(3-tert-Butyl-ureido)-2-(2-methoxy-5-nitro-benzy...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration against rat leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 2265-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.030 BindingDB Entry DOI: 10.7270/Q2GB23K1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585768 (US11530213, Example 89) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585694 (5-(2,5,8,11,14,17- hexaoxanonadecan-19-yloxy)-8- c...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585709 (8-chloro-1-(2,6-dichlorophenyl)-5- (2-(2-(2-(2- hy...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cholesteryl ester transfer protein (Homo sapiens (Human)) | BDBM124884 (US8759365, 16-2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 25 | n/a | n/a | n/a | n/a | 7.4 | 37 |
Novartis AG US Patent | Assay Description CETP Activity Kit (#RB-RPAK) was purchased from Roar Biochemical, Inc. (New York, N.Y., USA). To each well of a 96-well NBS half-area plate (costar #... | US Patent US8759365 (2014) BindingDB Entry DOI: 10.7270/Q2NG4P95 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585722 (3,5-dichloro-4-(8-chloro-5- (((3R,4S)-4- hydroxyte...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50165533 (6-(3-tert-Butyl-ureido)-2-(2-methoxy-5-nitro-benzy...) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
Kyoto 619-0216 Curated by ChEMBL | Assay Description Inhibitory concentration against human leutinizing releasing hormone receptor | Bioorg Med Chem Lett 15: 2265-9 (2005) Article DOI: 10.1016/j.bmcl.2005.03.030 BindingDB Entry DOI: 10.7270/Q2GB23K1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
G protein-activated inward rectifier potassium channel 1/4 (Homo sapiens (Human)) | BDBM585720 (8-chloro-1-(2,6-dichlorophenyl)-5- (3-hydroxy-2-(h...) | PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Quattro is controlled using IonWorks v2 software to perform the following steps:a. Add 3.5 ul cells plus 3.5 ul external buffer to wells of Quattro P... | Citation and Details BindingDB Entry DOI: 10.7270/Q2K64NXF | |||||||||||
More data for this Ligand-Target Pair |
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