Found 427 hits with Last Name = 'zhou' and Initial = 'yb' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human)) | BDBM50347243
(CHEMBL1795950)Show SMILES CC(C)(C)OC(=O)N[C@@H](COCc1cn(nn1)[C@@H]1O[C@H](COCc2ccccc2)[C@@H](OCc2ccccc2)[C@H](OCc2ccccc2)[C@H]1OCc1ccccc1)C(O)=O |r| Show InChI InChI=1S/C45H52N4O10/c1-45(2,3)59-44(52)46-37(43(50)51)30-54-29-36-24-49(48-47-36)42-41(57-28-35-22-14-7-15-23-35)40(56-27-34-20-12-6-13-21-34)39(55-26-33-18-10-5-11-19-33)38(58-42)31-53-25-32-16-8-4-9-17-32/h4-24,37-42H,25-31H2,1-3H3,(H,46,52)(H,50,51)/t37-,38+,39+,40-,41+,42+/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | 6.5 | n/a |
East China University of Science and Technology
Curated by ChEMBL
| Assay Description Competitive inhibition of human recombinant PTB1B catalytic domain using pNPP substrate at 30 degC and pH 6.5 by Eadie-Hofstee plot |
Bioorg Med Chem 19: 3892-900 (2011)
Article DOI: 10.1016/j.bmc.2011.05.049 BindingDB Entry DOI: 10.7270/Q2RJ4JTV |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-5
(Homo sapiens (Human)) | BDBM50531806
(CHEMBL4460323)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1nccs1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C34H48N6O6S/c1-21(2)17-25(28(41)34(5)20-46-34)36-31(44)27(19-23-9-7-6-8-10-23)37-30(43)26(18-22(3)4)38-33(45)40-14-11-24(12-15-40)29(42)39-32-35-13-16-47-32/h6-10,13,16,21-22,24-27H,11-12,14-15,17-20H2,1-5H3,(H,36,44)(H,37,43)(H,38,45)(H,35,39,42)/t25-,26-,27-,34+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20s constitutive proteasome beta5 chymotrypsin-like activity using Suc-LLVY-AMC as substrate preincubated for 15 mins followed by... |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531806
(CHEMBL4460323)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1nccs1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C34H48N6O6S/c1-21(2)17-25(28(41)34(5)20-46-34)36-31(44)27(19-23-9-7-6-8-10-23)37-30(43)26(18-22(3)4)38-33(45)40-14-11-24(12-15-40)29(42)39-32-35-13-16-47-32/h6-10,13,16,21-22,24-27H,11-12,14-15,17-20H2,1-5H3,(H,36,44)(H,37,43)(H,38,45)(H,35,39,42)/t25-,26-,27-,34+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50278411
(CHEMBL4170367)Show SMILES Cl.[H][C@]12Cc3ccccc3[C@@]1([H])[C@@]2([H])N[C@H]1CC[C@H](N)CC1 |r,wU:18.20,wD:10.11,2.0,15.16,12.14,(38.29,-9.18,;30.02,-9.7,;28.54,-9.31,;27.64,-10.57,;26.17,-10.09,;24.84,-10.87,;23.5,-10.1,;23.5,-8.55,;24.83,-7.78,;26.17,-8.54,;27.63,-8.06,;27.62,-6.52,;29.16,-7.91,;30.49,-8.67,;30.41,-7,;31.75,-7.74,;31.78,-9.28,;33.11,-10.02,;34.43,-9.23,;35.77,-9.98,;34.4,-7.7,;33.06,-6.95,)| Show InChI InChI=1S/C16H22N2.ClH/c17-11-5-7-12(8-6-11)18-16-14-9-10-3-1-2-4-13(10)15(14)16;/h1-4,11-12,14-16,18H,5-9,17H2;1H/t11-,12-,14-,15+,16-;/m0./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.20 | n/a | n/a | n/a | n/a | n/a | n/a |
East China Normal University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His/GST-tagged LSD1 (172 to 852 residues) expressed in baculovirus infected insect cells using biotin-labe... |
Eur J Med Chem 141: 101-112 (2017)
Article DOI: 10.1016/j.ejmech.2017.09.073 BindingDB Entry DOI: 10.7270/Q2474DCP |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531814
(CHEMBL4517600)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ccc(cc1)C(=O)c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C44H55N5O7/c1-28(2)24-35(39(51)44(5)27-56-44)46-42(54)37(26-30-12-8-6-9-13-30)47-41(53)36(25-29(3)4)48-43(55)49-22-20-33(21-23-49)40(52)45-34-18-16-32(17-19-34)38(50)31-14-10-7-11-15-31/h6-19,28-29,33,35-37H,20-27H2,1-5H3,(H,45,52)(H,46,54)(H,47,53)(H,48,55)/t35-,36-,37-,44+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531815
(CHEMBL4444107)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ccc(F)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C37H50FN5O6/c1-23(2)19-29(32(44)37(5)22-49-37)40-35(47)31(21-25-9-7-6-8-10-25)41-34(46)30(20-24(3)4)42-36(48)43-17-15-26(16-18-43)33(45)39-28-13-11-27(38)12-14-28/h6-14,23-24,26,29-31H,15-22H2,1-5H3,(H,39,45)(H,40,47)(H,41,46)(H,42,48)/t29-,30-,31-,37+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531807
(CHEMBL4541038)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1cccnc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C36H50N6O6/c1-23(2)18-28(31(43)36(5)22-48-36)39-34(46)30(20-25-10-7-6-8-11-25)40-33(45)29(19-24(3)4)41-35(47)42-16-13-26(14-17-42)32(44)38-27-12-9-15-37-21-27/h6-12,15,21,23-24,26,28-30H,13-14,16-20,22H2,1-5H3,(H,38,44)(H,39,46)(H,40,45)(H,41,47)/t28-,29-,30-,36+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531812
(CHEMBL4547405)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1nc2ccccc2s1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C38H50N6O6S/c1-23(2)19-28(32(45)38(5)22-50-38)39-35(48)30(21-25-11-7-6-8-12-25)40-34(47)29(20-24(3)4)42-37(49)44-17-15-26(16-18-44)33(46)43-36-41-27-13-9-10-14-31(27)51-36/h6-14,23-24,26,28-30H,15-22H2,1-5H3,(H,39,48)(H,40,47)(H,42,49)(H,41,43,46)/t28-,29-,30-,38+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 14
(Homo sapiens (Human)) | BDBM50527733
(CHEMBL4552922)Show SMILES C[C@@](O)(C#Cc1ccc2CCN(c2c1)c1nc(N)ncc1Cl)c1nccs1 |r| Show InChI InChI=1S/C19H16ClN5OS/c1-19(26,17-22-7-9-27-17)6-4-12-2-3-13-5-8-25(15(13)10-12)16-14(20)11-23-18(21)24-16/h2-3,7,9-11,26H,5,8H2,1H3,(H2,21,23,24)/t19-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of human NIK using ATP as substrate by kinase-glo assay |
J Med Chem 63: 4388-4407 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00396 BindingDB Entry DOI: 10.7270/Q2B85CKJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531813
(CHEMBL4542373)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1nncs1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C33H47N7O6S/c1-20(2)15-24(27(41)33(5)18-46-33)35-30(44)26(17-22-9-7-6-8-10-22)36-29(43)25(16-21(3)4)37-32(45)40-13-11-23(12-14-40)28(42)38-31-39-34-19-47-31/h6-10,19-21,23-26H,11-18H2,1-5H3,(H,35,44)(H,36,43)(H,37,45)(H,38,39,42)/t24-,25-,26-,33+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531826
(CHEMBL4558648)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C37H50ClN5O6/c1-23(2)19-29(32(44)37(5)22-49-37)40-35(47)31(21-25-9-7-6-8-10-25)41-34(46)30(20-24(3)4)42-36(48)43-17-15-26(16-18-43)33(45)39-28-13-11-27(38)12-14-28/h6-14,23-24,26,29-31H,15-22H2,1-5H3,(H,39,45)(H,40,47)(H,41,46)(H,42,48)/t29-,30-,31-,37+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531808
(CHEMBL4467618)Show SMILES COc1ccc(NC(=O)C2CCN(CC2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]2(C)CO2)cc1 |r| Show InChI InChI=1S/C38H53N5O7/c1-24(2)20-30(33(44)38(5)23-50-38)40-36(47)32(22-26-10-8-7-9-11-26)41-35(46)31(21-25(3)4)42-37(48)43-18-16-27(17-19-43)34(45)39-28-12-14-29(49-6)15-13-28/h7-15,24-25,27,30-32H,16-23H2,1-6H3,(H,39,45)(H,40,47)(H,41,46)(H,42,48)/t30-,31-,32-,38+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 14
(Homo sapiens (Human)) | BDBM50527759
(CHEMBL4448524)Show SMILES CN1CCC(O)(C#Cc2ccc(F)c(c2)-c2c[nH]c3cnc(N)nc23)C1=O Show InChI InChI=1S/C19H16FN5O2/c1-25-7-6-19(27,17(25)26)5-4-11-2-3-14(20)12(8-11)13-9-22-15-10-23-18(21)24-16(13)15/h2-3,8-10,22,27H,6-7H2,1H3,(H2,21,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal GST-tagged NIK (318 to 947 residues) expressed in baculovirus infected Sf9 cells using ultrapure ATP as su... |
J Med Chem 63: 4388-4407 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00396 BindingDB Entry DOI: 10.7270/Q2B85CKJ |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50595733
(CHEMBL5192697)Show SMILES CNc1nc(NCc2cccc(NC(=O)C=C)c2)nc(Nc2cc([nH]n2)C(C)(C)C)n1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00127 BindingDB Entry DOI: 10.7270/Q2QN6BTV |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531825
(CHEMBL4435814)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ccon1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C34H48N6O7/c1-21(2)17-25(29(41)34(5)20-46-34)35-32(44)27(19-23-9-7-6-8-10-23)36-31(43)26(18-22(3)4)37-33(45)40-14-11-24(12-15-40)30(42)38-28-13-16-47-39-28/h6-10,13,16,21-22,24-27H,11-12,14-15,17-20H2,1-5H3,(H,35,44)(H,36,43)(H,37,45)(H,38,39,42)/t25-,26-,27-,34+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50278459
(CHEMBL4176756)Show SMILES Cl.[H][C@]12Cc3ccccc3[C@@]1([H])[C@@]2([H])N[C@@H]1CC[C@H](N)CC1 |r,wD:10.11,2.0,15.16,18.20,12.14,(41.3,-22.41,;36.24,-22.94,;34.76,-22.56,;33.86,-23.81,;32.39,-23.33,;31.06,-24.11,;29.72,-23.34,;29.72,-21.79,;31.05,-21.03,;32.39,-21.79,;33.86,-21.31,;33.84,-19.76,;35.39,-21.15,;36.03,-19.77,;36.92,-21.01,;37.69,-22.33,;39.22,-22.33,;39.99,-23.66,;39.22,-24.99,;39.99,-26.32,;37.69,-24.99,;36.92,-23.67,)| Show InChI InChI=1S/C16H22N2.ClH/c17-11-5-7-12(8-6-11)18-16-14-9-10-3-1-2-4-13(10)15(14)16;/h1-4,11-12,14-16,18H,5-9,17H2;1H/t11-,12+,14-,15+,16-;/m0./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
East China Normal University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His/GST-tagged LSD1 (172 to 852 residues) expressed in baculovirus infected insect cells using biotin-labe... |
Eur J Med Chem 141: 101-112 (2017)
Article DOI: 10.1016/j.ejmech.2017.09.073 BindingDB Entry DOI: 10.7270/Q2474DCP |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531816
(CHEMBL4436430)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1cnccn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C35H49N7O6/c1-22(2)17-26(30(43)35(5)21-48-35)38-33(46)28(19-24-9-7-6-8-10-24)39-32(45)27(18-23(3)4)40-34(47)42-15-11-25(12-16-42)31(44)41-29-20-36-13-14-37-29/h6-10,13-14,20,22-23,25-28H,11-12,15-19,21H2,1-5H3,(H,38,46)(H,39,45)(H,40,47)(H,37,41,44)/t26-,27-,28-,35+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531811
(CHEMBL4559271)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ncccn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C35H49N7O6/c1-22(2)18-26(29(43)35(5)21-48-35)38-32(46)28(20-24-10-7-6-8-11-24)39-31(45)27(19-23(3)4)40-34(47)42-16-12-25(13-17-42)30(44)41-33-36-14-9-15-37-33/h6-11,14-15,22-23,25-28H,12-13,16-21H2,1-5H3,(H,38,46)(H,39,45)(H,40,47)(H,36,37,41,44)/t26-,27-,28-,35+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-8
(Homo sapiens (Human)) | BDBM50069989
((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r| Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20s immunoproteasome beta5i activity using Suc-LLVY-AMC as substrate preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50277889
(CARFILZOMIB | CHEMBL451887)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
Proteasome subunit beta type-5
(Homo sapiens (Human)) | BDBM50277889
(CARFILZOMIB | CHEMBL451887)Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE PC cid PC sid UniChem
Patents
Similars
| DrugBank Article PubMed
| n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20s constitutive proteasome beta5 chymotrypsin-like activity using Suc-LLVY-AMC as substrate preincubated for 15 mins followed by... |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50595734
(CHEMBL5197209)Show SMILES CNc1nc(NCc2cccc(NC(=O)CCl)c2)nc(Nc2cc([nH]n2)C(C)(C)C)n1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00127 BindingDB Entry DOI: 10.7270/Q2QN6BTV |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 14
(Homo sapiens (Human)) | BDBM50527726
(CHEMBL4445719)Show SMILES C[C@@](O)(C#Cc1ccc(F)c(c1)-c1c[nH]c2cnc(N)nc12)c1nccs1 |r| Show InChI InChI=1S/C19H14FN5OS/c1-19(26,17-22-6-7-27-17)5-4-11-2-3-14(20)12(8-11)13-9-23-15-10-24-18(21)25-16(13)15/h2-3,6-10,23,26H,1H3,(H2,21,24,25)/t19-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal GST-tagged NIK (318 to 947 residues) expressed in baculovirus infected Sf9 cells using ultrapure ATP as su... |
J Med Chem 63: 4388-4407 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00396 BindingDB Entry DOI: 10.7270/Q2B85CKJ |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531833
(CHEMBL4572638)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ccc(cc1)-c1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C43H55N5O6/c1-28(2)24-35(38(49)43(5)27-54-43)45-41(52)37(26-30-12-8-6-9-13-30)46-40(51)36(25-29(3)4)47-42(53)48-22-20-33(21-23-48)39(50)44-34-18-16-32(17-19-34)31-14-10-7-11-15-31/h6-19,28-29,33,35-37H,20-27H2,1-5H3,(H,44,50)(H,45,52)(H,46,51)(H,47,53)/t35-,36-,37-,43+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531832
(CHEMBL4441018)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1ccncc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C36H50N6O6/c1-23(2)19-28(31(43)36(5)22-48-36)39-34(46)30(21-25-9-7-6-8-10-25)40-33(45)29(20-24(3)4)41-35(47)42-17-13-26(14-18-42)32(44)38-27-11-15-37-16-12-27/h6-12,15-16,23-24,26,28-30H,13-14,17-22H2,1-5H3,(H,39,46)(H,40,45)(H,41,47)(H,37,38,44)/t28-,29-,30-,36+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50436459
(CHEMBL2396661)Show SMILES Cc1nc(NC(=O)N2CCC[C@H]2C(N)=O)sc1-c1ccnc(c1)C(C)(C)C(F)(F)F |r| Show InChI InChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 9.5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 1 hr by ADP-glo plus luminescence assay |
Citation and Details
Article DOI: 10.1016/j.bmc.2020.115863 BindingDB Entry DOI: 10.7270/Q2J38X7Z |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Histone deacetylase 6
(Homo sapiens (Human)) | BDBM50151278
(CHEMBL3769815)Show SMILES FC(F)(F)C(=O)CCCNC(=O)c1nc(sc1C1CC1)-c1nccs1 Show InChI InChI=1S/C15H14F3N3O2S2/c16-15(17,18)9(22)2-1-5-19-12(23)10-11(8-3-4-8)25-14(21-10)13-20-6-7-24-13/h6-8H,1-5H2,(H,19,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | >10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of full length His6-tagged GST-fused recombinant human HDAC6 expressed in High5 insect cells using Boc-Lys (e-acetyl)-AMC as substrate aft... |
Eur J Med Chem 112: 81-90 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.003 BindingDB Entry DOI: 10.7270/Q2ZS2ZDZ |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50069989
((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r| Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Proteasome subunit beta type-5
(Homo sapiens (Human)) | BDBM50069989
((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...)Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |r| Show InChI InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20s constitutive proteasome beta5 chymotrypsin-like activity using Suc-LLVY-AMC as substrate preincubated for 15 mins followed by... |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM254603
(US10214477, Example 5 | US9469597, 4 | US9670136, ...)Show SMILES NC1CCC(CC1)N[C@@H]1C[C@H]1c1ccccc1 |wU:10.12,wD:8.8,(11.17,-2.23,;9.76,-2.86,;8.52,-1.95,;7.11,-2.58,;6.95,-4.11,;8.19,-5.02,;9.6,-4.39,;5.54,-4.74,;4.21,-3.97,;2.67,-3.97,;3.44,-2.64,;3.44,-1.1,;2.1,-.33,;2.1,1.21,;3.44,1.98,;4.77,1.21,;4.77,-.33,)| Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12?,13?,14-,15+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
East China Normal University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His/GST-tagged LSD1 (172 to 852 residues) expressed in baculovirus infected insect cells using biotin-labe... |
Eur J Med Chem 141: 101-112 (2017)
Article DOI: 10.1016/j.ejmech.2017.09.073 BindingDB Entry DOI: 10.7270/Q2474DCP |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531809
(CHEMBL4578081)Show SMILES CC(C)C[C@H](NC(=O)C1CCN(CC1)C(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C37H50ClN5O6/c1-23(2)19-29(32(44)37(5)22-49-37)40-35(47)31(21-25-9-7-6-8-10-25)42-34(46)30(20-24(3)4)41-33(45)26-15-17-43(18-16-26)36(48)39-28-13-11-27(38)12-14-28/h6-14,23-24,26,29-31H,15-22H2,1-5H3,(H,39,48)(H,40,47)(H,41,45)(H,42,46)/t29-,30-,31-,37+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531822
(CHEMBL4443333)Show SMILES CC(C)C[C@H](NC(=O)N1CCC(CC1)NC(=O)c1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C37H50ClN5O6/c1-23(2)19-29(32(44)37(5)22-49-37)40-35(47)31(21-25-9-7-6-8-10-25)41-34(46)30(20-24(3)4)42-36(48)43-17-15-28(16-18-43)39-33(45)26-11-13-27(38)14-12-26/h6-14,23-24,28-31H,15-22H2,1-5H3,(H,39,45)(H,40,47)(H,41,46)(H,42,48)/t29-,30-,31-,37+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 14
(Homo sapiens (Human)) | BDBM50527733
(CHEMBL4552922)Show SMILES C[C@@](O)(C#Cc1ccc2CCN(c2c1)c1nc(N)ncc1Cl)c1nccs1 |r| Show InChI InChI=1S/C19H16ClN5OS/c1-19(26,17-22-7-9-27-17)6-4-12-2-3-13-5-8-25(15(13)10-12)16-14(20)11-23-18(21)24-16/h2-3,7,9-11,26H,5,8H2,1H3,(H2,21,23,24)/t19-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
| PDB Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal GST-tagged NIK (318 to 947 residues) expressed in baculovirus infected Sf9 cells using ultrapure ATP as su... |
J Med Chem 63: 4388-4407 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00396 BindingDB Entry DOI: 10.7270/Q2B85CKJ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Tyrosine-protein kinase BTK
(Homo sapiens (Human)) | BDBM50595732
(CHEMBL5202699)Show SMILES CNc1nc(Nc2cc[nH]n2)nc(n1)N1CC2CC1CN2C(=O)C=C | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acsmedchemlett.2c00127 BindingDB Entry DOI: 10.7270/Q2QN6BTV |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531835
(CHEMBL4557130)Show SMILES COc1ccc(NC(=O)N2CCC(CC2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]2(C)CO2)cc1 |r| Show InChI InChI=1S/C38H53N5O7/c1-24(2)20-30(33(44)38(5)23-50-38)40-36(47)32(22-26-10-8-7-9-11-26)42-35(46)31(21-25(3)4)41-34(45)27-16-18-43(19-17-27)37(48)39-28-12-14-29(49-6)15-13-28/h7-15,24-25,27,30-32H,16-23H2,1-6H3,(H,39,48)(H,40,47)(H,41,45)(H,42,46)/t30-,31-,32-,38+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50278460
(CHEMBL4166129)Show SMILES Cl.[H][C@]12Cc3ccccc3[C@@]1([H])[C@]2([H])N[C@@H]1CC[C@H](N)CC1 |r,wU:12.14,wD:10.11,2.0,15.16,18.20,(41.3,-22.41,;36.24,-22.94,;34.76,-22.56,;33.86,-23.81,;32.39,-23.33,;31.06,-24.11,;29.72,-23.34,;29.72,-21.79,;31.05,-21.03,;32.39,-21.79,;33.86,-21.31,;33.84,-19.76,;35.39,-21.15,;36.03,-19.77,;36.92,-21.01,;37.69,-22.33,;39.22,-22.33,;39.99,-23.66,;39.22,-24.99,;39.99,-26.32,;37.69,-24.99,;36.92,-23.67,)| Show InChI InChI=1S/C16H22N2.ClH/c17-11-5-7-12(8-6-11)18-16-14-9-10-3-1-2-4-13(10)15(14)16;/h1-4,11-12,14-16,18H,5-9,17H2;1H/t11-,12+,14-,15+,16+;/m0./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
East China Normal University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His/GST-tagged LSD1 (172 to 852 residues) expressed in baculovirus infected insect cells using biotin-labe... |
Eur J Med Chem 141: 101-112 (2017)
Article DOI: 10.1016/j.ejmech.2017.09.073 BindingDB Entry DOI: 10.7270/Q2474DCP |
More data for this Ligand-Target Pair | |
Histone deacetylase 6
(Homo sapiens (Human)) | BDBM50151281
(CHEMBL3770504)Show SMILES FC(F)(F)C(=O)CCCCNC(=O)c1nc(sc1C1CC1)-c1nc2CCCCc2s1 Show InChI InChI=1S/C20H22F3N3O2S2/c21-20(22,23)14(27)7-3-4-10-24-17(28)15-16(11-8-9-11)30-19(26-15)18-25-12-5-1-2-6-13(12)29-18/h11H,1-10H2,(H,24,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 18 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of full length His6-tagged GST-fused recombinant human HDAC6 expressed in High5 insect cells using Boc-Lys (e-acetyl)-AMC as substrate aft... |
Eur J Med Chem 112: 81-90 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.003 BindingDB Entry DOI: 10.7270/Q2ZS2ZDZ |
More data for this Ligand-Target Pair | |
Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50151281
(CHEMBL3770504)Show SMILES FC(F)(F)C(=O)CCCCNC(=O)c1nc(sc1C1CC1)-c1nc2CCCCc2s1 Show InChI InChI=1S/C20H22F3N3O2S2/c21-20(22,23)14(27)7-3-4-10-24-17(28)15-16(11-8-9-11)30-19(26-15)18-25-12-5-1-2-6-13(12)29-18/h11H,1-10H2,(H,24,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of full length His6-tagged GST-fused recombinant human HDAC1 expressed in High5 insect cells using Ac-Lys-Tyr-Lys (e-acetyl)-AMC as substr... |
Eur J Med Chem 112: 81-90 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.003 BindingDB Entry DOI: 10.7270/Q2ZS2ZDZ |
More data for this Ligand-Target Pair | |
Histone deacetylase 3
(Homo sapiens (Human)) | BDBM50151281
(CHEMBL3770504)Show SMILES FC(F)(F)C(=O)CCCCNC(=O)c1nc(sc1C1CC1)-c1nc2CCCCc2s1 Show InChI InChI=1S/C20H22F3N3O2S2/c21-20(22,23)14(27)7-3-4-10-24-17(28)15-16(11-8-9-11)30-19(26-15)18-25-12-5-1-2-6-13(12)29-18/h11H,1-10H2,(H,24,28) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of full length His6-tagged GST-fused recombinant human HDAC3 expressed in High5 insect cells using Ac-Lys-Tyr-Lys (e-acetyl)-AMC as substr... |
Eur J Med Chem 112: 81-90 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.003 BindingDB Entry DOI: 10.7270/Q2ZS2ZDZ |
More data for this Ligand-Target Pair | |
Histone deacetylase 6
(Homo sapiens (Human)) | BDBM50151277
(CHEMBL3770287)Show SMILES FC(F)(F)C(=O)CCCCNC(=O)c1nc(sc1C1CC1)-c1nccs1 Show InChI InChI=1S/C16H16F3N3O2S2/c17-16(18,19)10(23)3-1-2-6-20-13(24)11-12(9-4-5-9)26-15(22-11)14-21-7-8-25-14/h7-9H,1-6H2,(H,20,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of full length His6-tagged GST-fused recombinant human HDAC6 expressed in High5 insect cells using Boc-Lys (e-acetyl)-AMC as substrate aft... |
Eur J Med Chem 112: 81-90 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.003 BindingDB Entry DOI: 10.7270/Q2ZS2ZDZ |
More data for this Ligand-Target Pair | |
Lysine-specific histone demethylase 1A
(Homo sapiens (Human)) | BDBM50278484
(CHEMBL4170687)Show SMILES Cl.[H][C@]12Cc3ccccc3[C@@]1([H])[C@H]2NCC1CCNCC1 |r| Show InChI InChI=1S/C16H22N2.ClH/c1-2-4-13-12(3-1)9-14-15(13)16(14)18-10-11-5-7-17-8-6-11;/h1-4,11,14-18H,5-10H2;1H/t14-,15+,16-;/m0./s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
East China Normal University
Curated by ChEMBL
| Assay Description Inhibition of human recombinant N-terminal His/GST-tagged LSD1 (172 to 852 residues) expressed in baculovirus infected insect cells using biotin-labe... |
Eur J Med Chem 141: 101-112 (2017)
Article DOI: 10.1016/j.ejmech.2017.09.073 BindingDB Entry DOI: 10.7270/Q2474DCP |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 14
(Homo sapiens (Human)) | BDBM50527761
(CHEMBL4447392)Show SMILES CC(O)(C#Cc1cc(ccn1)-n1ccc2cnc(N)nc12)c1nccs1 Show InChI InChI=1S/C18H14N6OS/c1-18(25,16-21-7-9-26-16)5-2-13-10-14(3-6-20-13)24-8-4-12-11-22-17(19)23-15(12)24/h3-4,6-11,25H,1H3,(H2,19,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal GST-tagged NIK (318 to 947 residues) expressed in baculovirus infected Sf9 cells using ultrapure ATP as su... |
J Med Chem 63: 4388-4407 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00396 BindingDB Entry DOI: 10.7270/Q2B85CKJ |
More data for this Ligand-Target Pair | |
Histone deacetylase 6
(Homo sapiens (Human)) | BDBM50151282
(CHEMBL3770555)Show SMILES Cc1cnc(s1)-c1nc(C(=O)NCCCCC(=O)C(F)(F)F)c(s1)C1CC1 Show InChI InChI=1S/C17H18F3N3O2S2/c1-9-8-22-15(26-9)16-23-12(13(27-16)10-5-6-10)14(25)21-7-3-2-4-11(24)17(18,19)20/h8,10H,2-7H2,1H3,(H,21,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of full length His6-tagged GST-fused recombinant human HDAC6 expressed in High5 insect cells using Boc-Lys (e-acetyl)-AMC as substrate aft... |
Eur J Med Chem 112: 81-90 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.003 BindingDB Entry DOI: 10.7270/Q2ZS2ZDZ |
More data for this Ligand-Target Pair | |
Histone deacetylase 4
(Homo sapiens (Human)) | BDBM50151281
(CHEMBL3770504)Show SMILES FC(F)(F)C(=O)CCCCNC(=O)c1nc(sc1C1CC1)-c1nc2CCCCc2s1 Show InChI InChI=1S/C20H22F3N3O2S2/c21-20(22,23)14(27)7-3-4-10-24-17(28)15-16(11-8-9-11)30-19(26-15)18-25-12-5-1-2-6-13(12)29-18/h11H,1-10H2,(H,24,28) | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of full length His6-tagged GST-fused recombinant human HDAC4 expressed in High5 insect cells using Ac-Lys-Tyr-Lys (e-acetyl)-AMC as substr... |
Eur J Med Chem 112: 81-90 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.003 BindingDB Entry DOI: 10.7270/Q2ZS2ZDZ |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531829
(CHEMBL4580845)Show SMILES COc1ccc(cc1)C(=O)NC1CCN(CC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C38H53N5O7/c1-24(2)20-30(33(44)38(5)23-50-38)40-36(47)32(22-26-10-8-7-9-11-26)41-35(46)31(21-25(3)4)42-37(48)43-18-16-28(17-19-43)39-34(45)27-12-14-29(49-6)15-13-27/h7-15,24-25,28,30-32H,16-23H2,1-6H3,(H,39,45)(H,40,47)(H,41,46)(H,42,48)/t30-,31-,32-,38+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 14
(Homo sapiens (Human)) | BDBM50527744
(CHEMBL4520250)Show SMILES CN1CCC(O)(C#Cc2cc(ccn2)-n2ccc3cnc(N)nc23)C1=O Show InChI InChI=1S/C18H16N6O2/c1-23-9-6-18(26,16(23)25)5-2-13-10-14(3-7-20-13)24-8-4-12-11-21-17(19)22-15(12)24/h3-4,7-8,10-11,26H,6,9H2,1H3,(H2,19,21,22) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal GST-tagged NIK (318 to 947 residues) expressed in baculovirus infected Sf9 cells using ultrapure ATP as su... |
J Med Chem 63: 4388-4407 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00396 BindingDB Entry DOI: 10.7270/Q2B85CKJ |
More data for this Ligand-Target Pair | |
Histone deacetylase 1
(Homo sapiens (Human)) | BDBM50151277
(CHEMBL3770287)Show SMILES FC(F)(F)C(=O)CCCCNC(=O)c1nc(sc1C1CC1)-c1nccs1 Show InChI InChI=1S/C16H16F3N3O2S2/c17-16(18,19)10(23)3-1-2-6-20-13(24)11-12(9-4-5-9)26-15(22-11)14-21-7-8-25-14/h7-9H,1-6H2,(H,20,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of full length His6-tagged GST-fused recombinant human HDAC1 expressed in High5 insect cells using Ac-Lys-Tyr-Lys (e-acetyl)-AMC as substr... |
Eur J Med Chem 112: 81-90 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.003 BindingDB Entry DOI: 10.7270/Q2ZS2ZDZ |
More data for this Ligand-Target Pair | |
Mitogen-activated protein kinase kinase kinase 14
(Homo sapiens (Human)) | BDBM50527745
(CHEMBL4434804)Show SMILES CN1CCCC(O)(C#Cc2cc(ccn2)-n2ccc3cnc(N)nc23)C1=O Show InChI InChI=1S/C19H18N6O2/c1-24-9-2-6-19(27,17(24)26)7-3-14-11-15(4-8-21-14)25-10-5-13-12-22-18(20)23-16(13)25/h4-5,8,10-12,27H,2,6,9H2,1H3,(H2,20,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant human N-terminal GST-tagged NIK (318 to 947 residues) expressed in baculovirus infected Sf9 cells using ultrapure ATP as su... |
J Med Chem 63: 4388-4407 (2020)
Article DOI: 10.1021/acs.jmedchem.0c00396 BindingDB Entry DOI: 10.7270/Q2B85CKJ |
More data for this Ligand-Target Pair | |
Histone deacetylase 3
(Homo sapiens (Human)) | BDBM50151277
(CHEMBL3770287)Show SMILES FC(F)(F)C(=O)CCCCNC(=O)c1nc(sc1C1CC1)-c1nccs1 Show InChI InChI=1S/C16H16F3N3O2S2/c17-16(18,19)10(23)3-1-2-6-20-13(24)11-12(9-4-5-9)26-15(22-11)14-21-7-8-25-14/h7-9H,1-6H2,(H,20,24) | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Institute of Materia Medica
Curated by ChEMBL
| Assay Description Inhibition of full length His6-tagged GST-fused recombinant human HDAC3 expressed in High5 insect cells using Ac-Lys-Tyr-Lys (e-acetyl)-AMC as substr... |
Eur J Med Chem 112: 81-90 (2016)
Article DOI: 10.1016/j.ejmech.2016.02.003 BindingDB Entry DOI: 10.7270/Q2ZS2ZDZ |
More data for this Ligand-Target Pair | |
A5LHX3/O14818/P20618/P25786/P25787/P25788/P25789/P28062/P28065/P28066/P28070/P28072/P28074/P40306/P49720/P49721/P60900/Q8TAA3/Q99436
(Homo sapiens (Human)) | BDBM50531821
(CHEMBL4455910)Show SMILES CC(C)C[C@H](NC(=O)N1CCN(CC1)C(=O)Nc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1 |r| Show InChI InChI=1S/C36H49ClN6O6/c1-23(2)19-28(31(44)36(5)22-49-36)39-33(46)30(21-25-9-7-6-8-10-25)40-32(45)29(20-24(3)4)41-35(48)43-17-15-42(16-18-43)34(47)38-27-13-11-26(37)12-14-27/h6-14,23-24,28-30H,15-22H2,1-5H3,(H,38,47)(H,39,46)(H,40,45)(H,41,48)/t28-,29-,30-,36+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Hangzhou Institute of Innovative Medicine
Curated by ChEMBL
| Assay Description Inhibition of human 20S proteasome preincubated for 15 mins followed by substrate addition |
Eur J Med Chem 164: 602-614 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.064 BindingDB Entry DOI: 10.7270/Q2JM2F38 |
More data for this Ligand-Target Pair | |