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There are 3 purchasable compounds for target: HIV-2 Reverse Transcriptase RNase H

Wt: 266.2
BDBM1434
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Wt: 210.2
BDBM33045
Purchase
Wt: 264.3
BDBM33963
Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 1434,33045,33963   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-2 Reverse Transcriptase


(Human immunodeficiency virus type 2)
BDBM1434
PNG
(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Show SMILES Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12
Show InChI InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
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CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a>2.00E+4n/an/an/an/a7.837



Universita di Roma



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 39: 522-30 (1996)

More data for this
Ligand-Target Pair
HIV-2 Reverse Transcriptase


(Human immunodeficiency virus type 2)
BDBM33963
PNG
(vinylogous urea, NSC727448)
Show SMILES Cc1sc(NC(=O)c2ccco2)c(C(N)=O)c1C
Show InChI InChI=1S/C12H12N2O3S/c1-6-7(2)18-12(9(6)10(13)15)14-11(16)8-4-3-5-17-8/h3-5H,1-2H3,(H2,13,15)(H,14,16)
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 5.00E+3n/an/an/an/a8.020



National Cancer Institute



Assay Description
RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...


ACS Chem Biol 3: 635-44 (2008)

More data for this
Ligand-Target Pair
HIV-2 Reverse Transcriptase


(Human immunodeficiency virus type 2)
BDBM33045
PNG
(2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophe...)
Show SMILES NC(=O)c1c(N)sc2CCCCCc12
Show InChI InChI=1S/C10H14N2OS/c11-9(13)8-6-4-2-1-3-5-7(6)14-10(8)12/h1-5,12H2,(H2,11,13)
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.50E+3n/an/an/an/a8.020



National Cancer Institute



Assay Description
RNaseH assays were performed using an 18-nucleotide 3-fluorescein-labeled RNA annealed to a complementary 18-nucleotide 5-dabcyl conjugated DNA. The ...


ACS Chem Biol 3: 635-44 (2008)

More data for this
Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 1434,33045,33963
Cell (A)Syringe (B)Cell
Links
Syringe
Links
Cell + Syr
Links
ΔG°
kcal/mole
-TΔS°
kcal/mole
ΔH°
kcal/mole
log KpHTemp
°C
Reverse transcriptase (HIV-1 RT)(1-350)

(Human immunodeficiency virus type 1)
BDBM1434
JPEG
(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
GoogleScholar
PDB
CHEBI
DrugBank
KEGG
MMDB
PC cid
PC sid
-30.14.04-47.1n/an/a25



Chulalongkorn University





J Enzyme Inhib Med Chem 26: 29-36 (2011)