Compounds in cluster

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20 molecules are shown

Wt: 258.2
BDBM50107004

Wt: 357.4
BDBM50157741

Wt: 297.3
BDBM50284944

Wt: 434.3
BDBM50436752

Wt: 397.8
BDBM50436754

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 47 hits for monomerid = 50107004,50157741,50284944,50436752,50436754
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cathepsin B (Homo sapiens (Human))	BDBM50284944 (((S)-1-(S)-Oxiranyl-2-phenyl-ethyl)-carbamic acid ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article	0.0870	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Kinetic parameter (Ki 1/min) was evaluated for the inactivation of cathepsin B				Bioorg Med Chem Lett 5: 1767-1772 (1995) Article DOI: 10.1016/0960-894X(95)00312-H BindingDB Entry DOI: 10.7270/Q2MW2H4X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Papain (Carica papaya)	BDBM50284944 (((S)-1-(S)-Oxiranyl-2-phenyl-ethyl)-carbamic acid ...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article	0.208	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Kinetic parameter (Ki 1/min) was evaluated for the inactivation of papain				Bioorg Med Chem Lett 5: 1767-1772 (1995) Article DOI: 10.1016/0960-894X(95)00312-H BindingDB Entry DOI: 10.7270/Q2MW2H4X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina , Viale Annunziata, 98168 Messina, Italy. Curated by ChEMBL					Assay Description Inhibition of human cathepsin L using Cbz-Phe-Arg-AMC as substrate after 10 mins by fluorescence assay				J Med Chem 60: 6911-6923 (2017) Article DOI: 10.1021/acs.jmedchem.7b00405 BindingDB Entry DOI: 10.7270/Q2FJ2K73
					More data for this Ligand-Target Pair
Cysteine protease (Trypanosoma brucei rhodesiense)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	35	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina , Viale Annunziata, 98168 Messina, Italy. Curated by ChEMBL					Assay Description Inhibition of recombinant Trypanosoma brucei rhodesiense rhodesain expressed in Pichia pastoris using Cbz-Phe-Arg-AMC as substrate after 30 min by fl...				J Med Chem 60: 6911-6923 (2017) Article DOI: 10.1021/acs.jmedchem.7b00405 BindingDB Entry DOI: 10.7270/Q2FJ2K73
					More data for this Ligand-Target Pair
Falcipain 2 (Plasmodium falciparum)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Messina Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum recombinant falcipain-2				J Med Chem 51: 988-96 (2008) Article DOI: 10.1021/jm701141u BindingDB Entry DOI: 10.7270/Q2SX6F2M
University of Messina Curated by ChEMBL					More data for this Ligand-Target Pair
Falcipain 2 (Plasmodium falciparum)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Messina Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum recombinant falcipain-2 after 10 min				Bioorg Med Chem 18: 4928-38 (2010) Article DOI: 10.1016/j.bmc.2010.06.010 BindingDB Entry DOI: 10.7270/Q2NK3G1R
Universit£ di Messina Curated by ChEMBL					More data for this Ligand-Target Pair
Calpain-1 catalytic subunit (Sus scrofa (pig))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	3.96E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois College of Pharmacy Curated by ChEMBL					Assay Description Inhibition of pig full length Cal1 after using SucLLVYAMC as substrate by FRET assay				J Med Chem 56: 6054-68 (2013) Article DOI: 10.1021/jm4006719 BindingDB Entry DOI: 10.7270/Q2VT1TG7
					More data for this Ligand-Target Pair
Papain (Carica papaya)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	5.08E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Illinois College of Pharmacy Curated by ChEMBL					Assay Description Inhibition of papain after using SucLLVYAMC as substrate by FRET assay				J Med Chem 56: 6054-68 (2013) Article DOI: 10.1021/jm4006719 BindingDB Entry DOI: 10.7270/Q2VT1TG7
					More data for this Ligand-Target Pair
Falcipain 2 (Plasmodium falciparum)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	4.03E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Messina Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum Falcipain-2 after 10 to 15 mins				Eur J Med Chem 45: 3228-33 (2010) Article DOI: 10.1016/j.ejmech.2010.04.003 BindingDB Entry DOI: 10.7270/Q2SN094T
University of Messina Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50284944 (((S)-1-(S)-Oxiranyl-2-phenyl-ethyl)-carbamic acid ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article	3.67E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Kinetic parameter of the compound (Ki mM) was evaluated for the inactivation of cathepsin B				Bioorg Med Chem Lett 5: 1767-1772 (1995) Article DOI: 10.1016/0960-894X(95)00312-H BindingDB Entry DOI: 10.7270/Q2MW2H4X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Papain (Carica papaya)	BDBM50284944 (((S)-1-(S)-Oxiranyl-2-phenyl-ethyl)-carbamic acid ...) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	Article	5.74E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Kinetic parameter of the compound (Ki mM) was evaluated for the inactivation of papain				Bioorg Med Chem Lett 5: 1767-1772 (1995) Article DOI: 10.1016/0960-894X(95)00312-H BindingDB Entry DOI: 10.7270/Q2MW2H4X
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Falcipain-2 (Plasmodium falciparum)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	112	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum falcipain 2 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence ...				Eur J Med Chem 46: 927-33 (2011) Article DOI: 10.1016/j.ejmech.2011.01.008 BindingDB Entry DOI: 10.7270/Q2ZC8345
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteine proteinase falcipain 3 (Plasmodium falciparum)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	482	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum falcipain 3 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence ...				Eur J Med Chem 46: 927-33 (2011) Article DOI: 10.1016/j.ejmech.2011.01.008 BindingDB Entry DOI: 10.7270/Q2ZC8345
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Papain (Carica papaya)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon Curated by ChEMBL					Assay Description Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by spectrofluorometry				Bioorg Med Chem 19: 7635-42 (2011) Article DOI: 10.1016/j.bmc.2011.10.018 BindingDB Entry DOI: 10.7270/Q290247Z
University of Lisbon Curated by ChEMBL					More data for this Ligand-Target Pair
Papain (Carica papaya)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
University of Lisbon. Av. Prof. Gama Pinto Curated by ChEMBL					Assay Description Inhibition of papaya papain using Z-Leu-Leu-Arg-AMC as substrate after 30 mins by fluorescence microplate reader analysis				Eur J Med Chem 69: 365-72 (2013) Article DOI: 10.1016/j.ejmech.2013.08.037 BindingDB Entry DOI: 10.7270/Q2CN75BS
					More data for this Ligand-Target Pair
Cruzipain (Trypanosoma cruzi)	BDBM50436752 (CHEMBL2402102) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi cruzain				J Med Chem 56: 5637-58 (2014) Article DOI: 10.1021/jm301424d BindingDB Entry DOI: 10.7270/Q24T6KR9
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Cruzipain (Trypanosoma cruzi)	BDBM50436754 (CHEMBL2402103) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi cruzain				J Med Chem 56: 5637-58 (2014) Article DOI: 10.1021/jm301424d BindingDB Entry DOI: 10.7270/Q24T6KR9
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Papain (Carica papaya)	BDBM50436754 (CHEMBL2402103) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of papaya papain				J Med Chem 56: 5637-58 (2014) Article DOI: 10.1021/jm301424d BindingDB Entry DOI: 10.7270/Q24T6KR9
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Papain (Carica papaya)	BDBM50436752 (CHEMBL2402102) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ degli Studi di Milano Curated by ChEMBL					Assay Description Inhibition of papaya papain				J Med Chem 56: 5637-58 (2014) Article DOI: 10.1021/jm301424d BindingDB Entry DOI: 10.7270/Q24T6KR9
Universit£ degli Studi di Milano Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1039/d1md00316j BindingDB Entry DOI: 10.7270/Q23200VF
TBA					More data for this Ligand-Target Pair
Cysteine protease falcipain-3 [5-492] (Plasmodium falciparum)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi Curated by ChEMBL					Assay Description Inhibition of falcipain3				J Med Chem 49: 1576-84 (2006) Article DOI: 10.1021/jm0505765 BindingDB Entry DOI: 10.7270/Q2B27W35
University of Mississippi Curated by ChEMBL					More data for this Ligand-Target Pair
Neutrophil elastase (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. Curated by ChEMBL					Assay Description Inhibition of human leukocyte elastase using [14C]GS7340 substrate				Antimicrob Agents Chemother 51: 543-50 (2007) Article DOI: 10.1128/AAC.00968-06 BindingDB Entry DOI: 10.7270/Q2ZG6RW5
Gilead Sciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Lysosomal protective protein (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant CatA using [14C]GS7340 substrate				Antimicrob Agents Chemother 51: 543-50 (2007) Article DOI: 10.1128/AAC.00968-06 BindingDB Entry DOI: 10.7270/Q2ZG6RW5
Gilead Sciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Liver carboxylesterase (Sus scrofa)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. Curated by ChEMBL					Assay Description Inhibition of porcine liver carboxylesterase using [14C]GS7340 substrate				Antimicrob Agents Chemother 51: 543-50 (2007) Article DOI: 10.1128/AAC.00968-06 BindingDB Entry DOI: 10.7270/Q2ZG6RW5
Gilead Sciences, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Cysteine protease falcipain-3 [5-492] (Plasmodium falciparum)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum recombinant falcipain-3				J Med Chem 47: 6609-15 (2004) Article DOI: 10.1021/jm0493717 BindingDB Entry DOI: 10.7270/Q2GT5P0D
University of Mississippi Curated by ChEMBL					More data for this Ligand-Target Pair
Falcipain 2 (Plasmodium falciparum)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum recombinant falcipain-2				J Med Chem 47: 6609-15 (2004) Article DOI: 10.1021/jm0493717 BindingDB Entry DOI: 10.7270/Q2GT5P0D
University of Mississippi Curated by ChEMBL					More data for this Ligand-Target Pair
Dipeptidyl peptidase 1 (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	770	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant cathepsin C after 10 mins				J Biol Chem 282: 20836-46 (2007) Article DOI: 10.1074/jbc.M702615200 BindingDB Entry DOI: 10.7270/Q2125TJM
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Papain (Carica papaya)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Federal University of Alfenas Curated by ChEMBL					Assay Description Inhibition of Carica papaya papain by spectrofluorimetry				Eur J Med Chem 44: 1230-9 (2009) Article DOI: 10.1016/j.ejmech.2008.09.018 BindingDB Entry DOI: 10.7270/Q26974HM
Federal University of Alfenas Curated by ChEMBL					More data for this Ligand-Target Pair
Falcipain-2 (Plasmodium falciparum)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
University of Cape Town Curated by ChEMBL					Assay Description Inhibition of Plasmodium falciparum falcipain-2				Bioorg Med Chem Lett 20: 942-4 (2010) Article DOI: 10.1016/j.bmcl.2009.12.062 BindingDB Entry DOI: 10.7270/Q26M383G
University of Cape Town Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	13.7	n/a	n/a	n/a	n/a	n/a	n/a
The University of Tokyo Curated by ChEMBL					Assay Description Inhibitory activity against Cathepsin B was determined				Bioorg Med Chem Lett 9: 3397-402 (1999) BindingDB Entry DOI: 10.7270/Q2G44SGN
The University of Tokyo Curated by ChEMBL					More data for this Ligand-Target Pair
Falcipain 2 (Plasmodium falciparum)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina , Viale Annunziata, 98168 Messina, Italy. Curated by ChEMBL					Assay Description Inhibition of recombinant Plasmodium falciparum falcipain-2 expressed in Escherichia coli M15(pREP4) using Cbz-Phe-Arg-AMC as substrate by fluorescen...				J Med Chem 60: 6911-6923 (2017) Article DOI: 10.1021/acs.jmedchem.7b00405 BindingDB Entry DOI: 10.7270/Q2FJ2K73
					More data for this Ligand-Target Pair
Falcipain 2 (Plasmodium falciparum)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of Plasmodium falciparum recombinant falcipain 2 expressed in Escherichia coli using Z-Leu-Arg-AMC as substrate incubated for 30 min prior...				Citation and Details Article DOI: 10.1007/s00044-011-9854-3 BindingDB Entry DOI: 10.7270/Q2MC92XB
TBA					More data for this Ligand-Target Pair
Cruzipain (Trypanosoma cruzi)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant Trypanosoma cruzi cruzain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured for ...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116213 BindingDB Entry DOI: 10.7270/Q2183B90
TBA					More data for this Ligand-Target Pair
Cysteine protease (Trypanosoma brucei rhodesiense)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant Trypanosoma brucei rhodesain using Z-FR-AMC as substrate preincubated for 10 mins followed by substrate addition measured f...				Citation and Details Article DOI: 10.1016/j.bmc.2021.116213 BindingDB Entry DOI: 10.7270/Q2183B90
TBA					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.60	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1039/d1md00316j BindingDB Entry DOI: 10.7270/Q23200VF
TBA					More data for this Ligand-Target Pair
Cruzipain (Trypanosoma cruzi)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Federal University of Alagoas Curated by ChEMBL					Assay Description Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-aminomethylcoumarin as substrate measured after 5 mins by spectrofluorimetry				Bioorg Med Chem 24: 4228-4240 (2016) Article DOI: 10.1016/j.bmc.2016.07.013 BindingDB Entry DOI: 10.7270/Q2CZ393W
Federal University of Alagoas Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de S£o Carlos Curated by ChEMBL					Assay Description Inhibition of cathepsin L (unknown origin) using fluorometric Z-Phe-Arg-AMC as substrate by spectrofluorimetry				J Nat Prod 77: 2418-22 (2014) Article DOI: 10.1021/np500453x BindingDB Entry DOI: 10.7270/Q2TT4SJJ
Universidade Federal de S£o Carlos Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Universidade Federal de S£o Carlos Curated by ChEMBL					Assay Description Inhibition of cathepsin B (unknown origin) using fluorometric Z-Phe-Arg-AMC as substrate by spectrofluorimetry				J Nat Prod 77: 2418-22 (2014) Article DOI: 10.1021/np500453x BindingDB Entry DOI: 10.7270/Q2TT4SJJ
Universidade Federal de S£o Carlos Curated by ChEMBL					More data for this Ligand-Target Pair
Papain (Carica papaya)	BDBM50107004 (CHEMBL421215 \| Chrysene-1,4-dione) Show SMILES O=C1C=CC(=O)c2c1ccc1c2ccc2ccccc12 \|c:2\| Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against papain using HPLC assay				Bioorg Med Chem Lett 11: 3143-6 (2001) BindingDB Entry DOI: 10.7270/Q2T43SDG
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant cathepsin B after 10 mins				J Biol Chem 282: 20836-46 (2007) Article DOI: 10.1074/jbc.M702615200 BindingDB Entry DOI: 10.7270/Q2125TJM
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Pro-cathepsin H (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant cathepsin H after 10 mins				J Biol Chem 282: 20836-46 (2007) Article DOI: 10.1074/jbc.M702615200 BindingDB Entry DOI: 10.7270/Q2125TJM
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin S (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant cathepsin S after 10 mins				J Biol Chem 282: 20836-46 (2007) Article DOI: 10.1074/jbc.M702615200 BindingDB Entry DOI: 10.7270/Q2125TJM
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	13	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant cathepsin L after 10 mins				J Biol Chem 282: 20836-46 (2007) Article DOI: 10.1074/jbc.M702615200 BindingDB Entry DOI: 10.7270/Q2125TJM
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Procathepsin L (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Chemical Industries, Ltd. Curated by ChEMBL					Assay Description Inhibition of human cathepsin L.				J Med Chem 41: 4301-8 (1998) Article DOI: 10.1021/jm9803065 BindingDB Entry DOI: 10.7270/Q2VQ33CX
Takeda Chemical Industries, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin B (Homo sapiens (Human))	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Takeda Chemical Industries, Ltd. Curated by ChEMBL					Assay Description Inhibition of human cathepsin B				J Med Chem 41: 4301-8 (1998) Article DOI: 10.1021/jm9803065 BindingDB Entry DOI: 10.7270/Q2VQ33CX
Takeda Chemical Industries, Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
Genome polyprotein (Human rhinovirus B)	BDBM50107004 (CHEMBL421215 \| Chrysene-1,4-dione) Show SMILES O=C1C=CC(=O)c2c1ccc1c2ccc2ccccc12 \|c:2\| Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.65E+4	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory activity against HRV 3Cpro using HPLC assay				Bioorg Med Chem Lett 11: 3143-6 (2001) BindingDB Entry DOI: 10.7270/Q2T43SDG
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Falcipain 2 (Plasmodium falciparum)	BDBM50157741 (CHEMBL374508 \| E-64 \| E64) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi Curated by ChEMBL					Assay Description Inhibition of falcipain2				J Med Chem 49: 1576-84 (2006) Article DOI: 10.1021/jm0505765 BindingDB Entry DOI: 10.7270/Q2B27W35
University of Mississippi Curated by ChEMBL					More data for this Ligand-Target Pair