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There are 15 purchasable compounds for target: (PROTEIN-TYROSINE-PHOSPHATASE) (PTPase)

Wt: 380.4
BDBM50343142
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Wt: 418.4
BDBM50343143
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Wt: 424.8
BDBM50343144
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Wt: 520.5
BDBM50343145
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Wt: 492.5
BDBM50343146
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Wt: 482.5
BDBM50343147
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Wt: 481.5
BDBM50343148
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Wt: 533.6
BDBM50343149
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Wt: 510.6
BDBM50343150
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Wt: 506.6
BDBM50343151
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Wt: 297.2
BDBM50363161
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Wt: 297.2
BDBM50363152
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Wt: 303.3
BDBM50363158
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Wt: 327.2
BDBM50363159
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Wt: 297.2
BDBM50363136
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 32 hits for monomerid = 50343142,50343143,50343144,50343145,50343146,50343147,50343148,50343149,50343150,50343151,50363161,50363152,50363158,50363159,50363136   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343142
PNG
(CHEMBL1773168 | N-(4-butylphenyl)-2-oxo-1,2-dihydr...)
Show SMILES CCCCc1ccc(NS(=O)(=O)c2ccc3NC(=O)c4cccc2c34)cc1
Show InChI InChI=1S/C21H20N2O3S/c1-2-3-5-14-8-10-15(11-9-14)23-27(25,26)19-13-12-18-20-16(19)6-4-7-17(20)21(24)22-18/h4,6-13,23H,2-3,5H2,1H3,(H,22,24)
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1.10E+3n/an/an/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Non-competitive inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB assessed as production of p-nitrophenol from pNPP substrate by L...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343147
PNG
(CHEMBL1773180 | N1-(furan-2-ylmethyl)-N2-(1-(4-(4-...)
Show SMILES COc1ccc(cc1)N1CCN(CC1)C(C(C)NC(=O)C(=O)NCc1ccco1)c1cccs1
Show InChI InChI=1S/C25H30N4O4S/c1-18(27-25(31)24(30)26-17-21-5-3-15-33-21)23(22-6-4-16-34-22)29-13-11-28(12-14-29)19-7-9-20(32-2)10-8-19/h3-10,15-16,18,23H,11-14,17H2,1-2H3,(H,26,30)(H,27,31)
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3.20E+3n/an/an/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Competitive inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB assessed as production of p-nitrophenol from pNPP substrate by Linew...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343148
PNG
(CHEMBL1773181 | N1-(1-(4-(4-fluorophenyl)piperazin...)
Show SMILES CC(NC(=O)C(=O)NCc1cccnc1)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C25H28FN5O2S/c1-18(29-25(33)24(32)28-17-19-4-2-10-27-16-19)23(22-5-3-15-34-22)31-13-11-30(12-14-31)21-8-6-20(26)7-9-21/h2-10,15-16,18,23H,11-14,17H2,1H3,(H,28,32)(H,29,33)
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4.00E+3n/an/an/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Competitive inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB assessed as production of p-nitrophenol from pNPP substrate by Linew...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50363136
PNG
(CHEMBL455453)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)\C=C\c1ccc2OCOc2c1
Show InChI InChI=1S/C16H11NO5/c18-14(12-3-5-13(6-4-12)17(19)20)7-1-11-2-8-15-16(9-11)22-10-21-15/h1-9H,10H2/b7-1+
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1.30E+4n/an/an/an/an/an/an/an/a



Universidade Federal de Santa Catarina

Curated by ChEMBL


Assay Description
Competitive inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate measured for 10 mins by Lineweaver-Burk plot an...


J Med Chem 55: 390-402 (2012)


Article DOI: 10.1021/jm2012062
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50363152
PNG
(CHEMBL455469)
Show SMILES [O-][N+](=O)c1cccc(c1)C(=O)\C=C\c1ccc2OCOc2c1
Show InChI InChI=1S/C16H11NO5/c18-14(12-2-1-3-13(9-12)17(19)20)6-4-11-5-7-15-16(8-11)22-10-21-15/h1-9H,10H2/b6-4+
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n/an/a>1.00E+5n/an/an/an/an/an/a



Universidade Federal de Santa Catarina

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry


J Med Chem 55: 390-402 (2012)


Article DOI: 10.1021/jm2012062
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343143
PNG
(2-oxo-N-(6,7,8,9-tetrahydrodibenzo[b,d]furan-2-yl)...)
Show SMILES O=C1Nc2ccc(c3cccc1c23)S(=O)(=O)Nc1ccc2oc3CCCCc3c2c1
Show InChI InChI=1S/C23H18N2O4S/c26-23-16-6-3-5-15-21(11-9-18(24-23)22(15)16)30(27,28)25-13-8-10-20-17(12-13)14-4-1-2-7-19(14)29-20/h3,5-6,8-12,25H,1-2,4,7H2,(H,24,26)
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n/an/a 1.08E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB preincubated with compound for 30 mins before pNPP substrate addition by micropl...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343144
PNG
(CHEMBL1773170 | N-(3-chloro-4-hydroxynaphthalen-1-...)
Show SMILES Oc1c(Cl)cc(NS(=O)(=O)c2ccc3NC(=O)c4cccc2c34)c2ccccc12
Show InChI InChI=1S/C21H13ClN2O4S/c22-15-10-17(11-4-1-2-5-12(11)20(15)25)24-29(27,28)18-9-8-16-19-13(18)6-3-7-14(19)21(26)23-16/h1-10,24-25H,(H,23,26)
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n/an/a 1.28E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB preincubated with compound for 30 mins before pNPP substrate addition by micropl...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343145
PNG
(CHEMBL1773171 | heptyl 2-methyl-5-(2-oxo-1,2-dihyd...)
Show SMILES CCCCCCCOC(=O)c1c(C)oc2ccc(NS(=O)(=O)c3ccc4NC(=O)c5cccc3c45)cc12
Show InChI InChI=1S/C28H28N2O6S/c1-3-4-5-6-7-15-35-28(32)25-17(2)36-23-13-11-18(16-21(23)25)30-37(33,34)24-14-12-22-26-19(24)9-8-10-20(26)27(31)29-22/h8-14,16,30H,3-7,15H2,1-2H3,(H,29,31)
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n/an/a 2.28E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB preincubated with compound for 30 mins before pNPP substrate addition by micropl...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343146
PNG
(CHEMBL1773172 | pentyl 2-methyl-5-(2-oxo-1,2-dihyd...)
Show SMILES CCCCCOC(=O)c1c(C)oc2ccc(NS(=O)(=O)c3ccc4NC(=O)c5cccc3c45)cc12
Show InChI InChI=1S/C26H24N2O6S/c1-3-4-5-13-33-26(30)23-15(2)34-21-11-9-16(14-19(21)23)28-35(31,32)22-12-10-20-24-17(22)7-6-8-18(24)25(29)27-20/h6-12,14,28H,3-5,13H2,1-2H3,(H,27,29)
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n/an/a 2.08E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB preincubated with compound for 30 mins before pNPP substrate addition by micropl...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343142
PNG
(CHEMBL1773168 | N-(4-butylphenyl)-2-oxo-1,2-dihydr...)
Show SMILES CCCCc1ccc(NS(=O)(=O)c2ccc3NC(=O)c4cccc2c34)cc1
Show InChI InChI=1S/C21H20N2O3S/c1-2-3-5-14-8-10-15(11-9-14)23-27(25,26)19-13-12-18-20-16(19)6-4-7-17(20)21(24)22-18/h4,6-13,23H,2-3,5H2,1H3,(H,22,24)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis PTPB expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343147
PNG
(CHEMBL1773180 | N1-(furan-2-ylmethyl)-N2-(1-(4-(4-...)
Show SMILES COc1ccc(cc1)N1CCN(CC1)C(C(C)NC(=O)C(=O)NCc1ccco1)c1cccs1
Show InChI InChI=1S/C25H30N4O4S/c1-18(27-25(31)24(30)26-17-21-5-3-15-33-21)23(22-6-4-16-34-22)29-13-11-28(12-14-29)19-7-9-20(32-2)10-8-19/h3-10,15-16,18,23H,11-14,17H2,1-2H3,(H,26,30)(H,27,31)
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n/an/a 5.60E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis PTPB expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343148
PNG
(CHEMBL1773181 | N1-(1-(4-(4-fluorophenyl)piperazin...)
Show SMILES CC(NC(=O)C(=O)NCc1cccnc1)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C25H28FN5O2S/c1-18(29-25(33)24(32)28-17-19-4-2-10-27-16-19)23(22-5-3-15-34-22)31-13-11-30(12-14-31)21-8-6-20(26)7-9-21/h2-10,15-16,18,23H,11-14,17H2,1H3,(H,28,32)(H,29,33)
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n/an/a 1.15E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis PTPB expressed in Escherichia coli after 5 mins by microplate spectrophotometer analysis


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343148
PNG
(CHEMBL1773181 | N1-(1-(4-(4-fluorophenyl)piperazin...)
Show SMILES CC(NC(=O)C(=O)NCc1cccnc1)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C25H28FN5O2S/c1-18(29-25(33)24(32)28-17-19-4-2-10-27-16-19)23(22-5-3-15-34-22)31-13-11-30(12-14-31)21-8-6-20(26)7-9-21/h2-10,15-16,18,23H,11-14,17H2,1H3,(H,28,32)(H,29,33)
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n/an/a 1.40E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB preincubated with compound for 30 mins before pNPP substrate addition by micropl...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343149
PNG
(CHEMBL1773182 | N1-(2-(1H-indol-3-yl)ethyl)-N2-(1-...)
Show SMILES CC(NC(=O)C(=O)NCCc1c[nH]c2ccccc12)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C29H32FN5O2S/c1-20(33-29(37)28(36)31-13-12-21-19-32-25-6-3-2-5-24(21)25)27(26-7-4-18-38-26)35-16-14-34(15-17-35)23-10-8-22(30)9-11-23/h2-11,18-20,27,32H,12-17H2,1H3,(H,31,36)(H,33,37)
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n/an/a 1.75E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB preincubated with compound for 30 mins before pNPP substrate addition by micropl...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343150
PNG
(CHEMBL1773183 | N1-(1-(4-(4-fluorophenyl)piperazin...)
Show SMILES COc1ccccc1CNC(=O)C(=O)NC(C)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C27H31FN4O3S/c1-19(30-27(34)26(33)29-18-20-6-3-4-7-23(20)35-2)25(24-8-5-17-36-24)32-15-13-31(14-16-32)22-11-9-21(28)10-12-22/h3-12,17,19,25H,13-16,18H2,1-2H3,(H,29,33)(H,30,34)
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n/an/a 1.58E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB preincubated with compound for 30 mins before pNPP substrate addition by micropl...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343151
PNG
(CHEMBL1773184 | N1-(benzo[d][1,3]dioxol-5-ylmethyl...)
Show SMILES CC(NC(=O)C(=O)NCc1ccc2OCOc2c1)C(N1CCN(CC1)c1ccccc1)c1cccs1
Show InChI InChI=1S/C27H30N4O4S/c1-19(29-27(33)26(32)28-17-20-9-10-22-23(16-20)35-18-34-22)25(24-8-5-15-36-24)31-13-11-30(12-14-31)21-6-3-2-4-7-21/h2-10,15-16,19,25H,11-14,17-18H2,1H3,(H,28,32)(H,29,33)
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n/an/a 2.51E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB preincubated with compound for 30 mins before pNPP substrate addition by micropl...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343147
PNG
(CHEMBL1773180 | N1-(furan-2-ylmethyl)-N2-(1-(4-(4-...)
Show SMILES COc1ccc(cc1)N1CCN(CC1)C(C(C)NC(=O)C(=O)NCc1ccco1)c1cccs1
Show InChI InChI=1S/C25H30N4O4S/c1-18(27-25(31)24(30)26-17-21-5-3-15-33-21)23(22-6-4-16-34-22)29-13-11-28(12-14-29)19-7-9-20(32-2)10-8-19/h3-10,15-16,18,23H,11-14,17H2,1-2H3,(H,26,30)(H,27,31)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343148
PNG
(CHEMBL1773181 | N1-(1-(4-(4-fluorophenyl)piperazin...)
Show SMILES CC(NC(=O)C(=O)NCc1cccnc1)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C25H28FN5O2S/c1-18(29-25(33)24(32)28-17-19-4-2-10-27-16-19)23(22-5-3-15-34-22)31-13-11-30(12-14-31)21-8-6-20(26)7-9-21/h2-10,15-16,18,23H,11-14,17H2,1H3,(H,28,32)(H,29,33)
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n/an/a 9.10E+3n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343149
PNG
(CHEMBL1773182 | N1-(2-(1H-indol-3-yl)ethyl)-N2-(1-...)
Show SMILES CC(NC(=O)C(=O)NCCc1c[nH]c2ccccc12)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C29H32FN5O2S/c1-20(33-29(37)28(36)31-13-12-21-19-32-25-6-3-2-5-24(21)25)27(26-7-4-18-38-26)35-16-14-34(15-17-35)23-10-8-22(30)9-11-23/h2-11,18-20,27,32H,12-17H2,1H3,(H,31,36)(H,33,37)
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Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343150
PNG
(CHEMBL1773183 | N1-(1-(4-(4-fluorophenyl)piperazin...)
Show SMILES COc1ccccc1CNC(=O)C(=O)NC(C)C(N1CCN(CC1)c1ccc(F)cc1)c1cccs1
Show InChI InChI=1S/C27H31FN4O3S/c1-19(30-27(34)26(33)29-18-20-6-3-4-7-23(20)35-2)25(24-8-5-17-36-24)32-15-13-31(14-16-32)22-11-9-21(28)10-12-22/h3-12,17,19,25H,13-16,18H2,1-2H3,(H,29,33)(H,30,34)
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n/an/a 1.14E+4n/an/an/an/an/an/a



Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343151
PNG
(CHEMBL1773184 | N1-(benzo[d][1,3]dioxol-5-ylmethyl...)
Show SMILES CC(NC(=O)C(=O)NCc1ccc2OCOc2c1)C(N1CCN(CC1)c1ccccc1)c1cccs1
Show InChI InChI=1S/C27H30N4O4S/c1-19(29-27(33)26(32)28-17-20-9-10-22-23(16-20)35-18-34-22)25(24-8-5-15-36-24)31-13-11-30(12-14-31)21-6-3-2-4-7-21/h2-10,15-16,19,25H,11-14,17-18H2,1H3,(H,28,32)(H,29,33)
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Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343142
PNG
(CHEMBL1773168 | N-(4-butylphenyl)-2-oxo-1,2-dihydr...)
Show SMILES CCCCc1ccc(NS(=O)(=O)c2ccc3NC(=O)c4cccc2c34)cc1
Show InChI InChI=1S/C21H20N2O3S/c1-2-3-5-14-8-10-15(11-9-14)23-27(25,26)19-13-12-18-20-16(19)6-4-7-17(20)21(24)22-18/h4,6-13,23H,2-3,5H2,1H3,(H,22,24)
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Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343143
PNG
(2-oxo-N-(6,7,8,9-tetrahydrodibenzo[b,d]furan-2-yl)...)
Show SMILES O=C1Nc2ccc(c3cccc1c23)S(=O)(=O)Nc1ccc2oc3CCCCc3c2c1
Show InChI InChI=1S/C23H18N2O4S/c26-23-16-6-3-5-15-21(11-9-18(24-23)22(15)16)30(27,28)25-13-8-10-20-17(12-13)14-4-1-2-7-19(14)29-20/h3,5-6,8-12,25H,1-2,4,7H2,(H,24,26)
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Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343144
PNG
(CHEMBL1773170 | N-(3-chloro-4-hydroxynaphthalen-1-...)
Show SMILES Oc1c(Cl)cc(NS(=O)(=O)c2ccc3NC(=O)c4cccc2c34)c2ccccc12
Show InChI InChI=1S/C21H13ClN2O4S/c22-15-10-17(11-4-1-2-5-12(11)20(15)25)24-29(27,28)18-9-8-16-19-13(18)6-3-7-14(19)21(26)23-16/h1-10,24-25H,(H,23,26)
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Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343145
PNG
(CHEMBL1773171 | heptyl 2-methyl-5-(2-oxo-1,2-dihyd...)
Show SMILES CCCCCCCOC(=O)c1c(C)oc2ccc(NS(=O)(=O)c3ccc4NC(=O)c5cccc3c45)cc12
Show InChI InChI=1S/C28H28N2O6S/c1-3-4-5-6-7-15-35-28(32)25-17(2)36-23-13-11-18(16-21(23)25)30-37(33,34)24-14-12-22-26-19(24)9-8-10-20(26)27(31)29-22/h8-14,16,30H,3-7,15H2,1-2H3,(H,29,31)
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Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343146
PNG
(CHEMBL1773172 | pentyl 2-methyl-5-(2-oxo-1,2-dihyd...)
Show SMILES CCCCCOC(=O)c1c(C)oc2ccc(NS(=O)(=O)c3ccc4NC(=O)c5cccc3c45)cc12
Show InChI InChI=1S/C26H24N2O6S/c1-3-4-5-13-33-26(30)23-15(2)34-21-11-9-16(14-19(21)23)28-35(31,32)22-12-10-20-24-17(22)7-6-8-18(24)25(29)27-20/h6-12,14,28H,3-5,13H2,1-2H3,(H,27,29)
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Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343147
PNG
(CHEMBL1773180 | N1-(furan-2-ylmethyl)-N2-(1-(4-(4-...)
Show SMILES COc1ccc(cc1)N1CCN(CC1)C(C(C)NC(=O)C(=O)NCc1ccco1)c1cccs1
Show InChI InChI=1S/C25H30N4O4S/c1-18(27-25(31)24(30)26-17-21-5-3-15-33-21)23(22-6-4-16-34-22)29-13-11-28(12-14-29)19-7-9-20(32-2)10-8-19/h3-10,15-16,18,23H,11-14,17H2,1-2H3,(H,26,30)(H,27,31)
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Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB preincubated with compound for 30 mins before pNPP substrate addition by micropl...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50363161
PNG
(CHEMBL1946439)
Show SMILES [O-][N+](=O)c1ccccc1\C=C\C(=O)c1ccc2OCOc2c1
Show InChI InChI=1S/C16H11NO5/c18-14(12-6-8-15-16(9-12)22-10-21-15)7-5-11-3-1-2-4-13(11)17(19)20/h1-9H,10H2/b7-5+
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n/an/a 8.10E+4n/an/an/an/an/an/a



Universidade Federal de Santa Catarina

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry


J Med Chem 55: 390-402 (2012)


Article DOI: 10.1021/jm2012062
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50363159
PNG
(CHEMBL1946001)
Show SMILES Clc1ccc(\C=C\C(=O)c2ccc3ccccc3c2)c(Cl)c1
Show InChI InChI=1S/C19H12Cl2O/c20-17-9-7-14(18(21)12-17)8-10-19(22)16-6-5-13-3-1-2-4-15(13)11-16/h1-12H/b10-8+
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Universidade Federal de Santa Catarina

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry


J Med Chem 55: 390-402 (2012)


Article DOI: 10.1021/jm2012062
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50343142
PNG
(CHEMBL1773168 | N-(4-butylphenyl)-2-oxo-1,2-dihydr...)
Show SMILES CCCCc1ccc(NS(=O)(=O)c2ccc3NC(=O)c4cccc2c34)cc1
Show InChI InChI=1S/C21H20N2O3S/c1-2-3-5-14-8-10-15(11-9-14)23-27(25,26)19-13-12-18-20-16(19)6-4-7-17(20)21(24)22-18/h4,6-13,23H,2-3,5H2,1H3,(H,22,24)
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Indiana University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis N-terminal His6-tagged PTPB preincubated with compound for 30 mins before pNPP substrate addition by micropl...


ACS Med Chem Lett 1: 355-359 (2010)


Article DOI: 10.1021/ml1001135
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50363136
PNG
(CHEMBL455453)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)\C=C\c1ccc2OCOc2c1
Show InChI InChI=1S/C16H11NO5/c18-14(12-3-5-13(6-4-12)17(19)20)7-1-11-2-8-15-16(9-11)22-10-21-15/h1-9H,10H2/b7-1+
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Universidade Federal de Santa Catarina

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry


J Med Chem 55: 390-402 (2012)


Article DOI: 10.1021/jm2012062
More data for this
Ligand-Target Pair
Protein Tyrosine Phosphatase PTPB


(Mycobacterium tuberculosis)
BDBM50363158
PNG
(CHEMBL1096287)
Show SMILES [O-][N+](=O)c1ccc(\C=C\C(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C19H13NO3/c21-19(12-7-14-5-10-18(11-6-14)20(22)23)17-9-8-15-3-1-2-4-16(15)13-17/h1-13H/b12-7+
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Universidade Federal de Santa Catarina

Curated by ChEMBL


Assay Description
Inhibition of Mycobacterium tuberculosis PTP-B using p-nitrophenyl phosphate as substrate measured for 10 mins by spectrofluorimetry


J Med Chem 55: 390-402 (2012)


Article DOI: 10.1021/jm2012062
More data for this
Ligand-Target Pair