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There are 5 purchasable compounds for target: Kynurenine--oxoglutarate transaminase 1

Wt: 189.2
BDBM31879
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Wt: 205.2
BDBM31881
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Wt: 362.3
BDBM50324539
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Wt: 263.2
BDBM50364919
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Wt: 178.1
BDBM50386292
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 31879,31881,50324539,50364919,50386292   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynurenine Aminotransferase 1/Glutamine Transaminase K


(Homo sapiens (Human))
BDBM31879
PNG
(3-indolepropionic acid | Acid, 7)
Show SMILES OC(=O)CCc1c[nH]c2ccccc12
Show InChI InChI=1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14)
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n/an/a 1.40E+5n/an/an/an/a7.538



Virginia Tech



Assay Description
A typical reaction mixture contains kynurenine, alpha-ketobutyrate, PLP and hKAT-I in the presence of test compound. The reaction mixture was incubat...


J Med Chem 52: 2786-93 (2009)

More data for this
Ligand-Target Pair
Kynurenine Aminotransferase 1/Glutamine Transaminase K


(Homo sapiens (Human))
BDBM31881
PNG
(DL-indole-3-lactic acid)
Show SMILES OC(Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C11H11NO3/c13-10(11(14)15)5-7-6-12-9-4-2-1-3-8(7)9/h1-4,6,10,12-13H,5H2,(H,14,15)
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PubMed
n/an/a 2.20E+5n/an/an/an/a7.538



Virginia Tech



Assay Description
A typical reaction mixture contains kynurenine, alpha-ketobutyrate, PLP and hKAT-I in the presence of test compound. The reaction mixture was incubat...


J Med Chem 52: 2786-93 (2009)

More data for this
Ligand-Target Pair
Kynurenine Aminotransferase 1/Glutamine Transaminase K


(Homo sapiens (Human))
BDBM50324539
PNG
((S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methy...)
Show SMILES C[C@H]1COc2c(N3CCN(N)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O
Show InChI InChI=1S/C17H19FN4O4/c1-9-8-26-16-13-10(15(23)11(17(24)25)7-22(9)13)6-12(18)14(16)20-2-4-21(19)5-3-20/h6-7,9H,2-5,8,19H2,1H3,(H,24,25)/t9-/m0/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Piemonte Orientale Amedeo Avogadro

Curated by ChEMBL


Assay Description
Inhibition of KAT1 in human prefrontal cortex homogenates


J Med Chem 53: 5684-9 (2010)

More data for this
Ligand-Target Pair
Kynurenine Aminotransferase 1/Glutamine Transaminase K


(Homo sapiens (Human))
BDBM50386292
PNG
(CHEMBL2047851)
Show SMILES N[C@H]1Cc2ccccc2N(O)C1=O
Show InChI InChI=1S/C9H10N2O2/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12/h1-4,7,13H,5,10H2/t7-/m0/s1
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n/an/a 2.20E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human KAT1


ACS Med Chem Lett 3: 187-192 (2012)

More data for this
Ligand-Target Pair
Kynurenine Aminotransferase 1/Glutamine Transaminase K


(Homo sapiens (Human))
BDBM50364919
PNG
(CHEMBL1508899)
Show SMILES COc1ccc2[nH]c(C(O)=O)c(CCC(O)=O)c2c1
Show InChI InChI=1S/C13H13NO5/c1-19-7-2-4-10-9(6-7)8(3-5-11(15)16)12(14-10)13(17)18/h2,4,6,14H,3,5H2,1H3,(H,15,16)(H,17,18)
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PC cid
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UniChem
Article
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n/an/a>6.00E+6n/an/an/an/an/an/a



The University of Sydney

Curated by ChEMBL


Assay Description
Inhibition of human recombinant KAT1 after 20 mins by RP-HPLC analysis


Bioorg Med Chem Lett 22: 1579-81 (2012)

More data for this
Ligand-Target Pair
Kynurenine Aminotransferase 1/Glutamine Transaminase K


(Homo sapiens (Human))
BDBM50386292
PNG
(CHEMBL2047851)
Show SMILES N[C@H]1Cc2ccccc2N(O)C1=O
Show InChI InChI=1S/C9H10N2O2/c10-7-5-6-3-1-2-4-8(6)11(13)9(7)12/h1-4,7,13H,5,10H2/t7-/m0/s1
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Article
n/an/a 3.04E+4n/an/an/an/an/an/a



Pfizer Worldwide Research and Development , Neuroscience Medicinal Chemistry, Eastern Point Road, Groton, Connecticut 06340, United States.

Curated by ChEMBL


Assay Description
Inhibition of human KAT1 using L-kynurenine as substrate measured after 16 hrs by SpectraMax plate reader analysis


ACS Med Chem Lett 4: 37-40 (2013)

More data for this
Ligand-Target Pair
Kynurenine Aminotransferase 1/Glutamine Transaminase K


(Homo sapiens (Human))
BDBM50324539
PNG
((S)-(-)-9-(4-aminopiperazin-1-yl)-8-fluoro-3-methy...)
Show SMILES C[C@H]1COc2c(N3CCN(N)CC3)c(F)cc3c2n1cc(C(O)=O)c3=O
Show InChI InChI=1S/C17H19FN4O4/c1-9-8-26-16-13-10(15(23)11(17(24)25)7-22(9)13)6-12(18)14(16)20-2-4-21(19)5-3-20/h6-7,9H,2-5,8,19H2,1H3,(H,24,25)/t9-/m0/s1
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Article
PubMed
n/an/a>3.00E+4n/an/an/an/an/an/a



University of Piemonte Orientale Amedeo Avogadro

Curated by ChEMBL


Assay Description
Inhibition of human recombinant MBP-KAT1 expressed in HEK293 cells assessed as conversion of L-kynurenine to kynurenic acid after 1 hr


J Med Chem 53: 5684-9 (2010)

More data for this
Ligand-Target Pair