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There are 667 purchasable compounds for target: karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b

Wt: 413.4
BDBM29638
Purchase
Wt: 389.4
BDBM29641
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Wt: 470.5
BDBM29663
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Wt: 285.3
BDBM29642
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Wt: 438.5
BDBM29675
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Wt: 310.2
BDBM29681
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Wt: 403.4
BDBM29630
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Wt: 401.5
BDBM30644
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Wt: 391.8
BDBM30737
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Wt: 328.3
BDBM30856
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Wt: 469.4
BDBM33129
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Wt: 319.4
BDBM33675
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Wt: 276.2
BDBM32136
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Wt: 315.3
BDBM32344
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Wt: 325.7
BDBM32106
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Displayed 1 to 15 (of 667 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 29630,29638,29641,29642,29663,29675,29681,30644,30737,30856,32106,32136,32344,33129,33675   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM30737
PNG
(2-(2-amino-3-cyanopyrrolo[3,2-b]quinoxalin-1-yl)et...)
Show SMILES Nc1c(C#N)c2nc3ccccc3nc2n1CCOC(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H14ClN5O2/c21-13-7-5-12(6-8-13)20(27)28-10-9-26-18(23)14(11-22)17-19(26)25-16-4-2-1-3-15(16)24-17/h1-8H,9-10,23H2
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n/an/an/an/a 3.73E+3n/an/an/an/a



Broad Institute

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Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


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Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM32344
PNG
(MLS000723809 | N-(4-nitrophenyl)-9-acridinamine | ...)
Show SMILES [O-][N+](=O)c1ccc(Nc2c3ccccc3nc3ccccc23)cc1
Show InChI InChI=1S/C19H13N3O2/c23-22(24)14-11-9-13(10-12-14)20-19-15-5-1-3-7-17(15)21-18-8-4-2-6-16(18)19/h1-12H,(H,20,21)
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

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Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


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More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM30856
PNG
(1-(4-methylphenyl)-2,5-bis(oxidanylidene)dipyrido[...)
Show SMILES Cc1ccc(cc1)-n1c2nc3ccccn3c(=O)c2cc(C#N)c1=O
Show InChI InChI=1S/C19H12N4O2/c1-12-5-7-14(8-6-12)23-17-15(10-13(11-20)18(23)24)19(25)22-9-3-2-4-16(22)21-17/h2-10H,1H3
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n/an/an/an/a 720n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


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Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


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More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM32106
PNG
(MLS000099937 | N-(1,3-benzodioxol-5-yl)-1-(4-chlor...)
Show SMILES Clc1ccc(CS(=O)(=O)Nc2ccc3OCOc3c2)cc1
Show InChI InChI=1S/C14H12ClNO4S/c15-11-3-1-10(2-4-11)8-21(17,18)16-12-5-6-13-14(7-12)20-9-19-13/h1-7,16H,8-9H2
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

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Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


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More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM29638
PNG
(1-[4-(2-furoyl)piperazino]-3-isopropyl-pyrido[1,2-...)
Show SMILES CC(C)c1cc(N2CCN(CC2)C(=O)c2ccco2)n2c3ccccc3nc2c1C#N
Show InChI InChI=1S/C24H23N5O2/c1-16(2)17-14-22(27-9-11-28(12-10-27)24(30)21-8-5-13-31-21)29-20-7-4-3-6-19(20)26-23(29)18(17)15-25/h3-8,13-14,16H,9-12H2,1-2H3
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n/an/an/an/a 1.61E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


Citation and Details
More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM32136
PNG
((7-acetyloxy-4-methyl-2-oxidanylidene-chromen-6-yl...)
Show SMILES CC(=O)Oc1cc2oc(=O)cc(C)c2cc1OC(C)=O
Show InChI InChI=1S/C14H12O6/c1-7-4-14(17)20-11-6-13(19-9(3)16)12(5-10(7)11)18-8(2)15/h4-6H,1-3H3
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n/an/an/an/a 4.48E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


Citation and Details
More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM29641
PNG
(1-(2-methoxyethyl)-4-(4-propoxyphenyl)-4H-pyridine...)
Show SMILES CCCOc1ccc(cc1)C1C(=CN(CCOC)C=C1C(=O)OC)C(=O)OC
Show InChI InChI=1S/C21H27NO6/c1-5-11-28-16-8-6-15(7-9-16)19-17(20(23)26-3)13-22(10-12-25-2)14-18(19)21(24)27-4/h6-9,13-14,19H,5,10-12H2,1-4H3
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n/an/an/an/a 1.67E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


Citation and Details
More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM29642
PNG
(4-[(5-thiophen-2-yl-2-thiophenyl)methylideneamino]...)
Show SMILES Oc1ccc(cc1)\N=C\c1ccc(s1)-c1cccs1
Show InChI InChI=1S/C15H11NOS2/c17-12-5-3-11(4-6-12)16-10-13-7-8-15(19-13)14-2-1-9-18-14/h1-10,17H/b16-10+
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n/an/an/an/a 1.13E+5n/an/an/an/a



Broad Institute

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Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


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More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM30644
PNG
(5-ethyl-N-(4-thiazolo[5,4-b]pyridin-2-ylphenyl)thi...)
Show SMILES CCc1ccc(s1)S(=O)(=O)Nc1ccc(cc1)-c1nc2cccnc2s1
Show InChI InChI=1S/C18H15N3O2S3/c1-2-14-9-10-16(24-14)26(22,23)21-13-7-5-12(6-8-13)17-20-15-4-3-11-19-18(15)25-17/h3-11,21H,2H2,1H3
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n/an/an/an/a 9.71E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


Citation and Details
More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM33675
PNG
(1-(2-methylphenyl)-N-(thiophen-2-ylmethyl)-5-benzi...)
Show SMILES Cc1ccccc1-n1cnc2cc(NCc3cccs3)ccc12
Show InChI InChI=1S/C19H17N3S/c1-14-5-2-3-7-18(14)22-13-21-17-11-15(8-9-19(17)22)20-12-16-6-4-10-23-16/h2-11,13,20H,12H2,1H3
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


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More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM29663
PNG
(MLS000573239 | N-(1-benzyl-3-besyl-pyrrolo[3,2-b]q...)
Show SMILES CCC(=O)Nc1c(c2nc3ccccc3nc2n1Cc1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H22N4O3S/c1-2-22(31)29-26-24(34(32,33)19-13-7-4-8-14-19)23-25(28-21-16-10-9-15-20(21)27-23)30(26)17-18-11-5-3-6-12-18/h3-16H,2,17H2,1H3,(H,29,31)
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n/an/an/an/a 1.73E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


Citation and Details
More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM29675
PNG
(2-methyl-N-(4-thiazolo[5,4-b]pyridin-2-ylphenyl)-1...)
Show SMILES Cc1nc2ccc(cc2s1)S(=O)(=O)Nc1ccc(cc1)-c1nc2cccnc2s1
Show InChI InChI=1S/C20H14N4O2S3/c1-12-22-16-9-8-15(11-18(16)27-12)29(25,26)24-14-6-4-13(5-7-14)19-23-17-3-2-10-21-20(17)28-19/h2-11,24H,1H3
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n/an/an/an/a 3.85E+4n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


Citation and Details
More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM33129
PNG
(2-(9-ketoacridin-10-yl)-N-[(3-nitro-4-pyrrolidino-...)
Show SMILES [O-][N+](=O)c1cc(\C=N\NC(=O)Cn2c3ccccc3c(=O)c3ccccc23)ccc1N1CCCC1
Show InChI InChI=1S/C26H23N5O4/c32-25(17-30-21-9-3-1-7-19(21)26(33)20-8-2-4-10-22(20)30)28-27-16-18-11-12-23(24(15-18)31(34)35)29-13-5-6-14-29/h1-4,7-12,15-16H,5-6,13-14,17H2,(H,28,32)/b27-16+
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n/an/an/an/a>5.00E+5n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


Citation and Details
More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM29681
PNG
(2-[(1,2,3,4-tetrafluoro-9-acridinyl)amino]ethanol ...)
Show SMILES OCCNc1c2ccccc2nc2c(F)c(F)c(F)c(F)c12
Show InChI InChI=1S/C15H10F4N2O/c16-10-9-14(20-5-6-22)7-3-1-2-4-8(7)21-15(9)13(19)12(18)11(10)17/h1-4,22H,5-6H2,(H,20,21)
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n/an/an/an/a 6.49E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


Citation and Details
More data for this
Ligand-Target Pair
karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b


(Homo sapiens (Human))
BDBM29630
PNG
(MLS000084335 | SMR000048147 | cid_666800)
Show SMILES CCc1ccc(cc1)C1C2=C(CC(C)(C)CC2=O)Nc2c1c(=O)nc1nc(C)[nH]n21
Show InChI InChI=1S/C23H25N5O2/c1-5-13-6-8-14(9-7-13)17-18-15(10-23(3,4)11-16(18)29)25-20-19(17)21(30)26-22-24-12(2)27-28(20)22/h6-9,17,25H,5,10-11H2,1-4H3,(H,24,26,27,30)
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n/an/an/an/a 7.12E+3n/an/an/an/a



Broad Institute

Curated by PubChem BioAssay


Assay Description
Keywords: Counterscreen, FRET assay, HTS, YIC probe, Dose response, Assay Overview: This is a fluorescence resonance energy transfer (FRET)-based b...


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Ligand-Target Pair