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There are 8 purchasable compounds for target: C-mpl

Wt: 358.3
BDBM50105944
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Wt: 438.4
BDBM50105956
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Wt: 262.2
BDBM50377370
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Wt: 262.2
BDBM50377373
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Wt: 262.2
BDBM50377374
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Wt: 262.2
BDBM50377375
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Wt: 212.2
BDBM50377377
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Wt: 194.2
BDBM50377378
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50105944,50105956,50377370,50377373,50377374,50377375,50377377,50377378   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Thrombopoietin receptor


(Homo sapiens (Human))
BDBM50105944
PNG
(3-Hydroxy-4-(2-hydroxy-5-methyl-phenylazo)-naphtha...)
Show SMILES Cc1ccc(O)c(c1)N=Nc1c(O)cc(c2ccccc12)S(O)(=O)=O |w:8.8|
Show InChI InChI=1S/C17H14N2O5S/c1-10-6-7-14(20)13(8-10)18-19-17-12-5-3-2-4-11(12)16(9-15(17)21)25(22,23)24/h2-9,20-21H,1H3,(H,22,23,24)
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PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 3.00E+3n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))
BDBM50105956
PNG
(3-Hydroxy-4-(2-hydroxy-4-sulfo-naphthalen-1-ylazo)...)
Show SMILES OC(=O)c1cc2ccccc2c(N=Nc2c(O)cc(c3ccccc23)S(O)(=O)=O)c1O |w:12.12|
Show InChI InChI=1S/C21H14N2O7S/c24-16-10-17(31(28,29)30)13-7-3-4-8-14(13)18(16)22-23-19-12-6-2-1-5-11(12)9-15(20(19)25)21(26)27/h1-10,24-25H,(H,26,27)(H,28,29,30)
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n/an/an/an/a 1.00E+4n/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Effective concentration for thrombopoietin luciferase activity was determined in BAF-3 cells


J Med Chem 44: 3730-45 (2001)

More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))
BDBM50377370
PNG
(CHEMBL260846)
Show SMILES Nc1nc(cs1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C10H6F4N2S/c11-7-2-1-5(3-6(7)10(12,13)14)8-4-17-9(15)16-8/h1-4H,(H2,15,16)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 100n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))
BDBM50377378
PNG
(CHEMBL261023)
Show SMILES Nc1nc(cs1)-c1ccccc1F
Show InChI InChI=1S/C9H7FN2S/c10-7-4-2-1-3-6(7)8-5-13-9(11)12-8/h1-5H,(H2,11,12)
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PC cid
PC sid
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n/an/an/an/a 6.80E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))
BDBM50377374
PNG
(CHEMBL405478)
Show SMILES Nc1nc(cs1)-c1ccc(cc1F)C(F)(F)F
Show InChI InChI=1S/C10H6F4N2S/c11-7-3-5(10(12,13)14)1-2-6(7)8-4-17-9(15)16-8/h1-4H,(H2,15,16)
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n/an/an/an/a 260n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))
BDBM50377375
PNG
(CHEMBL263109)
Show SMILES Nc1nc(cs1)-c1cccc(c1F)C(F)(F)F
Show InChI InChI=1S/C10H6F4N2S/c11-8-5(7-4-17-9(15)16-7)2-1-3-6(8)10(12,13)14/h1-4H,(H2,15,16)
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PC cid
PC sid
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Article
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n/an/an/an/a 57n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))
BDBM50377377
PNG
(CHEMBL412807)
Show SMILES Nc1nc(cs1)-c1c(F)cccc1F
Show InChI InChI=1S/C9H6F2N2S/c10-5-2-1-3-6(11)8(5)7-4-14-9(12)13-7/h1-4H,(H2,12,13)
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PC cid
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
More data for this
Ligand-Target Pair
Thrombopoietin receptor


(Homo sapiens (Human))
BDBM50377373
PNG
(CHEMBL261539)
Show SMILES Nc1nc(cs1)-c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C10H6F4N2S/c11-7-2-1-5(10(12,13)14)3-6(7)8-4-17-9(15)16-8/h1-4H,(H2,15,16)
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 5.20E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at TPO receptor


Bioorg Med Chem Lett 18: 3000-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.03.052
More data for this
Ligand-Target Pair