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There are 3 purchasable compounds for target: p75 ICD

Wt: 362.3
BDBM50029495
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Wt: 204.1
BDBM50029496
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Wt: 301.2
BDBM50111443
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50029495,50029496,50111443   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Low affinity neurotrophin receptor p75NTR


(Homo sapiens (Human))
BDBM50029495
PNG
(7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo...)
Show SMILES Cn1c2cc(nn2c(=O)c2cc(NC(=O)c3ccccc3)ccc12)C(O)=O
Show InChI InChI=1S/C19H14N4O4/c1-22-15-8-7-12(20-17(24)11-5-3-2-4-6-11)9-13(15)18(25)23-16(22)10-14(21-23)19(26)27/h2-10H,1H3,(H,20,24)(H,26,27)
PDB
MMDB

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PC sid
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PubMed
n/an/a 200n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of [125I]- NGF binding to extracellular domain of p75 receptor


Citation and Details
More data for this
Ligand-Target Pair
Low affinity neurotrophin receptor p75NTR


(Homo sapiens (Human))
BDBM50029496
PNG
(6-Amino-4-oxo-1,4-dihydro-quinoline-2-carboxylic a...)
Show SMILES Nc1ccc2nc(cc(O)c2c1)C(O)=O
Show InChI InChI=1S/C10H8N2O3/c11-5-1-2-7-6(3-5)9(13)4-8(12-7)10(14)15/h1-4H,11H2,(H,12,13)(H,14,15)
PDB
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CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 3.10E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibition of [125I]- NGF binding to extracellular domain of p75 receptor


Citation and Details
More data for this
Ligand-Target Pair
Low affinity neurotrophin receptor p75NTR


(Homo sapiens (Human))
BDBM50111443
PNG
(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Show SMILES OCCNN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O
Show InChI InChI=1S/C14H11N3O5/c18-5-4-15-16-13(19)10-3-1-2-8-6-9(17(21)22)7-11(12(8)10)14(16)20/h1-3,6-7,15,18H,4-5H2
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Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse NGF binding to p75 (unknown origin) by SPR method


J Med Chem 60: 66-88 (2017)

More data for this
Ligand-Target Pair
Low affinity neurotrophin receptor p75NTR


(Homo sapiens (Human))
BDBM50029495
PNG
(7-Benzoylamino-4-methyl-9-oxo-4,9-dihydro-pyrazolo...)
Show SMILES Cn1c2cc(nn2c(=O)c2cc(NC(=O)c3ccccc3)ccc12)C(O)=O
Show InChI InChI=1S/C19H14N4O4/c1-22-15-8-7-12(20-17(24)11-5-3-2-4-6-11)9-13(15)18(25)23-16(22)10-14(21-23)19(26)27/h2-10H,1H3,(H,20,24)(H,26,27)
PDB
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Article
PubMed
n/an/a 1.10E+5n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of mouse NGF binding to p75 (unknown origin) by SPR method


J Med Chem 60: 66-88 (2017)

More data for this
Ligand-Target Pair
Low affinity neurotrophin receptor p75NTR


(Homo sapiens (Human))
BDBM50111443
PNG
(2-(2-Hydroxy-ethylamino)-5-nitro-benzo[de]isoquino...)
Show SMILES OCCNN1C(=O)c2cccc3cc(cc(C1=O)c23)[N+]([O-])=O
Show InChI InChI=1S/C14H11N3O5/c18-5-4-15-16-13(19)10-3-1-2-8-6-9(17(21)22)7-11(12(8)10)14(16)20/h1-3,6-7,15,18H,4-5H2
PDB
MMDB

NCI pathway
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KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
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CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 3.72E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Competitive binding against Nerve growth factor to p75-NGF receptor in PC12 cells


Citation and Details
More data for this
Ligand-Target Pair