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There are 6 purchasable compounds for target: Kynureninase

Wt: 238.1
BDBM50061907
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Wt: 238.1
BDBM50083950
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Wt: 195.1
BDBM50265459
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Wt: 238.1
BDBM50284766
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Wt: 193.1
BDBM50288254
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Wt: 209.2
BDBM50288255
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50061907,50083950,50265459,50284766,50288254,50288255   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kynureninase


(Homo sapiens (Human))
BDBM50288255
PNG
(2-ammonio-4-(2-ammoniophenyl)-4-oxo-(2S)-butanoate)
Show SMILES [NH3+][C@@H](CC(=O)c1ccccc1[NH3+])C([O-])=O
Show InChI InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/p+1/t8-/m0/s1
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4.28E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence


Bioorg Med Chem Lett 6: 2643-2646 (1996)

More data for this
Ligand-Target Pair
Kynureninase


(Homo sapiens (Human))
BDBM50288254
PNG
(2-ammonio-4-oxo-4-phenyl-(2S)-butanoate | CHEMBL31...)
Show SMILES [NH3+][C@@H](CC(=O)c1ccccc1)C([O-])=O
Show InChI InChI=1S/C10H11NO3/c11-8(10(13)14)6-9(12)7-4-2-1-3-5-7/h1-5,8H,6,11H2,(H,13,14)/t8-/m0/s1
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2.34E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for its binding affinity against kynureninase isolated from Pseudomonas fluorescence


Bioorg Med Chem Lett 6: 2643-2646 (1996)

More data for this
Ligand-Target Pair
Kynureninase


(Homo sapiens (Human))
BDBM50265459
PNG
(3-Hydroxyhippuric acid | CHEMBL447627)
Show SMILES OC(=O)CNC(=O)c1cccc(O)c1
Show InChI InChI=1S/C9H9NO4/c11-7-3-1-2-6(4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)
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PubMed
6.00E+4n/an/an/an/an/an/an/an/a



University of Georgia

Curated by ChEMBL


Assay Description
Inhibition of human kynureninase


J Med Chem 52: 389-96 (2009)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kynureninase


(Rattus norvegicus)
BDBM50061907
PNG
((+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric aci...)
Show SMILES NC(CC(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C10H10N2O5/c11-8(10(14)15)5-9(13)6-2-1-3-7(4-6)12(16)17/h1-4,8H,5,11H2,(H,14,15)
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n/an/a 1.00E+5n/an/an/an/an/an/a



Universit£ di Perugia

Curated by ChEMBL


Assay Description
Ability to inhibit kynureninase was determined in a competitive inhibition assay.


Citation and Details
More data for this
Ligand-Target Pair
Kynureninase


(Rattus norvegicus)
BDBM50083950
PNG
((S)-(+)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric a...)
Show SMILES N[C@@H](CC(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C10H10N2O5/c11-8(10(14)15)5-9(13)6-2-1-3-7(4-6)12(16)17/h1-4,8H,5,11H2,(H,14,15)/t8-/m0/s1
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UniChem
Article
n/an/a 6.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibitory activity against kynureninase from rat liver


Bioorg Med Chem Lett 5: 1451-1454 (1995)

More data for this
Ligand-Target Pair
Kynureninase


(Rattus norvegicus)
BDBM50284766
PNG
((R)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric acid ...)
Show SMILES N[C@H](CC(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C10H10N2O5/c11-8(10(14)15)5-9(13)6-2-1-3-7(4-6)12(16)17/h1-4,8H,5,11H2,(H,14,15)/t8-/m1/s1
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CHEMBL
PC cid
PC sid
UniChem
Article
n/an/a 1.00E+5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Tested for inhibitory activity against kynureninase from rat liver


Bioorg Med Chem Lett 5: 1451-1454 (1995)

More data for this
Ligand-Target Pair