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There are 9 purchasable compounds for target: Heart phosphodiesterase

Wt: 180.1
BDBM10847
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Wt: 474.5
BDBM14390
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Wt: 271.2
BDBM14363
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Wt: 389.4
BDBM14777
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Wt: 211.2
BDBM15296
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Wt: 240.2
BDBM50000315
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Wt: 350.4
BDBM50059033
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Wt: 266.2
BDBM50059035
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Wt: 345.2
BDBM50369127
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 10847,14390,14363,14777,15296,50000315,50059033,50059035,50369127   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Heart phosphodiesterase


(Bos taurus)
BDBM10847
PNG
(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dion...)
Show SMILES Cn1c2nc[nH]c2c(=O)n(C)c1=O
Show InChI InChI=1S/C7H8N4O2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13/h3H,1-2H3,(H,8,9)
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7.70E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of bovine heart phosphodiesterase


Citation and Details
More data for this
Ligand-Target Pair
Heart phosphodiesterase


(Bos taurus)
BDBM50059033
PNG
((11aS,11bS)-11a-Ethyl-2,3,4,5,11a,11b-hexahydro-1H...)
Show SMILES CCOC(=O)C1=C[C@]2(CC)CCCN3CCc4c([C@H]23)n1c1ccccc41
Show InChI InChI=1S/C22H26N2O2/c1-3-22-11-7-12-23-13-10-16-15-8-5-6-9-17(15)24(19(16)20(22)23)18(14-22)21(25)26-4-2/h5-6,8-9,14,20H,3-4,7,10-13H2,1-2H3/t20-,22+/m1/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 3 (PDE3) purified from bovine heart


J Med Chem 40: 2196-210 (1997)

More data for this
Ligand-Target Pair
Heart phosphodiesterase


(Bos taurus)
BDBM50059035
PNG
(3-Isobutyl-8-methoxymethyl-1-methyl-3,7-dihydro-pu...)
Show SMILES COCc1nc2n(CC(C)C)c(=O)n(C)c(=O)c2[nH]1
Show InChI InChI=1S/C12H18N4O3/c1-7(2)5-16-10-9(11(17)15(3)12(16)18)13-8(14-10)6-19-4/h7H,5-6H2,1-4H3,(H,13,14)
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n/an/a 2.40E+5n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 3 (PDE3) purified from bovine heart


J Med Chem 40: 2196-210 (1997)

More data for this
Ligand-Target Pair
Heart phosphodiesterase


(Bos taurus)
BDBM14390
PNG
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
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n/an/a 9.20E+3n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of bovine aorta PDE3 (Phosphodiesterase 3)


J Med Chem 46: 4533-42 (2003)

More data for this
Ligand-Target Pair
Heart phosphodiesterase


(Bos taurus)
BDBM14777
PNG
((2R,8R)-2-(2H-1,3-benzodioxol-5-yl)-6-methyl-3,6,1...)
Show SMILES CN1CC(=O)N2[C@H](Cc3c([nH]c4ccccc34)[C@H]2c2ccc3OCOc3c2)C1=O
Show InChI InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of bovine aorta PDE3 (Phosphodiesterase 3)


J Med Chem 46: 4533-42 (2003)

More data for this
Ligand-Target Pair
Heart phosphodiesterase


(Bos taurus)
BDBM50369127
PNG
(CHEMBL395336)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2CO[P@](O)(=O)O[C@H]2[C@H]1O
Show InChI InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1
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n/an/a 100n/an/an/an/an/an/a



Kyowa Hakka Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of bovine arterial Phosphodiesterase 3


J Med Chem 39: 297-303 (1996)

More data for this
Ligand-Target Pair
Heart phosphodiesterase


(Bos taurus)
BDBM15296
PNG
(6-methyl-2-oxo-5-(pyridin-4-yl)-1,2-dihydropyridin...)
Show SMILES Cc1[nH]c(=O)c(cc1-c1ccncc1)C#N
Show InChI InChI=1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Kyowa Hakka Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of bovine arterial Phosphodiesterase 3


J Med Chem 39: 297-303 (1996)

More data for this
Ligand-Target Pair
Heart phosphodiesterase


(Bos taurus)
BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of bovine aorta PDE3 (phosphodiesterase 3)


J Med Chem 46: 4525-32 (2003)

More data for this
Ligand-Target Pair
Heart phosphodiesterase


(Bos taurus)
BDBM14390
PNG
(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Show SMILES CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1
Show InChI InChI=1S/C22H30N6O4S/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29)
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n/an/a 9.20E+3n/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of bovine aorta PDE3 (phosphodiesterase 3)


J Med Chem 46: 4525-32 (2003)

More data for this
Ligand-Target Pair
Heart phosphodiesterase


(Bos taurus)
BDBM14363
PNG
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)
Show SMILES CCCOc1ccccc1-c1nc2nn[nH]c2c(=O)[nH]1
Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19)
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n/an/a 1.22E+5n/an/an/an/an/an/a



Schering-Plough Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against phosphodiesterase 3 (PDE3) purified from bovine heart


J Med Chem 40: 2196-210 (1997)

More data for this
Ligand-Target Pair
Heart phosphodiesterase


(Bos taurus)
BDBM50000315
PNG
((CI-914)6-(4-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-...)
Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1ccnc1
Show InChI InChI=1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
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n/an/a 9.40E+4n/an/an/an/an/an/a



Ayerst Laboratories Research, Inc.

Curated by ChEMBL


Assay Description
Inhibition of bovine cardiac phosphodiesterase fraction III


Citation and Details
More data for this
Ligand-Target Pair