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There are 23 purchasable compounds for target: C-C chemokine receptor type 8

Wt: 233.2
BDBM38924
Purchase
Wt: 208.2
BDBM64740
Purchase
Wt: 156.1
BDBM50042874
Purchase
Wt: 180.2
BDBM50092158
Purchase
Wt: 339.4
BDBM50185903
Purchase
Wt: 311.3
BDBM50185914
Purchase
Wt: 432.4
BDBM50203868
Purchase
Wt: 396.4
BDBM50203890
Wt: 458.4
BDBM50203901
Purchase
Wt: 236.2
BDBM50401341
Purchase
Wt: 240.2
BDBM50401342
Purchase
Wt: 216.2
BDBM50401349
Purchase
Wt: 184.2
BDBM50401350
Purchase
Wt: 184.2
BDBM50401351
Purchase
Wt: 267.7
BDBM50401354
Purchase
Displayed 1 to 15 (of 23 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 23 hits for monomerid = 38924,64740,50042874,50092158,50185903,50185914,50203868,50203890,50203901,50401341,50401342,50401349,50401350,50401351,50401354   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50203868
PNG
(CHEMBL412116 | N-[4-(4-methoxy-phenylsulfamoyl)-na...)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)c3ccccc23)cc1
Show InChI InChI=1S/C24H20N2O4S/c1-30-19-13-11-18(12-14-19)26-31(28,29)23-16-15-22(20-9-5-6-10-21(20)23)25-24(27)17-7-3-2-4-8-17/h2-16,26H,1H3,(H,25,27)
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42.6n/an/an/an/an/an/an/an/a



Millennium Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human CCR8 expressed in L1.2 cells by FMAT assay


J Med Chem 50: 566-84 (2007)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50185903
PNG
(1-(3-phenoxy-benzyl)-piperidine-4-carboxylic acid ...)
Show SMILES CCOC(=O)C1CCN(Cc2cccc(Oc3ccccc3)c2)CC1
Show InChI InChI=1S/C21H25NO3/c1-2-24-21(23)18-11-13-22(14-12-18)16-17-7-6-10-20(15-17)25-19-8-4-3-5-9-19/h3-10,15,18H,2,11-14,16H2,1H3
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2.60E+3n/an/an/an/an/an/an/an/a



Millennium Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]I309 from human CCR8 expressed in L1.2 cells


J Med Chem 49: 2669-72 (2006)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50203890
PNG
(CHEMBL218207 | N-(4-(morpholinosulfonyl)naphthalen...)
Show SMILES O=C(Nc1ccc(c2ccccc12)S(=O)(=O)N1CCOCC1)c1ccccc1
Show InChI InChI=1S/C21H20N2O4S/c24-21(16-6-2-1-3-7-16)22-19-10-11-20(18-9-5-4-8-17(18)19)28(25,26)23-12-14-27-15-13-23/h1-11H,12-15H2,(H,22,24)
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Millennium Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human CCR8 expressed in L1.2 cells by FMAT assay


J Med Chem 50: 566-84 (2007)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50185914
PNG
(1-(3-phenoxybenzyl)piperidine-4-carboxylic acid | ...)
Show SMILES OC(=O)C1CCN(Cc2cccc(Oc3ccccc3)c2)CC1
Show InChI InChI=1S/C19H21NO3/c21-19(22)16-9-11-20(12-10-16)14-15-5-4-8-18(13-15)23-17-6-2-1-3-7-17/h1-8,13,16H,9-12,14H2,(H,21,22)
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>3.00E+4n/an/an/an/an/an/an/an/a



Millennium Pharmaceuticals

Curated by ChEMBL


Assay Description
Displacement of [125I]I309 from human CCR8 expressed in L1.2 cells


J Med Chem 49: 2669-72 (2006)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50203901
PNG
(4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-naphthalen...)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(N3C(=O)c4ccccc4C3=O)c3ccccc23)cc1
Show InChI InChI=1S/C25H18N2O5S/c1-32-17-12-10-16(11-13-17)26-33(30,31)23-15-14-22(18-6-2-3-7-19(18)23)27-24(28)20-8-4-5-9-21(20)25(27)29/h2-15,26H,1H3
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>4.40E+4n/an/an/an/an/an/an/an/a



Millennium Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human CCR8 expressed in L1.2 cells by FMAT assay


J Med Chem 50: 566-84 (2007)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM64740
PNG
(2,9-dimethyl-1,10-phenanthroline | MLS001194484 | ...)
Show SMILES Cc1ccc2ccc3ccc(C)nc3c2n1
Show InChI InChI=1S/C14H12N2/c1-9-3-5-11-7-8-12-6-4-10(2)16-14(12)13(11)15-9/h3-8H,1-2H3
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n/an/an/an/a>1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50042874
PNG
(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Show SMILES c1ccc(nc1)-c1ccccn1
Show InChI InChI=1S/C10H8N2/c1-3-7-11-9(5-1)10-6-2-4-8-12-10/h1-8H
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n/an/an/an/a 3.98E+4n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50401350
PNG
(CHEMBL101165)
Show SMILES Cc1ccnc(c1)-c1cc(C)ccn1
Show InChI InChI=1S/C12H12N2/c1-9-3-5-13-11(7-9)12-8-10(2)4-6-14-12/h3-8H,1-2H3
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n/an/an/an/a 3.30E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50401351
PNG
(CHEMBL2205807)
Show SMILES Cc1ccc(nc1)-c1ccc(C)cn1
Show InChI InChI=1S/C12H12N2/c1-9-3-5-11(13-7-9)12-6-4-10(2)8-14-12/h3-8H,1-2H3
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n/an/an/an/a 7.50E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50092158
PNG
(1,10-phenanthroline | CHEMBL415879 | US9187406, 1,...)
Show SMILES c1cnc2c(c1)ccc1cccnc21
Show InChI InChI=1S/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H
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n/an/an/an/a 3.90E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50042874
PNG
(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Show SMILES c1ccc(nc1)-c1ccccn1
Show InChI InChI=1S/C10H8N2/c1-3-7-11-9(5-1)10-6-2-4-8-12-10/h1-8H
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n/an/an/an/a 4.20E+4n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50401354
PNG
(CHEMBL2205805)
Show SMILES Clc1cc(nc(c1)-c1ccccn1)-c1ccccn1
Show InChI InChI=1S/C15H10ClN3/c16-11-9-14(12-5-1-3-7-17-12)19-15(10-11)13-6-2-4-8-18-13/h1-10H
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n/an/an/an/a 398n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM38924
PNG
(2,6-bis(2-pyridinyl)pyridine | 2,6-bis(2-pyridyl)p...)
Show SMILES c1ccc(nc1)-c1cccc(n1)-c1ccccn1
Show InChI InChI=1S/C15H11N3/c1-3-10-16-12(6-1)14-8-5-9-15(18-14)13-7-2-4-11-17-13/h1-11H
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n/an/an/an/a 5.01E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50401349
PNG
(CHEMBL2205808)
Show SMILES COc1ccnc(c1)-c1cc(OC)ccn1
Show InChI InChI=1S/C12H12N2O2/c1-15-9-3-5-13-11(7-9)12-8-10(16-2)4-6-14-12/h3-8H,1-2H3
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n/an/an/an/a 5.01E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50401350
PNG
(CHEMBL101165)
Show SMILES Cc1ccnc(c1)-c1cc(C)ccn1
Show InChI InChI=1S/C12H12N2/c1-9-3-5-13-11(7-9)12-8-10(2)4-6-14-12/h3-8H,1-2H3
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n/an/an/an/a 3.16E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50401351
PNG
(CHEMBL2205807)
Show SMILES Cc1ccc(nc1)-c1ccc(C)cn1
Show InChI InChI=1S/C12H12N2/c1-9-3-5-11(13-7-9)12-6-4-10(2)8-14-12/h3-8H,1-2H3
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n/an/an/an/a 7.94E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50092158
PNG
(1,10-phenanthroline | CHEMBL415879 | US9187406, 1,...)
Show SMILES c1cnc2c(c1)ccc1cccnc21
Show InChI InChI=1S/C12H8N2/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1/h1-8H
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n/an/an/an/a 3.98E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50401342
PNG
(CHEMBL2205802)
Show SMILES OCc1ccc2ccc3ccc(CO)nc3c2n1
Show InChI InChI=1S/C14H12N2O2/c17-7-11-5-3-9-1-2-10-4-6-12(8-18)16-14(10)13(9)15-11/h1-6,17-18H,7-8H2
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n/an/an/an/a>1.00E+6n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50401341
PNG
(CHEMBL2205803)
Show SMILES O=Cc1ccc2ccc3ccc(C=O)nc3c2n1
Show InChI InChI=1S/C14H8N2O2/c17-7-11-5-3-9-1-2-10-4-6-12(8-18)16-14(10)13(9)15-11/h1-8H
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University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM38924
PNG
(2,6-bis(2-pyridinyl)pyridine | 2,6-bis(2-pyridyl)p...)
Show SMILES c1ccc(nc1)-c1cccc(n1)-c1ccccn1
Show InChI InChI=1S/C15H11N3/c1-3-10-16-12(6-1)14-8-5-9-15(18-14)13-7-2-4-11-17-13/h1-11H
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n/an/an/an/a 4.90E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50401354
PNG
(CHEMBL2205805)
Show SMILES Clc1cc(nc(c1)-c1ccccn1)-c1ccccn1
Show InChI InChI=1S/C15H10ClN3/c16-11-9-14(12-5-1-3-7-17-12)19-15(10-11)13-6-2-4-8-18-13/h1-10H
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n/an/an/an/a 390n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50203868
PNG
(CHEMBL412116 | N-[4-(4-methoxy-phenylsulfamoyl)-na...)
Show SMILES COc1ccc(NS(=O)(=O)c2ccc(NC(=O)c3ccccc3)c3ccccc23)cc1
Show InChI InChI=1S/C24H20N2O4S/c1-30-19-13-11-18(12-14-19)26-31(28,29)23-16-15-22(20-9-5-6-10-21(20)23)25-24(27)17-7-3-2-4-8-17/h2-16,26H,1H3,(H,25,27)
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n/an/a 150n/an/an/an/an/an/a



Millennium Pharmaceuticals

Curated by ChEMBL


Assay Description
Antagonist activity against human CCR8 expressed in CHO/Galpha16 cells assessed as inhibition of CCL1-induced increase of intracellular calcium by FL...


J Med Chem 50: 566-84 (2007)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 8


(Homo sapiens (Human))
BDBM50401349
PNG
(CHEMBL2205808)
Show SMILES COc1ccnc(c1)-c1cc(OC)ccn1
Show InChI InChI=1S/C12H12N2O2/c1-15-9-3-5-13-11(7-9)12-8-10(16-2)4-6-14-12/h3-8H,1-2H3
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n/an/an/an/a 5.40E+3n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis


J Med Chem 55: 8164-77 (2012)

More data for this
Ligand-Target Pair