BindingDB logo
myBDB logout

There are 10 purchasable compounds for target: cAMP-regulated guanine nucleotide exchange factor II

Wt: 299.3
BDBM89901
Purchase
Wt: 279.3
BDBM50294336
Purchase
Wt: 329.2
BDBM50384264
Purchase
Wt: 353.4
BDBM50384265
Purchase
Wt: 235.3
BDBM50384266
Purchase
Wt: 277.3
BDBM50425531
Purchase
Wt: 290.3
BDBM50425550
Purchase
Wt: 274.3
BDBM50425555
Purchase
Wt: 330.7
BDBM50011360
Purchase
Wt: 432.3
BDBM50011368
Purchase

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 89901,50294336,50384264,50384265,50384266,50425531,50425550,50425555,50011360,50011368   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50011360
PNG
(CHEMBL3260990)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 7.00E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from EPAC2 (unknown origin) by fluorescence plate reader analysis


J Med Chem 57: 3651-65 (2014)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384266
PNG
(CHEMBL2030605)
Show SMILES O=c1[nH]c(=S)[nH]c(C2CCCCC2)c1C#N
Show InChI InChI=1S/C11H13N3OS/c12-6-8-9(7-4-2-1-3-5-7)13-11(16)14-10(8)15/h7H,1-5H2,(H2,13,14,15,16)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>3.00E+5n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Bioorg Med Chem Lett 22: 4038-43 (2012)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425555
PNG
(CHEMBL2313653)
Show SMILES Cc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 400n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of EPAC2 (unknown origin)


J Med Chem 57: 3651-65 (2014)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50011368
PNG
(CHEMBL3260989)
Show SMILES [I-].COCCC[n+]1c(C)csc1Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C17H24N2OS.HI/c1-12-9-13(2)16(14(3)10-12)18-17-19(7-6-8-20-5)15(4)11-21-17;/h9-11H,6-8H2,1-5H3;1H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 600n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of EPAC2 (unknown origin)


J Med Chem 57: 3651-65 (2014)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Mus musculus)
BDBM50011360
PNG
(CHEMBL3260990)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 8.90E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from mouse recombinant EPAC2 by fluorescence assay


J Med Chem 58: 6033-47 (2015)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50011360
PNG
(CHEMBL3260990)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 4.40E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Antagonist activity at EPAC2 (unknown origin) assessed as cAMP-induced guanine nucleotide exchange factor activity


J Med Chem 58: 6033-47 (2015)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50011360
PNG
(CHEMBL3260990)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 9.00E+3n/an/an/an/an/an/a



?Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555, United States.

Curated by ChEMBL


Assay Description
Displacement of 8-NBD-cAMP from EPAC2 (unknown origin)


J Med Chem 58: 6033-47 (2015)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50011360
PNG
(CHEMBL3260990)
Show SMILES CC(C)(C)c1cc(no1)C(=O)C(=N\Nc1cccc(Cl)c1)\C#N
Show InChI InChI=1S/C16H15ClN4O2/c1-16(2,3)14-8-12(21-23-14)15(22)13(9-18)20-19-11-6-4-5-10(17)7-11/h4-8,19H,1-3H3/b20-13+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

PubMed
n/an/a 4.40E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of recombinant C-terminal FLAG/HA-tagged EPAC2 (unknown origin) expressed in retrovirus infected human HeLaS3 cells assessed as reduction ...


Citation and Details
More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384264
PNG
(CHEMBL316966)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2CO[P@](O)(=O)O[C@H]2[C@H]1O
Show InChI InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 4.00E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


J Med Chem 56: 952-62 (2013)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM89901
PNG
(1-(2,4,6-Trimethyl-benzenesulfonyl)-1H-indole | 1-...)
Show SMILES Cc1cc(C)c(c(C)c1)S(=O)(=O)n1ccc2ccccc12
Show InChI InChI=1S/C17H17NO2S/c1-12-10-13(2)17(14(3)11-12)21(19,20)18-9-8-15-6-4-5-7-16(15)18/h4-11H,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


J Med Chem 56: 952-62 (2013)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425531
PNG
(CHEMBL2313646)
Show SMILES Cc1cc(C)n(c1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C15H19NO2S/c1-10-6-12(3)15(13(4)7-10)19(17,18)16-9-11(2)8-14(16)5/h6-9H,1-5H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 300n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


J Med Chem 56: 952-62 (2013)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425550
PNG
(CHEMBL2313658)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H18O3S/c1-11-9-12(2)16(13(3)10-11)20(17,18)15-7-5-14(19-4)6-8-15/h5-10H,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.90E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


J Med Chem 56: 952-62 (2013)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50294336
PNG
(5-amino-2-(4-aminophenylamino)benzenesulfonic acid...)
Show SMILES Nc1ccc(Nc2ccc(N)cc2S(O)(=O)=O)cc1
Show InChI InChI=1S/C12H13N3O3S/c13-8-1-4-10(5-2-8)15-11-6-3-9(14)7-12(11)19(16,17)18/h1-7,15H,13-14H2,(H,16,17,18)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 1.80E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


J Med Chem 56: 952-62 (2013)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50425555
PNG
(CHEMBL2313653)
Show SMILES Cc1ccc(cc1)S(=O)(=O)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H18O2S/c1-11-5-7-15(8-6-11)19(17,18)16-13(3)9-12(2)10-14(16)4/h5-10H,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 500n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Antagonist activity at recombinant EPAC2 (unknown origin) assessed 8-NBD-cAMP substrate fluorescence intensity by substrate competing assay


J Med Chem 56: 952-62 (2013)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384264
PNG
(CHEMBL316966)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2CO[P@](O)(=O)O[C@H]2[C@H]1O
Show InChI InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 4.80E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Bioorg Med Chem Lett 22: 4038-43 (2012)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384265
PNG
(CHEMBL2030452)
Show SMILES Cc1ccc(C)c(CSc2nc(C3CCCCC3)c(C#N)c(=O)[nH]2)c1
Show InChI InChI=1S/C20H23N3OS/c1-13-8-9-14(2)16(10-13)12-25-20-22-18(15-6-4-3-5-7-15)17(11-21)19(24)23-20/h8-10,15H,3-7,12H2,1-2H3,(H,22,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 8.40E+3n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Competitive inhibition of Epac2 using fluorescent nucleotide analog 8-NBD-cAMP by fluorescence analysis


Bioorg Med Chem Lett 22: 4038-43 (2012)

More data for this
Ligand-Target Pair
Rap guanine nucleotide exchange factor 4


(Homo sapiens)
BDBM50384264
PNG
(CHEMBL316966)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]2CO[P@](O)(=O)O[C@H]2[C@H]1O
Show InChI InChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 4.00E+4n/an/an/an/an/an/a



University of Texas Medical Branch

Curated by ChEMBL


Assay Description
Inhibition of EPAC2 (unknown origin)


J Med Chem 57: 3651-65 (2014)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)