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There are 7 purchasable compounds for target: HCN1

Wt: 345.4
BDBM50419062
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Wt: 373.5
BDBM50419067
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Wt: 332.4
BDBM50419072
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Wt: 367.4
BDBM50419076
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Wt: 359.5
BDBM50419080
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Wt: 349.8
BDBM50419081
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Wt: 257.3
BDBM50419053

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50419062,50419067,50419072,50419076,50419080,50419081,50419053   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens (Human))
BDBM50419053
PNG
(CHEMBL2052019 | ZD-7288)
Show SMILES CC\[N+](c1ccccc1)=c1/cc(NC)n(C)c(C)n1
Show InChI InChI=1S/C15H20N4/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15/h6-11H,5H2,1-4H3/p+1
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n/an/a 158n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)

More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens (Human))
BDBM50419062
PNG
(CHEMBL1435630)
Show SMILES COc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(C)CC1
Show InChI InChI=1S/C20H31N3O2/c1-22-12-14-23(15-13-22)20(10-6-3-7-11-20)16-21-19(24)17-8-4-5-9-18(17)25-2/h4-5,8-9H,3,6-7,10-16H2,1-2H3,(H,21,24)
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PC sid
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n/an/a 398n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)

More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens (Human))
BDBM50419067
PNG
(CHEMBL1823878)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(CC)CC1
Show InChI InChI=1S/C22H35N3O2/c1-3-24-14-16-25(17-15-24)22(12-8-5-9-13-22)18-23-21(26)19-10-6-7-11-20(19)27-4-2/h6-7,10-11H,3-5,8-9,12-18H2,1-2H3,(H,23,26)
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PC cid
PC sid
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n/an/a 31.6n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)

More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens (Human))
BDBM50419081
PNG
(CHEMBL1823679)
Show SMILES CN1CCN(CC1)C1(CNC(=O)c2ccccc2Cl)CCCCC1
Show InChI InChI=1S/C19H28ClN3O/c1-22-11-13-23(14-12-22)19(9-5-2-6-10-19)15-21-18(24)16-7-3-4-8-17(16)20/h3-4,7-8H,2,5-6,9-15H2,1H3,(H,21,24)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)

More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens (Human))
BDBM50419076
PNG
(CHEMBL1823889)
Show SMILES COc1ccccc1C(=O)NCC(N1CCN(C)CC1)c1ccc(C)cc1
Show InChI InChI=1S/C22H29N3O2/c1-17-8-10-18(11-9-17)20(25-14-12-24(2)13-15-25)16-23-22(26)19-6-4-5-7-21(19)27-3/h4-11,20H,12-16H2,1-3H3,(H,23,26)
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PC cid
PC sid
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Article
PubMed
n/an/a 2.51E+3n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)

More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens (Human))
BDBM50419080
PNG
(CHEMBL1823677)
Show SMILES CCOc1ccccc1C(=O)NCC1(CCCCC1)N1CCN(C)CC1
Show InChI InChI=1S/C21H33N3O2/c1-3-26-19-10-6-5-9-18(19)20(25)22-17-21(11-7-4-8-12-21)24-15-13-23(2)14-16-24/h5-6,9-10H,3-4,7-8,11-17H2,1-2H3,(H,22,25)
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PC cid
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n/an/a 126n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)

More data for this
Ligand-Target Pair
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


(Homo sapiens (Human))
BDBM50419072
PNG
(CHEMBL1332972)
Show SMILES COc1ccccc1C(=O)NCC1(CCCCC1)N1CCOCC1
Show InChI InChI=1S/C19H28N2O3/c1-23-17-8-4-3-7-16(17)18(22)20-15-19(9-5-2-6-10-19)21-11-13-24-14-12-21/h3-4,7-8H,2,5-6,9-15H2,1H3,(H,20,22)
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.00E+5n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Inhibition of human HCN1 heterologously expressed in HEK-293 cells after 30 mins by VIPR assay


Bioorg Med Chem Lett 21: 5197-201 (2011)

More data for this
Ligand-Target Pair