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There are 9 purchasable compounds for target: Heart KATP channel

Wt: 352.8
BDBM95731
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Wt: 292.3
BDBM50115223
Purchase
Wt: 580.5
BDBM50241582
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Wt: 328.3
BDBM50437983
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Wt: 366.8
BDBM50439403
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Wt: 350.4
BDBM50439404
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Wt: 352.8
BDBM50439405
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Wt: 259.7
BDBM50439406
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Wt: 313.7
BDBM50439407
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 95731,50115223,50241582,50437983,50439403,50439404,50439405,50439406,50439407   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G protein-activated inward rectifier potassium channel 4


(Homo sapiens)
BDBM50439403
PNG
(CHEMBL1558022)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Cc2ccccc2Cl)ccc1C
Show InChI InChI=1S/C17H19ClN2O3S/c1-12-8-9-14(11-16(12)24(22,23)20(2)3)19-17(21)10-13-6-4-5-7-15(13)18/h4-9,11H,10H2,1-3H3,(H,19,21)
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UniChem
Article
PubMed
n/an/an/an/a 1.10E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/4 (unknown origin) by cell-based thallium flux assay


Bioorg Med Chem Lett 23: 5195-8 (2013)

More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens)
BDBM50437983
PNG
(CHEMBL2409106)
Show SMILES Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C17H14F2N4O/c1-11-9-16(23(22-11)13-5-3-2-4-6-13)21-17(24)20-12-7-8-14(18)15(19)10-12/h2-10H,1H3,(H2,20,21,24)
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PC sid
UniChem
Article
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n/an/an/an/a 1.80E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/4 (unknown origin) by cell-based thallium flux assay


Bioorg Med Chem Lett 23: 5195-8 (2013)

More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens)
BDBM50115223
PNG
(1-(5-Methyl-2-phenyl-2H-pyrazol-3-yl)-3-phenyl-ure...)
Show SMILES Cc1cc(NC(=O)Nc2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C17H16N4O/c1-13-12-16(21(20-13)15-10-6-3-7-11-15)19-17(22)18-14-8-4-2-5-9-14/h2-12H,1H3,(H2,18,19,22)
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n/an/an/an/a 690n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/4 (unknown origin) by cell-based thallium flux assay


Bioorg Med Chem Lett 23: 5195-8 (2013)

More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens)
BDBM50241582
PNG
((S)-7-((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxyme...)
Show SMILES C[C@@H]1O[C@@H](O[C@@H]2[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]2Oc2cc(O)c3C(=O)C[C@H](Oc3c2)c2ccc(O)cc2)[C@H](O)[C@H](O)[C@H]1O
Show InChI InChI=1S/C27H32O14/c1-10-20(32)22(34)24(36)26(37-10)41-25-23(35)21(33)18(9-28)40-27(25)38-13-6-14(30)19-15(31)8-16(39-17(19)7-13)11-2-4-12(29)5-3-11/h2-7,10,16,18,20-30,32-36H,8-9H2,1H3/t10-,16-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1
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n/an/an/an/a>1.00E+5n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of recombinant human GIRK1/4 expressed in Xenopus oocytes by two-electrode voltage clamp method


Bioorg Med Chem Lett 23: 5195-8 (2013)

More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens)
BDBM50439404
PNG
(CHEMBL2420539)
Show SMILES CN(C)S(=O)(=O)c1cc(NC(=O)Cc2ccc(F)cc2)ccc1C
Show InChI InChI=1S/C17H19FN2O3S/c1-12-4-9-15(11-16(12)24(22,23)20(2)3)19-17(21)10-13-5-7-14(18)8-6-13/h4-9,11H,10H2,1-3H3,(H,19,21)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 5.20E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/4 (unknown origin) by cell-based thallium flux assay


Bioorg Med Chem Lett 23: 5195-8 (2013)

More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens)
BDBM50115223
PNG
(1-(5-Methyl-2-phenyl-2H-pyrazol-3-yl)-3-phenyl-ure...)
Show SMILES Cc1cc(NC(=O)Nc2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C17H16N4O/c1-13-12-16(21(20-13)15-10-6-3-7-11-15)19-17(22)18-14-8-4-2-5-9-14/h2-12H,1H3,(H2,18,19,22)
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PubMed
n/an/an/an/a 690n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)

More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens)
BDBM50439405
PNG
(CHEMBL2420538)
Show SMILES CN(C)S(=O)(=O)c1cccc(NC(=O)Cc2ccccc2Cl)c1
Show InChI InChI=1S/C16H17ClN2O3S/c1-19(2)23(21,22)14-8-5-7-13(11-14)18-16(20)10-12-6-3-4-9-15(12)17/h3-9,11H,10H2,1-2H3,(H,18,20)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.60E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/4 (unknown origin) by cell-based thallium flux assay


Bioorg Med Chem Lett 23: 5195-8 (2013)

More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens)
BDBM50439406
PNG
(CHEMBL2420536)
Show SMILES Cc1cccc(NC(=O)Cc2ccccc2Cl)c1
Show InChI InChI=1S/C15H14ClNO/c1-11-5-4-7-13(9-11)17-15(18)10-12-6-2-3-8-14(12)16/h2-9H,10H2,1H3,(H,17,18)
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PC sid
UniChem
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PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/4 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Bioorg Med Chem Lett 23: 5195-8 (2013)

More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens)
BDBM50439407
PNG
(CHEMBL2420535)
Show SMILES FC(F)(F)c1ccc(NC(=O)Cc2ccccc2Cl)cc1
Show InChI InChI=1S/C15H11ClF3NO/c16-13-4-2-1-3-10(13)9-14(21)20-12-7-5-11(6-8-12)15(17,18)19/h1-8H,9H2,(H,20,21)
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PubMed
n/an/an/an/a 2.10E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/4 (unknown origin) transfected in HEK293 cells after 4 mins by thallium flux-based fluorescence assay


Bioorg Med Chem Lett 23: 5195-8 (2013)

More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens)
BDBM50437983
PNG
(CHEMBL2409106)
Show SMILES Cc1cc(NC(=O)Nc2ccc(F)c(F)c2)n(n1)-c1ccccc1
Show InChI InChI=1S/C17H14F2N4O/c1-11-9-16(23(22-11)13-5-3-2-4-6-13)21-17(24)20-12-7-8-14(18)15(19)10-12/h2-10H,1H3,(H2,20,21,24)
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PC sid
UniChem
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PubMed
n/an/an/an/a 1.80E+3n/an/an/an/a



Northwest Agriculture& Forestry University

Curated by ChEMBL


Assay Description
Activation of GIRK1/4 (unknown origin)


Bioorg Med Chem Lett 23: 4562-6 (2013)

More data for this
Ligand-Target Pair
G protein-activated inward rectifier potassium channel 4


(Homo sapiens)
BDBM95731
PNG
(2-(4-chlorophenyl)-N-[3-(dimethylsulfamoyl)phenyl]...)
Show SMILES CN(C)S(=O)(=O)c1cccc(NC(=O)Cc2ccc(Cl)cc2)c1
Show InChI InChI=1S/C16H17ClN2O3S/c1-19(2)23(21,22)15-5-3-4-14(11-15)18-16(20)10-12-6-8-13(17)9-7-12/h3-9,11H,10H2,1-2H3,(H,18,20)
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n/an/an/an/a 2.20E+3n/an/an/an/a



Vanderbilt University

Curated by ChEMBL


Assay Description
Activation of GIRK1/4 (unknown origin) by cell-based thallium flux assay


Bioorg Med Chem Lett 23: 5195-8 (2013)

More data for this
Ligand-Target Pair