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There are 7 purchasable compounds for target: HGF activator

Wt: 347.3
BDBM50063698
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Wt: 398.4
BDBM50424712
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Wt: 494.5
BDBM50069121
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Wt: 254.2
BDBM50069123
Wt: 592.7
BDBM50069112
Wt: 504.6
BDBM50069114
Wt: 300.2
BDBM50069132
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50063698,50424712,50069121,50069123,50069112,50069114,50069132   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor activator


(Homo sapiens)
BDBM50063698
PNG
(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Show SMILES NC(N)=Nc1ccc(cc1)C(=O)Oc1ccc2cc(ccc2c1)C(N)=N
Show InChI InChI=1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24)
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25n/an/an/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant HGFA (unknown origin) using Boc-QLR-AMC as substrate by chromogenic proteolytic assay


ACS Med Chem Lett 5: 1219-24 (2014)

More data for this
Ligand-Target Pair
Hepatocyte growth factor activator


(Homo sapiens)
BDBM50063698
PNG
(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Show SMILES NC(N)=Nc1ccc(cc1)C(=O)Oc1ccc2cc(ccc2c1)C(N)=N
Show InChI InChI=1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24)
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25n/an/an/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells using Boc-QLR-AMC as substrate incu...


Bioorg Med Chem 23: 2328-43 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor activator


(Homo sapiens)
BDBM50069121
PNG
(CHEMBL3403521)
Show SMILES CCc1cc(cc2c(C)coc12)C(Nc1ccc(cc1)C(N)=N)C(=O)NS(=O)(=O)c1cn(C)cn1
Show InChI InChI=1/C24H26N6O4S/c1-4-15-9-17(10-19-14(2)12-34-22(15)19)21(28-18-7-5-16(6-8-18)23(25)26)24(31)29-35(32,33)20-11-30(3)13-27-20/h5-13,21,28H,4H2,1-3H3,(H3,25,26)(H,29,31)
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7.10E+3n/an/an/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells using Boc-QLR-AMC as substrate incu...


Bioorg Med Chem 23: 2328-43 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor activator


(Homo sapiens)
BDBM50069114
PNG
(CHEMBL3403532)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N[C@@H](Cc1cccc(c1)C(N)=N)C(=O)N1CCC(CC1)c1ccccc1
Show InChI InChI=1/C28H32N4O3S/c1-20-10-12-25(13-11-20)36(34,35)31-26(19-21-6-5-9-24(18-21)27(29)30)28(33)32-16-14-23(15-17-32)22-7-3-2-4-8-22/h2-13,18,23,26,31H,14-17,19H2,1H3,(H3,29,30)/t26-/s2
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2.00E+4n/an/an/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells using Boc-QLR-AMC as substrate incu...


Bioorg Med Chem 23: 2328-43 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor activator


(Homo sapiens)
BDBM50069112
PNG
(CHEMBL3400827)
Show SMILES CCCCCCNC(=O)N1CCN(CC1)C(=O)[C@H](Cc1cccc(c1)C(N)=N)NS(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1/C31H40N6O4S/c1-2-3-4-7-15-34-31(39)37-18-16-36(17-19-37)30(38)28(21-23-9-8-12-26(20-23)29(32)33)35-42(40,41)27-14-13-24-10-5-6-11-25(24)22-27/h5-6,8-14,20,22,28,35H,2-4,7,15-19,21H2,1H3,(H3,32,33)(H,34,39)/t28-/s2
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>5.00E+4n/an/an/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells using Boc-QLR-AMC as substrate incu...


Bioorg Med Chem 23: 2328-43 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor activator


(Homo sapiens)
BDBM50063698
PNG
(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Show SMILES NC(N)=Nc1ccc(cc1)C(=O)Oc1ccc2cc(ccc2c1)C(N)=N
Show InChI InChI=1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24)
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n/an/a 150n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells incubated for 30 mins prior to crom...


Bioorg Med Chem 23: 2328-43 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor activator


(Homo sapiens)
BDBM50069123
PNG
(CHEMBL579653)
Show SMILES NC(=N)Nc1ccc(NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H14N4O/c15-14(16)18-12-8-6-11(7-9-12)17-13(19)10-4-2-1-3-5-10/h1-9H,(H,17,19)(H4,15,16,18)
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PC sid
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n/an/a>5.00E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells incubated for 30 mins prior to crom...


Bioorg Med Chem 23: 2328-43 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor activator


(Homo sapiens)
BDBM50069132
PNG
(CHEMBL550687)
Show SMILES NC(=N)Nc1ccc(cc1)C(=O)Oc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C14H12N4O4/c15-14(16)17-10-3-1-9(2-4-10)13(19)22-12-7-5-11(6-8-12)18(20)21/h1-8H,(H4,15,16,17)
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CHEMBL
PC cid
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n/an/a 820n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells incubated for 30 mins prior to crom...


Bioorg Med Chem 23: 2328-43 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor activator


(Homo sapiens)
BDBM50424712
PNG
(CAMOSTAT | Camostat Mesilate | Foipan)
Show SMILES CN(C)C(=O)COC(=O)Cc1ccc(OC(=O)c2ccc(cc2)N=C(N)N)cc1
Show InChI InChI=1S/C20H22N4O5/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22/h3-10H,11-12H2,1-2H3,(H4,21,22,23)
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n/an/a 3.20E+4n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminal His-tagged HGFA (unknown origin) expressed in baculovirus-infected Sf9 cells incubated for 30 mins prior to crom...


Bioorg Med Chem 23: 2328-43 (2015)

More data for this
Ligand-Target Pair
Hepatocyte growth factor activator


(Homo sapiens)
BDBM50063698
PNG
(4-Guanidino-benzoic acid 6-carbamimidoyl-naphthale...)
Show SMILES NC(N)=Nc1ccc(cc1)C(=O)Oc1ccc2cc(ccc2c1)C(N)=N
Show InChI InChI=1S/C19H17N5O2/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23/h1-10H,(H3,20,21)(H4,22,23,24)
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PubMed
n/an/an/an/a 490n/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
Inhibition of HGFA in human MDA-MB-231 cells assessed as inhibition of c-MET phosphorylation after 15 mins by immunoblotting


ACS Med Chem Lett 5: 1219-24 (2014)

More data for this
Ligand-Target Pair