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There are 18 purchasable compounds for target: H-l(3)mbt protein

Wt: 313.2
BDBM154545
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Wt: 274.7
BDBM35938
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Wt: 357.4
BDBM50165019
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Wt: 315.4
BDBM50330490
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Wt: 330.4
BDBM50330493
Wt: 338.2
BDBM50341828
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Wt: 269.3
BDBM50330494
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Wt: 322.8
BDBM50330497
Wt: 282.4
BDBM50330498
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Wt: 269.3
BDBM50330499
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Wt: 241.7
BDBM50330500
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Wt: 223.3
BDBM50330501
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Wt: 163.2
BDBM50330502
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Wt: 285.4
BDBM50330504
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Wt: 277.4
BDBM50378025
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Displayed 1 to 15 (of 18 total )  |  Next  |  Last  >>

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 154545,35938,50165019,50330490,50330493,50341828,50330494,50330497,50330498,50330499,50330500,50330501,50330502,50330504,50378025   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM154545
PNG
(3-Bromo-N-(3-(tert-butylamino)propyl)benzamide (UN...)
Show SMILES CC(C)(C)NCCCNC(=O)c1cccc(Br)c1
Show InChI InChI=1S/C14H21BrN2O/c1-14(2,3)17-9-5-8-16-13(18)11-6-4-7-12(15)10-11/h4,6-7,10,17H,5,8-9H2,1-3H3,(H,16,18)
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n/an/a>5.00E+5n/an/an/an/a8.01,663.9



University of North Carolina at Chapel Hill



Assay Description
In brief, compound plates (1 μL at 10 mM highest concentration; 3-fold, 10-point dilutions in DMSO) were diluted in 1X assay buffer (20 mM TRIS ...


ACS Chem Biol 10: 1072-81 (2015)


Article DOI: 10.1021/cb500956g
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50330504
PNG
(3-(11H-dibenzo[b,f][1,4]oxathiepin-11-yl)-N-methyl...)
Show SMILES CNCCCC1Sc2ccccc2Oc2ccccc12
Show InChI InChI=1S/C17H19NOS/c1-18-12-6-11-16-13-7-2-3-8-14(13)19-15-9-4-5-10-17(15)20-16/h2-5,7-10,16,18H,6,11-12H2,1H3
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50341828
PNG
(3-bromo-5-[(4-pyrrolidin-1-ylpiperidin-1-yl)carbon...)
Show SMILES Brc1cncc(c1)C(=O)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C15H20BrN3O/c16-13-9-12(10-17-11-13)15(20)19-7-3-14(4-8-19)18-5-1-2-6-18/h9-11,14H,1-8H2
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n/an/a 6.00E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Binding affinity to human L3MBTL1 by chemiluminescent assay


J Med Chem 54: 2504-11 (2011)


Article DOI: 10.1021/jm200045v
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50341828
PNG
(3-bromo-5-[(4-pyrrolidin-1-ylpiperidin-1-yl)carbon...)
Show SMILES Brc1cncc(c1)C(=O)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C15H20BrN3O/c16-13-9-12(10-17-11-13)15(20)19-7-3-14(4-8-19)18-5-1-2-6-18/h9-11,14H,1-8H2
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n/an/an/a 1.00E+4n/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Displacement of FAM-AHA-ARTKQTARK(Me)STGGKA-CO2H from human L3MBTL1 assessed as apparent disociation constant after 20 mins by FP-displacement Assay


J Med Chem 54: 2504-11 (2011)


Article DOI: 10.1021/jm200045v
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50341828
PNG
(3-bromo-5-[(4-pyrrolidin-1-ylpiperidin-1-yl)carbon...)
Show SMILES Brc1cncc(c1)C(=O)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C15H20BrN3O/c16-13-9-12(10-17-11-13)15(20)19-7-3-14(4-8-19)18-5-1-2-6-18/h9-11,14H,1-8H2
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n/an/a 4.20E+3n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 (unknown origin) after 30 mins by AlphaScreen assay


J Med Chem 56: 7358-71 (2013)


Article DOI: 10.1021/jm400919p
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50330493
PNG
(CHEMBL1277748 | N-(3-(diethylamino)propyl)-2,5-dim...)
Show SMILES CCN(CC)CCCNS(=O)(=O)c1cc(OC)ccc1OC
Show InChI InChI=1S/C15H26N2O4S/c1-5-17(6-2)11-7-10-16-22(18,19)15-12-13(20-3)8-9-14(15)21-4/h8-9,12,16H,5-7,10-11H2,1-4H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50330494
PNG
(4-(4-benzylphenoxy)-N-methylbutan-1-amine | CHEMBL...)
Show SMILES CNCCCCOc1ccc(Cc2ccccc2)cc1
Show InChI InChI=1S/C18H23NO/c1-19-13-5-6-14-20-18-11-9-17(10-12-18)15-16-7-3-2-4-8-16/h2-4,7-12,19H,5-6,13-15H2,1H3
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n/an/a 9.10E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50165019
PNG
(4-(Diethylamino)-2-butynyl alpha-phenylcyclohexane...)
Show SMILES CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)c1ccccc1
Show InChI InChI=1S/C22H31NO3/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50330497
PNG
(3-chloro-N-(3-(diethylamino)propyl)-4-fluorobenzen...)
Show SMILES CCN(CC)CCCNS(=O)(=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C13H20ClFN2O2S/c1-3-17(4-2)9-5-8-16-20(18,19)11-6-7-13(15)12(14)10-11/h6-7,10,16H,3-5,8-9H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50330498
PNG
(4-methyl-N-(3-(pyrrolidin-1-yl)propyl)benzenesulfo...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NCCCN1CCCC1
Show InChI InChI=1S/C14H22N2O2S/c1-13-5-7-14(8-6-13)19(17,18)15-9-4-12-16-10-2-3-11-16/h5-8,15H,2-4,9-12H2,1H3
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n/an/a 1.70E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50330499
PNG
(4-(2-benzylphenoxy)-N-methylbutan-1-amine | CHEMBL...)
Show SMILES CNCCCCOc1ccccc1Cc1ccccc1
Show InChI InChI=1S/C18H23NO/c1-19-13-7-8-14-20-18-12-6-5-11-17(18)15-16-9-3-2-4-10-16/h2-6,9-12,19H,7-8,13-15H2,1H3
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n/an/a 9.10E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50330500
PNG
(4-(4-chloro-3-ethylphenoxy)-N-methylbutan-1-amine ...)
Show SMILES CCc1cc(OCCCCNC)ccc1Cl
Show InChI InChI=1S/C13H20ClNO/c1-3-11-10-12(6-7-13(11)14)16-9-5-4-8-15-2/h6-7,10,15H,3-5,8-9H2,1-2H3
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n/an/a 9.60E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50330501
PNG
(4-(2-methoxy-4-methylphenoxy)-N-methylbutan-1-amin...)
Show SMILES CNCCCCOc1ccc(C)cc1OC
Show InChI InChI=1S/C13H21NO2/c1-11-6-7-12(13(10-11)15-3)16-9-5-4-8-14-2/h6-7,10,14H,4-5,8-9H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50330502
PNG
(CHEMBL45868 | Methyl-(4-phenyl-butyl)-amine | N-me...)
Show SMILES CNCCCCc1ccccc1
Show InChI InChI=1S/C11H17N/c1-12-10-6-5-9-11-7-3-2-4-8-11/h2-4,7-8,12H,5-6,9-10H2,1H3
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n/an/a 6.80E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM35938
PNG
(1-(p-chlorophenyl)-1-(2-pyridyl)-3-N,N-dimethylpro...)
Show SMILES CN(C)CCC(c1ccc(Cl)cc1)c1ccccn1
Show InChI InChI=1S/C16H19ClN2/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13/h3-9,11,15H,10,12H2,1-2H3
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n/an/a 4.10E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50330490
PNG
(CHEMBL1277562 | N,N-dimethyl-3-(5-(1-phenylethyl)f...)
Show SMILES CC(CCN(C)C)OC(=O)c1ccc(o1)C(C)c1ccccc1
Show InChI InChI=1S/C19H25NO3/c1-14(12-13-20(3)4)22-19(21)18-11-10-17(23-18)15(2)16-8-6-5-7-9-16/h5-11,14-15H,12-13H2,1-4H3
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n/an/a 8.40E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50378025
PNG
(BA-34276 | MAPROTILINE)
Show SMILES CNCCC[C@@]12CC[C@@H](c3ccccc13)c1ccccc21 |r,wU:8.7,5.4,TLB:10:9:20.15:6.7,16:15:14.9:6.7,THB:19:20:14.9:6.7,(13.7,-13.36,;12.37,-14.14,;11.04,-13.36,;11.07,-11.84,;9.76,-11.03,;9.77,-9.52,;10.03,-7.65,;9.58,-6.54,;9.53,-8.17,;10.87,-8.76,;11.98,-7.68,;13.44,-8.18,;13.75,-9.68,;12.6,-10.68,;11.13,-10.14,;8.07,-8.82,;6.63,-8.16,;5.41,-9.11,;5.63,-10.63,;7.06,-11.2,;8.26,-10.19,)|
Show InChI InChI=1S/C20H23N/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20/h2-5,7-10,15,21H,6,11-14H2,1H3/t15-,20+
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n/an/a 6.10E+4n/an/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Inhibition of L3MBTL1 by alpha-screening


J Med Chem 53: 7625-31 (2010)


Article DOI: 10.1021/jm1007374
More data for this
Ligand-Target Pair
Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)


(Homo sapiens (Human))
BDBM50341828
PNG
(3-bromo-5-[(4-pyrrolidin-1-ylpiperidin-1-yl)carbon...)
Show SMILES Brc1cncc(c1)C(=O)N1CCC(CC1)N1CCCC1
Show InChI InChI=1S/C15H20BrN3O/c16-13-9-12(10-17-11-13)15(20)19-7-3-14(4-8-19)18-5-1-2-6-18/h9-11,14H,1-8H2
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n/an/an/a 5.00E+3n/an/an/an/an/a



University of North Carolina at Chapel Hill

Curated by ChEMBL


Assay Description
Binding affinity to human L3MBTL1 assessed as dissociation constant by isothermal titration calorimetric assay


J Med Chem 54: 2504-11 (2011)


Article DOI: 10.1021/jm200045v
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)