Compile Data Set for Download or QSAR

Found 32 hits Enz. Inhib. hit(s) with Target = 'N-glycosylase/DNA lyase'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM570794 (US11440887, Compound 41) Show SMILES NC(=O)c1cccc(c1)-c1ccc(cc1)S(=O)(=O)Nc1ccc2CCCN(C(=O)C3CC3)c2c1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	59	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In view of the deficiencies with conventional assays and inhibitors, many embodiments are directed to assays that directly measure excision by OGG1. ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PKM
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163679 (3,4‐Dichloro‐1‐benzothiophene...) Show SMILES NNC(=O)c1sc2cccc(Cl)c2c1Cl Show InChI InChI=1S/C9H6Cl2N2OS/c10-4-2-1-3-5-6(4)7(11)8(15-5)9(14)13-12/h1-3H,12H2,(H,13,14)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Oregon Health & Science University					Assay Description Gel-based assays were performed by combining 4 µL of OGG1 (62.5 nM) with 1 µL of inhibitor or buffer. Substrate (5 µL, 50 nM) was added to bring the ...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM570793 (US11440887, Compound 39) Show SMILES CC(=O)Nc1cccc(c1)-c1ccc(cc1)S(=O)(=O)Nc1ccc2CCCN(C(=O)C3CC3)c2c1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In view of the deficiencies with conventional assays and inhibitors, many embodiments are directed to assays that directly measure excision by OGG1. ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PKM
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163680 (3‐Chloro‐N'‐[(1Z)‐2...) Show SMILES CC1CCCC\C1=N\NC(=O)c1sc2ccccc2c1Cl Show InChI InChI=1S/C16H17ClN2OS/c1-10-6-2-4-8-12(10)18-19-16(20)15-14(17)11-7-3-5-9-13(11)21-15/h3,5,7,9-10H,2,4,6,8H2,1H3,(H,19,20)/b18-12-	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Oregon Health & Science University					Assay Description Gel-based assays were performed by combining 4 µL of OGG1 (62.5 nM) with 1 µL of inhibitor or buffer. Substrate (5 µL, 50 nM) was added to bring the ...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM570792 (US11440887, Compound 34) Show SMILES O=C(C1CC1)N1CCCc2ccc(NS(=O)(=O)c3ccc(cc3)-c3cccnc3)cc12 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In view of the deficiencies with conventional assays and inhibitors, many embodiments are directed to assays that directly measure excision by OGG1. ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PKM
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163683 (N'‐Cyclohexylidene‐3‐hydroxy...) Show SMILES [#8]-c1cc2ccccc2cc1-[#6](=O)-[#7]\[#7]=[#6]-1/[#6]-[#6]-[#6]-[#6]-[#6]-1 Show InChI InChI=1S/C17H18N2O2/c20-16-11-13-7-5-4-6-12(13)10-15(16)17(21)19-18-14-8-2-1-3-9-14/h4-7,10-11,20H,1-3,8-9H2,(H,19,21)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163694 (3‐Chloro‐1‐benzothiophene‐...) Show SMILES NNC(=O)c1sc2ccccc2c1Cl Show InChI InChI=1S/C9H7ClN2OS/c10-7-5-3-1-2-4-6(5)14-8(7)9(13)12-11/h1-4H,11H2,(H,12,13)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163681 (3-Chloro‐N'‐[(1E)‐(4‐f...) Show SMILES Fc1ccc(\C=N\NC(=O)c2sc3ccccc3c2Cl)cc1 Show InChI InChI=1S/C16H10ClFN2OS/c17-14-12-3-1-2-4-13(12)22-15(14)16(21)20-19-9-10-5-7-11(18)8-6-10/h1-9H,(H,20,21)/b19-9+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Oregon Health & Science University					Assay Description Gel-based assays were performed by combining 4 µL of OGG1 (62.5 nM) with 1 µL of inhibitor or buffer. Substrate (5 µL, 50 nM) was added to bring the ...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163683 (N'‐Cyclohexylidene‐3‐hydroxy...) Show SMILES [#8]-c1cc2ccccc2cc1-[#6](=O)-[#7]\[#7]=[#6]-1/[#6]-[#6]-[#6]-[#6]-[#6]-1 Show InChI InChI=1S/C17H18N2O2/c20-16-11-13-7-5-4-6-12(13)10-15(16)17(21)19-18-14-8-2-1-3-9-14/h4-7,10-11,20H,1-3,8-9H2,(H,19,21)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Oregon Health & Science University					Assay Description Gel-based assays were performed by combining 4 µL of OGG1 (62.5 nM) with 1 µL of inhibitor or buffer. Substrate (5 µL, 50 nM) was added to bring the ...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163679 (3,4‐Dichloro‐1‐benzothiophene...) Show SMILES NNC(=O)c1sc2cccc(Cl)c2c1Cl Show InChI InChI=1S/C9H6Cl2N2OS/c10-4-2-1-3-5-6(4)7(11)8(15-5)9(14)13-12/h1-3H,12H2,(H,13,14)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163680 (3‐Chloro‐N'‐[(1Z)‐2...) Show SMILES CC1CCCC\C1=N\NC(=O)c1sc2ccccc2c1Cl Show InChI InChI=1S/C16H17ClN2OS/c1-10-6-2-4-8-12(10)18-19-16(20)15-14(17)11-7-3-5-9-13(11)21-15/h3,5,7,9-10H,2,4,6,8H2,1H3,(H,19,20)/b18-12-	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163695 (Benzoylhydrazine, P‐bromo (0151-Hy)) Show SMILES NNC(=O)c1ccc(Br)cc1 Show InChI InChI=1S/C7H7BrN2O/c8-6-3-1-5(2-4-6)7(11)10-9/h1-4H,9H2,(H,10,11)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	390	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163681 (3-Chloro‐N'‐[(1E)‐(4‐f...) Show SMILES Fc1ccc(\C=N\NC(=O)c2sc3ccccc3c2Cl)cc1 Show InChI InChI=1S/C16H10ClFN2OS/c17-14-12-3-1-2-4-13(12)22-15(14)16(21)20-19-9-10-5-7-11(18)8-6-10/h1-9H,(H,20,21)/b19-9+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163682 (4‐Bromo‐N'‐cyclohexylidenebe...) Show SMILES Brc1ccc(cc1)-[#6](=O)-[#7]\[#7]=[#6]-1/[#6]-[#6]-[#6]-[#6]-[#6]-1 Show InChI InChI=1S/C13H15BrN2O/c14-11-8-6-10(7-9-11)13(17)16-15-12-4-2-1-3-5-12/h6-9H,1-5H2,(H,16,17)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	610	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163682 (4‐Bromo‐N'‐cyclohexylidenebe...) Show SMILES Brc1ccc(cc1)-[#6](=O)-[#7]\[#7]=[#6]-1/[#6]-[#6]-[#6]-[#6]-[#6]-1 Show InChI InChI=1S/C13H15BrN2O/c14-11-8-6-10(7-9-11)13(17)16-15-12-4-2-1-3-5-12/h6-9H,1-5H2,(H,16,17)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	630	n/a	n/a	n/a	n/a	n/a	n/a
Oregon Health & Science University					Assay Description Gel-based assays were performed by combining 4 µL of OGG1 (62.5 nM) with 1 µL of inhibitor or buffer. Substrate (5 µL, 50 nM) was added to bring the ...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM570790 (US11440887, Compound 7) Show SMILES CCOc1ccc(cc1)S(=O)(=O)Nc1ccc2CCCN(C(=O)C3CC3)c2c1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In view of the deficiencies with conventional assays and inhibitors, many embodiments are directed to assays that directly measure excision by OGG1. ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PKM
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM570791 (US11440887, Compound 28) Show SMILES O=C(C1CC1)N1CCCc2ccc(NS(=O)(=O)c3ccc(Oc4ccccc4)cc3)cc12 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In view of the deficiencies with conventional assays and inhibitors, many embodiments are directed to assays that directly measure excision by OGG1. ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PKM
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163685 (2‐(4‐Chloro‐3,5‐dimethylph...) Show SMILES Cc1cc(OCC(=O)NN)cc(C)c1Cl Show InChI InChI=1S/C10H13ClN2O2/c1-6-3-8(4-7(2)10(6)11)15-5-9(14)13-12/h3-4H,5,12H2,1-2H3,(H,13,14)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.53E+3	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163686 (2‐(Naphthalen‐1‐yloxy)acetohydra...) Show SMILES NNC(=O)COc1cccc2ccccc12 Show InChI InChI=1S/C12H12N2O2/c13-14-12(15)8-16-11-7-3-5-9-4-1-2-6-10(9)11/h1-7H,8,13H2,(H,14,15)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.56E+3	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM570789 (US11440887, Compound 1) Show SMILES CCOc1ccc(cc1)S(=O)(=O)Nc1ccc2CCCN(C(C)=O)c2c1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description In view of the deficiencies with conventional assays and inhibitors, many embodiments are directed to assays that directly measure excision by OGG1. ...				Citation and Details BindingDB Entry DOI: 10.7270/Q2PV6PKM
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163690 (3‐Bromo‐N'‐[(2Z)‐hexan...) Show SMILES CCCC\C(C)=N/NC(=O)c1cccc(Br)c1 Show InChI InChI=1S/C13H17BrN2O/c1-3-4-6-10(2)15-16-13(17)11-7-5-8-12(14)9-11/h5,7-9H,3-4,6H2,1-2H3,(H,16,17)/b15-10-	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.13E+3	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163684 (2‐(3‐Chlorophenoxy)propanehydrazide (0...) Show SMILES CC(Oc1cccc(Cl)c1)C(=O)NN Show InChI InChI=1S/C9H11ClN2O2/c1-6(9(13)12-11)14-8-4-2-3-7(10)5-8/h2-6H,11H2,1H3,(H,12,13)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.38E+3	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163689 (3‐Bromo‐N'‐[(2Z)‐hex&#...) Show SMILES C\C(CCC=C)=N\NC(=O)c1cccc(Br)c1 Show InChI InChI=1S/C13H15BrN2O/c1-3-4-6-10(2)15-16-13(17)11-7-5-8-12(14)9-11/h3,5,7-9H,1,4,6H2,2H3,(H,16,17)/b15-10-	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.78E+3	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163691 (1‐(4‐Methoxy‐2,5‐dimethylb...) Show SMILES COc1cc(C)c(cc1C)S(=O)(=O)n1cc(C)nc1-c1ccccc1 Show InChI InChI=1S/C19H20N2O3S/c1-13-11-18(14(2)10-17(13)24-4)25(22,23)21-12-15(3)20-19(21)16-8-6-5-7-9-16/h5-12H,1-4H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.15E+3	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163688 (2,4‐Dichloro‐N'‐(1‐pro...) Show SMILES [#6]-[#6]-[#6]-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#7]/[#7]-[#6](=O)-c1ccc(Cl)cc1Cl Show InChI InChI=1S/C15H19Cl2N3O/c1-2-7-20-8-5-12(6-9-20)18-19-15(21)13-4-3-11(16)10-14(13)17/h3-4,10H,2,5-9H2,1H3,(H,19,21)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.56E+3	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163687 (N'‐[(1E)‐1‐(2H‐1,3R...) Show SMILES C\C(=N/NC(=O)c1cc2ccccc2cc1O)c1ccc2OCOc2c1 Show InChI InChI=1S/C20H16N2O4/c1-12(13-6-7-18-19(10-13)26-11-25-18)21-22-20(24)16-8-14-4-2-3-5-15(14)9-17(16)23/h2-10,23H,11H2,1H3,(H,22,24)/b21-12+	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.17E+3	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) | CHEMBL64 | D...) Show SMILES NNC(=O)c1ccncc1 Show InChI InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Oregon Health & Science University					Assay Description Gel-based assays were performed by combining 4 µL of OGG1 (62.5 nM) with 1 µL of inhibitor or buffer. Substrate (5 µL, 50 nM) was added to bring the ...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM81461 (CAS_86-54-4 | Hydralazine | Hydralazine (HZN) | NS...) Show SMILES NNc1nncc2ccccc12 Show InChI InChI=1S/C8H8N4/c9-11-8-7-4-2-1-3-6(7)5-10-12-8/h1-5H,9H2,(H,11,12)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM50106186 (4‐Bromobenzamide (0151-Am) | 4-Bromo-benzami...) Show SMILES NC(=O)c1ccc(Br)cc1 Show InChI InChI=1S/C7H6BrNO/c8-6-3-1-5(2-4-6)7(9)10/h1-4H,(H2,9,10)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163693 (Nialamide) Show SMILES O=C(CCNNC(=O)c1ccncc1)NCc1ccccc1 Show InChI InChI=1S/C16H18N4O2/c21-15(18-12-13-4-2-1-3-5-13)8-11-19-20-16(22)14-6-9-17-10-7-14/h1-7,9-10,19H,8,11-12H2,(H,18,21)(H,20,22)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM163692 (ISOCARBOXAZID | Isocarboxazid (ICD) | Isocarboxazi...) Show SMILES Cc1cc(no1)C(=O)NNCc1ccccc1 Show InChI InChI=1S/C12H13N3O2/c1-9-7-11(15-17-9)12(16)14-13-8-10-5-3-2-4-6-10/h2-7,13H,8H2,1H3,(H,14,16)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase DrugBank MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair
N-glycosylase/DNA lyase (Homo sapiens (Human))	BDBM50336507 (4-pyridinecarbohydrazide(Isoniazid) | CHEMBL64 | D...) Show SMILES NNC(=O)c1ccncc1 Show InChI InChI=1S/C6H7N3O/c7-9-6(10)5-1-3-8-4-2-5/h1-4H,7H2,(H,9,10)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	7.5	37
Oregon Health & Science University					Assay Description A total of 4 µL of OGG1 (125 nM) was mixed with 1 µL of inhibitor. In a separate tube, 1 µL of freshly prepared 10 mM NaBH3CN (diluted in H2O) was mi...				ACS Chem Biol 10: 2334-43 (2015) Article DOI: 10.1021/acschembio.5b00452 BindingDB Entry DOI: 10.7270/Q22F7M6H
					More data for this Ligand-Target Pair