Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ATP-dependent Clp protease proteolytic subunit, mitochondrial (Homo sapiens) | BDBM50502333 (CHEMBL4466041) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 390 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of C-terminal recombinant human ClpP expressed in Escherichia coli Rosetta2 (DE3) cells using Suc-Leu-Tyr-AMC as substrate incubated for 1... | J Med Chem 62: 6377-6390 (2019) Article DOI: 10.1021/acs.jmedchem.9b00878 BindingDB Entry DOI: 10.7270/Q24B34KQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518615 (CHEMBL4551942) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518613 (CHEMBL4448860) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518616 (CHEMBL4483092) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518612 (CHEMBL4444802) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50527098 (CHEMBL4446834) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) pre-incubated for 10 mins be... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50527099 (CHEMBL4438765) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) pre-incubated for 10 mins be... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50527100 (CHEMBL4457363) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) pre-incubated for 10 mins be... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit, mitochondrial (Homo sapiens) | BDBM50502328 (CHEMBL4472444) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.54E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of C-terminal recombinant human ClpP (57 to 277 amino acids) expressed in Escherichia coli Rosetta2 cells using Suc-Leu-Tyr-AMC as substra... | J Med Chem 62: 6377-6390 (2019) Article DOI: 10.1021/acs.jmedchem.9b00878 BindingDB Entry DOI: 10.7270/Q24B34KQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50527101 (CHEMBL4540126) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) pre-incubated for 10 mins be... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50527102 (CHEMBL4536802) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) pre-incubated for 10 mins be... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit, mitochondrial (Homo sapiens) | BDBM50502328 (CHEMBL4472444) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of human ClpP expressed in Escherichia coli SG1146 cells using N-acetyl-Trp-Leu-Ala-AMC as substrate incubated for 1 hr and measured at 20... | J Med Chem 62: 6377-6390 (2019) Article DOI: 10.1021/acs.jmedchem.9b00878 BindingDB Entry DOI: 10.7270/Q24B34KQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50398609 (CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) pre-incubated for 10 mins be... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50069989 ((R)-3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) pre-incubated for 10 mins be... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518619 (CHEMBL4575669) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit, mitochondrial (Homo sapiens) | BDBM50502334 (CHEMBL4459457) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 8.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of human ClpP expressed in Escherichia coli SG1146 cells using N-acetyl-Trp-Leu-Ala-AMC as substrate incubated for 1 hr and measured at 20... | J Med Chem 62: 6377-6390 (2019) Article DOI: 10.1021/acs.jmedchem.9b00878 BindingDB Entry DOI: 10.7270/Q24B34KQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit, mitochondrial (Homo sapiens) | BDBM50502335 (CHEMBL4566080) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 1.02E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of human ClpP expressed in Escherichia coli SG1146 cells using N-acetyl-Trp-Leu-Ala-AMC as substrate incubated for 1 hr and measured at 20... | J Med Chem 62: 6377-6390 (2019) Article DOI: 10.1021/acs.jmedchem.9b00878 BindingDB Entry DOI: 10.7270/Q24B34KQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit, mitochondrial (Homo sapiens) | BDBM50502327 (CHEMBL4440170) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.24E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of human ClpP expressed in Escherichia coli SG1146 cells using N-acetyl-Trp-Leu-Ala-AMC as substrate incubated for 1 hr and measured at 20... | J Med Chem 62: 6377-6390 (2019) Article DOI: 10.1021/acs.jmedchem.9b00878 BindingDB Entry DOI: 10.7270/Q24B34KQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518624 (CHEMBL4472140) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518623 (CHEMBL4446383) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518611 (CHEMBL4461379) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50527103 (CHEMBL4449233) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.44E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of Escherichia coli ClpP | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit, mitochondrial (Homo sapiens) | BDBM50502331 (CHEMBL4453096) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of human ClpP expressed in Escherichia coli SG1146 cells using N-acetyl-Trp-Leu-Ala-AMC as substrate incubated for 1 hr and measured at 20... | J Med Chem 62: 6377-6390 (2019) Article DOI: 10.1021/acs.jmedchem.9b00878 BindingDB Entry DOI: 10.7270/Q24B34KQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit, mitochondrial (Homo sapiens) | BDBM50502336 (CHEMBL4440056) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.89E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of human ClpP expressed in Escherichia coli SG1146 cells using N-acetyl-Trp-Leu-Ala-AMC as substrate incubated for 1 hr and measured at 20... | J Med Chem 62: 6377-6390 (2019) Article DOI: 10.1021/acs.jmedchem.9b00878 BindingDB Entry DOI: 10.7270/Q24B34KQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit, mitochondrial (Homo sapiens) | BDBM50502330 (CHEMBL4459890) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.43E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of human ClpP expressed in Escherichia coli SG1146 cells using N-acetyl-Trp-Leu-Ala-AMC as substrate incubated for 1 hr and measured at 20... | J Med Chem 62: 6377-6390 (2019) Article DOI: 10.1021/acs.jmedchem.9b00878 BindingDB Entry DOI: 10.7270/Q24B34KQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518621 (CHEMBL4561263) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518617 (CHEMBL3770879) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.98E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit, mitochondrial (Homo sapiens) | BDBM50502332 (CHEMBL4563482) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | n/a | n/a | 4.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of human ClpP expressed in Escherichia coli SG1146 cells using N-acetyl-Trp-Leu-Ala-AMC as substrate incubated for 1 hr and measured at 20... | J Med Chem 62: 6377-6390 (2019) Article DOI: 10.1021/acs.jmedchem.9b00878 BindingDB Entry DOI: 10.7270/Q24B34KQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518622 (CHEMBL4585066) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.81E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518618 (CHEMBL4469279) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.95E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518620 (CHEMBL4442349) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.13E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518614 (CHEMBL4476496) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 7.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50518625 (CHEMBL4549411) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.01E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Antwerp Curated by ChEMBL | Assay Description Inhibition of Escherichia coli C-terminal His6-tagged ClpP expressed Escherichia coli SG1146a using Suc-LY-AMC as substrate preincubated for 10 mins ... | J Med Chem 62: 774-797 (2019) Article DOI: 10.1021/acs.jmedchem.8b01466 BindingDB Entry DOI: 10.7270/Q28D00NR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit, mitochondrial (Homo sapiens) | BDBM50502329 (CHEMBL4451932) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.18E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Inhibition of human ClpP expressed in Escherichia coli SG1146 cells using N-acetyl-Trp-Leu-Ala-AMC as substrate incubated for 1 hr and measured at 20... | J Med Chem 62: 6377-6390 (2019) Article DOI: 10.1021/acs.jmedchem.9b00878 BindingDB Entry DOI: 10.7270/Q24B34KQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50028480 (CHEMBL3342324) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Activation of Escherichia coli ClpP by ITC method | J Nat Prod 77: 2170-81 (2014) Article DOI: 10.1021/np500158q BindingDB Entry DOI: 10.7270/Q22R3T71 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50028481 (CHEMBL3342325) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a |
University of Toronto Curated by ChEMBL | Assay Description Activation of Escherichia coli ClpP by ITC method | J Nat Prod 77: 2170-81 (2014) Article DOI: 10.1021/np500158q BindingDB Entry DOI: 10.7270/Q22R3T71 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50360279 (CHEMBL1933113) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a |
Technische Universit£t M£nchen Curated by ChEMBL | Assay Description Inhibition of recombinant Staphylococcus aureus NCTC 8325 peptidase activity of clpP expressed in Escherichia coli BL21 after 10 mins using SLY-AMC a... | Bioorg Med Chem 20: 583-91 (2012) Article DOI: 10.1016/j.bmc.2011.07.047 BindingDB Entry DOI: 10.7270/Q26W9BHQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50360280 (CHEMBL1933114) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 4.50E+3 | n/a | n/a | n/a | n/a |
Technische Universit£t M£nchen Curated by ChEMBL | Assay Description Inhibition of recombinant Staphylococcus aureus NCTC 8325 peptidase activity of clpP expressed in Escherichia coli BL21 after 10 mins using SLY-AMC a... | Bioorg Med Chem 20: 583-91 (2012) Article DOI: 10.1016/j.bmc.2011.07.047 BindingDB Entry DOI: 10.7270/Q26W9BHQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50360281 (CHEMBL1933116) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a |
Technische Universit£t M£nchen Curated by ChEMBL | Assay Description Inhibition of recombinant Staphylococcus aureus NCTC 8325 peptidase activity of clpP expressed in Escherichia coli BL21 after 10 mins using SLY-AMC a... | Bioorg Med Chem 20: 583-91 (2012) Article DOI: 10.1016/j.bmc.2011.07.047 BindingDB Entry DOI: 10.7270/Q26W9BHQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50535809 (Sclerotiamide) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 3.96E+4 | n/a | n/a | n/a | n/a |
University of Oklahoma COBRE in Structural Biology Curated by ChEMBL | Assay Description Activation of Escherichia coli BLR (DE3) ClpP using Abz-DFAPKMALVPYNO2 as substrate assessed as degradation of substrate peptide preincubated for 15 ... | J Nat Prod 79: 1193-7 (2016) Article DOI: 10.1021/acs.jnatprod.5b01091 BindingDB Entry DOI: 10.7270/Q2TH8R62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50535810 (CHEMBL4593796) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.22E+4 | n/a | n/a | n/a | n/a |
University of Oklahoma COBRE in Structural Biology Curated by ChEMBL | Assay Description Activation of Escherichia coli BLR (DE3) ClpP using FITC-beta casein as substrate assessed as degradation of substrate peptide preincubated for 15 mi... | J Nat Prod 79: 1193-7 (2016) Article DOI: 10.1021/acs.jnatprod.5b01091 BindingDB Entry DOI: 10.7270/Q2TH8R62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50535809 (Sclerotiamide) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 8.75E+4 | n/a | n/a | n/a | n/a |
University of Oklahoma COBRE in Structural Biology Curated by ChEMBL | Assay Description Activation of Escherichia coli BLR (DE3) ClpP using FITC-beta casein as substrate assessed as degradation of substrate peptide preincubated for 15 mi... | J Nat Prod 79: 1193-7 (2016) Article DOI: 10.1021/acs.jnatprod.5b01091 BindingDB Entry DOI: 10.7270/Q2TH8R62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50535811 (CHEMBL4549588) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 100 | n/a | n/a | n/a | n/a |
University of Oklahoma COBRE in Structural Biology Curated by ChEMBL | Assay Description Activation of Escherichia coli BLR (DE3) ClpP using Abz-DFAPKMALVPYNO2 as substrate assessed as degradation of substrate peptide preincubated for 15 ... | J Nat Prod 79: 1193-7 (2016) Article DOI: 10.1021/acs.jnatprod.5b01091 BindingDB Entry DOI: 10.7270/Q2TH8R62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50535811 (CHEMBL4549588) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
University of Oklahoma COBRE in Structural Biology Curated by ChEMBL | Assay Description Activation of Escherichia coli BLR (DE3) ClpP using FITC-beta casein as substrate assessed as degradation of substrate peptide preincubated for 15 mi... | J Nat Prod 79: 1193-7 (2016) Article DOI: 10.1021/acs.jnatprod.5b01091 BindingDB Entry DOI: 10.7270/Q2TH8R62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Escherichia coli (strain K12)) | BDBM50535810 (CHEMBL4593796) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.54E+4 | n/a | n/a | n/a | n/a |
University of Oklahoma COBRE in Structural Biology Curated by ChEMBL | Assay Description Activation of Escherichia coli BLR (DE3) ClpP using Abz-DFAPKMALVPYNO2 as substrate assessed as degradation of substrate peptide preincubated for 15 ... | J Nat Prod 79: 1193-7 (2016) Article DOI: 10.1021/acs.jnatprod.5b01091 BindingDB Entry DOI: 10.7270/Q2TH8R62 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50527098 (CHEMBL4446834) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of ClpP in methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as reduction in bacteria-induced hemolysis of sheep erythrocyte... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50527098 (CHEMBL4446834) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | n/a | 1.27E+3 | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Binding affinity to N-terminal His6-sumo-tagged full length Staphylococcus aureus ClpP expressed in Escherichia coli BL2 (DE3) assessed as shifting o... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50398609 (CHEMBL2141296 | IXAZOMIB CITRATE | Ixazomib | MLN2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of ClpP in methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as reduction in bacteria-induced hemolysis of sheep erythrocyte... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50527101 (CHEMBL4540126) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of ClpP in methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as reduction in bacteria-induced hemolysis of sheep erythrocyte... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
ATP-dependent Clp protease proteolytic subunit (Staphylococcus aureus (strain NCTC 8325)) | BDBM50527100 (CHEMBL4457363) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.48E+4 | n/a | n/a | n/a | n/a |
Sichuan University Curated by ChEMBL | Assay Description Inhibition of ClpP in methicillin-resistant Staphylococcus aureus ATCC 33591 assessed as reduction in bacteria-induced hemolysis of sheep erythrocyte... | J Med Chem 63: 3104-3119 (2020) Article DOI: 10.1021/acs.jmedchem.9b01746 BindingDB Entry DOI: 10.7270/Q21Z47V6 | |||||||||||
More data for this Ligand-Target Pair |
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