BindingDB PrimarySearch

Found 23 hits Enz. Inhib. hit(s) with Target = 'Cathepsin Z'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cathepsin Z (Homo sapiens (Human))	BDBM50255753 (CHEMBL481611 \| MK-0822 \| Odanacatib) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a	n/a
Merck Frosst Centre for Therapeutic Research Curated by ChEMBL					Assay Description Inhibition of cathepsin Z				Bioorg Med Chem Lett 18: 923-8 (2008) Article DOI: 10.1016/j.bmcl.2007.12.047 BindingDB Entry DOI: 10.7270/Q21J9BM2
					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50303441 (9-(3,5-Difluorophenyl)-6-(ethylamino)-9H-purine-2-...) Show SMILES CCNc1nc(nc2n(cnc12)-c1cc(F)cc(F)c1)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	316	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of human Cathepsin X/Z				J Med Chem 53: 52-60 (2010) Article DOI: 10.1021/jm901069a BindingDB Entry DOI: 10.7270/Q2TX3FG5
National Human Genome Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50303420 (6-(3,5-Difluorophenylamino)-9-ethyl-9H-purine-2-ca...) Show SMILES CCn1cnc2c(Nc3cc(F)cc(F)c3)nc(nc12)C#N Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	933	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of human Cathepsin X/Z				J Med Chem 53: 52-60 (2010) Article DOI: 10.1021/jm901069a BindingDB Entry DOI: 10.7270/Q2TX3FG5
National Human Genome Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin Z (Rattus norvegicus)	BDBM36325 (Cathepsin Inhibitor III) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	5.5	37
Stanford University					Assay Description Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H				Nat Chem Biol 1: 33-8 (2005) Article DOI: 10.1038/nchembio707 BindingDB Entry DOI: 10.7270/Q22V2DGV
Stanford University					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50303417 (4-(Cyclopentylamino)-6-(3,5-difluorophenylamino)-1...) Show SMILES Fc1cc(F)cc(Nc2nc(NC3CCCC3)nc(n2)C#N)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.16E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of human Cathepsin X/Z				J Med Chem 53: 52-60 (2010) Article DOI: 10.1021/jm901069a BindingDB Entry DOI: 10.7270/Q2TX3FG5
National Human Genome Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin Z (Rattus norvegicus)	BDBM36331 (Ac-YFR-AMOK 10b) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.70E+3	n/a	n/a	n/a	n/a	5.5	37
Stanford University					Assay Description Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H				Nat Chem Biol 1: 33-8 (2005) Article DOI: 10.1038/nchembio707 BindingDB Entry DOI: 10.7270/Q22V2DGV
Stanford University					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50303410 (4-(3-chlorophenylamino)-6-(cyclopentylamino)-1,3,5...) Show SMILES Clc1cccc(Nc2nc(NC3CCCC3)nc(n2)C#N)c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of human Cathepsin X/Z				J Med Chem 53: 52-60 (2010) Article DOI: 10.1021/jm901069a BindingDB Entry DOI: 10.7270/Q2TX3FG5
National Human Genome Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50551801 (CHEMBL4754916) Show SMILES O=C(CSc1nccn1CC#N)c1ccc2OCCOc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.13E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112218 BindingDB Entry DOI: 10.7270/Q2HQ43JF
TBA					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50551800 (CHEMBL4743093) Show SMILES Cn1ccnc1SCC(=O)c1ccc2OCCOc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.54E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112218 BindingDB Entry DOI: 10.7270/Q2HQ43JF
TBA					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50302107 (CHEMBL567893 \| Grassystatin A) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of cathepsin Z after 10 to 15 mins by fluorescence assay				J Med Chem 52: 5732-47 (2009) Article DOI: 10.1021/jm9009394 BindingDB Entry DOI: 10.7270/Q2BG2PXP
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM397464 (US10676470, Compound 43 \| US10730826, Compound 73 ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
CORTEXYME, INC. US Patent					Assay Description The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...				US Patent US10730826 (2020) BindingDB Entry DOI: 10.7270/Q2QR5158
CORTEXYME, INC. US Patent					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM397464 (US10676470, Compound 43 \| US10730826, Compound 73 ...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0XQ1
TBA					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM453332 (BDBM553835 \| US10730826, Compound 69a) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0XQ1
TBA					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM453332 (BDBM553835 \| US10730826, Compound 69a) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
CORTEXYME, INC. US Patent					Assay Description The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...				US Patent US10730826 (2020) BindingDB Entry DOI: 10.7270/Q2QR5158
CORTEXYME, INC. US Patent					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM453275 (BDBM453327 \| US10730826, Compound 1a-non-racemic \|...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
CORTEXYME, INC. US Patent					Assay Description The capacities of compounds of the present invention to inhibit the activity of lysine gingipain were measured in a fluorogenic assay similar to thos...				US Patent US10730826 (2020) BindingDB Entry DOI: 10.7270/Q2QR5158
CORTEXYME, INC. US Patent					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM453275 (BDBM453327 \| US10730826, Compound 1a-non-racemic \|...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description The capacities of compounds of the present invention to inhibit the activity of cathepsins B, H, K, L, and S were measured in similar assays. Boc-Leu...				Citation and Details BindingDB Entry DOI: 10.7270/Q2GF0XQ1
TBA					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50551796 (CHEMBL4798763) Show SMILES CC(C)n1cnnc1SCC(=O)c1ccc2OCCOc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.15E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112218 BindingDB Entry DOI: 10.7270/Q2HQ43JF
TBA					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50551797 (CHEMBL1331625) Show SMILES Cn1cnnc1SCC(=O)c1ccc2OCCOc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.18E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112218 BindingDB Entry DOI: 10.7270/Q2HQ43JF
TBA					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50551798 (CHEMBL4752735) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.24E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112218 BindingDB Entry DOI: 10.7270/Q2HQ43JF
TBA					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50551799 (CHEMBL4744124) Show SMILES O=C(CSc1ncc[nH]1)c1ccc2OCCOc2c1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human cathepsin X expressed in Pichia pastoris assessed as residual activity using Abz-FEK(Dnp)-OH as substrate incubated for 30 to 45 ...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112218 BindingDB Entry DOI: 10.7270/Q2HQ43JF
TBA					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50303436 (9-(2,2-difluoroethyl)-6-(3,5-difluorophenylamino)-...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.48E+4	n/a	n/a	n/a	n/a	n/a	n/a
National Human Genome Research Institute Curated by ChEMBL					Assay Description Inhibition of human Cathepsin X/Z				J Med Chem 53: 52-60 (2010) Article DOI: 10.1021/jm901069a BindingDB Entry DOI: 10.7270/Q2TX3FG5
National Human Genome Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Cathepsin Z (Homo sapiens (Human))	BDBM50195235 (CHEMBL3900409 \| US10287258, Example 2 \| US10669245...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
CHARLES RIVER DISCOVERY RESEARCH SERVICES UK LIMITED Curated by ChEMBL					Assay Description Inhibition of human recombinant cathepsin Z				J Med Chem 59: 9457-9472 (2016) Article DOI: 10.1021/acs.jmedchem.6b01127 BindingDB Entry DOI: 10.7270/Q2Z321K4
					More data for this Ligand-Target Pair
Cathepsin Z (Rattus norvegicus)	BDBM36330 (AC-YFG-AMOK 10a) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90E+4	n/a	n/a	n/a	n/a	5.5	37
Stanford University					Assay Description Protease enzyme inhibition assay targeting diverse member of the cysteine protease families:cathepsin B, Z, and H				Nat Chem Biol 1: 33-8 (2005) Article DOI: 10.1038/nchembio707 BindingDB Entry DOI: 10.7270/Q22V2DGV
Stanford University					More data for this Ligand-Target Pair