Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50034949 (2-Amino-6-(3,5-dichloro-phenylamino)-3H-pyrimidin-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 770 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50034955 (CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50034950 (2-Amino-6-(3,4-dichloro-phenylamino)-3H-pyrimidin-...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 850 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50013091 (2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50034947 (2-(3,5-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 910 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50034963 (CHEMBL51501 | N*2*-(3,5-Dichloro-phenyl)-9H-purine...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 920 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50034952 (6-(3,5-Dichloro-phenylamino)-1H-pyrimidine-2,4-dio...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50028342 (6-(3,4-Dichloro-phenylamino)-1H-pyrimidine-2,4-dio...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against DNA-Dependent GTPase activity of HSV-1 helicase-primase in HSV-1-infected CV-1 cells | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Bacillus anthracis (Firmicutes)) | BDBM22984 ((8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-me...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | 8.8 | n/a |
University of Michigan | Assay Description The reaction mixture contained DNA (1.25 uM or as specified), NTP (110 uM or as specified), 50 mM NaCl, 150 mM potassium glutamate, buffer [20 mM CAP... | Biochemistry 52: 6905-10 (2013) Article DOI: 10.1021/bi4011286 BindingDB Entry DOI: 10.7270/Q2ZC81JQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Bacillus anthracis (Firmicutes)) | BDBM50364890 (Amixin IC | TILORONE | cid_5475) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 7.10E+3 | n/a | n/a | n/a | n/a | 8.8 | n/a |
University of Michigan | Assay Description The reaction mixture contained DNA (1.25 uM or as specified), NTP (110 uM or as specified), 50 mM NaCl, 150 mM potassium glutamate, buffer [20 mM CAP... | Biochemistry 52: 6905-10 (2013) Article DOI: 10.1021/bi4011286 BindingDB Entry DOI: 10.7270/Q2ZC81JQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Bacillus anthracis (Firmicutes)) | BDBM50336799 (5,5',5''-[1,3,6-naphthalenetriyltris(sulfonylimino...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 8.20E+3 | n/a | n/a | n/a | n/a | 8.8 | n/a |
University of Michigan | Assay Description The reaction mixture contained DNA (1.25 uM or as specified), NTP (110 uM or as specified), 50 mM NaCl, 150 mM potassium glutamate, buffer [20 mM CAP... | Biochemistry 52: 6905-10 (2013) Article DOI: 10.1021/bi4011286 BindingDB Entry DOI: 10.7270/Q2ZC81JQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50034961 (6-Chloro-N*4*-(3,4-dichloro-phenyl)-pyrimidine-2,4...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 8.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primase | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Mycobacterium tuberculosis) | BDBM22984 ((8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-me...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 9.30E+3 | n/a | n/a | n/a | n/a | 8.8 | n/a |
University of Michigan | Assay Description The reaction mixture contained DNA (1.25 uM or as specified), NTP (110 uM or as specified), 50 mM NaCl, 150 mM potassium glutamate, buffer [20 mM CAP... | Biochemistry 52: 6905-10 (2013) Article DOI: 10.1021/bi4011286 BindingDB Entry DOI: 10.7270/Q2ZC81JQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50034955 (CHEMBL53605 | N*2*-(3,4-Dichloro-phenyl)-9H-purine...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primase | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50013091 (2-(3,4-Dichloro-phenylamino)-1,9-dihydro-purin-6-o...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Stanford University Medical School Curated by ChEMBL | Assay Description Inhibition against Primase by coupled primase-DNA polymerase-I assay with the two subunit recombinant HSV-1 helicase primase | J Med Chem 38: 1820-5 (1995) BindingDB Entry DOI: 10.7270/Q29K4983 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Mycobacterium tuberculosis) | BDBM50364890 (Amixin IC | TILORONE | cid_5475) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.90E+4 | n/a | n/a | n/a | n/a | 8.8 | n/a |
University of Michigan | Assay Description The reaction mixture contained DNA (1.25 uM or as specified), NTP (110 uM or as specified), 50 mM NaCl, 150 mM potassium glutamate, buffer [20 mM CAP... | Biochemistry 52: 6905-10 (2013) Article DOI: 10.1021/bi4011286 BindingDB Entry DOI: 10.7270/Q2ZC81JQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Bacillus anthracis (Firmicutes)) | BDBM50366826 (DR-3355 | Floxacin | Iquix | LEVOFLOXACIN | Levaqu...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 7.50E+4 | n/a | n/a | n/a | n/a | 8.8 | n/a |
University of Michigan | Assay Description The reaction mixture contained DNA (1.25 uM or as specified), NTP (110 uM or as specified), 50 mM NaCl, 150 mM potassium glutamate, buffer [20 mM CAP... | Biochemistry 52: 6905-10 (2013) Article DOI: 10.1021/bi4011286 BindingDB Entry DOI: 10.7270/Q2ZC81JQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Human herpesvirus 1 (strain 17) (HHV-1) (Human her...) | BDBM50137912 ((Biphenyl-4-sulfinyl)-acetic acid | (Biphenyl-4-su...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Boehringer Ingelheim (Canada) Ltd. Curated by ChEMBL | Assay Description Inhibitory concentration against herpes simplex virus helicase primase 8 (HSV) | J Med Chem 47: 18-21 (2003) Article DOI: 10.1021/jm034206x BindingDB Entry DOI: 10.7270/Q23F4P2Q | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase (Bacillus anthracis (Firmicutes)) | BDBM4078 (6,7,13,14-tetrahydroxy-2,9-dioxatetracyclo[6.6.2.0...) | KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | 8.8 | n/a |
University of Michigan | Assay Description The reaction mixture contained DNA (1.25 uM or as specified), NTP (110 uM or as specified), 50 mM NaCl, 150 mM potassium glutamate, buffer [20 mM CAP... | Biochemistry 52: 6905-10 (2013) Article DOI: 10.1021/bi4011286 BindingDB Entry DOI: 10.7270/Q2ZC81JQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
DNA primase TraC (Escherichia coli) | BDBM15236 (3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4H-chr...) | UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 7.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Nebraska-Lincoln Curated by ChEMBL | Assay Description Inhibition of Escherichia coli primase | Bioorg Med Chem 15: 7203-8 (2007) Article DOI: 10.1016/j.bmc.2007.07.057 BindingDB Entry DOI: 10.7270/Q26H4J7X | |||||||||||
More data for this Ligand-Target Pair |