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Compile Data Set for Download or QSAR

Found 48 hits Enz. Inhib. hit(s) with Target = 'DNA-directed RNA polymerase subunit beta''   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA-directed RNA polymerase subunit beta'


(Escherichia coli K-12)		BDBM43866
PNG
(2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,1...)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3oc4c(C)c(=O)c(N)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C1=O
Show InChI InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1
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n/an/a 160n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli DNA-dependent RNA polymerase

J Med Chem 22: 1051-5 (1979)


BindingDB Entry DOI: 10.7270/Q2SQ91WG
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592133
PNG
(US11572337, Compound 0MTK127)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Cl)cc2)c(O)c1
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n/an/a 1.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592137
PNG
(US11572337, Compound 0MTK149)
Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccccc3)cc2)c(O)c1
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TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592173
PNG
(US11572337, Compound 0MTK267)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(cc3)-c3cccnc3)cc2)c(O)c1
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n/an/a 1.70E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592141
PNG
(US11572337, Compound 0MTK158)
Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccccc3)cc2C(F)(F)F)c(O)c1
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n/an/a 1.80E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592132
PNG
(US11572337, Compound 0MTK107)
Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Cl)cc2)c(O)c1
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n/an/a 2.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


(Escherichia coli K-12)		BDBM50000057
PNG
(CHEMBL3228737)
Show SMILES [H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(NCCCNC5CC(C)(C)[N+]([O-])C(C)(C)C5)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C |r,wU:12.13,8.111,55.57,50.52,1.0,wD:49.50,76.83,91.98,86.93,68.70,^1:39,(37.15,-26.86,;38.9,-26.18,;37.87,-25.04,;38.62,-23.71,;40.14,-24.02,;40.32,-25.53,;41.66,-26.3,;41.66,-27.84,;42.99,-25.53,;44.32,-26.3,;46.86,-32.42,;48.19,-33.19,;45.52,-33.16,;45.51,-34.7,;46.84,-35.5,;48.17,-34.73,;46.83,-37.04,;45.5,-37.78,;45.48,-39.32,;46.81,-40.12,;46.79,-41.65,;48.14,-39.35,;49.47,-40.12,;50.8,-39.36,;52.11,-40.13,;52.09,-41.68,;53.43,-39.37,;54.77,-40.16,;53.44,-37.85,;54.77,-37.08,;56.11,-37.85,;57.44,-37.08,;58.77,-37.85,;58.77,-39.39,;60.11,-40.16,;60.1,-41.7,;61.43,-42.46,;61.42,-44,;60.09,-43.22,;62.77,-41.7,;64.1,-42.48,;62.77,-40.16,;63.53,-38.82,;64.31,-40.15,;61.43,-39.38,;52.11,-37.08,;52.13,-35.54,;50.8,-34.77,;53.46,-34.77,;53.46,-33.23,;54.81,-32.46,;54.82,-30.94,;56.14,-33.25,;57.48,-32.48,;57.48,-30.95,;58.81,-33.26,;58.8,-34.8,;60.14,-35.57,;57.47,-35.57,;60.15,-32.49,;61.48,-33.27,;60.16,-30.95,;58.82,-30.18,;61.49,-30.19,;61.49,-28.64,;62.84,-27.88,;60.16,-27.87,;58.83,-28.64,;60.18,-26.33,;61.85,-27.2,;61.44,-25.43,;60.95,-23.96,;59.41,-23.96,;58.94,-25.42,;57.59,-26.18,;57.59,-27.73,;56.26,-25.41,;54.93,-26.16,;52.13,-32.46,;50.8,-33.23,;56.26,-23.85,;54.93,-23.08,;57.61,-23.08,;50.8,-37.83,;49.47,-37.06,;48.16,-37.81,;44.19,-32.39,;44.2,-30.85,;42.85,-33.16,;41.52,-32.37,;41.54,-30.83,;40.19,-33.13,;40.16,-34.67,;41.49,-35.45,;38.83,-35.43,;38.85,-32.35,;37.52,-33.11,;38.86,-30.81,;40.21,-30.05,;37.53,-30.03,;37.55,-28.49,;36.22,-27.7,;38.9,-27.73,;40.21,-28.5,;42.96,-23.99,;44.31,-23.22,;41.63,-23.22,)|
Show InChI InChI=1S/C74H109N14O17/c1-36(2)51-69(98)86-30-21-24-46(86)67(96)82(17)34-48(89)84(19)58(38(5)6)71(100)103-42(11)53(65(94)78-51)80-63(92)45-27-26-40(9)61-55(45)77-57-50(56(60(91)41(10)62(57)105-61)76-29-23-28-75-44-32-73(13,14)88(102)74(15,16)33-44)64(93)81-54-43(12)104-72(101)59(39(7)8)85(20)49(90)35-83(18)68(97)47-25-22-31-87(47)70(99)52(37(3)4)79-66(54)95/h26-27,36-39,42-44,46-47,51-54,58-59,75-76H,21-25,28-35H2,1-20H3,(H,78,94)(H,79,95)(H,80,92)(H,81,93)/t42-,43-,46+,47+,51-,52-,53+,54+,58+,59+/m1/s1
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n/an/a 2.70E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli DNA-dependent RNA polymerase

J Med Chem 22: 1051-5 (1979)


BindingDB Entry DOI: 10.7270/Q2SQ91WG
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592135
PNG
(US11572337, Compound 0MTK146)
Show SMILES CC(C)(CNC(=O)c1c(O)cc(O)cc1O)c1ccc(Cl)cc1
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n/an/a 2.70E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


(Escherichia coli K-12)		BDBM50000055
PNG
(CHEMBL3228736)
Show SMILES [H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@@H](NC(=O)c1ccc(C)c3oc4c(C)c(=O)c(NCCNC5CC(C)(C)[N+]([O-])C(C)(C)C5)c(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@]6([H])CCCN6C(=O)[C@H](NC5=O)C(C)C)c4nc13)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C2=O)C(C)C |r,wU:12.13,8.110,54.56,49.51,1.0,wD:48.49,75.82,90.97,85.92,67.69,^1:38,(.5,-24.4,;2.24,-23.73,;1.21,-22.59,;1.96,-21.26,;3.48,-21.57,;3.66,-23.08,;4.99,-23.85,;4.99,-25.39,;6.32,-23.08,;7.65,-23.85,;10.2,-29.97,;11.53,-30.74,;8.86,-30.71,;8.84,-32.25,;10.17,-33.05,;11.5,-32.28,;10.17,-34.59,;8.84,-35.33,;8.81,-36.87,;10.14,-37.67,;10.13,-39.2,;11.48,-36.9,;12.8,-37.67,;14.13,-36.91,;15.45,-37.68,;15.42,-39.23,;16.77,-36.92,;18.11,-37.71,;16.78,-35.4,;18.11,-34.63,;19.44,-35.4,;20.77,-34.63,;22.11,-35.4,;22.11,-36.94,;23.44,-37.7,;23.43,-39.24,;24.97,-39.24,;24.2,-40.57,;22.1,-40.01,;22.1,-41.55,;20.77,-39.23,;19.99,-40.56,;19.23,-39.22,;20.77,-37.7,;15.45,-34.63,;15.46,-33.09,;14.14,-32.32,;16.8,-32.32,;16.8,-30.78,;18.15,-30.01,;18.15,-28.49,;19.48,-30.8,;20.81,-30.03,;20.81,-28.5,;22.14,-30.81,;22.14,-32.35,;23.47,-33.12,;20.81,-33.12,;23.49,-30.04,;24.82,-30.82,;23.5,-28.5,;22.16,-27.73,;24.83,-27.74,;24.83,-26.19,;26.18,-25.43,;23.5,-25.42,;22.17,-26.19,;23.51,-23.88,;25.17,-24.74,;24.77,-22.98,;24.29,-21.51,;22.75,-21.51,;22.28,-22.97,;20.93,-23.73,;20.93,-25.28,;19.6,-22.96,;18.26,-23.71,;15.47,-30.01,;14.14,-30.78,;19.6,-21.4,;18.27,-20.63,;20.95,-20.63,;14.14,-35.38,;12.81,-34.61,;11.5,-35.36,;7.53,-29.94,;7.54,-28.4,;6.18,-30.71,;4.85,-29.92,;4.88,-28.38,;3.52,-30.68,;3.5,-32.22,;4.83,-33,;2.17,-32.98,;2.19,-29.9,;.86,-30.66,;2.19,-28.36,;3.55,-27.6,;.86,-27.58,;.89,-26.04,;-.44,-25.25,;2.23,-25.28,;3.55,-26.05,;6.3,-21.54,;7.65,-20.77,;4.97,-20.77,)|
Show InChI InChI=1S/C73H107N14O17/c1-35(2)50-68(97)85-29-21-23-45(85)66(95)81(17)33-47(88)83(19)57(37(5)6)70(99)102-41(11)52(64(93)77-50)79-62(91)44-26-25-39(9)60-54(44)76-56-49(55(59(90)40(10)61(56)104-60)75-28-27-74-43-31-72(13,14)87(101)73(15,16)32-43)63(92)80-53-42(12)103-71(100)58(38(7)8)84(20)48(89)34-82(18)67(96)46-24-22-30-86(46)69(98)51(36(3)4)78-65(53)94/h25-26,35-38,41-43,45-46,50-53,57-58,74-75H,21-24,27-34H2,1-20H3,(H,77,93)(H,78,94)(H,79,91)(H,80,92)/t41-,42-,45+,46+,50-,51-,52+,53+,57+,58+/m1/s1
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n/an/a 2.80E+3n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli DNA-dependent RNA polymerase

J Med Chem 22: 1051-5 (1979)


BindingDB Entry DOI: 10.7270/Q2SQ91WG
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592174
PNG
(US11572337, Compound 0MTK268)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cccc(c3)C(=O)NC3CC3)cc2)c(O)c1
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n/an/a 2.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592175
PNG
(US11572337, Compound 0MTK269)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cccc(c3)-c3ccncc3)cc2)c(O)c1
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n/an/a 3.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592162
PNG
(US11572337, Compound 0MTK238)
Show SMILES Oc1c(Cl)c(O)c(C(=O)NCCc2ccc(Oc3cc(Cl)cc(Cl)c3)cc2)c(O)c1Cl
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TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592161
PNG
(US11572337, Compound 0MTK237)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cc(Cl)cc(Cl)c3)cc2)c(O)c1Cl
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TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592138
PNG
(US11572337, Compound 0MTK154)
Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccc(F)cc3)cc2)c(O)c1
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n/an/a 3.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592170
PNG
(US11572337, Compound 0MTK264)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cccnc3)cc2)c(O)c1
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n/an/a 3.80E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592136
PNG
(US11572337, Compound 0MTK148)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccccc3)cc2)c(O)c1
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n/an/a 3.90E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592152
PNG
(US11572337, Compound 0MTK208)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(cc2C(F)(F)F)C(F)(F)F)c(O)c1
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n/an/a 5.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592172
PNG
(US11572337, Compound 0MTK266)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(cc3)-c3ccncc3)cc2)c(O)c1
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n/an/a 5.10E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592140
PNG
(US11572337, Compound 0MTK156)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(F)cc3)cc2)c(O)c1
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n/an/a 5.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592166
PNG
(US11572337, Compound 0MTK260)
Show SMILES COc1ccc(Oc2ccc(CCNC(=O)c3c(O)cc(O)cc3O)cc2)cc1
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n/an/a 6.20E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592171
PNG
(US11572337, Compound 0MTK265)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccncc3)cc2)c(O)c1
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n/an/a 6.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592147
PNG
(US11572337, Compound 0MTK180)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cc(Cl)cc(Cl)c3)cc2)c(O)c1
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n/an/a 6.60E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592144
PNG
(US11572337, Compound 0MTK175)
Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccc(F)cc3)c(F)c2)c(O)c1
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n/an/a 7.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592169
PNG
(US11572337, Compound 0MTK263)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cccc(c3)N3CCOCC3)cc2)c(O)c1
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n/an/a 7.10E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592168
PNG
(US11572337, Compound 0MTK262)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cncnc3)cc2)c(O)c1
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n/an/a 7.40E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592167
PNG
(US11572337, Compound 0MTK261)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(cc3)N3CCOCC3)cc2)c(O)c1
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n/an/a 7.50E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592159
PNG
(US11572337, Compound 0MTK232)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(Cl)cc3)cc2)c(O)c1Cl
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n/an/a 8.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592150
PNG
(US11572337, Compound 0MTK204)
Show SMILES Oc1cc(O)c(C(=O)NCCCc2ccc(Cl)cc2)c(O)c1
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n/an/a 8.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592139
PNG
(US11572337, Compound 0MTK155)
Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccc(F)cc3)cc2C(F)(F)F)c(O)c1
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n/an/a 8.10E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592154
PNG
(US11572337, Compound 0MTK222)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Cl)cc2)c(O)c1Cl
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n/an/a 9.00E+3n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592155
PNG
(US11572337, Compound 0MTK223)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(cc2)C(F)(F)F)c(O)c1Cl
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n/an/a 1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592164
PNG
(US11572337, Compound 0MTK256)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3cccc(Cl)c3)cc2)c(O)c1
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n/an/a 1.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592165
PNG
(US11572337, Compound 0MTK257)
Show SMILES Cc1ccc(Oc2ccc(CCNC(=O)c3c(O)cc(O)cc3O)cc2)cc1
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n/an/a 1.10E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592145
PNG
(US11572337, Compound 0MTK176)
Show SMILES Cc1cc(Oc2ccc(F)cc2)ccc1CNC(=O)c1c(O)cc(O)cc1O
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n/an/a 1.20E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592151
PNG
(US11572337, Compound 0MTK207)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(cc2)C(F)(F)F)c(O)c1
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n/an/a 1.30E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592176
PNG
(US11572337, Compound 3RKHTK161)
Show SMILES CCC1=C(O)C(CC)(CC)C(=O)C(C(=O)NCCc2ccc(Oc3ccc(F)cc3)cc2)=C1O |c:2,33|
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TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592142
PNG
(US11572337, Compound 0MTK174)
Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccc(F)cc3)c(Cl)c2)c(O)c1
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n/an/a 1.40E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592149
PNG
(US11572337, Compound 0MTK183)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(Cl)cc3)cc2)c(O)c1
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n/an/a 1.40E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592163
PNG
(US11572337, Compound 0MTK240)
Show SMILES Oc1cc(O)c(C(=O)NCCc2ccc(Oc3ccc(F)cc3)cc2)c(O)c1Cl
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n/an/a 1.50E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592146
PNG
(US11572337, Compound 0MTK178)
Show SMILES COc1cc(Oc2ccc(F)cc2)ccc1CNC(=O)c1c(O)cc(O)cc1O
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n/an/a 1.80E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


(Escherichia coli K-12)		BDBM50015214
PNG
(6-chloro-2-methoxy-9-acridinyl(4-diethylamino-1-me...)
Show SMILES CCN(CC)CCCC(C)Nc1c2ccc(Cl)cc2nc2ccc(OC)cc12
Show InChI InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)
PDB
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n/an/a 2.00E+4n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli DNA-primed RNA polymerase activity using [8-14C]ATP by scintillation counting

J Med Chem 19: 994-8 (1976)


BindingDB Entry DOI: 10.7270/Q2668FQC
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592160
PNG
(US11572337, Compound 0MTK233)
Show SMILES Oc1c(Cl)c(O)c(C(=O)NCCc2ccc(Oc3ccc(Cl)cc3)cc2)c(O)c1Cl
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n/an/a 2.30E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592158
PNG
(US11572337, Compound 0MTK231)
Show SMILES Oc1c(Cl)c(O)c(C(=O)NCCc2ccc(Oc3ccc(F)cc3)cc2)c(O)c1Cl
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n/an/a 3.10E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592157
PNG
(US11572337, Compound 0MTK230)
Show SMILES Oc1c(Cl)c(O)c(C(=O)NCCc2ccc(Oc3ccccc3)cc2)c(O)c1Cl
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n/an/a 3.50E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592148
PNG
(US11572337, Compound 0MTK181)
Show SMILES Oc1cc(O)c(C(=O)NCc2ccc(Oc3ccc(F)cc3)cc2Cl)c(O)c1
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n/an/a>6.00E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592153
PNG
(US11572337, Compound 0MTK221)
Show SMILES Oc1c(Cl)c(O)c(C(=O)NCCc2ccc(Cl)cc2)c(O)c1Cl
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n/an/a 9.80E+4n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592156
PNG
(US11572337, Compound 0MTK224)
Show SMILES Oc1c(Cl)c(O)c(C(=O)NCCc2ccc(cc2)C(F)(F)F)c(O)c1Cl
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n/an/a>1.00E+5n/an/an/an/an/an/a


TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair
DNA-directed RNA polymerase subunit beta'


()		BDBM592134
PNG
(US11572337, Compound 0MTK128)
Show SMILES CN(CCc1ccc(Cl)cc1)C(=O)c1c(O)cc(O)cc1O
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TBA

Assay Description
Escherichia coli: Fluorescence-detected RNA polymerase assays with E.coli RNA polymerase were performed by a modification of the procedure of Khulman...

Citation and Details

BindingDB Entry DOI: 10.7270/Q2PZ5DR6
More data for this
Ligand-Target Pair