Found 26 hits Enz. Inhib. hit(s) with Target = 'Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287072
(CHEMBL4159112 | US10759787, Example 12 | US1105981...)Show SMILES CCN(C1CCOCC1)c1cc2oc(CN3CCN(C)CC3)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1CC Show InChI InChI=1S/C32H45N5O5/c1-6-24-27(37(7-2)22-8-14-41-15-9-22)18-29-25(17-23(42-29)20-36-12-10-35(4)11-13-36)30(24)32(39)33-19-26-28(40-5)16-21(3)34-31(26)38/h16-18,22H,6-15,19-20H2,1-5H3,(H,33,39)(H,34,38) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287050
(CHEMBL4161265)Show SMILES CCN(C1CCOCC1)c1cc2oc(Cl)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H30ClN3O5/c1-5-29(16-6-8-33-9-7-16)19-12-21-17(11-22(26)34-21)23(15(19)3)25(31)27-13-18-20(32-4)10-14(2)28-24(18)30/h10-12,16H,5-9,13H2,1-4H3,(H,27,31)(H,28,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287052
(CHEMBL4165937)Show SMILES CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C)C1CC1 Show InChI InChI=1S/C28H35N3O5/c1-5-31(19-8-10-35-11-9-19)22-14-25-20(13-23(36-25)18-6-7-18)26(17(22)3)28(33)29-15-21-24(34-4)12-16(2)30-27(21)32/h12-14,18-19H,5-11,15H2,1-4H3,(H,29,33)(H,30,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287284
(CHEMBL4160111)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2c(CC)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H33N3O4/c1-5-18-13-16(3)28-25(30)21(18)15-27-26(31)24-17(4)22(14-23-20(24)9-12-33-23)29(6-2)19-7-10-32-11-8-19/h9,12-14,19H,5-8,10-11,15H2,1-4H3,(H,27,31)(H,28,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.600 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287068
(CHEMBL4172576 | US10759787, Example 30 | US1105981...)Show SMILES CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C)C#N Show InChI InChI=1S/C26H30N4O5/c1-5-30(17-6-8-34-9-7-17)21-12-23-19(11-18(13-27)35-23)24(16(21)3)26(32)28-14-20-22(33-4)10-15(2)29-25(20)31/h10-12,17H,5-9,14H2,1-4H3,(H,28,32)(H,29,31) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287071
(CHEMBL4164687 | US10759787, Example 29 | US1105981...)Show SMILES CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C)C(F)(F)F Show InChI InChI=1S/C26H30F3N3O5/c1-5-32(16-6-8-36-9-7-16)19-12-21-17(11-22(37-21)26(27,28)29)23(15(19)3)25(34)30-13-18-20(35-4)10-14(2)31-24(18)33/h10-12,16H,5-9,13H2,1-4H3,(H,30,34)(H,31,33) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287125
(CHEMBL4170327 | US10759787, Example 19 | US1105981...)Show SMILES CCN(C1CCOCC1)c1cc2oc(C)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H33N3O5/c1-6-29(18-7-9-33-10-8-18)21-13-23-19(12-16(3)34-23)24(17(21)4)26(31)27-14-20-22(32-5)11-15(2)28-25(20)30/h11-13,18H,6-10,14H2,1-5H3,(H,27,31)(H,28,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287049
(CHEMBL4162316)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1CC Show InChI InChI=1S/C26H33N3O5/c1-5-18-21(29(6-2)17-7-10-33-11-8-17)14-23-19(9-12-34-23)24(18)26(31)27-15-20-22(32-4)13-16(3)28-25(20)30/h9,12-14,17H,5-8,10-11,15H2,1-4H3,(H,27,31)(H,28,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287283
(CHEMBL4177454)Show SMILES CCN(C1CCOCC1)c1cc2oc(C)cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H33N3O4/c1-6-29(19-7-9-32-10-8-19)22-13-23-20(12-17(4)33-23)24(18(22)5)26(31)27-14-21-15(2)11-16(3)28-25(21)30/h11-13,19H,6-10,14H2,1-5H3,(H,27,31)(H,28,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287054
(CHEMBL4174176)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H31N3O4/c1-5-28(18-6-9-31-10-7-18)21-13-22-19(8-11-32-22)23(17(21)4)25(30)26-14-20-15(2)12-16(3)27-24(20)29/h8,11-13,18H,5-7,9-10,14H2,1-4H3,(H,26,30)(H,27,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287048
(CHEMBL4162499 | US10759787, Example 9 | US11059811...)Show SMILES CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1CC)C1CCN(CC1)C(C)C Show InChI InChI=1S/C34H48N4O4/c1-7-26-29(38(8-2)25-11-15-41-16-12-25)19-31-27(18-30(42-31)24-9-13-37(14-10-24)21(3)4)32(26)34(40)35-20-28-22(5)17-23(6)36-33(28)39/h17-19,21,24-25H,7-16,20H2,1-6H3,(H,35,40)(H,36,39) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM172038
(US10155002, Compound 44 | US10647700, Compound EPZ...)Show SMILES CCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1 Show InChI InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287277
(CHEMBL4170753 | US10759787, Example 18 | US1105981...)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H31N3O5/c1-5-28(17-6-9-32-10-7-17)20-13-22-18(8-11-33-22)23(16(20)3)25(30)26-14-19-21(31-4)12-15(2)27-24(19)29/h8,11-13,17H,5-7,9-10,14H2,1-4H3,(H,26,30)(H,27,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287058
(CHEMBL4169191)Show SMILES CCN(C1CCOCC1)c1cc2oc(F)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H30FN3O5/c1-5-29(16-6-8-33-9-7-16)19-12-21-17(11-22(26)34-21)23(15(19)3)25(31)27-13-18-20(32-4)10-14(2)28-24(18)30/h10-12,16H,5-9,13H2,1-4H3,(H,27,31)(H,28,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287051
(CHEMBL4169368)Show SMILES CCN(C1CCOCC1)c1cc2oc(CN3CCOCC3)cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1CC Show InChI InChI=1S/C31H42N4O5/c1-5-24-27(35(6-2)22-7-11-38-12-8-22)17-28-25(16-23(40-28)19-34-9-13-39-14-10-34)29(24)31(37)32-18-26-20(3)15-21(4)33-30(26)36/h15-17,22H,5-14,18-19H2,1-4H3,(H,32,37)(H,33,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287276
(CHEMBL4162406)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2c(cc(C)[nH]c2=O)C(F)(F)F)c1C Show InChI InChI=1S/C25H28F3N3O4/c1-4-31(16-5-8-34-9-6-16)20-12-21-17(7-10-35-21)22(15(20)3)24(33)29-13-18-19(25(26,27)28)11-14(2)30-23(18)32/h7,10-12,16H,4-6,8-9,13H2,1-3H3,(H,29,33)(H,30,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287056
(CHEMBL4169598 | US10759787, Example 20 | US1105981...)Show SMILES CCN(C1CCOCC1)c1cc2occ(C)c2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C26H33N3O5/c1-6-29(18-7-9-33-10-8-18)20-12-22-23(15(2)14-34-22)24(17(20)4)26(31)27-13-19-21(32-5)11-16(3)28-25(19)30/h11-12,14,18H,6-10,13H2,1-5H3,(H,27,31)(H,28,30) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 5.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287306
(CHEMBL4167587)Show SMILES CCN(C1CCOCC1)c1cc2sccc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C25H31N3O3S/c1-5-28(18-6-9-31-10-7-18)21-13-22-19(8-11-32-22)23(17(21)4)25(30)26-14-20-15(2)12-16(3)27-24(20)29/h8,11-13,18H,5-7,9-10,14H2,1-4H3,(H,26,30)(H,27,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287119
(CHEMBL4169762)Show SMILES CCN(C1CCOCC1)c1cc2oc(cc2c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1CC)C1CCN(C)CC1 Show InChI InChI=1S/C32H44N4O4/c1-6-24-27(36(7-2)23-10-14-39-15-11-23)18-29-25(17-28(40-29)22-8-12-35(5)13-9-22)30(24)32(38)33-19-26-20(3)16-21(4)34-31(26)37/h16-18,22-23H,6-15,19H2,1-5H3,(H,33,38)(H,34,37) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287053
(CHEMBL4161444 | US10759787, Example 1 | US11059811...)Show SMILES CCN(C1CCOCC1)c1cc2oc(CN3CCCCC3)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1CC Show InChI InChI=1S/C32H44N4O5/c1-5-24-27(36(6-2)22-10-14-40-15-11-22)18-29-25(17-23(41-29)20-35-12-8-7-9-13-35)30(24)32(38)33-19-26-28(39-4)16-21(3)34-31(26)37/h16-18,22H,5-15,19-20H2,1-4H3,(H,33,38)(H,34,37) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287047
(CHEMBL4176373)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2ccc(C)[nH]c2=O)c1Cl Show InChI InChI=1S/C23H26ClN3O4/c1-3-27(16-6-9-30-10-7-16)18-12-19-17(8-11-31-19)20(21(18)24)23(29)25-13-15-5-4-14(2)26-22(15)28/h4-5,8,11-12,16H,3,6-7,9-10,13H2,1-2H3,(H,25,29)(H,26,28) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 6.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287307
(CHEMBL4176554 | US10759787, Example 6 | US11059811...)Show SMILES CCN(C1CCOCC1)c1cc2oc(CN3CCOCC3)cc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1CC Show InChI InChI=1S/C31H42N4O6/c1-5-23-26(35(6-2)21-7-11-39-12-8-21)17-28-24(16-22(41-28)19-34-9-13-40-14-10-34)29(23)31(37)32-18-25-27(38-4)15-20(3)33-30(25)36/h15-17,21H,5-14,18-19H2,1-4H3,(H,32,37)(H,33,36) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50149895
(CHEMBL3770000)Show SMILES CCN(C1CCOCC1)c1cc(Br)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C Show InChI InChI=1S/C23H30BrN3O3/c1-5-27(18-6-8-30-9-7-18)21-12-17(24)11-19(16(21)4)22(28)25-13-20-14(2)10-15(3)26-23(20)29/h10-12,18H,5-9,13H2,1-4H3,(H,25,28)(H,26,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM225230
(EED226 | US11013745, Compound EED226)Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(NCc2ccco2)n2cnnc12 Show InChI InChI=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22)18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
| Assay Description
All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383]. |
Nat Chem Biol 13: 381-388 (2017)
Article DOI: 10.1038/nchembio.2304
BindingDB Entry DOI: 10.7270/Q2S75F64 |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287055
(CHEMBL4172992)Show SMILES CCN(C1CCOCC1)c1cc(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c2ccoc2c1 Show InChI InChI=1S/C24H29N3O5/c1-4-27(16-5-8-31-9-6-16)17-12-19(18-7-10-32-22(18)13-17)23(28)25-14-20-21(30-3)11-15(2)26-24(20)29/h7,10-13,16H,4-6,8-9,14H2,1-3H3,(H,25,28)(H,26,29) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 331 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH1/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2
(Homo sapiens (Human)) | BDBM50287057
(CHEMBL4165760)Show SMILES CCN(C1CCOCC1)c1cc2occc2c(C(=O)NCc2c(OC)cc(C)[nH]c2=O)c1C(F)(F)F Show InChI InChI=1S/C25H28F3N3O5/c1-4-31(15-5-8-35-9-6-15)18-12-20-16(7-10-36-20)21(22(18)25(26,27)28)24(33)29-13-17-19(34-3)11-14(2)30-23(17)32/h7,10-12,15H,4-6,8-9,13H2,1-3H3,(H,29,33)(H,30,32) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Shanghai Hengrui Pharmaceutical Co. Ltd.
Curated by ChEMBL
| Assay Description
Inhibition of human N-terminal His-tagged EZH2/flag-tagged EED/SUZ12/AEBP2/RBAP48 A677G mutant (2 to end residues) expressed in baculovirus infected ... |
ACS Med Chem Lett 9: 98-102 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00437
BindingDB Entry DOI: 10.7270/Q2ZS3028 |
More data for this
Ligand-Target Pair | |
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