BindingDB PrimarySearch

Found 18 hits Enz. Inhib. hit(s) with Target = 'Geranylgeranyl pyrophosphate synthase BTS1'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25297 (1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Binding affinity to Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25266 (BPH-628 \| bisphosphonate, 21 \| {1-hydroxy-2-[3-(4-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Binding affinity to Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25279 (BPH-608 \| bisphosphonate, 31 \| {1-hydroxy-2-[3-(3-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Binding affinity to Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25289 (bisphosphonate, 38 \| {1-hydroxy-2-[3-(3-phenylphen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Binding affinity to Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25284 ((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Binding affinity to Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25288 (BPH-629 \| [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Binding affinity to Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25308 ((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...) Show SMILES OC(Cc1cnc2ccccn12)(P(O)(O)=O)P(O)(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	130	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Binding affinity to Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM12578 (2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...) Show SMILES OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Binding affinity to Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25297 (1-(2-hydrogen phosphonato-2-hydroxy-2-phosphonoeth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Inhibition of Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25266 (BPH-628 \| bisphosphonate, 21 \| {1-hydroxy-2-[3-(4-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Inhibition of Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25279 (BPH-608 \| bisphosphonate, 31 \| {1-hydroxy-2-[3-(3-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Inhibition of Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25289 (bisphosphonate, 38 \| {1-hydroxy-2-[3-(3-phenylphen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Inhibition of Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25284 ((1-hydroxy-2-{3-[3-(naphthalene-2-sulfonamido)phen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Inhibition of Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25288 (BPH-629 \| [1-hydroxy-2-(3-{8-oxatricyclo[7.4.0.0^{...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Inhibition of Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM25308 ((1-hydroxy-2-{imidazo[1,2-a]pyridin-3-yl}-1-phosph...) Show SMILES OC(Cc1cnc2ccccn12)(P(O)(O)=O)P(O)(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Inhibition of Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM12578 (2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...) Show SMILES OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Academia Sinica					Assay Description To measure the kinetic constants by radioactive assays, 0.2 μM wild-type E. coli OPPS and the wild-type or mutant S. cerevisiae GGPPS and human ...				Biochemistry 55: 4366-74 (2016) Article DOI: 10.1021/acs.biochem.6b00486 BindingDB Entry DOI: 10.7270/Q2BR8QZK
Academia Sinica					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl pyrophosphate synthase BTS1 (Saccharomyces cerevisiae (Yeast))	BDBM12578 (2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...) Show SMILES OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Biological Chemistry Curated by ChEMBL					Assay Description Inhibition of Saccharomyces cerevisiae GGPPS				Proc Natl Acad Sci USA 104: 10022-7 (2007) Article DOI: 10.1073/pnas.0702254104 BindingDB Entry DOI: 10.7270/Q2MW2J2F
Institute of Biological Chemistry Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl pyrophosphate synthase BTS1 [Y107A,F108A] (Saccharomyces cerevisiae (Yeast))	BDBM12578 (2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosp...) Show SMILES OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
Academia Sinica					Assay Description The assays were performed by mixing either 0.2 μM E. coli OPPS, Y107A/F108A S. cerevisiae GGPPS, or Y96A/F97A human GGPPS with various concentra...				Biochemistry 55: 4366-74 (2016) Article DOI: 10.1021/acs.biochem.6b00486 BindingDB Entry DOI: 10.7270/Q2BR8QZK
Academia Sinica					More data for this Ligand-Target Pair				3D Structure (crystal)