Compile Data Set for Download or QSAR

Found 43 hits Enz. Inhib. hit(s) with Target = 'Histamine N-methyltransferase'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine N-methyltransferase (Homo sapiens (Human))	BDBM50041457 (4-[(7-chloroquinolin-4-yl)amino]-2-[(diethylamino)...) Show SMILES CCN(CC)Cc1cc(Nc2ccnc3cc(Cl)ccc23)ccc1O Show InChI InChI=1S/C20H22ClN3O/c1-3-24(4-2)13-14-11-16(6-8-20(14)25)23-18-9-10-22-19-12-15(21)5-7-17(18)19/h5-12,25H,3-4,13H2,1-2H3,(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank PDB Article PubMed	19	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Washington University Curated by ChEMBL					Assay Description Inhibition of histamine N-methyltransferase by radiochemical assay				Bioorg Med Chem Lett 22: 4990-3 (2012) Article DOI: 10.1016/j.bmcl.2012.06.032 BindingDB Entry DOI: 10.7270/Q29G5NWN
					More data for this Ligand-Target Pair				3D Structure (crystal)
Histamine N-methyltransferase (Homo sapiens (Human))	BDBM50026331 (2-Amino-4-[4-(6-amino-purin-9-yl)-2,3-dihydroxy-cy...) Show SMILES NC(CCSCC1CC(C(O)C1O)n1cnc2c(N)ncnc12)C(O)=O Show InChI InChI=1S/C15H22N6O4S/c16-8(15(24)25)1-2-26-4-7-3-9(12(23)11(7)22)21-6-20-10-13(17)18-5-19-14(10)21/h5-9,11-12,22-23H,1-4,16H2,(H,24,25)(H2,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition constant was evaluated against Histamine N-methyl-transferase				J Med Chem 28: 478-82 (1985) BindingDB Entry DOI: 10.7270/Q2WM1DZS
					More data for this Ligand-Target Pair				3D Structure (docked)
Histamine N-methyltransferase (Homo sapiens (Human))	BDBM50026331 (2-Amino-4-[4-(6-amino-purin-9-yl)-2,3-dihydroxy-cy...) Show SMILES NC(CCSCC1CC(C(O)C1O)n1cnc2c(N)ncnc12)C(O)=O Show InChI InChI=1S/C15H22N6O4S/c16-8(15(24)25)1-2-26-4-7-3-9(12(23)11(7)22)21-6-20-10-13(17)18-5-19-14(10)21/h5-9,11-12,22-23H,1-4,16H2,(H,24,25)(H2,17,18,19)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition constant was evaluated against Histamine N-methyl-transferase				J Med Chem 28: 478-82 (1985) BindingDB Entry DOI: 10.7270/Q2WM1DZS
					More data for this Ligand-Target Pair				3D Structure (docked)
Histamine N-methyltransferase (Homo sapiens (Human))	BDBM50009672 (AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...) Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	1.81E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition constant was evaluated against Histamine N-methyl-transferase				J Med Chem 28: 478-82 (1985) BindingDB Entry DOI: 10.7270/Q2WM1DZS
					More data for this Ligand-Target Pair				3D Structure (crystal)
Histamine N-methyltransferase (Homo sapiens (Human))	BDBM50009672 (AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...) Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	1.81E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition constant was evaluated against Histamine N-methyl-transferase				J Med Chem 28: 478-82 (1985) BindingDB Entry DOI: 10.7270/Q2WM1DZS
					More data for this Ligand-Target Pair				3D Structure (crystal)
Histamine N-methyltransferase (Cavia porcellus)	BDBM50016564 (CHEMBL3272448) Show SMILES CN(C)[C@@H]1CC[C@@H](N(Cc2ccccc2)C1)c1ccccc1 |r| Show InChI InChI=1S/C20H26N2/c1-21(2)19-13-14-20(18-11-7-4-8-12-18)22(16-19)15-17-9-5-3-6-10-17/h3-12,19-20H,13-16H2,1-2H3/t19-,20-/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.16E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of histamine N-methyltransferase in guinea pig brain using S-adenosyl-L-methionine-14C as substrate by scintillation spectrophotometer				J Med Chem 19: 117-22 (1976) BindingDB Entry DOI: 10.7270/Q29W0H2G
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Cavia porcellus)	BDBM50016547 (CHEMBL3272447) Show SMILES CN(C)[C@H]1CC[C@@H](N(Cc2ccccc2)C1)c1ccccc1 |r| Show InChI InChI=1S/C20H26N2/c1-21(2)19-13-14-20(18-11-7-4-8-12-18)22(16-19)15-17-9-5-3-6-10-17/h3-12,19-20H,13-16H2,1-2H3/t19-,20+/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	2.47E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of histamine N-methyltransferase in guinea pig brain using S-adenosyl-L-methionine-14C as substrate by scintillation spectrophotometer				J Med Chem 19: 117-22 (1976) BindingDB Entry DOI: 10.7270/Q29W0H2G
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110309 (CHEMBL14740 | Methyl-(3-piperidin-1-yl-propyl)-qui...) Show SMILES CN(CCCN1CCCCC1)c1ccnc2ccccc12 Show InChI InChI=1S/C18H25N3/c1-20(12-7-15-21-13-5-2-6-14-21)18-10-11-19-17-9-4-3-8-16(17)18/h3-4,8-11H,2,5-7,12-15H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110306 ((6-Piperidin-1-yl-hexyl)-(1,2,3,4-tetrahydro-acrid...) Show SMILES C(CCCN1CCCCC1)CCNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C24H35N3/c1(2-9-17-27-18-10-3-11-19-27)8-16-25-24-20-12-4-6-14-22(20)26-23-15-7-5-13-21(23)24/h4,6,12,14H,1-3,5,7-11,13,15-19H2,(H,25,26)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	21	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110285 (CHEMBL274041 | {3-[4-(3-Piperidin-1-yl-propoxy)-ph...) Show SMILES C(COc1ccc(CCCNc2ccnc3ccccc23)cc1)CN1CCCCC1 Show InChI InChI=1S/C26H33N3O/c1-4-18-29(19-5-1)20-7-21-30-23-13-11-22(12-14-23)8-6-16-27-26-15-17-28-25-10-3-2-9-24(25)26/h2-3,9-15,17H,1,4-8,16,18-21H2,(H,27,28)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110303 ((2-Piperidin-1-yl-ethyl)-(1,2,3,4-tetrahydro-acrid...) Show SMILES C(CN1CCCCC1)Nc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C20H27N3/c1-6-13-23(14-7-1)15-12-21-20-16-8-2-4-10-18(16)22-19-11-5-3-9-17(19)20/h2,4,8,10H,1,3,5-7,9,11-15H2,(H,21,22)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	34	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110286 ((3-Piperidin-1-yl-propyl)-(1,2,3,4-tetrahydro-acri...) Show SMILES C(CNc1c2CCCCc2nc2ccccc12)CN1CCCCC1 Show InChI InChI=1S/C21H29N3/c1-6-14-24(15-7-1)16-8-13-22-21-17-9-2-4-11-19(17)23-20-12-5-3-10-18(20)21/h2,4,9,11H,1,3,5-8,10,12-16H2,(H,22,23)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110296 (CHEMBL14868 | {4-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(CCc1ccc(OCCCN2CCCCC2)cc1)CNc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C31H41N3O/c1-8-21-34(22-9-1)23-10-24-35-26-18-16-25(17-19-26)11-6-7-20-32-31-27-12-2-4-14-29(27)33-30-15-5-3-13-28(30)31/h2,4,12,14,16-19H,1,3,5-11,13,15,20-24H2,(H,32,33)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110300 (CHEMBL15056 | N-(4-(3-(piperidin-1-yl)propoxy)phen...) Show SMILES C(COc1ccc(CCNc2c3CCCCc3nc3ccccc23)cc1)CN1CCCCC1 Show InChI InChI=1S/C29H37N3O/c1-6-19-32(20-7-1)21-8-22-33-24-15-13-23(14-16-24)17-18-30-29-25-9-2-4-11-27(25)31-28-12-5-3-10-26(28)29/h2,4,9,11,13-16H,1,3,5-8,10,12,17-22H2,(H,30,31)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110298 (CHEMBL277113 | Ethyl-(3-piperidin-1-yl-propyl)-qui...) Show SMILES CCN(CCCN1CCCCC1)c1ccnc2ccccc12 Show InChI InChI=1S/C19H27N3/c1-2-22(16-8-15-21-13-6-3-7-14-21)19-11-12-20-18-10-5-4-9-17(18)19/h4-5,9-12H,2-3,6-8,13-16H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110288 (CHEMBL15153 | N-(4-(3-(piperidin-1-yl)propoxy)phen...) Show SMILES C(COc1ccc(Nc2ccnc3ccccc23)cc1)CN1CCCCC1 Show InChI InChI=1S/C23H27N3O/c1-4-15-26(16-5-1)17-6-18-27-20-11-9-19(10-12-20)25-23-13-14-24-22-8-3-2-7-21(22)23/h2-3,7-14H,1,4-6,15-18H2,(H,24,25)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	51	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110294 ((5-Piperidin-1-yl-pentyl)-quinolin-4-yl-amine; Oxa...) Show SMILES C(CCNc1ccnc2ccccc12)CCN1CCCCC1 Show InChI InChI=1S/C19H27N3/c1(6-14-22-15-7-2-8-16-22)5-12-20-19-11-13-21-18-10-4-3-9-17(18)19/h3-4,9-11,13H,1-2,5-8,12,14-16H2,(H,20,21)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110284 ((4-Piperidin-1-yl-butyl)-quinolin-4-yl-amine; Oxal...) Show SMILES C(CCN1CCCCC1)CNc1ccnc2ccccc12 Show InChI InChI=1S/C18H25N3/c1-5-13-21(14-6-1)15-7-4-11-19-18-10-12-20-17-9-3-2-8-16(17)18/h2-3,8-10,12H,1,4-7,11,13-15H2,(H,19,20)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110287 ((3-Piperidin-1-yl-propyl)-quinolin-4-yl-amine; Oxa...) Show SMILES C(CNc1ccnc2ccccc12)CN1CCCCC1 Show InChI InChI=1S/C17H23N3/c1-4-12-20(13-5-1)14-6-10-18-17-9-11-19-16-8-3-2-7-15(16)17/h2-3,7-9,11H,1,4-6,10,12-14H2,(H,18,19)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110290 (CHEMBL14484 | {4-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(CCc1ccc(OCCCN2CCCCC2)cc1)CNc1ccnc2ccccc12 Show InChI InChI=1S/C27H35N3O/c1-6-19-30(20-7-1)21-8-22-31-24-14-12-23(13-15-24)9-4-5-17-28-27-16-18-29-26-11-3-2-10-25(26)27/h2-3,10-16,18H,1,4-9,17,19-22H2,(H,28,29)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	73	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110297 ((6-Piperidin-1-yl-hexyl)-quinolin-4-yl-amine; Oxal...) Show SMILES C(CCCN1CCCCC1)CCNc1ccnc2ccccc12 Show InChI InChI=1S/C20H29N3/c1(2-7-15-23-16-8-3-9-17-23)6-13-21-20-12-14-22-19-11-5-4-10-18(19)20/h4-5,10-12,14H,1-3,6-9,13,15-17H2,(H,21,22)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	84	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110299 (CHEMBL14754 | {3-[4-(3-Piperidin-1-yl-propoxy)-phe...) Show SMILES C(COc1ccc(CCCNc2c3CCCCc3nc3ccccc23)cc1)CN1CCCCC1 Show InChI InChI=1S/C30H39N3O/c1-6-20-33(21-7-1)22-9-23-34-25-17-15-24(16-18-25)10-8-19-31-30-26-11-2-4-13-28(26)32-29-14-5-3-12-27(29)30/h2,4,11,13,15-18H,1,3,5-10,12,14,19-23H2,(H,31,32)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	95	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM8961 (1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...) Show SMILES Nc1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110302 (Acridin-9-yl-(3-piperidin-1-yl-propyl)-amine; Oxal...) Show SMILES C(CNc1c2ccccc2nc2ccccc12)CN1CCCCC1 Show InChI InChI=1S/C21H25N3/c1-6-14-24(15-7-1)16-8-13-22-21-17-9-2-4-11-19(17)23-20-12-5-3-10-18(20)21/h2-5,9-12H,1,6-8,13-16H2,(H,22,23)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110293 (CHEMBL14860 | Methyl-(2-piperidin-1-yl-ethyl)-quin...) Show SMILES CN(CCN1CCCCC1)c1ccnc2ccccc12 Show InChI InChI=1S/C17H23N3/c1-19(13-14-20-11-5-2-6-12-20)17-9-10-18-16-8-4-3-7-15(16)17/h3-4,7-10H,2,5-6,11-14H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110311 (CHEMBL276938 | {2-[4-(3-Piperidin-1-yl-propoxy)-ph...) Show SMILES C(COc1ccc(CCNc2ccnc3ccccc23)cc1)CN1CCCCC1 Show InChI InChI=1S/C25H31N3O/c1-4-17-28(18-5-1)19-6-20-29-22-11-9-21(10-12-22)13-15-26-25-14-16-27-24-8-3-2-7-23(24)25/h2-3,7-12,14,16H,1,4-6,13,15,17-20H2,(H,26,27)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110282 ((7-Chloro-quinolin-4-yl)-(7-piperidin-1-yl-heptyl)...) Show SMILES Clc1ccc2c(NCCCCCCCN3CCCCC3)ccnc2c1 Show InChI InChI=1S/C21H30ClN3/c22-18-9-10-19-20(11-13-24-21(19)17-18)23-12-5-2-1-3-6-14-25-15-7-4-8-16-25/h9-11,13,17H,1-8,12,14-16H2,(H,23,24)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110304 ((7-Chloro-quinolin-4-yl)-(5-piperidin-1-yl-pentyl)...) Show SMILES Clc1ccc2c(NCCCCCN3CCCCC3)ccnc2c1 Show InChI InChI=1S/C19H26ClN3/c20-16-7-8-17-18(9-11-22-19(17)15-16)21-10-3-1-4-12-23-13-5-2-6-14-23/h7-9,11,15H,1-6,10,12-14H2,(H,21,22)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110283 ((7-Chloro-quinolin-4-yl)-(4-piperidin-1-yl-butyl)-...) Show SMILES Clc1ccc2c(NCCCCN3CCCCC3)ccnc2c1 Show InChI InChI=1S/C18H24ClN3/c19-15-6-7-16-17(8-10-21-18(16)14-15)20-9-2-5-13-22-11-3-1-4-12-22/h6-8,10,14H,1-5,9,11-13H2,(H,20,21)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110295 ((7-Chloro-quinolin-4-yl)-(6-piperidin-1-yl-hexyl)-...) Show SMILES Clc1ccc2c(NCCCCCCN3CCCCC3)ccnc2c1 Show InChI InChI=1S/C20H28ClN3/c21-17-8-9-18-19(10-12-23-20(18)16-17)22-11-4-1-2-5-13-24-14-6-3-7-15-24/h8-10,12,16H,1-7,11,13-15H2,(H,22,23)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110305 ((7-Chloro-quinolin-4-yl)-(3-piperidin-1-yl-propyl)...) Show SMILES Clc1ccc2c(NCCCN3CCCCC3)ccnc2c1 Show InChI InChI=1S/C17H22ClN3/c18-14-5-6-15-16(7-9-20-17(15)13-14)19-8-4-12-21-10-2-1-3-11-21/h5-7,9,13H,1-4,8,10-12H2,(H,19,20)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110313 ((2-Piperidin-1-yl-ethyl)-quinolin-4-yl-amine; Oxal...) Show SMILES C(CN1CCCCC1)Nc1ccnc2ccccc12 Show InChI InChI=1S/C16H21N3/c1-4-11-19(12-5-1)13-10-18-16-8-9-17-15-7-3-2-6-14(15)16/h2-3,6-9H,1,4-5,10-13H2,(H,17,18)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110289 ((7-Chloro-quinolin-4-yl)-(10-piperidin-1-yl-decyl)...) Show SMILES Clc1ccc2c(NCCCCCCCCCCN3CCCCC3)ccnc2c1 Show InChI InChI=1S/C24H36ClN3/c25-21-12-13-22-23(14-16-27-24(22)20-21)26-15-8-5-3-1-2-4-6-9-17-28-18-10-7-11-19-28/h12-14,16,20H,1-11,15,17-19H2,(H,26,27)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110312 ((7-Chloro-quinolin-4-yl)-(8-piperidin-1-yl-octyl)-...) Show SMILES Clc1ccc2c(NCCCCCCCCN3CCCCC3)ccnc2c1 Show InChI InChI=1S/C22H32ClN3/c23-19-10-11-20-21(12-14-25-22(20)18-19)24-13-6-3-1-2-4-7-15-26-16-8-5-9-17-26/h10-12,14,18H,1-9,13,15-17H2,(H,24,25)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110301 ((7-Chloro-quinolin-4-yl)-(12-piperidin-1-yl-dodecy...) Show SMILES Clc1ccc2c(NCCCCCCCCCCCCN3CCCCC3)ccnc2c1 Show InChI InChI=1S/C26H40ClN3/c27-23-14-15-24-25(16-18-29-26(24)22-23)28-17-10-7-5-3-1-2-4-6-8-11-19-30-20-12-9-13-21-30/h14-16,18,22H,1-13,17,19-21H2,(H,28,29)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110291 ((7-Chloro-quinolin-4-yl)-[4-(3-piperidin-1-yl-prop...) Show SMILES Clc1ccc2c(Nc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1 Show InChI InChI=1S/C23H26ClN3O/c24-18-5-10-21-22(11-12-25-23(21)17-18)26-19-6-8-20(9-7-19)28-16-4-15-27-13-2-1-3-14-27/h5-12,17H,1-4,13-16H2,(H,25,26)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110310 ((3-Methyl-quinolin-4-yl)-(6-piperidin-1-yl-hexyl)-...) Show SMILES Cc1cnc2ccccc2c1NCCCCCCN1CCCCC1 Show InChI InChI=1S/C21H31N3/c1-18-17-23-20-12-6-5-11-19(20)21(18)22-13-7-2-3-8-14-24-15-9-4-10-16-24/h5-6,11-12,17H,2-4,7-10,13-16H2,1H3,(H,22,23)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	340	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110281 (CHEMBL14656 | Methyl-(3-piperidin-1-yl-propyl)-(1,...) Show SMILES CN(CCCN1CCCCC1)c1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C22H31N3/c1-24(14-9-17-25-15-7-2-8-16-25)22-18-10-3-5-12-20(18)23-21-13-6-4-11-19(21)22/h3,5,10,12H,2,4,6-9,11,13-17H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110308 ((7-Chloro-quinolin-4-yl)-{2-[4-(3-piperidin-1-yl-p...) Show SMILES Clc1ccc2c(NCCc3ccc(OCCCN4CCCCC4)cc3)ccnc2c1 Show InChI InChI=1S/C25H30ClN3O/c26-21-7-10-23-24(12-14-28-25(23)19-21)27-13-11-20-5-8-22(9-6-20)30-18-4-17-29-15-2-1-3-16-29/h5-10,12,14,19H,1-4,11,13,15-18H2,(H,27,28)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	420	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110307 ((3-Methyl-quinolin-4-yl)-(3-piperidin-1-yl-propyl)...) Show SMILES Cc1cnc2ccccc2c1NCCCN1CCCCC1 Show InChI InChI=1S/C18H25N3/c1-15-14-20-17-9-4-3-8-16(17)18(15)19-10-7-13-21-11-5-2-6-12-21/h3-4,8-9,14H,2,5-7,10-13H2,1H3,(H,19,20)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	590	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50110292 (CHEMBL14781 | Methyl-(2-piperidin-1-yl-ethyl)-(1,2...) Show SMILES CN(CCN1CCCCC1)c1c2CCCCc2nc2ccccc12 Show InChI InChI=1S/C21H29N3/c1-23(15-16-24-13-7-2-8-14-24)21-17-9-3-5-11-19(17)22-20-12-6-4-10-18(20)21/h3,5,9,11H,2,4,6-8,10,12-16H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Inhibition of rat kidney Histamine N-Methyltransferase (HMT) activity determined by the formation of N-methylhistamine				J Med Chem 45: 1128-41 (2002) BindingDB Entry DOI: 10.7270/Q2H70F4V
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM27213 (4-[3-(4-cyclopropanecarbonylphenoxy)propyl]-1H-imi...) Show SMILES O=C(C1CC1)c1ccc(OCCCc2cnc[nH]2)cc1 Show InChI InChI=1S/C16H18N2O2/c19-16(12-3-4-12)13-5-7-15(8-6-13)20-9-1-2-14-10-17-11-18-14/h5-8,10-12H,1-4,9H2,(H,17,18)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Inhibition against histamine-metabolizing enzyme Histamine N-methyl-transferase				J Med Chem 43: 3987-94 (2000) BindingDB Entry DOI: 10.7270/Q2833SRN
					More data for this Ligand-Target Pair
Histamine N-methyltransferase (Rattus norvegicus)	BDBM50126884 (1-[4-(4-Piperidin-1-ylmethyl-benzyloxy)-phenyl]-et...) Show SMILES CC(=O)c1ccc(OCc2ccc(CN3CCCCC3)cc2)cc1 Show InChI InChI=1S/C21H25NO2/c1-17(23)20-9-11-21(12-10-20)24-16-19-7-5-18(6-8-19)15-22-13-3-2-4-14-22/h5-12H,2-4,13-16H2,1H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universit£t Berlin Curated by ChEMBL					Assay Description Compound was tested against histamine N-methyl-transferase in rat brain [EC 2.1.1.8](relative weak affinity on rat enzyme)				J Med Chem 46: 1523-30 (2003) Article DOI: 10.1021/jm021084k BindingDB Entry DOI: 10.7270/Q2C24X5N
					More data for this Ligand-Target Pair