Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Inositol 1,4,5-trisphosphate receptor type 3 (Bos taurus) | BDBM50132166 (1,2,4,5-InsP4 | CHEMBL100498 | Phosphoric acid mon...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article | 26.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for its ability to displace [3H]Ins(1,4,5)P3 from membranes prepared from bovine adrenal corticles | Bioorg Med Chem Lett 3: 1505-1510 (1993) Article DOI: 10.1016/S0960-894X(00)80007-4 BindingDB Entry DOI: 10.7270/Q27M08F4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Homo sapiens (Human)) | BDBM50075651 (1D-myo-inositol 1,3,4,5-tetrakis(dihydrogen phosph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Bergische Universität Wuppertal Curated by ChEMBL | Assay Description Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membrane | J Med Chem 42: 1262-73 (1999) Article DOI: 10.1021/jm981113k BindingDB Entry DOI: 10.7270/Q2CF9P8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Homo sapiens (Human)) | BDBM50075647 (CHEMBL283791 | Phosphoric acid mono-((1R,2S,3R,4S,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MMDB PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 6.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Bergische Universität Wuppertal Curated by ChEMBL | Assay Description Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membrane | J Med Chem 42: 1262-73 (1999) Article DOI: 10.1021/jm981113k BindingDB Entry DOI: 10.7270/Q2CF9P8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Bos taurus) | BDBM50069314 (CHEMBL346769 | D-MYO-INOSITOL 1,2,4,5-TETRAKISPHOS...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Pohang University of Science & Technology Curated by ChEMBL | Assay Description Binding affinity towards Inositol 1,4,5-trisphosphate receptor was evaluated by the standard competitive binding assay using 1.25 nM [3H]-D-I(1,4,5)P... | Bioorg Med Chem Lett 8: 659-62 (1999) BindingDB Entry DOI: 10.7270/Q28051SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Homo sapiens (Human)) | BDBM50075648 ((1R,3S,4R,6R)-4,5,6-trihydroxy-2-methyl-2,3-bis(ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Bergische Universität Wuppertal Curated by ChEMBL | Assay Description Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membrane | J Med Chem 42: 1262-73 (1999) Article DOI: 10.1021/jm981113k BindingDB Entry DOI: 10.7270/Q2CF9P8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Homo sapiens (Human)) | BDBM50075649 (1D-myo-inositol 1,4,5,6-tetrakis(dihydrogen phosph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 430 | n/a | n/a | n/a | n/a | n/a | n/a |
Bergische Universität Wuppertal Curated by ChEMBL | Assay Description Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membrane | J Med Chem 42: 1262-73 (1999) Article DOI: 10.1021/jm981113k BindingDB Entry DOI: 10.7270/Q2CF9P8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Bos taurus) | BDBM50069313 (CHEMBL158474 | Phosphoric acid mono-((1S,2S,3R,4S,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 598 | n/a | n/a | n/a | n/a | n/a | n/a |
Pohang University of Science & Technology Curated by ChEMBL | Assay Description Binding affinity towards Inositol 1,4,5-trisphosphate receptor was evaluated by the standard competitive binding assay using 1.25 nM [3H]-D-I(1,4,5)P... | Bioorg Med Chem Lett 8: 659-62 (1999) BindingDB Entry DOI: 10.7270/Q28051SQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Homo sapiens (Human)) | BDBM50075650 (1D-myo-inositol 3,4,5,6-tetrakisphosphate | 1L-myo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 620 | n/a | n/a | n/a | n/a | n/a | n/a |
Bergische Universität Wuppertal Curated by ChEMBL | Assay Description Inhibition of Ins(1,3,4,5)P4-PtdIns(3,4,5)P3-specific receptor from Pig cerebellum membrane | J Med Chem 42: 1262-73 (1999) Article DOI: 10.1021/jm981113k BindingDB Entry DOI: 10.7270/Q2CF9P8S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Bos taurus) | BDBM50082885 (CHEMBL144954 | Phosphoric acid mono-((1R,2R,3S,4R,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Pharmacochimie de la Communication Cellulaire UMR 7081 du CNRS Curated by ChEMBL | Assay Description Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes. | J Med Chem 42: 4824-35 (1999) BindingDB Entry DOI: 10.7270/Q21N80B0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Bos taurus) | BDBM50082887 (CHEMBL18162 | Phosphoric acid mono-((1R,2S,3S,4R,5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Pharmacochimie de la Communication Cellulaire UMR 7081 du CNRS Curated by ChEMBL | Assay Description Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes. | J Med Chem 42: 4824-35 (1999) BindingDB Entry DOI: 10.7270/Q21N80B0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Bos taurus) | BDBM50082886 (CHEMBL355920 | Phosphoric acid mono-((1R,2R,3R,4R,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Pharmacochimie de la Communication Cellulaire UMR 7081 du CNRS Curated by ChEMBL | Assay Description Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes. | J Med Chem 42: 4824-35 (1999) BindingDB Entry DOI: 10.7270/Q21N80B0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Bos taurus) | BDBM50082888 (CHEMBL278700 | Phosphoric acid mono-((1R,3R,4R)-3,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 3.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Pharmacochimie de la Communication Cellulaire UMR 7081 du CNRS Curated by ChEMBL | Assay Description Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes. | J Med Chem 42: 4824-35 (1999) BindingDB Entry DOI: 10.7270/Q21N80B0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Bos taurus) | BDBM50082889 (CHEMBL145009 | Phosphoric acid mono-((1R,2S,3S,4R,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Pharmacochimie de la Communication Cellulaire UMR 7081 du CNRS Curated by ChEMBL | Assay Description Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes. | J Med Chem 42: 4824-35 (1999) BindingDB Entry DOI: 10.7270/Q21N80B0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Bos taurus) | BDBM50075183 (1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoire de Pharmacochimie de la Communication Cellulaire UMR 7081 du CNRS Curated by ChEMBL | Assay Description Binding affinity against Inositol 1,4,5-trisphosphate receptor on bovine adrenal cortex microsomes. | J Med Chem 42: 4824-35 (1999) BindingDB Entry DOI: 10.7270/Q21N80B0 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Homo sapiens (Human)) | BDBM50078574 (CHEMBL46273 | inositol 1,4,5-trisphosphate analogu...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | 188 | n/a | n/a | n/a | 7.4 | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4 | Bioorg Med Chem Lett 9: 1697-702 (1999) BindingDB Entry DOI: 10.7270/Q2GH9H50 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Homo sapiens (Human)) | BDBM50078572 (CHEMBL172534 | CHEMBL297496 | {4-[(4-Dimethylamino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | 7.4 | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4 | Bioorg Med Chem Lett 9: 1697-702 (1999) BindingDB Entry DOI: 10.7270/Q2GH9H50 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Homo sapiens (Human)) | BDBM50075183 (1,4,5-Insp3 | 1D-myo-inositol 1,4,5-triphosphate |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | PDB PubMed | n/a | n/a | n/a | 195 | n/a | n/a | n/a | 7.4 | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4 | Bioorg Med Chem Lett 9: 1697-702 (1999) BindingDB Entry DOI: 10.7270/Q2GH9H50 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Homo sapiens (Human)) | BDBM50279840 ((D)-2,2-difluoro-2-deoxy-myo-inositol 1,4,5-tripho...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | n/a | n/a | 210 | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Compound was evaluated for its effective dose to inhibit the calcium release as a measure of affinity for Ins(1,4,5)P3 receptor | Bioorg Med Chem Lett 1: 705-710 (1991) Article DOI: 10.1016/S0960-894X(01)81052-0 BindingDB Entry DOI: 10.7270/Q2348KV6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Inositol 1,4,5-trisphosphate receptor type 3 (Homo sapiens (Human)) | BDBM50078573 (CHEMBL297235 | Phosphoric acid 3-amino-propyl este...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | n/a | 1.12E+3 | n/a | n/a | n/a | 7.4 | n/a |
The University of Tokyo Curated by ChEMBL | Assay Description Dissociation constant of compound was measured in IP3-binding domain(IBD) of human Inositol 1,4,5-trisphosphate receptor at pH 7.4 | Bioorg Med Chem Lett 9: 1697-702 (1999) BindingDB Entry DOI: 10.7270/Q2GH9H50 | |||||||||||
More data for this Ligand-Target Pair |