BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase, H3 lysine-36 specific'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histone-lysine N-methyltransferase, H3 lysine-36 specific (Homo sapiens (Human))	BDBM50572749 (CHEMBL4854710) Show SMILES Cl.Nc1cccc2c(cccc12)S(=O)(=O)NCc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of NSD1 (unknown origin) using SAM as substrate preincubated for 10 mins followed by substrate addition measured after 4 hrs by AlphaLISA ...				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113592 BindingDB Entry DOI: 10.7270/Q2HQ43QP
TBA					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-36 specific (Homo sapiens (Human))	BDBM225230 (EED226 \| US11013745, Compound EED226) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Novartis Institutes for BioMedical Research					Assay Description All HMT reactions were performed as described previously [Nasveschuk et al., ACS Med. Chem. Lett., 5:378-383].				Nat Chem Biol 13: 381-388 (2017) Article DOI: 10.1038/nchembio.2304 BindingDB Entry DOI: 10.7270/Q2S75F64
Novartis Institutes for BioMedical Research					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-36 specific (Homo sapiens (Human))	BDBM50238541 (CHEMBL4092336) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Shandong University Curated by ChEMBL					Assay Description Inhibition of NSD1 (unknown origin) preincubated for 15 mins followed by [3H]-SAM addition measured after 4 hrs by liquid scintillation counting				J Med Chem 60: 6289-6304 (2017) Article DOI: 10.1021/acs.jmedchem.7b00587 BindingDB Entry DOI: 10.7270/Q2D220XW
Shandong University Curated by ChEMBL					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-36 specific (Homo sapiens (Human))	BDBM50498655 (CHEMBL1895209) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.12E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human NSD1-SET using histone H3.1 as substrate incubated for 1 hr by Western blot analysis				Citation and Details Article DOI: 10.1016/j.ejmech.2021.113592 BindingDB Entry DOI: 10.7270/Q2HQ43QP
TBA					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-36 specific (Homo sapiens (Human))	CHEMBL5270736 Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	1.40E+6	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-36 specific (Homo sapiens (Human))	CHEMBL5281547 Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	6.60E+7	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase, H3 lysine-36 specific (Homo sapiens (Human))	CHEMBL5281547 Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL UniChem		n/a	n/a	n/a	1.00E+7	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair