BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'DNA-dependent protein kinase catalytic subunit/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
DNA-dependent protein kinase catalytic subunit/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM36408 (1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3...) Show SMILES COc1ccc(cc1OC)-c1nn(C2CCC2)c2ncnc(N)c12 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
University of California, San Francisco					More data for this Ligand-Target Pair
DNA-dependent protein kinase catalytic subunit/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM36410 (1-cyclopentyl-3-(H-imidazo[1,2-a]pyridin-7-yl)-1H-...) Show SMILES Nc1ncnc2n(nc(-c3ccn4ccnc4c3)c12)C1CCCC1 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of California, San Francisco					Assay Description Inhibition of PI3K enzyme activity is measured in a microtiter plate-based fluorescence polarization (FP) assay.				Nat Chem Biol 4: 691-9 (2008) Article DOI: 10.1038/nchembio.117 BindingDB Entry DOI: 10.7270/Q2NP22S9
University of California, San Francisco					More data for this Ligand-Target Pair