Compile Data Set for Download or QSAR

Found 1707 hits Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM340336 (US9758538, Example 24) Show SMILES CC(C)(C)OC(=O)N1CC[C@@](CO)(C1)Nc1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1 |r| Show InChI InChI=1S/C22H32N8O4/c1-21(2,3)34-20(32)30-5-4-22(13-30,14-31)28-17-10-16(15-11-24-18(23)25-12-15)26-19(27-17)29-6-8-33-9-7-29/h10-12,31H,4-9,13-14H2,1-3H3,(H2,23,24,25)(H,26,27,28)/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<0.0180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207217 (US9260439, 194 | US9260439, 238 | US9260439, 239) Show SMILES CC(C)(C)OC(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C24H34N8O3/c1-23(2,3)35-22(33)31-8-6-24(4,15-31)32-7-5-17-18(16-13-26-20(25)27-14-16)28-21(29-19(17)32)30-9-11-34-12-10-30/h13-14H,5-12,15H2,1-4H3,(H2,25,26,27)/t24-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	<0.0180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM340314 ((Scheme A): Preparation of 2,2-difluoroethyl (3S)-...) Show SMILES Nc1ncc(cn1)-c1nc(nc(N[C@@]2(CO)CCN(C2)C(=O)OCC(F)F)c1F)N1CCOCC1 |r| Show InChI InChI=1S/C20H25F3N8O4/c21-13(22)9-35-19(33)31-2-1-20(10-31,11-32)29-16-14(23)15(12-7-25-17(24)26-8-12)27-18(28-16)30-3-5-34-6-4-30/h7-8,13,32H,1-6,9-11H2,(H2,24,25,26)(H,27,28,29)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem	PDB Article PubMed	<0.0180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207378 (US9260439, 262) Show SMILES CC(C)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 Show InChI InChI=1S/C23H32N8O2/c1-15(2)20(32)30-7-5-23(3,14-30)31-6-4-17-18(16-12-25-21(24)26-13-16)27-22(28-19(17)31)29-8-10-33-11-9-29/h12-13,15H,4-11,14H2,1-3H3,(H2,24,25,26)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<0.0180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207196 (US9260439, 173) Show SMILES CNS(=O)(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C20H29N9O3S/c1-20(4-6-28(13-20)33(30,31)22-2)29-5-3-15-16(14-11-23-18(21)24-12-14)25-19(26-17(15)29)27-7-9-32-10-8-27/h11-12,22H,3-10,13H2,1-2H3,(H2,21,23,24)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<0.0180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM340384 (US9758538, Example 72) Show SMILES COC(=O)N1CC[C@@](CO)(C1)Nc1nc(nc(c1F)-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C19H25FN8O4/c1-31-18(30)28-3-2-19(10-28,11-29)26-15-13(20)14(12-8-22-16(21)23-9-12)24-17(25-15)27-4-6-32-7-5-27/h8-9,29H,2-7,10-11H2,1H3,(H2,21,22,23)(H,24,25,26)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<0.0180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM340346 (US9758538, Example 34) Show SMILES COC(=O)N1CC[C@@](CO)(C1)Nc1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1 |r| Show InChI InChI=1S/C19H26N8O4/c1-30-18(29)27-3-2-19(11-27,12-28)25-15-8-14(13-9-21-16(20)22-10-13)23-17(24-15)26-4-6-31-7-5-26/h8-10,28H,2-7,11-12H2,1H3,(H2,20,21,22)(H,23,24,25)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.0190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM340391 (US9758538, Example 79) Show SMILES Nc1ncc(cn1)-c1cc(N[C@@]2(CO)CCN(C2)C(=O)OCC(F)F)nc(n1)N1CCOCC1 |r| Show InChI InChI=1S/C20H26F2N8O4/c21-15(22)10-34-19(32)30-2-1-20(11-30,12-31)28-16-7-14(13-8-24-17(23)25-9-13)26-18(27-16)29-3-5-33-6-4-29/h7-9,15,31H,1-6,10-12H2,(H2,23,24,25)(H,26,27,28)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.0210	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207236 (US9260439, 213) Show SMILES COC(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C21H28N8O3/c1-21(4-6-28(13-21)20(30)31-2)29-5-3-15-16(14-11-23-18(22)24-12-14)25-19(26-17(15)29)27-7-9-32-10-8-27/h11-12H,3-10,13H2,1-2H3,(H2,22,23,24)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<0.0230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207028 (US9260439, 10 | US9260439, 4) Show SMILES CC(C)(N)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C23H33N9O2/c1-22(2,25)19(33)31-7-5-23(3,14-31)32-6-4-16-17(15-12-26-20(24)27-13-15)28-21(29-18(16)32)30-8-10-34-11-9-30/h12-13H,4-11,14,25H2,1-3H3,(H2,24,26,27)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.0230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207172 (US9260439, 149) Show SMILES C[C@@]1(CCN(C1)S(C)(=O)=O)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C20H28N8O3S/c1-20(4-6-27(13-20)32(2,29)30)28-5-3-15-16(14-11-22-18(21)23-12-14)24-19(25-17(15)28)26-7-9-31-10-8-26/h11-12H,3-10,13H2,1-2H3,(H2,21,22,23)/t20-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	<0.0290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207391 (US9260439, 275) Show SMILES CC(C)(O)C(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 Show InChI InChI=1S/C23H32N8O3/c1-22(2,33)19(32)30-7-5-23(3,14-30)31-6-4-16-17(15-12-25-20(24)26-13-15)27-21(28-18(16)31)29-8-10-34-11-9-29/h12-13,33H,4-11,14H2,1-3H3,(H2,24,25,26)/t23-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.0300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50145416 (GSK2126458 | Omipalisib) Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2nccc(-c3ccnnc3)c2c1 Show InChI InChI=1S/C25H17F2N5O3S/c1-35-25-23(32-36(33,34)24-5-3-18(26)12-21(24)27)11-17(13-29-25)15-2-4-22-20(10-15)19(7-8-28-22)16-6-9-30-31-14-16/h2-14,32H,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid PDB UniChem Similars	Article PubMed	0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human p110alpha/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.113109 BindingDB Entry DOI: 10.7270/Q2JH3QZ4
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207234 (US9260439, 211) Show SMILES CC(=O)N1CC[C@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C21H28N8O2/c1-14(30)28-6-4-21(2,13-28)29-5-3-16-17(15-11-23-19(22)24-12-15)25-20(26-18(16)29)27-7-9-31-10-8-27/h11-12H,3-10,13H2,1-2H3,(H2,22,23,24)/t21-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.0780	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207239 (US9260439, 216) Show SMILES CNC(=O)N1CC[C@@](C)(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C21H29N9O2/c1-21(4-6-29(13-21)20(31)23-2)30-5-3-15-16(14-11-24-18(22)25-12-14)26-19(27-17(15)30)28-7-9-32-10-8-28/h11-12H,3-10,13H2,1-2H3,(H,23,31)(H2,22,24,25)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.0840	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM340352 (US9758538, Example 40) Show SMILES CC(C)(C)OC(=O)N1CC[C@@](C)(C1)Nc1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1 |r| Show InChI InChI=1S/C22H32N8O3/c1-21(2,3)33-20(31)30-6-5-22(4,14-30)28-17-11-16(15-12-24-18(23)25-13-15)26-19(27-17)29-7-9-32-10-8-29/h11-13H,5-10,14H2,1-4H3,(H2,23,24,25)(H,26,27,28)/t22-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.0950	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50570237 (CHEMBL4864407) Show SMILES COc1ncc-2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1cnc3ccc-2cn13 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of p110alpha H1047R mutant/p85alpha (unknown origin) using PIP2:3PS lipid kinase as substrate in presence of ATP measured by ADP-Glo lipid...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.113109 BindingDB Entry DOI: 10.7270/Q2JH3QZ4
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207061 (US9260439, 38) Show SMILES CNS(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C19H27N9O3S/c1-21-32(29,30)27-4-2-14(12-27)28-5-3-15-16(13-10-22-18(20)23-11-13)24-19(25-17(15)28)26-6-8-31-9-7-26/h10-11,14,21H,2-9,12H2,1H3,(H2,20,22,23)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	0.120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM340347 (US9758538, Example 35) Show SMILES CC(C)C(=O)N1CC[C@@](CO)(C1)Nc1cc(nc(n1)N1CCOCC1)-c1cnc(N)nc1 |r| Show InChI InChI=1S/C21H30N8O3/c1-14(2)18(31)29-4-3-21(12-29,13-30)27-17-9-16(15-10-23-19(22)24-11-15)25-20(26-17)28-5-7-32-8-6-28/h9-11,14,30H,3-8,12-13H2,1-2H3,(H2,22,23,24)(H,25,26,27)/t21-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207043 (US9260439, 20) Show SMILES CS(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C19H26N8O3S/c1-31(28,29)26-4-2-14(12-26)27-5-3-15-16(13-10-21-18(20)22-11-13)23-19(24-17(15)27)25-6-8-30-9-7-25/h10-11,14H,2-9,12H2,1H3,(H2,20,21,22)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human full-length PI3K p110alpha/p85alpha (322 to 600) expressed in baculovirus infected Sf21 cells using phosphatidylinosi...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01652 BindingDB Entry DOI: 10.7270/Q2TH8RC9
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM50570237 (CHEMBL4864407) Show SMILES COc1ncc-2cc1NS(=O)(=O)c1cccc(c1)C(=O)NCc1cncc(c1)-c1cnc3ccc-2cn13 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human p110alpha/p85alpha using PIP2 as substrate in presence of ATP measured by HTRF assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.113109 BindingDB Entry DOI: 10.7270/Q2JH3QZ4
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207061 (US9260439, 38) Show SMILES CNS(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C19H27N9O3S/c1-21-32(29,30)27-4-2-14(12-27)28-5-3-15-16(13-10-22-18(20)23-11-13)24-19(25-17(15)28)26-6-8-31-9-7-26/h10-11,14,21H,2-9,12H2,1H3,(H2,20,22,23)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	0.228	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207159 (US9260439, 136) Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@@H]1CCN(C1)C(=O)OC1CN(C1)C(C)=O |r| Show InChI InChI=1S/C25H33N9O4/c1-15-14-37-8-7-33(15)24-29-21(17-9-27-23(26)28-10-17)20-4-6-34(22(20)30-24)18-3-5-31(11-18)25(36)38-19-12-32(13-19)16(2)35/h9-10,15,18-19H,3-8,11-14H2,1-2H3,(H2,26,27,28)/t15-,18+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207169 (US9260439, 146) Show SMILES CC1(CCN(C1)S(C)(=O)=O)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 Show InChI InChI=1S/C20H28N8O3S/c1-20(4-6-27(13-20)32(2,29)30)28-5-3-15-16(14-11-22-18(21)23-12-14)24-19(25-17(15)28)26-7-9-31-10-8-26/h11-12H,3-10,13H2,1-2H3,(H2,21,22,23)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207025 (US9260439, 1) Show SMILES CC(C)S(=O)(=O)N1CC(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C21H30N8O3S/c1-13(2)33(30,31)27-10-16(11-27)29-5-4-17-18(15-8-23-20(22)24-9-15)25-21(26-19(17)29)28-6-7-32-12-14(28)3/h8-9,13-14,16H,4-7,10-12H2,1-3H3,(H2,22,23,24)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207043 (US9260439, 20) Show SMILES CS(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C19H26N8O3S/c1-31(28,29)26-4-2-14(12-26)27-5-3-15-16(13-10-21-18(20)22-11-13)23-19(24-17(15)27)25-6-8-30-9-7-25/h10-11,14H,2-9,12H2,1H3,(H2,20,21,22)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207048 (US9260439, 25) Show SMILES Nc1ncc(cn1)-c1nc(nc2N(CCc12)[C@H]1CCN(C1)C(=O)CO)N1CCOCC1 |r| Show InChI InChI=1S/C20H26N8O3/c21-19-22-9-13(10-23-19)17-15-2-4-28(14-1-3-27(11-14)16(30)12-29)18(15)25-20(24-17)26-5-7-31-8-6-26/h9-10,14,29H,1-8,11-12H2,(H2,21,22,23)/t14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207088 (US9260439, 65) Show SMILES Nc1ncc(cn1)-c1nc(nc2N(CCc12)[C@H]1C[C@H](F)C1)N1CCOCC1 |r,wU:16.18,wD:18.21,(-.05,6.75,;-.05,5.21,;1.29,4.44,;1.29,2.9,;-.05,2.13,;-1.38,2.9,;-1.38,4.44,;-.05,.59,;-1.38,-.18,;-1.38,-1.72,;-.05,-2.49,;1.29,-1.72,;2.75,-2.2,;3.66,-.95,;2.75,.3,;1.29,-.18,;3.52,-3.53,;5.01,-3.93,;4.61,-5.42,;5.38,-6.75,;3.12,-5.02,;-2.71,-2.49,;-4.05,-1.72,;-5.38,-2.49,;-5.38,-4.03,;-4.05,-4.8,;-2.71,-4.03,)| Show InChI InChI=1S/C18H22FN7O/c19-12-7-13(8-12)26-2-1-14-15(11-9-21-17(20)22-10-11)23-18(24-16(14)26)25-3-5-27-6-4-25/h9-10,12-13H,1-8H2,(H2,20,21,22)/t12-,13-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207118 (US9260439, 95) Show SMILES CNS(=O)(=O)O[C@H]1C[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r,wU:6.5,wD:8.10,(6.07,-6.82,;4.73,-7.59,;3.4,-6.82,;4.17,-5.49,;2.63,-8.15,;2.07,-6.05,;2.07,-4.51,;.98,-3.42,;2.07,-2.33,;3.15,-3.42,;2.07,-.79,;2.97,.45,;2.07,1.7,;.6,1.22,;.6,-.32,;-.73,-1.09,;-2.07,-.32,;-2.07,1.22,;-.73,1.99,;-.73,3.53,;.6,4.3,;.6,5.84,;-.73,6.61,;-.73,8.15,;-2.07,5.84,;-2.07,4.3,;-3.4,-1.09,;-4.73,-.32,;-6.07,-1.09,;-6.07,-2.63,;-4.73,-3.4,;-3.4,-2.63,)| Show InChI InChI=1S/C19H26N8O4S/c1-21-32(28,29)31-14-8-13(9-14)27-3-2-15-16(12-10-22-18(20)23-11-12)24-19(25-17(15)27)26-4-6-30-7-5-26/h10-11,13-14,21H,2-9H2,1H3,(H2,20,22,23)/t13-,14-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207123 (US9260439, 100) Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@H]1CCN(C1)S(N)(=O)=O |r| Show InChI InChI=1S/C19H27N9O3S/c1-12-11-31-7-6-27(12)19-24-16(13-8-22-18(20)23-9-13)15-3-5-28(17(15)25-19)14-2-4-26(10-14)32(21,29)30/h8-9,12,14H,2-7,10-11H2,1H3,(H2,20,22,23)(H2,21,29,30)/t12-,14-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207124 (US9260439, 101) Show SMILES CCS(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C20H28N8O3S/c1-2-32(29,30)27-5-3-15(13-27)28-6-4-16-17(14-11-22-19(21)23-12-14)24-20(25-18(16)28)26-7-9-31-10-8-26/h11-12,15H,2-10,13H2,1H3,(H2,21,22,23)/t15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207125 (US9260439, 102) Show SMILES Nc1ncc(cn1)-c1nc(nc2N(CCc12)[C@H]1CCN(C1)S(=O)(=O)C1CC1)N1CCOCC1 |r| Show InChI InChI=1S/C21H28N8O3S/c22-20-23-11-14(12-24-20)18-17-4-6-29(15-3-5-28(13-15)33(30,31)16-1-2-16)19(17)26-21(25-18)27-7-9-32-10-8-27/h11-12,15-16H,1-10,13H2,(H2,22,23,24)/t15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207131 (US9260439, 108) Show SMILES CCS(=O)(=O)N1CC(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 Show InChI InChI=1S/C19H26N8O3S/c1-2-31(28,29)26-11-14(12-26)27-4-3-15-16(13-9-21-18(20)22-10-13)23-19(24-17(15)27)25-5-7-30-8-6-25/h9-10,14H,2-8,11-12H2,1H3,(H2,20,21,22)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207136 (US9260439, 113) Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)C1CN(C1)S(C)(=O)=O |r| Show InChI InChI=1S/C19H26N8O3S/c1-12-11-30-6-5-26(12)19-23-16(13-7-21-18(20)22-8-13)15-3-4-27(17(15)24-19)14-9-25(10-14)31(2,28)29/h7-8,12,14H,3-6,9-11H2,1-2H3,(H2,20,21,22)/t12-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207138 (US9260439, 115) Show SMILES CCS(=O)(=O)N1CC(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C20H28N8O3S/c1-3-32(29,30)26-10-15(11-26)28-5-4-16-17(14-8-22-19(21)23-9-14)24-20(25-18(16)28)27-6-7-31-12-13(27)2/h8-9,13,15H,3-7,10-12H2,1-2H3,(H2,21,22,23)/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207141 (US9260439, 118) Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)C1CN(C1)S(=O)(=O)C1CC1 |r| Show InChI InChI=1S/C21H28N8O3S/c1-13-12-32-7-6-28(13)21-25-18(14-8-23-20(22)24-9-14)17-4-5-29(19(17)26-21)15-10-27(11-15)33(30,31)16-2-3-16/h8-9,13,15-16H,2-7,10-12H2,1H3,(H2,22,23,24)/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207143 (US9260439, 120) Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)C1CN(C1)S(=O)(=O)N(C)C |r| Show InChI InChI=1S/C20H29N9O3S/c1-13-12-32-7-6-28(13)20-24-17(14-8-22-19(21)23-9-14)16-4-5-29(18(16)25-20)15-10-27(11-15)33(30,31)26(2)3/h8-9,13,15H,4-7,10-12H2,1-3H3,(H2,21,22,23)/t13-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207146 (US9260439, 123) Show SMILES COC(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C21H28N8O3/c1-13-12-32-8-7-28(13)20-25-17(14-9-23-19(22)24-10-14)16-4-6-29(18(16)26-20)15-3-5-27(11-15)21(30)31-2/h9-10,13,15H,3-8,11-12H2,1-2H3,(H2,22,23,24)/t13-,15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207148 (US9260439, 125) Show SMILES CCOC(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C22H30N8O3/c1-3-33-22(31)28-6-4-16(12-28)30-7-5-17-18(15-10-24-20(23)25-11-15)26-21(27-19(17)30)29-8-9-32-13-14(29)2/h10-11,14,16H,3-9,12-13H2,1-2H3,(H2,23,24,25)/t14-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207151 (US9260439, 128) Show SMILES CNS(=O)(=O)N1C[C@@H](O)[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C20H29N9O4S/c1-12-11-33-6-5-28(12)20-25-17(13-7-23-19(21)24-8-13)14-3-4-29(18(14)26-20)15-9-27(10-16(15)30)34(31,32)22-2/h7-8,12,15-16,22,30H,3-6,9-11H2,1-2H3,(H2,21,23,24)/t12-,15+,16+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207082 (US9260439, 59) Show SMILES Nc1ncc(cn1)-c1nc(nc2N(CCc12)[C@H]1C[C@@H](C1)C#N)N1CCOCC1 |r,wU:16.18,wD:18.23,(-.43,7.42,;-.43,5.88,;.9,5.11,;.9,3.57,;-.43,2.8,;-1.76,3.57,;-1.76,5.11,;-.43,1.26,;-1.76,.49,;-1.76,-1.05,;-.43,-1.82,;.9,-1.05,;2.37,-1.53,;3.27,-.28,;2.37,.96,;.9,.49,;3.14,-2.86,;4.62,-3.26,;4.23,-4.75,;2.74,-4.35,;5,-6.08,;5.77,-7.42,;-3.1,-1.82,;-4.43,-1.05,;-5.77,-1.82,;-5.77,-3.36,;-4.43,-4.13,;-3.1,-3.36,)| Show InChI InChI=1S/C19H22N8O/c20-9-12-7-14(8-12)27-2-1-15-16(13-10-22-18(21)23-11-13)24-19(25-17(15)27)26-3-5-28-6-4-26/h10-12,14H,1-8H2,(H2,21,22,23)/t12-,14-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207095 (US9260439, 72) Show SMILES Nc1ncc(cn1)-c1nc(nc2N(CCc12)C1CN(C1)S(N)(=O)=O)N1CCOCC1 Show InChI InChI=1S/C17H23N9O3S/c18-16-20-7-11(8-21-16)14-13-1-2-26(12-9-25(10-12)30(19,27)28)15(13)23-17(22-14)24-3-5-29-6-4-24/h7-8,12H,1-6,9-10H2,(H2,18,20,21)(H2,19,27,28)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207102 (US9260439, 79) Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@H]1CCN(C1)S(C)(=O)=O |r| Show InChI InChI=1S/C20H28N8O3S/c1-13-12-31-8-7-27(13)20-24-17(14-9-22-19(21)23-10-14)16-4-6-28(18(16)25-20)15-3-5-26(11-15)32(2,29)30/h9-10,13,15H,3-8,11-12H2,1-2H3,(H2,21,22,23)/t13-,15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207127 (US9260439, 104) Show SMILES CNS(=O)(=O)O[C@H]1C[C@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r,wD:8.10,6.5,(6.07,-6.82,;4.73,-7.59,;3.4,-6.82,;4.17,-5.49,;2.63,-8.15,;2.07,-6.05,;2.07,-4.51,;3.15,-3.42,;2.07,-2.33,;.98,-3.42,;2.07,-.79,;2.97,.45,;2.07,1.7,;.6,1.22,;.6,-.32,;-.73,-1.09,;-2.07,-.32,;-2.07,1.22,;-.73,1.99,;-.73,3.53,;.6,4.3,;.6,5.84,;-.73,6.61,;-.73,8.15,;-2.07,5.84,;-2.07,4.3,;-3.4,-1.09,;-4.73,-.32,;-6.07,-1.09,;-6.07,-2.63,;-4.73,-3.4,;-3.4,-2.63,)| Show InChI InChI=1S/C19H26N8O4S/c1-21-32(28,29)31-14-8-13(9-14)27-3-2-15-16(12-10-22-18(20)23-11-12)24-19(25-17(15)27)26-4-6-30-7-5-26/h10-11,13-14,21H,2-9H2,1H3,(H2,20,22,23)/t13-,14+	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207129 (US9260439, 106) Show SMILES CC(C)S(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C21H30N8O3S/c1-14(2)33(30,31)28-5-3-16(13-28)29-6-4-17-18(15-11-23-20(22)24-12-15)25-21(26-19(17)29)27-7-9-32-10-8-27/h11-12,14,16H,3-10,13H2,1-2H3,(H2,22,23,24)/t16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207132 (US9260439, 109) Show SMILES Nc1ncc(cn1)-c1nc(nc2N(CCc12)C1CN(C1)S(=O)(=O)C1CC1)N1CCOCC1 Show InChI InChI=1S/C20H26N8O3S/c21-19-22-9-13(10-23-19)17-16-3-4-28(14-11-27(12-14)32(29,30)15-1-2-15)18(16)25-20(24-17)26-5-7-31-8-6-26/h9-10,14-15H,1-8,11-12H2,(H2,21,22,23)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207134 (US9260439, 111) Show SMILES CC(C)S(=O)(=O)N1CC[C@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOCC1 |r| Show InChI InChI=1S/C21H30N8O3S/c1-14(2)33(30,31)28-5-3-16(13-28)29-6-4-17-18(15-11-23-20(22)24-12-15)25-21(26-19(17)29)27-7-9-32-10-8-27/h11-12,14,16H,3-10,13H2,1-2H3,(H2,22,23,24)/t16-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207142 (US9260439, 119) Show SMILES CCS(=O)(=O)N1CC[C@@H](C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C21H30N8O3S/c1-3-33(30,31)27-6-4-16(12-27)29-7-5-17-18(15-10-23-20(22)24-11-15)25-21(26-19(17)29)28-8-9-32-13-14(28)2/h10-11,14,16H,3-9,12-13H2,1-2H3,(H2,22,23,24)/t14-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207144 (US9260439, 121) Show SMILES C[C@H]1COCCN1c1nc2N(CCc2c(n1)-c1cnc(N)nc1)[C@H]1CCN(C1)S(=O)(=O)C1CC1 |r| Show InChI InChI=1S/C22H30N8O3S/c1-14-13-33-9-8-29(14)22-26-19(15-10-24-21(23)25-11-15)18-5-7-30(20(18)27-22)16-4-6-28(12-16)34(31,32)17-2-3-17/h10-11,14,16-17H,2-9,12-13H2,1H3,(H2,23,24,25)/t14-,16-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM207145 (US9260439, 122) Show SMILES CNS(=O)(=O)N1CC(C1)N1CCc2c1nc(nc2-c1cnc(N)nc1)N1CCOC[C@@H]1C |r| Show InChI InChI=1S/C19H27N9O3S/c1-12-11-31-6-5-27(12)19-24-16(13-7-22-18(20)23-8-13)15-3-4-28(17(15)25-19)14-9-26(10-14)32(29,30)21-2/h7-8,12,14,21H,3-6,9-11H2,1-2H3,(H2,20,22,23)/t12-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	<0.229	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
PFIZER INC. US Patent					Assay Description PI3KA_FL: Genes encoding for full length p110alpha and p85alpha subunits of PI3Kalpha complex were subcloned from existing constructs into pFASTBAC D...				US Patent US9260439 (2016) BindingDB Entry DOI: 10.7270/Q2VH5MPV
					More data for this Ligand-Target Pair

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