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Compile Data Set for Download or QSAR

Found 8 hits Enz. Inhib. hit(s) with Target = 'Potassium voltage-gated channel subfamily B member 2'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium voltage-gated channel subfamily B member 2


(Homo sapiens (Human))		BDBM50004798
PNG
(CHEMBL2324356)
Show SMILES CC(C)C(=O)Nc1ccc(N(C)C)c(c1)C(=O)N[C@@H](C)c1ccccc1 |r|
Show InChI InChI=1S/C21H27N3O2/c1-14(2)20(25)23-17-11-12-19(24(4)5)18(13-17)21(26)22-15(3)16-9-7-6-8-10-16/h6-15H,1-5H3,(H,22,26)(H,23,25)/t15-/m0/s1
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n/an/a 100n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated K channel 2.2 (unknown origin) by automated patch clamp assay

J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 2


(Homo sapiens (Human))		BDBM50476060
PNG
(CHEMBL375083)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NCCOCCOCCOCCNS(=O)(=O)c1ccc(C)cc1
Show InChI InChI=1S/C22H32N2O7S2/c1-19-3-7-21(8-4-19)32(25,26)23-11-13-29-15-17-31-18-16-30-14-12-24-33(27,28)22-9-5-20(2)6-10-22/h3-10,23-24H,11-18H2,1-2H3
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n/an/a 2.08E+3n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated potassium channel

J Med Chem 50: 83-93 (2007)


Article DOI: 10.1021/jm060414o
BindingDB Entry DOI: 10.7270/Q20R9S5C
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 2


(Homo sapiens (Human))		BDBM50375645
PNG
(CHEMBL219301 | US11542290, Compound A-3)
Show SMILES NCCNS(=O)(=O)c1cccc2c(Cl)cccc12
Show InChI InChI=1S/C12H13ClN2O2S/c13-11-5-1-4-10-9(11)3-2-6-12(10)18(16,17)15-8-7-14/h1-6,15H,7-8,14H2
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n/an/a 1.81E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated potassium channel

J Med Chem 50: 83-93 (2007)


Article DOI: 10.1021/jm060414o
BindingDB Entry DOI: 10.7270/Q20R9S5C
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 2


(Homo sapiens (Human))		BDBM50476062
PNG
(CHEMBL219249)
Show SMILES Clc1ccc(cc1)S(=O)(=O)CCN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C19H23ClN2O2S/c20-18-6-8-19(9-7-18)25(23,24)15-14-21-10-12-22(13-11-21)16-17-4-2-1-3-5-17/h1-9H,10-16H2
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n/an/a 6.02E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated potassium channel

J Med Chem 50: 83-93 (2007)


Article DOI: 10.1021/jm060414o
BindingDB Entry DOI: 10.7270/Q20R9S5C
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 2


(Homo sapiens (Human))		BDBM50476061
PNG
(CHEMBL218975)
Show SMILES Cl.NC(COc1ccccc1)c1ccc2OCCOc2c1
Show InChI InChI=1S/C16H17NO3.ClH/c17-14(11-20-13-4-2-1-3-5-13)12-6-7-15-16(10-12)19-9-8-18-15;/h1-7,10,14H,8-9,11,17H2;1H
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n/an/a 6.76E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated potassium channel

J Med Chem 50: 83-93 (2007)


Article DOI: 10.1021/jm060414o
BindingDB Entry DOI: 10.7270/Q20R9S5C
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 2


(Homo sapiens (Human))		BDBM50476059
PNG
(CHEMBL386028)
Show SMILES Cc1nc(nc(NCCN)c1Cl)-c1cccnc1
Show InChI InChI=1S/C12H14ClN5/c1-8-10(13)12(16-6-4-14)18-11(17-8)9-3-2-5-15-7-9/h2-3,5,7H,4,6,14H2,1H3,(H,16,17,18)
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n/an/a 8.31E+4n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated potassium channel

J Med Chem 50: 83-93 (2007)


Article DOI: 10.1021/jm060414o
BindingDB Entry DOI: 10.7270/Q20R9S5C
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 2


(Homo sapiens (Human))		BDBM50028124
PNG
(2-(6-Methoxy-1H-indol-3-yl)-ethylamine | 2-(6-meth...)
Show SMILES COc1ccc2c(CCN)c[nH]c2c1
Show InChI InChI=1S/C11H14N2O/c1-14-9-2-3-10-8(4-5-12)7-13-11(10)6-9/h2-3,6-7,13H,4-5,12H2,1H3
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n/an/a 5.24E+5n/an/an/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of voltage-gated potassium channel

J Med Chem 50: 83-93 (2007)


Article DOI: 10.1021/jm060414o
BindingDB Entry DOI: 10.7270/Q20R9S5C
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily B member 2


(Homo sapiens (Human))		BDBM50593373
PNG
(CHEMBL5182581)
Show SMILES Cc1cc(NC(=O)COc2ccc(Cl)cc2Cl)n(n1)C1CCS(=O)(=O)C1
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n/an/an/an/a>3.00E+4n/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1039/d1md00129a
BindingDB Entry DOI: 10.7270/Q2Z60T26
More data for this
Ligand-Target Pair