Compile Data Set for Download or QSAR

Found 159 hits Enz. Inhib. hit(s) with Target = 'Genome polyprotein [2420-3010]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243470 (US9427440, 18) Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCN(C)S(=O)(=O)NC5=O |c:25| Show InChI InChI=1S/C32H38N4O5S/c1-34-15-7-8-16-35(2)42(39,40)33-31(37)22-11-13-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)12-14-26(23)30(36)29(27)21-9-5-4-6-10-21/h11-14,17-19,21H,4-10,15-16,20H2,1-3H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	25
Janssen Sciences Ireland UC US Patent					Assay Description IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243471 (US9427440, 19) Show SMILES CN1CCOCCN(C)S(=O)(=O)NC(=O)c2ccc3c(C4CCCCC4)c4-c5ccc(F)cc5C=C(Cn4c3c2)C1=O |c:36| Show InChI InChI=1S/C31H35FN4O5S/c1-34-12-14-41-15-13-35(2)42(39,40)33-30(37)21-8-10-26-27(18-21)36-19-23(31(34)38)16-22-17-24(32)9-11-25(22)29(36)28(26)20-6-4-3-5-7-20/h8-11,16-18,20H,3-7,12-15,19H2,1-2H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	25
Janssen Sciences Ireland UC US Patent					Assay Description IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243472 (US9427440, 20) Show SMILES CN1CCOCCN(C)S(=O)(=O)NC(=O)c2ccc3c(C4CCCCC4)c4-c5ccc(F)cc5C(C)=C(Cn4c3c2)C1=O |c:37| Show InChI InChI=1S/C32H37FN4O5S/c1-20-26-18-23(33)10-12-24(26)30-29(21-7-5-4-6-8-21)25-11-9-22-17-28(25)37(30)19-27(20)32(39)35(2)13-15-42-16-14-36(3)43(40,41)34-31(22)38/h9-12,17-18,21H,4-8,13-16,19H2,1-3H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	25
Janssen Sciences Ireland UC US Patent					Assay Description IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243456 (US9427440, 1) Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25| Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	25
Janssen Sciences Ireland UC US Patent					Assay Description IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243468 (US9427440, 16) Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=C(C)c2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |t:25| Show InChI InChI=1S/C33H40N4O6S/c1-21-27-19-24(42-4)11-13-25(27)31-30(22-8-6-5-7-9-22)26-12-10-23-18-29(26)37(31)20-28(21)33(39)35(2)14-16-43-17-15-36(3)44(40,41)34-32(23)38/h10-13,18-19,22H,5-9,14-17,20H2,1-4H3,(H,34,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	25
Janssen Sciences Ireland UC US Patent					Assay Description IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV))	BDBM243461 (US9427440, 13) Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NC\C=C\CN(C)S(=O)(=O)NC5=O |c:25,t:35| Show InChI InChI=1S/C31H34N4O5S/c1-34-15-7-6-14-32-30(36)23-16-22-17-24(40-2)11-13-25(22)29-28(20-8-4-3-5-9-20)26-12-10-21(18-27(26)35(29)19-23)31(37)33-41(34,38)39/h6-7,10-13,16-18,20H,3-5,8-9,14-15,19H2,1-2H3,(H,32,36)(H,33,37)/b7-6+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	190	n/a	n/a	n/a	n/a	7.5	25
Janssen Sciences Ireland UC US Patent					Assay Description Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV))	BDBM243457 (US9427440, 11) Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC3(CC3c2c1)C(=O)N1CCN(CC1)CCN(C)S(=O)(=O)NC5=O |(8.09,-.74,;7,-1.83,;5.51,-1.43,;4.5,-2.59,;2.99,-2.3,;2.49,-.84,;.95,-.84,;.05,-2.09,;.44,-3.57,;-.64,-4.66,;-.25,-6.15,;1.24,-6.55,;2.33,-5.46,;1.93,-3.97,;-1.42,-1.61,;-2.75,-2.38,;-4.09,-1.61,;-4.09,-.07,;-2.75,.7,;-1.42,-.07,;.05,.41,;.46,1.96,;1.87,2.57,;3.23,3.52,;3.23,1.84,;3.5,.32,;5.01,.02,;.78,3.65,;-.71,3.26,;1.25,4.55,;-.09,5.32,;-1.42,4.55,;-2.75,5.32,;-1.21,5.32,;.25,6.55,;-4.09,4.55,;-5.42,5.32,;-6.75,4.55,;-8.09,5.32,;-6.75,3.01,;-8.09,2.24,;-5.42,3.78,;-5.42,2.24,;-5.42,.7,;-6.75,-.07,)| Show InChI InChI=1S/C34H41N5O5S/c1-36-12-13-37-14-16-38(17-15-37)33(41)34-20-28(34)27-19-24(44-2)9-11-25(27)31-30(22-6-4-3-5-7-22)26-10-8-23(18-29(26)39(31)21-34)32(40)35-45(36,42)43/h8-11,18-19,22,28H,3-7,12-17,20-21H2,1-2H3,(H,35,40)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	220	n/a	n/a	n/a	n/a	7.5	25
Janssen Sciences Ireland UC US Patent					Assay Description Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV))	BDBM243456 (US9427440, 1) Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |c:25| Show InChI InChI=1S/C32H38N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,17-19,21H,4-8,13-16,20H2,1-3H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	US Patent	n/a	n/a	240	n/a	n/a	n/a	n/a	7.5	25
Janssen Sciences Ireland UC US Patent					Assay Description Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV))	BDBM243460 (US9427440, 10) Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC3(CC3c2c1)C(=O)NCCCCN(C)S(=O)(=O)NC5=O Show InChI InChI=1S/C32H38N4O5S/c1-35-15-7-6-14-33-31(38)32-18-26(32)25-17-22(41-2)11-13-23(25)29-28(20-8-4-3-5-9-20)24-12-10-21(16-27(24)36(29)19-32)30(37)34-42(35,39)40/h10-13,16-17,20,26H,3-9,14-15,18-19H2,1-2H3,(H,33,38)(H,34,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	280	n/a	n/a	n/a	n/a	7.5	25
Janssen Sciences Ireland UC US Patent					Assay Description Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV))	BDBM243458 (US9427440, 5) Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)NCCN1CCN(CC1)S(=O)(=O)NC5=O |c:25,(8.09,-.48,;7,-1.57,;5.51,-1.17,;4.5,-2.33,;2.99,-2.03,;2.49,-.57,;.95,-.57,;.05,-1.82,;.44,-3.31,;-.64,-4.4,;-.25,-5.88,;1.24,-6.28,;2.33,-5.19,;1.93,-3.71,;-1.42,-1.34,;-2.75,-2.11,;-4.09,-1.34,;-4.09,.2,;-2.75,.97,;-1.42,.2,;.05,.67,;.46,2.22,;1.87,2.83,;3.23,2.1,;3.5,.59,;5.01,.29,;.78,3.92,;-.71,3.52,;1.25,4.82,;-.09,5.59,;-1.42,4.82,;-2.75,5.59,;-4.09,4.82,;-5.42,5.59,;-6.75,4.82,;-5.31,6.28,;-4.29,5.59,;-6.75,3.28,;-8.09,2.51,;-5.42,4.05,;-5.42,2.51,;-5.42,.97,;-6.75,.2,)| Show InChI InChI=1S/C32H37N5O5S/c1-42-25-8-10-26-23(18-25)17-24-20-37-28-19-22(7-9-27(28)29(30(26)37)21-5-3-2-4-6-21)32(39)34-43(40,41)36-15-13-35(14-16-36)12-11-33-31(24)38/h7-10,17-19,21H,2-6,11-16,20H2,1H3,(H,33,38)(H,34,39)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	290	n/a	n/a	n/a	n/a	7.5	25
Janssen Sciences Ireland UC US Patent					Assay Description Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV))	BDBM243455 (US9427440, 2) Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O Show InChI InChI=1S/C32H40N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,18-19,21,24H,4-8,13-17,20H2,1-3H3,(H,33,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	410	n/a	n/a	n/a	n/a	7.5	25
Janssen Sciences Ireland UC US Patent					Assay Description Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243462 (US9427440, 3) Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3C[C@@H](Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |r| Show InChI InChI=1S/C32H40N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,18-19,21,24H,4-8,13-17,20H2,1-3H3,(H,33,37)/t24-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	25
Janssen Sciences Ireland UC US Patent					Assay Description IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM249199 (US9457039, 22) Show SMILES C[C@@]1(N=[N+]=[N-])[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)O[C@H]1c1cnc2c(N)ncnn12 |r| Show InChI InChI=1S/C11H17N8O12P3/c1-11(17-18-13)7(20)6(3-28-33(24,25)31-34(26,27)30-32(21,22)23)29-8(11)5-2-14-10-9(12)15-4-16-19(5)10/h2,4,6-8,20H,3H2,1H3,(H,24,25)(H,26,27)(H2,12,15,16)(H2,21,22,23)/p-4/t6-,7-,8+,11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	930	n/a	n/a	n/a	n/a	7.3	25
Merck Sharp & Dohme Corp. US Patent					Assay Description To measure inhibition of the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase by the nucleoside triphosphate compounds of the present ...				US Patent US9457039 (2016) BindingDB Entry DOI: 10.7270/Q2VD6XCW
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (strain HC-J4) (HCV))	BDBM243459 (US9427440, 12) Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC3(CC3c2c1)C(=O)NCC\C=C\CN(C)S(=O)(=O)NC5=O |t:38| Show InChI InChI=1S/C33H38N4O5S/c1-36-16-8-4-7-15-34-32(39)33-19-27(33)26-18-23(42-2)12-14-24(26)30-29(21-9-5-3-6-10-21)25-13-11-22(17-28(25)37(30)20-33)31(38)35-43(36,40)41/h4,8,11-14,17-18,21,27H,3,5-7,9-10,15-16,19-20H2,1-2H3,(H,34,39)(H,35,38)/b8-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	930	n/a	n/a	n/a	n/a	7.5	25
Janssen Sciences Ireland UC US Patent					Assay Description Measurement of HCV NS5B polymerization activity was performed by evaluating the amount of radiolabeled GTP incorporated by the enzyme in a newly synt...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM249201 (US9457039, 24) Show SMILES C[C@@]1(N)[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)O[C@H]1c1ccc2c(N)ncnn12 |r| Show InChI InChI=1S/C12H20N5O12P3/c1-12(14)9(18)8(4-26-31(22,23)29-32(24,25)28-30(19,20)21)27-10(12)6-2-3-7-11(13)15-5-16-17(6)7/h2-3,5,8-10,18H,4,14H2,1H3,(H,22,23)(H,24,25)(H2,13,15,16)(H2,19,20,21)/p-4/t8-,9-,10+,12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	7.3	25
Merck Sharp & Dohme Corp. US Patent					Assay Description To measure inhibition of the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase by the nucleoside triphosphate compounds of the present ...				US Patent US9457039 (2016) BindingDB Entry DOI: 10.7270/Q2VD6XCW
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM246468 (US9447132, Formula IV) Show SMILES C[C@@]1(O)[C@H](O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC1n1ccc(=O)[nH]c1=O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	7.5	n/a
Achillion Pharmaceuticals, Inc. US Patent					Assay Description NS5B RNA polymerase reactions for IC50 determination were performed in 96-well microtiter plates in 20 μL reactions containing assay buffer (50 ...				US Patent US9447132 (2016) BindingDB Entry DOI: 10.7270/Q2P26X2V
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM64587 (US9447132, GS-7977 | sofosbuvir) Show SMILES CC(C)OC(=O)C(C)NP(=O)(OCC1OC(n2ccc(=O)[nH]c2=O)C(C)(F)C1O)Oc1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem Similars	US Patent	n/a	n/a	2.10E+3	n/a	n/a	n/a	n/a	7.5	n/a
Achillion Pharmaceuticals, Inc. US Patent					Assay Description NS5B RNA polymerase reactions for IC50 determination were performed in 96-well microtiter plates in 20 μL reactions containing assay buffer (50 ...				US Patent US9447132 (2016) BindingDB Entry DOI: 10.7270/Q2P26X2V
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM243463 (US9427440, 4) Show SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3C[C@H](Cc2c1)C(=O)N(C)CCOCCN(C)S(=O)(=O)NC5=O |r| Show InChI InChI=1S/C32H40N4O6S/c1-34-13-15-42-16-14-35(2)43(39,40)33-31(37)22-9-11-27-28(19-22)36-20-24(32(34)38)17-23-18-25(41-3)10-12-26(23)30(36)29(27)21-7-5-4-6-8-21/h9-12,18-19,21,24H,4-8,13-17,20H2,1-3H3,(H,33,37)/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.42E+3	n/a	n/a	n/a	n/a	n/a	25
Janssen Sciences Ireland UC US Patent					Assay Description IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...				US Patent US9427440 (2016) BindingDB Entry DOI: 10.7270/Q2DN43Z6
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM249200 (US9457039, 23) Show SMILES C[C@@]1(N)[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)O[C@H]1c1cnc2c(N)ncnn12 |r| Show InChI InChI=1S/C11H19N6O12P3/c1-11(13)7(18)6(3-26-31(22,23)29-32(24,25)28-30(19,20)21)27-8(11)5-2-14-10-9(12)15-4-16-17(5)10/h2,4,6-8,18H,3,13H2,1H3,(H,22,23)(H,24,25)(H2,12,15,16)(H2,19,20,21)/p-4/t6-,7-,8+,11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a	7.3	25
Merck Sharp & Dohme Corp. US Patent					Assay Description To measure inhibition of the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase by the nucleoside triphosphate compounds of the present ...				US Patent US9457039 (2016) BindingDB Entry DOI: 10.7270/Q2VD6XCW
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM241872 (US9416154, 15) Show SMILES CC(OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(F)[C@@H]1O |r| Show InChI InChI=1S/C13H20FN4O12P3/c1-6(28-32(23,24)30-33(25,26)29-31(20,21)22)8-9(19)13(2,14)12(27-8)18-4-3-7-10(15)16-5-17-11(7)18/h3-6,8-9,12,19H,1-2H3,(H,23,24)(H,25,26)(H2,15,16,17)(H2,20,21,22)/t6?,8-,9-,12-,13-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	7.3	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...				US Patent US9416154 (2016) BindingDB Entry DOI: 10.7270/Q2KK99PV
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM241899 (US9416154, 37) Show SMILES C[C@H](OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r| Show InChI InChI=1S/C13H21N4O13P3/c1-6(28-32(23,24)30-33(25,26)29-31(20,21)22)8-9(18)13(2,19)12(27-8)17-4-3-7-10(14)15-5-16-11(7)17/h3-6,8-9,12,18-19H,1-2H3,(H,23,24)(H,25,26)(H2,14,15,16)(H2,20,21,22)/t6-,8+,9+,12+,13+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	7.3	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...				US Patent US9416154 (2016) BindingDB Entry DOI: 10.7270/Q2KK99PV
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM249202 (US9457039, 25) Show SMILES C[C@@]1(N)[C@H](O)[C@@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)O[C@H]1c1cnn2c(N)ncnc12 |r| Show InChI InChI=1S/C11H19N6O12P3/c1-11(13)7(18)6(3-26-31(22,23)29-32(24,25)28-30(19,20)21)27-8(11)5-2-16-17-9(5)14-4-15-10(17)12/h2,4,6-8,18H,3,13H2,1H3,(H,22,23)(H,24,25)(H2,12,14,15)(H2,19,20,21)/p-4/t6-,7-,8+,11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a	7.3	25
Merck Sharp & Dohme Corp. US Patent					Assay Description To measure inhibition of the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase by the nucleoside triphosphate compounds of the present ...				US Patent US9457039 (2016) BindingDB Entry DOI: 10.7270/Q2VD6XCW
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate BK) (HCV))	BDBM241898 (US9416154, 36) Show SMILES C[C@@H](OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@@H](n2ccc3c(N)ncnc23)[C@](C)(O)[C@@H]1O |r| Show InChI InChI=1S/C13H21N4O13P3/c1-6(28-32(23,24)30-33(25,26)29-31(20,21)22)8-9(18)13(2,19)12(27-8)17-4-3-7-10(14)15-5-16-11(7)17/h3-6,8-9,12,18-19H,1-2H3,(H,23,24)(H,25,26)(H2,14,15,16)(H2,20,21,22)/t6-,8-,9-,12-,13-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	KEGG PC cid PC sid UniChem	US Patent	n/a	n/a	6.50E+4	n/a	n/a	n/a	n/a	7.3	25
Merck Sharp & Dohme Corp. US Patent					Assay Description The ability of the nucleoside triphosphate derivatives to inhibit the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase was measured in...				US Patent US9416154 (2016) BindingDB Entry DOI: 10.7270/Q2KK99PV
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240838 (US9394331, 135 | US9394331, 32) Show SMILES OCC1OC(n2ccc(=O)[nH]c2=O)[C@]2(CCCO2)[C@@H]1O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240839 (US9394331, 138 | US9394331, 50) Show SMILES Nc1ccn(C2OC(CO)[C@@H](O)[C@@]22CCCO2)c(=O)n1 |r| Show InChI InChI=1S/C12H17N3O5/c13-8-2-4-15(11(18)14-8)10-12(3-1-5-19-12)9(17)7(6-16)20-10/h2,4,7,9-10,16-17H,1,3,5-6H2,(H2,13,14,18)/t7?,9-,10?,12+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240840 (US9394331, 36) Show SMILES OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@]2(CCO2)[C@@H]1O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240841 (US9394331, 139 | US9394331, 51) Show SMILES Nc1ccn(C2OC(CO)[C@@H](O)[C@@]22CCO2)c(=O)n1 |r| Show InChI InChI=1S/C11H15N3O5/c12-7-1-3-14(10(17)13-7)9-11(2-4-18-11)8(16)6(5-15)19-9/h1,3,6,8-9,15-16H,2,4-5H2,(H2,12,13,17)/t6?,8-,9?,11+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240842 (US9394331, 44) Show SMILES OCC1OC(n2ccc(=O)[nH]c2=O)[C@@]2(CCCO2)C1O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240843 (US9394331, 137 | US9394331, 49) Show SMILES Nc1ccn(C2OC(CO)[C@@H](O)[C@]22CCCO2)c(=O)n1 |r| Show InChI InChI=1S/C12H17N3O5/c13-8-2-4-15(11(18)14-8)10-12(3-1-5-19-12)9(17)7(6-16)20-10/h2,4,7,9-10,16-17H,1,3,5-6H2,(H2,13,14,18)/t7?,9-,10?,12-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240844 (US9394331, 136 | US9394331, 48) Show SMILES OCC1OC(n2ccc(=O)[nH]c2=O)[C@@]2(CCO2)[C@@H]1O |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240845 (US9394331, 140 | US9394331, 52) Show SMILES Nc1ccn(C2OC(CO)[C@@H](O)[C@]22CCO2)c(=O)n1 |r| Show InChI InChI=1S/C11H15N3O5/c12-7-1-3-14(10(17)13-7)9-11(2-4-18-11)8(16)6(5-15)19-9/h1,3,6,8-9,15-16H,2,4-5H2,(H2,12,13,17)/t6?,8-,9?,11-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>5.45E+4	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240846 (US9394331, 62) Show SMILES COc1nc(N)nc2n(cnc12)C1OC(CO)[C@@H](O)[C@@]11CCCO1 |r| Show InChI InChI=1S/C14H19N5O5/c1-22-11-8-10(17-13(15)18-11)19(6-16-8)12-14(3-2-4-23-14)9(21)7(5-20)24-12/h6-7,9,12,20-21H,2-5H2,1H3,(H2,15,17,18)/t7?,9-,12?,14+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>2.00E+4	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240847 (US9394331, 72) Show SMILES COc1nc(N)nc2n(cnc12)C1OC(CO)[C@@H](O)[C@]11CCCO1 |r| Show InChI InChI=1S/C14H19N5O5/c1-22-11-8-10(17-13(15)18-11)19(6-16-8)12-14(3-2-4-23-14)9(21)7(5-20)24-12/h6-7,9,12,20-21H,2-5H2,1H3,(H2,15,17,18)/t7?,9-,12?,14-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>2.00E+4	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240848 (US9394331, 76) Show SMILES COc1nc(N)nc2n(cnc12)C1OC(CO)[C@@H](O)[C@]11CCO1 |r| Show InChI InChI=1S/C13H17N5O5/c1-21-10-7-9(16-12(14)17-10)18(5-15-7)11-13(2-3-22-13)8(20)6(4-19)23-11/h5-6,8,11,19-20H,2-4H2,1H3,(H2,14,16,17)/t6?,8-,11?,13-/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240849 (US9394331, 77) Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1OC(CO)[C@@H](O)[C@]11CCO1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>2.00E+4	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240850 (US9394331, 66) Show SMILES COc1nc(N)nc2n(cnc12)C1O[C@H](CO)[C@@H](O)[C@@]11CCO1 |r| Show InChI InChI=1S/C13H17N5O5/c1-21-10-7-9(16-12(14)17-10)18(5-15-7)11-13(2-3-22-13)8(20)6(4-19)23-11/h5-6,8,11,19-20H,2-4H2,1H3,(H2,14,16,17)/t6-,8-,11?,13+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>2.00E+4	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240851 (US9394331, 114) Show SMILES COC(=O)[C@H](C)NP(=O)(OCC1OC(n2ccc(=O)[nH]c2=O)[C@]2(CCCO2)[C@@H]1O)Oc1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.06E+4	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240852 (US9394331, 115) Show SMILES COC(=O)[C@H](C)NP(=O)(OCC1OC(n2ccc(=O)[nH]c2=O)[C@]2(CCO2)[C@@H]1O)Oc1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.85E+4	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240853 (US9394331, 116) Show SMILES COC(=O)[C@H](C)NP(=O)(OCC1OC(n2ccc(=O)[nH]c2=O)[C@@]2(CCCO2)[C@@H]1O)Oc1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.83E+4	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240854 (US9394331, 117) Show SMILES COC(=O)[C@H](C)NP(=O)(OCC1OC(n2ccc(=O)[nH]c2=O)[C@@]2(CCO2)[C@@H]1O)Oc1ccccc1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.67E+4	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240855 (US9394331, 113) Show SMILES COC(=O)[C@H](C)NP(=O)(OCC1OC(n2cnc3c(OC)nc(N)nc23)[C@@]2(CCO2)[C@@H]1O)Oc1ccccc1 |r| Show InChI InChI=1S/C23H29N6O9P/c1-13(20(31)34-3)28-39(32,38-14-7-5-4-6-8-14)36-11-15-17(30)23(9-10-35-23)21(37-15)29-12-25-16-18(29)26-22(24)27-19(16)33-2/h4-8,12-13,15,17,21,30H,9-11H2,1-3H3,(H,28,32)(H2,24,26,27)/t13-,15?,17+,21?,23+,39?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.55E+3	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240856 (US9394331, 118 | US9394331, 119) Show SMILES COc1nc(N)nc2n(cnc12)C1O[C@H](COP(=O)(N[C@@H](C)C(=O)OC(C)C)Oc2ccccc2)[C@@H](O)[C@]11CCO1 |r| Show InChI InChI=1S/C25H33N6O9P/c1-14(2)38-22(33)15(3)30-41(34,40-16-8-6-5-7-9-16)37-12-17-19(32)25(10-11-36-25)23(39-17)31-13-27-18-20(31)28-24(26)29-21(18)35-4/h5-9,13-15,17,19,23,32H,10-12H2,1-4H3,(H,30,34)(H2,26,28,29)/t15-,17+,19+,23?,25+,41?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	1.49E+3	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240856 (US9394331, 118 | US9394331, 119) Show SMILES COc1nc(N)nc2n(cnc12)C1O[C@H](COP(=O)(N[C@@H](C)C(=O)OC(C)C)Oc2ccccc2)[C@@H](O)[C@]11CCO1 |r| Show InChI InChI=1S/C25H33N6O9P/c1-14(2)38-22(33)15(3)30-41(34,40-16-8-6-5-7-9-16)37-12-17-19(32)25(10-11-36-25)23(39-17)31-13-27-18-20(31)28-24(26)29-21(18)35-4/h5-9,13-15,17,19,23,32H,10-12H2,1-4H3,(H,30,34)(H2,26,28,29)/t15-,17+,19+,23?,25+,41?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.52E+3	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240858 (US9394331, 120 | US9394331, 121) Show SMILES COc1nc(N)nc2n(cnc12)C1O[C@H](COP(=O)(N[C@@H](C)C(=O)OCC(C)(C)C)Oc2ccccc2)[C@@H](O)[C@]11CCO1 |r| Show InChI InChI=1S/C27H37N6O9P/c1-16(23(35)38-14-26(2,3)4)32-43(36,42-17-9-7-6-8-10-17)40-13-18-20(34)27(11-12-39-27)24(41-18)33-15-29-19-21(33)30-25(28)31-22(19)37-5/h6-10,15-16,18,20,24,34H,11-14H2,1-5H3,(H,32,36)(H2,28,30,31)/t16-,18+,20+,24?,27+,43?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	390	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240858 (US9394331, 120 | US9394331, 121) Show SMILES COc1nc(N)nc2n(cnc12)C1O[C@H](COP(=O)(N[C@@H](C)C(=O)OCC(C)(C)C)Oc2ccccc2)[C@@H](O)[C@]11CCO1 |r| Show InChI InChI=1S/C27H37N6O9P/c1-16(23(35)38-14-26(2,3)4)32-43(36,42-17-9-7-6-8-10-17)40-13-18-20(34)27(11-12-39-27)24(41-18)33-15-29-19-21(33)30-25(28)31-22(19)37-5/h6-10,15-16,18,20,24,34H,11-14H2,1-5H3,(H,32,36)(H2,28,30,31)/t16-,18+,20+,24?,27+,43?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	9.31E+3	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240860 (US9394331, 122) Show SMILES CCOC(=O)[C@H](C)NP(=O)(OCC1OC(n2cnc3c(OC)nc(N)nc23)[C@@]2(CCO2)[C@@H]1O)Oc1ccccc1 |r| Show InChI InChI=1S/C24H31N6O9P/c1-4-35-21(32)14(2)29-40(33,39-15-8-6-5-7-9-15)37-12-16-18(31)24(10-11-36-24)22(38-16)30-13-26-17-19(30)27-23(25)28-20(17)34-3/h5-9,13-14,16,18,22,31H,4,10-12H2,1-3H3,(H,29,33)(H2,25,27,28)/t14-,16?,18+,22?,24+,40?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	857	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240861 (US9394331, 123) Show SMILES COc1nc(N)nc2n(cnc12)C1OC(COP(=O)(N[C@@H](C)C(=O)OCC(C)(C)C)Oc2cccc3ccccc23)[C@@H](O)[C@]11CCO1 |r| Show InChI InChI=1S/C31H39N6O9P/c1-18(27(39)42-16-30(2,3)4)36-47(40,46-21-12-8-10-19-9-6-7-11-20(19)21)44-15-22-24(38)31(13-14-43-31)28(45-22)37-17-33-23-25(37)34-29(32)35-26(23)41-5/h6-12,17-18,22,24,28,38H,13-16H2,1-5H3,(H,36,40)(H2,32,34,35)/t18-,22?,24+,28?,31+,47?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	310	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240862 (US9394331, 124) Show SMILES COc1nc(N)nc2n(cnc12)C1OC(COP(=O)(N[C@@H](C)C(=O)OCC(C)C)Oc2ccccc2)[C@@H](O)[C@]11CCO1 |r| Show InChI InChI=1S/C26H35N6O9P/c1-15(2)12-37-23(34)16(3)31-42(35,41-17-8-6-5-7-9-17)39-13-18-20(33)26(10-11-38-26)24(40-18)32-14-28-19-21(32)29-25(27)30-22(19)36-4/h5-9,14-16,18,20,24,33H,10-13H2,1-4H3,(H,31,35)(H2,27,29,30)/t16-,18?,20+,24?,26+,42?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	566	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240863 (US9394331, 125) Show SMILES COc1nc(N)nc2n(cnc12)C1O[C@H](COP(=O)(N[C@@H](C)C(=O)OCC(C)C)Oc2ccccc2)[C@@H](O)[C@]11CCO1 |r| Show InChI InChI=1S/C26H35N6O9P/c1-15(2)12-37-23(34)16(3)31-42(35,41-17-8-6-5-7-9-17)39-13-18-20(33)26(10-11-38-26)24(40-18)32-14-28-19-21(32)29-25(27)30-22(19)36-4/h5-9,14-16,18,20,24,33H,10-13H2,1-4H3,(H,31,35)(H2,27,29,30)/t16-,18+,20+,24?,26+,42?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	4.42E+3	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair
Genome polyprotein [2420-3010] (Hepatitis C virus genotype 1b (isolate Con1) (HCV))	BDBM240864 (US9394331, 126 | US9394331, 127) Show SMILES CCCCOC(=O)[C@H](C)NP(=O)(OCC1OC(n2cnc3c(OC)nc(N)nc23)[C@@]2(CCO2)[C@@H]1O)Oc1ccccc1 |r| Show InChI InChI=1S/C26H35N6O9P/c1-4-5-12-37-23(34)16(2)31-42(35,41-17-9-7-6-8-10-17)39-14-18-20(33)26(11-13-38-26)24(40-18)32-15-28-19-21(32)29-25(27)30-22(19)36-3/h6-10,15-16,18,20,24,33H,4-5,11-14H2,1-3H3,(H,31,35)(H2,27,29,30)/t16-,18?,20+,24?,26+,42?/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	274	n/a	n/a	7.5	27
Gilead Pharmasset LLC US Patent					Assay Description The HCV NS5B reaction was performed in a 20 μL mixture containing varying concentrations of the test compound, 1 μM of all four natural ribonuc...				US Patent US9394331 (2016) BindingDB Entry DOI: 10.7270/Q2W094TH
					More data for this Ligand-Target Pair

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