Compile Data Set for Download or QSAR

Found 86 hits Enz. Inhib. hit(s) with Target = 'Rho-associated protein kinase 1 [1-535]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598584 (N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-6-methyl...) Show SMILES Cc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)N1C2CC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598581 (N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-6-methyl...) Show SMILES Cc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)N1CC2CC1CN2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2.90	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM578438 ((R)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...) Show SMILES CNCCN[C@@H](C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(OC)c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598577 (N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)-5-fluoro...) Show SMILES Fc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1C2CC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598517 (N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)pyrimidin-...) Show SMILES C1CC2CNCC1N2c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598586 (N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-methoxy...) Show SMILES COc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	4.10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598569 (N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-6-methylp...) Show SMILES Cc1cc(Nc2ccc3[nH]ncc3c2)nc(n1)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598570 (N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5-chlorop...) Show SMILES Clc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598571 (N-(2-(3,8-diazabicyclo[3.2.1]octan-3-yl)-5-fluorop...) Show SMILES Fc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1CC2CCC(C1)N2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	6	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM578435 ((R)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethyla...) Show SMILES COc1cccc(c1)[C@@H](NCCN(C)C)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	7.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598649 (6-((1H-indazol-5-yl)amino)-2-(3,8-diazabicyclo[3.2...) Show SMILES Oc1nc(nc(Nc2ccc3[nH]ncc3c2)c1F)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	8.70	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM578409 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(2-methoxyphenyl)-...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccccc1OC |$;HN;;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598567 (N-(6-methyl-2-(2-methyl-1,4-diazepan-1-yl)pyrimidi...) Show SMILES CC1CNCCCN1c1nc(C)cc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598609 (N-(2-(1,4-diazepan-1-yl)pyrimidin-4-yl)-1H-indazol...) Show SMILES C1CNCCN(C1)c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM578411 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphenyl)-...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(OC)c1 |$;HN;;;;;;;;;;;;;;;;;;;;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	17	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598575 (N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-5-fluoro...) Show SMILES Fc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1CC2CC1CN2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598552 (N-(6-methyl-2-(3-methylpiperazin-1-yl)pyrimidin-4-...) Show SMILES CC1CN(CCN1)c1nc(C)cc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598562 (N-(2-(3,6-diazabicyclo[3.1.1]heptan-6-yl)pyrimidin...) Show SMILES C1C2CNCC1N2c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598608 (N-(2-(piperazin-1-yl)pyrimidin-4-yl)-1H-indazol-5-...) Show SMILES C1CN(CCN1)c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598568 (N-(2-(2,5-dimethylpiperazin-1-yl)pyrimidin-4-yl)-1...) Show SMILES CC1CN(C(C)CN1)c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	35.4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598540 (2-(3-ethyl-1,4-diazepan-1-yl)-N-(4-(pyridin-4-yl)p...) Show SMILES CCC1CN(CCCN1)c1nccc(Nc2ccc(cc2)-c2ccncc2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598565 (N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)pyrimidin...) Show SMILES C1NC2CC1N(C2)c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598546 (N-(5-fluoro-2-(piperazin-1-yl)pyrimidin-4-yl)-1H-i...) Show SMILES Fc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1CCNCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598547 (N-(2-(1,4-diazepan-1-yl)-5-fluoropyrimidin-4-yl)-1...) Show SMILES Fc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1CCCNCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598557 (N-(6-methyl-2-(2-methylpiperazin-1-yl)pyrimidin-4-...) Show SMILES CC1CNCCN1c1nc(C)cc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598582 (N-(2-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-5-chloro...) Show SMILES Clc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1CC2CC1CN2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598585 (N-(2-(3,8-diazabicyclo[3.2.1]octan-8-yl)-5,6-dimet...) Show SMILES Cc1nc(nc(Nc2ccc3[nH]ncc3c2)c1C)N1C2CCC1CNC2 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	42	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598529 (N-(2-(3-methyl-1,4-diazepan-1-yl)pyrimidin-4-yl)-1...) Show SMILES CC1CN(CCCN1)c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	46	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598559 (N-(6-methyl-2-(3-methyl-1,4-diazepan-1-yl)pyrimidi...) Show SMILES CC1CNCCN(C1)c1nc(C)cc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598528 (N-(2-(2-methyl-1,4-diazepan-1-yl)pyrimidin-4-yl)-1...) Show SMILES CC1CNCCCN1c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	55	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM578447 (N-(2-fluoro-5-methoxy-4-(1H-pyrazol-4-yl)phenyl)-2...) Show SMILES CNC(C(=O)Nc1cc(OC)c(cc1F)-c1cn[nH]c1)c1cccc(OC)c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	56	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598544 (2-(3-isopropyl-1,4-diazepan-1-yl)-N-(4-(pyridin-4-...) Show SMILES CC(C)C1CN(CCCN1)c1nccc(Nc2ccc(cc2)-c2ccncc2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM578433 ((R)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-methoxyeth...) Show SMILES COCCN[C@@H](C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(OC)c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598554 (N-(5-chloro-2-(2-ethylpiperazin-1-yl)pyrimidin-4-y...) Show SMILES CCC1CNCCN1c1ncc(Cl)c(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598527 (N-(2-(6-methyl-1,4-diazepan-1-yl)pyrimidin-4-yl)-1...) Show SMILES CC1CNCCN(C1)c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	63	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598572 (N-(5-fluoro-2-(6-methyl-1,4-diazepan-1-yl)pyrimidi...) Show SMILES CC1CNCCN(C1)c1ncc(F)c(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598522 (N-(2-(1,4-diazepan-1-yl)-5-methoxypyrimidin-4-yl)-...) Show SMILES COc1cnc(nc1Nc1ccc2[nH]ncc2c1)N1CCCNCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	65	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598519 (N-(2-(2-methylpiperazin-1-yl)pyrimidin-4-yl)-1H-in...) Show SMILES CC1CNCCN1c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM578439 ((S)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methoxyphen...) Show SMILES CNCCN[C@H](C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(OC)c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	81	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM578444 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-methyl-1H-indaz...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1ccc2c(C)n[nH]c2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	85	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM578428 (N-(4-(1H-pyrazol-4-yl)phenyl)-2-(3-(difluoromethox...) Show SMILES CNC(C(=O)Nc1ccc(cc1)-c1cn[nH]c1)c1cccc(OC(F)F)c1 |$;N;;;;;;;;;;;;;;;;;;;;;O;;;;$| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598549 (N-(2-(3-isopropyl-1,4-diazepan-1-yl)pyrimidin-4-yl...) Show SMILES CC(C)C1CN(CCCN1)c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	98	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598535 (6-methyl-2-(3-methyl-1,4-diazepan-1-yl)-N-(4-(pyri...) Show SMILES CC1CN(CCCN1)c1nc(C)cc(Nc2ccc(cc2)-c2ccncc2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	132	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598531 (2-(3-methyl-1,4-diazepan-1-yl)-N-(4-(pyridin-4-yl)...) Show SMILES CC1CN(CCCN1)c1nccc(Nc2ccc(cc2)-c2ccncc2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	135	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598539 (N-(2-(3-ethyl-1,4-diazepan-1-yl)pyrimidin-4-yl)-1H...) Show SMILES CCC1CN(CCCN1)c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	179	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598532 (N-(2-(3-ethylpiperazin-1-yl)pyrimidin-4-yl)-1H-ind...) Show SMILES CCC1CN(CCN1)c1nccc(Nc2ccc3[nH]ncc3c2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	192	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM578434 ((S)—N-(4-(1H-pyrazol-4-yl)phenyl)-2-((2-(dimethyla...) Show SMILES COc1cccc(c1)[C@H](NCCN(C)C)C(=O)Nc1ccc(cc1)-c1cn[nH]c1 |r| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	258	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Compounds activities were measured by Z'-lyte kinase kit (ThermoFisher Scientific). The percent inhibition rate was calculated by normalizing the...				Citation and Details BindingDB Entry DOI: 10.7270/Q2R78JGS
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598530 (2-(5-methyl-1,4-diazepan-1-yl)-N-(4-(pyridin-4-yl)...) Show SMILES CC1CCN(CCN1)c1nccc(Nc2ccc(cc2)-c2ccncc2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	307	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598548 (N-(2-(3-phenyl-1,4-diazepan-1-yl)pyrimidin-4-yl)-1...) Show SMILES C1CNC(CN(C1)c1nccc(Nc2ccc3[nH]ncc3c2)n1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	325	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1 [1-535] (Homo sapiens (Human))	BDBM598551 (2-(3-phenyl-1,4-diazepan-1-yl)-N-(4-(pyridin-4-yl)...) Show SMILES C1CNC(CN(C1)c1nccc(Nc2ccc(cc2)-c2ccncc2)n1)c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	332	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Recombinant ROCK1 (amino acids 1-535) and ROCK2 (amino acids 1-552) proteins were purchased from ThermoFisher Scientific. Compound's activities w...				Citation and Details BindingDB Entry DOI: 10.7270/Q2MP576K
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 86 total )  |  Next  |  Last  >>

Jump to: