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Compile Data Set for Download or QSAR

Found 29 hits Enz. Inhib. hit(s) with Target = 'Sentrin-specific protease 7'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103834
PNG
(SPI-09 | US11041859, Code SPI-09 | US9791447, Comp...)
Show SMILES Nc1ccc2cc(cc(c2c1\N=N\c1ccc(cc1)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O
Show InChI InChI=1S/C16H13N3O9S3/c17-13-6-1-9-7-12(30(23,24)25)8-14(31(26,27)28)15(9)16(13)19-18-10-2-4-11(5-3-10)29(20,21)22/h1-8H,17H2,(H,20,21,22)(H,23,24,25)(H,26,27,28)/b19-18+
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n/an/a 1.90E+3n/an/an/an/an/an/a



City of Hope

US Patent


Assay Description
The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...

US Patent US9791447 (2017)


BindingDB Entry DOI: 10.7270/Q2J67K27
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103832
PNG
(SPI-07 | US11041859, Code SPI-07)
Show SMILES Cc1cc(N)ccc1\N=N\c1cc(c2cccc(c2c1)S([O-])(=O)=O)S([O-])(=O)=O
Show InChI InChI=1S/C17H15N3O6S2/c1-10-7-11(18)5-6-15(10)20-19-12-8-14-13(17(9-12)28(24,25)26)3-2-4-16(14)27(21,22)23/h2-9H,18H2,1H3,(H,21,22,23)(H,24,25,26)/p-2/b20-19+
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n/an/a 1.90E+3n/an/an/an/an/an/a


TBA

Assay Description
The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...

Citation and Details

BindingDB Entry DOI: 10.7270/Q29W0JKM
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM348889
PNG
(NSC58046 | US9791447, Compound SPI-07)
Show SMILES Cc1cc(N)ccc1\N=N\c1cc(c2cccc(c2c1)S([O-])(=O)=O)S(O)(=O)=O
Show InChI InChI=1S/C17H15N3O6S2/c1-10-7-11(18)5-6-15(10)20-19-12-8-14-13(17(9-12)28(24,25)26)3-2-4-16(14)27(21,22)23/h2-9H,18H2,1H3,(H,21,22,23)(H,24,25,26)/p-1/b20-19+
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n/an/a 1.90E+3n/an/an/an/an/an/a



City of Hope

US Patent


Assay Description
The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...

US Patent US9791447 (2017)


BindingDB Entry DOI: 10.7270/Q2J67K27
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103834
PNG
(SPI-09 | US11041859, Code SPI-09 | US9791447, Comp...)
Show SMILES Nc1ccc2cc(cc(c2c1\N=N\c1ccc(cc1)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O
Show InChI InChI=1S/C16H13N3O9S3/c17-13-6-1-9-7-12(30(23,24)25)8-14(31(26,27)28)15(9)16(13)19-18-10-2-4-11(5-3-10)29(20,21)22/h1-8H,17H2,(H,20,21,22)(H,23,24,25)(H,26,27,28)/b19-18+
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TBA

Assay Description
The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...

Citation and Details

BindingDB Entry DOI: 10.7270/Q29W0JKM
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103835
PNG
(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Show SMILES Nc1ccc(\N=N\c2cccc(c2)S([O-])(=O)=O)c2ccccc12
Show InChI InChI=1S/C16H13N3O3S/c17-15-8-9-16(14-7-2-1-6-13(14)15)19-18-11-4-3-5-12(10-11)23(20,21)22/h1-10H,17H2,(H,20,21,22)/p-1/b19-18+
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n/an/a 2.00E+3n/an/an/an/an/an/a



City of Hope

US Patent


Assay Description
The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...

US Patent US9791447 (2017)


BindingDB Entry DOI: 10.7270/Q2J67K27
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103835
PNG
(SPI-10 | US11041859, Code SPI-10 | US9791447, Comp...)
Show SMILES Nc1ccc(\N=N\c2cccc(c2)S([O-])(=O)=O)c2ccccc12
Show InChI InChI=1S/C16H13N3O3S/c17-15-8-9-16(14-7-2-1-6-13(14)15)19-18-11-4-3-5-12(10-11)23(20,21)22/h1-10H,17H2,(H,20,21,22)/p-1/b19-18+
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n/an/a 2.00E+3n/an/an/an/an/an/a


TBA

Assay Description
The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...

Citation and Details

BindingDB Entry DOI: 10.7270/Q29W0JKM
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103827
PNG
(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Show SMILES Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1
Show InChI InChI=1S/C34H28N6O9S3/c1-18-13-20(4-11-29(18)37-39-33-26-8-6-24(50(41,42)43)15-22(26)3-10-28(33)35)21-5-12-30(19(2)14-21)38-40-34-27-9-7-25(51(44,45)46)16-23(27)17-31(32(34)36)52(47,48)49/h3-17H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)(H,47,48,49)/b39-37+,40-38+
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n/an/a 2.70E+3n/an/an/an/an/an/a



City of Hope

US Patent


Assay Description
The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...

US Patent US9791447 (2017)


BindingDB Entry DOI: 10.7270/Q2J67K27
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103827
PNG
(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Show SMILES Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1
Show InChI InChI=1S/C34H28N6O9S3/c1-18-13-20(4-11-29(18)37-39-33-26-8-6-24(50(41,42)43)15-22(26)3-10-28(33)35)21-5-12-30(19(2)14-21)38-40-34-27-9-7-25(51(44,45)46)16-23(27)17-31(32(34)36)52(47,48)49/h3-17H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)(H,47,48,49)/b39-37+,40-38+
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n/an/a 2.70E+3n/an/an/an/an/an/a


TBA

Assay Description
The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...

Citation and Details

BindingDB Entry DOI: 10.7270/Q29W0JKM
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103827
PNG
(SPI-02 | US11041859, Code SPI-02 | US9791447, Comp...)
Show SMILES Cc1cc(ccc1\N=N\c1c(N)ccc2cc(ccc12)S(O)(=O)=O)-c1ccc(\N=N\c2c(N)c(cc3cc(ccc23)S(O)(=O)=O)S(O)(=O)=O)c(C)c1
Show InChI InChI=1S/C34H28N6O9S3/c1-18-13-20(4-11-29(18)37-39-33-26-8-6-24(50(41,42)43)15-22(26)3-10-28(33)35)21-5-12-30(19(2)14-21)38-40-34-27-9-7-25(51(44,45)46)16-23(27)17-31(32(34)36)52(47,48)49/h3-17H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)(H,47,48,49)/b39-37+,40-38+
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n/an/a 2.70E+3n/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.ejmech.2022.114227
BindingDB Entry DOI: 10.7270/Q2T43Z3H
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103833
PNG
(SPI-08 | US11041859, Code SPI-08 | US9791447, Comp...)
Show SMILES Nc1c(cc(c2ccccc12)S([O-])(=O)=O)\N=N\c1ccccc1
Show InChI InChI=1S/C16H13N3O3S/c17-16-13-9-5-4-8-12(13)15(23(20,21)22)10-14(16)19-18-11-6-2-1-3-7-11/h1-10H,17H2,(H,20,21,22)/p-1/b19-18+
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n/an/a 2.80E+3n/an/an/an/an/an/a


TBA

Assay Description
The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...

Citation and Details

BindingDB Entry DOI: 10.7270/Q29W0JKM
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103833
PNG
(SPI-08 | US11041859, Code SPI-08 | US9791447, Comp...)
Show SMILES Nc1c(cc(c2ccccc12)S([O-])(=O)=O)\N=N\c1ccccc1
Show InChI InChI=1S/C16H13N3O3S/c17-16-13-9-5-4-8-12(13)15(23(20,21)22)10-14(16)19-18-11-6-2-1-3-7-11/h1-10H,17H2,(H,20,21,22)/p-1/b19-18+
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n/an/a 2.80E+3n/an/an/an/an/an/a



City of Hope

US Patent


Assay Description
The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...

US Patent US9791447 (2017)


BindingDB Entry DOI: 10.7270/Q2J67K27
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103829
PNG
(SPI-04 | US11041859, Code SPI-04 | US9791447, Comp...)
Show SMILES Nc1ccc(\N=N\c2ccc(\C=C\c3ccc(cc3S(O)(=O)=O)\N=N\c3ccc(N)c4ccc(cc34)S([O-])(=O)=O)c(c2)S(O)(=O)=O)c2cc(ccc12)S(O)(=O)=O
Show InChI InChI=1S/C34H26N6O12S4/c35-29-11-13-31(27-17-23(53(41,42)43)7-9-25(27)29)39-37-21-5-3-19(33(15-21)55(47,48)49)1-2-20-4-6-22(16-34(20)56(50,51)52)38-40-32-14-12-30(36)26-10-8-24(18-28(26)32)54(44,45)46/h1-18H,35-36H2,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)/p-1/b2-1+,39-37+,40-38+
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n/an/a 3.40E+3n/an/an/an/an/an/a


TBA

Assay Description
The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...

Citation and Details

BindingDB Entry DOI: 10.7270/Q29W0JKM
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103829
PNG
(SPI-04 | US11041859, Code SPI-04 | US9791447, Comp...)
Show SMILES Nc1ccc(\N=N\c2ccc(\C=C\c3ccc(cc3S(O)(=O)=O)\N=N\c3ccc(N)c4ccc(cc34)S([O-])(=O)=O)c(c2)S(O)(=O)=O)c2cc(ccc12)S(O)(=O)=O
Show InChI InChI=1S/C34H26N6O12S4/c35-29-11-13-31(27-17-23(53(41,42)43)7-9-25(27)29)39-37-21-5-3-19(33(15-21)55(47,48)49)1-2-20-4-6-22(16-34(20)56(50,51)52)38-40-32-14-12-30(36)26-10-8-24(18-28(26)32)54(44,45)46/h1-18H,35-36H2,(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)/p-1/b2-1+,39-37+,40-38+
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n/an/a 3.40E+3n/an/an/an/an/an/a



City of Hope

US Patent


Assay Description
The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...

US Patent US9791447 (2017)


BindingDB Entry DOI: 10.7270/Q2J67K27
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103826
PNG
(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Show SMILES Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2c(N)ccc3ccccc23)c(c1)S(O)(=O)=O
Show InChI InChI=1S/C34H26N6O6S2/c35-29-17-13-21-5-1-3-7-27(21)33(29)39-37-25-15-11-23(31(19-25)47(41,42)43)9-10-24-12-16-26(20-32(24)48(44,45)46)38-40-34-28-8-4-2-6-22(28)14-18-30(34)36/h1-20H,35-36H2,(H,41,42,43)(H,44,45,46)/b10-9+,39-37+,40-38+
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n/an/a 3.50E+3n/an/an/an/an/an/a


TBA

Assay Description
The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...

Citation and Details

BindingDB Entry DOI: 10.7270/Q29W0JKM
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103826
PNG
(SPI-01 | US11041859, Code SPI-01 | US9791447, Comp...)
Show SMILES Nc1ccc2ccccc2c1\N=N\c1ccc(\C=C\c2ccc(cc2S(O)(=O)=O)\N=N\c2c(N)ccc3ccccc23)c(c1)S(O)(=O)=O
Show InChI InChI=1S/C34H26N6O6S2/c35-29-17-13-21-5-1-3-7-27(21)33(29)39-37-25-15-11-23(31(19-25)47(41,42)43)9-10-24-12-16-26(20-32(24)48(44,45)46)38-40-34-28-8-4-2-6-22(28)14-18-30(34)36/h1-20H,35-36H2,(H,41,42,43)(H,44,45,46)/b10-9+,39-37+,40-38+
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n/an/a 3.50E+3n/an/an/an/an/an/a



City of Hope

US Patent


Assay Description
The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...

US Patent US9791447 (2017)


BindingDB Entry DOI: 10.7270/Q2J67K27
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM81517
PNG
(VEA-561)
Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6]-c1ccc(-[#8])c(c1)N(=O)=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-[#6]-[#6](=O)-[#6]-[#8]-[#6](=O)-c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C40H46N8O10/c1-23(2)16-31(46-34(51)18-24-13-14-33(50)32(17-24)48(56)57)38(54)47-30(12-7-15-43-40(41)42)37(53)45-21-35(52)44-20-27(49)22-58-39(55)36-28-10-5-3-8-25(28)19-26-9-4-6-11-29(26)36/h3-6,8-11,13-14,17,19,23,30-31,50H,7,12,15-16,18,20-22H2,1-2H3,(H,44,52)(H,45,53)(H,46,51)(H,47,54)(H4,41,42,43)/t30-,31-/m0/s1
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n/an/a 4.30E+3n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...

Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103830
PNG
(SPI-05 | US11041859, Code SPI-05 | US9791447, Comp...)
Show SMILES Nc1ccc(\N=N\c2ccc(\C=C\c3ccc(cc3S(O)(=O)=O)\N=N\c3ccc(N)c4ccccc34)c(c2)S(O)(=O)=O)c2ccccc12
Show InChI InChI=1S/C34H26N6O6S2/c35-29-15-17-31(27-7-3-1-5-25(27)29)39-37-23-13-11-21(33(19-23)47(41,42)43)9-10-22-12-14-24(20-34(22)48(44,45)46)38-40-32-18-16-30(36)26-6-2-4-8-28(26)32/h1-20H,35-36H2,(H,41,42,43)(H,44,45,46)/b10-9+,39-37+,40-38+
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n/an/a 4.60E+3n/an/an/an/an/an/a


TBA

Assay Description
The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...

Citation and Details

BindingDB Entry DOI: 10.7270/Q29W0JKM
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103830
PNG
(SPI-05 | US11041859, Code SPI-05 | US9791447, Comp...)
Show SMILES Nc1ccc(\N=N\c2ccc(\C=C\c3ccc(cc3S(O)(=O)=O)\N=N\c3ccc(N)c4ccccc34)c(c2)S(O)(=O)=O)c2ccccc12
Show InChI InChI=1S/C34H26N6O6S2/c35-29-15-17-31(27-7-3-1-5-25(27)29)39-37-23-13-11-21(33(19-23)47(41,42)43)9-10-22-12-14-24(20-34(22)48(44,45)46)38-40-32-18-16-30(36)26-6-2-4-8-28(26)32/h1-20H,35-36H2,(H,41,42,43)(H,44,45,46)/b10-9+,39-37+,40-38+
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n/an/a 4.60E+3n/an/an/an/an/an/a



City of Hope

US Patent


Assay Description
The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...

US Patent US9791447 (2017)


BindingDB Entry DOI: 10.7270/Q2J67K27
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM348888
PNG
(NSC70551 | US11041859, Code SPI-06 | US9791447, Co...)
Show SMILES Cc1ccccc1\N=N\c1cc(c2ccccc2c1N)S([O-])(=O)=O
Show InChI InChI=1S/C17H15N3O3S/c1-11-6-2-5-9-14(11)19-20-15-10-16(24(21,22)23)12-7-3-4-8-13(12)17(15)18/h2-10H,18H2,1H3,(H,21,22,23)/p-1/b20-19+
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n/an/a 4.70E+3n/an/an/an/an/an/a


TBA

Assay Description
The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...

Citation and Details

BindingDB Entry DOI: 10.7270/Q29W0JKM
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM348888
PNG
(NSC70551 | US11041859, Code SPI-06 | US9791447, Co...)
Show SMILES Cc1ccccc1\N=N\c1cc(c2ccccc2c1N)S([O-])(=O)=O
Show InChI InChI=1S/C17H15N3O3S/c1-11-6-2-5-9-14(11)19-20-15-10-16(24(21,22)23)12-7-3-4-8-13(12)17(15)18/h2-10H,18H2,1H3,(H,21,22,23)/p-1/b20-19+
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n/an/a 4.70E+3n/an/an/an/an/an/a



City of Hope

US Patent


Assay Description
The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...

US Patent US9791447 (2017)


BindingDB Entry DOI: 10.7270/Q2J67K27
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM103828
PNG
(SPI-03 | US11041859, Code SPI-03)
Show SMILES Cc1cc(ccc1-c1ccc(cc1C)\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O)\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O
Show InChI InChI=1S/C34H28N6O6S2/c1-19-15-21(37-39-29-17-31(47(41,42)43)25-7-3-5-9-27(25)33(29)35)11-13-23(19)24-14-12-22(16-20(24)2)38-40-30-18-32(48(44,45)46)26-8-4-6-10-28(26)34(30)36/h3-18H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)/b39-37+,40-38+
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n/an/a 4.80E+3n/an/an/an/an/an/a


TBA

Assay Description
The inhibitors confer the non-competitive inhibitory mechanism, as shown by nuclear magnetic resonance (NMR) and quantitative enzyme kinetic analysis...

Citation and Details

BindingDB Entry DOI: 10.7270/Q29W0JKM
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM348885
PNG
(NSC8676 | US9791447, Compound SPI-03)
Show SMILES Cc1cc(ccc1-c1ccc(cc1C)\N=N\c1cc(c2ccccc2c1N)S([O-])(=O)=O)\N=N\c1cc(c2ccccc2c1N)S(O)(=O)=O
Show InChI InChI=1S/C34H28N6O6S2/c1-19-15-21(37-39-29-17-31(47(41,42)43)25-7-3-5-9-27(25)33(29)35)11-13-23(19)24-14-12-22(16-20(24)2)38-40-30-18-32(48(44,45)46)26-8-4-6-10-28(26)34(30)36/h3-18H,35-36H2,1-2H3,(H,41,42,43)(H,44,45,46)/p-1/b39-37+,40-38+
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City of Hope

US Patent


Assay Description
The binding of SPI-01 to the enzyme-substrate complex was investigated. CSP analysis was carried out on the 40 kDa complex of 15N-labeled full length...

US Patent US9791447 (2017)


BindingDB Entry DOI: 10.7270/Q2J67K27
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM81514
PNG
(VEA-401)
Show SMILES OC(=O)c1cccc(c1)C(=O)NCc1ccc(cc1)C(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12
Show InChI InChI=1S/C34H26N2O7/c37-27(20-43-34(42)30-28-10-3-1-6-23(28)16-24-7-2-4-11-29(24)30)19-36-31(38)22-14-12-21(13-15-22)18-35-32(39)25-8-5-9-26(17-25)33(40)41/h1-17H,18-20H2,(H,35,39)(H,36,38)(H,40,41)
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n/an/a>2.00E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...

Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM81511
PNG
(VEA-260)
Show SMILES OC(=O)c1cccc(c1)C(=O)NCc1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C42H34N4O7/c47-38(30-12-7-13-31(22-30)42(51)52)43-23-26-18-20-29(21-19-26)39(48)44-45-40(49)36-37(53-36)41(50)46(24-32-14-5-10-27-8-1-3-16-34(27)32)25-33-15-6-11-28-9-2-4-17-35(28)33/h1-22,36-37H,23-25H2,(H,43,47)(H,44,48)(H,45,49)(H,51,52)/t36-,37-/m0/s1
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n/an/a 3.65E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...

Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM81513
PNG
(VEA-422)
Show SMILES NC(=O)[C@H](CC(O)=O)NC(=O)c1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C38H33N5O8/c39-34(46)30(19-31(44)45)40-35(47)24-15-17-25(18-16-24)36(48)41-42-37(49)32-33(51-32)38(50)43(20-26-11-5-9-22-7-1-3-13-28(22)26)21-27-12-6-10-23-8-2-4-14-29(23)27/h1-18,30,32-33H,19-21H2,(H2,39,46)(H,40,47)(H,41,48)(H,42,49)(H,44,45)/t30-,32-,33-/m0/s1
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n/an/a>7.00E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...

Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM81512
PNG
(VEA-417)
Show SMILES NC(=O)CNC(=O)c1ccc(cc1)C(=O)NNC(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C36H31N5O6/c37-30(42)19-38-33(43)24-15-17-25(18-16-24)34(44)39-40-35(45)31-32(47-31)36(46)41(20-26-11-5-9-22-7-1-3-13-28(22)26)21-27-12-6-10-23-8-2-4-14-29(23)27/h1-18,31-32H,19-21H2,(H2,37,42)(H,38,43)(H,39,44)(H,40,45)/t31-,32-/m0/s1
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n/an/a>7.00E+4n/an/an/an/a8.037



Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...

Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM81510
PNG
(JCP-666)
Show SMILES OC(=O)CN(NC(=O)c1ccc(CNC(=O)c2cccc(c2)C(O)=O)cc1)C(=O)[C@H]1O[C@@H]1C(=O)N(Cc1cccc2ccccc12)Cc1cccc2ccccc12 |r|
Show InChI InChI=1S/C44H36N4O9/c49-37(50)26-48(46-41(52)30-20-18-27(19-21-30)23-45-40(51)31-12-7-13-32(22-31)44(55)56)43(54)39-38(57-39)42(53)47(24-33-14-5-10-28-8-1-3-16-35(28)33)25-34-15-6-11-29-9-2-4-17-36(29)34/h1-22,38-39H,23-26H2,(H,45,51)(H,46,52)(H,49,50)(H,55,56)/t38-,39-/m0/s1
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Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...

Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM81515
PNG
(VEA-499)
Show SMILES C[C@H](O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1ccc(O)c(c1)N(=O)=O)C(=O)NCC(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C37H38N6O12/c1-20(44)34(42-35(50)27(11-13-30(38)47)41-31(48)15-21-10-12-29(46)28(14-21)43(53)54)36(51)40-18-32(49)39-17-24(45)19-55-37(52)33-25-8-4-2-6-22(25)16-23-7-3-5-9-26(23)33/h2-10,12,14,16,20,27,34,44,46H,11,13,15,17-19H2,1H3,(H2,38,47)(H,39,49)(H,40,51)(H,41,48)(H,42,50)/t20-,27-,34?/m0/s1
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Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...

Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair
Sentrin-specific protease 7


(Homo sapiens (Human))		BDBM81516
PNG
(VEA-500)
Show SMILES C[C@H](O)C(NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)Cc1ccc(O)c(c1)N(=O)=O)C(=O)NCC(=O)NCC(=O)COC(=O)c1c2ccccc2cc2ccccc12 |r|
Show InChI InChI=1S/C42H46N8O14/c1-22(51)38(41(60)46-20-36(57)45-19-26(52)21-64-42(61)37-27-8-4-2-6-24(27)18-25-7-3-5-9-28(25)37)49-40(59)30(12-15-34(44)55)48-39(58)29(11-14-33(43)54)47-35(56)17-23-10-13-32(53)31(16-23)50(62)63/h2-10,13,16,18,22,29-30,38,51,53H,11-12,14-15,17,19-21H2,1H3,(H2,43,54)(H2,44,55)(H,45,57)(H,46,60)(H,47,56)(H,48,58)(H,49,59)/t22-,29-,30-,38?/m0/s1
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Stanford University



Assay Description
The fluorogenic substrate library screen was performed with hSENP1 in low salt tris buffer at final concentration of 2uM. Fluorophore release (AFC) ...

Chem Biol 18: 722-32 (2011)


Article DOI: 10.1016/j.chembiol.2011.05.008
BindingDB Entry DOI: 10.7270/Q2542M2N
More data for this
Ligand-Target Pair