Compile Data Set for Download or QSAR

Found 31 hits Enz. Inhib. hit(s) with Target = 'Signal transducer and activator of transcription 5A'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM165193 (4-(Nonanamidomethyl)-1,2-phenylene bis(dihydrogen ...) Show SMILES CCCCCCCCC(=O)NCc1ccc(OP(O)(O)=O)c(OP(O)(O)=O)c1 Show InChI InChI=1S/C16H27NO9P2/c1-2-3-4-5-6-7-8-16(18)17-12-13-9-10-14(25-27(19,20)21)15(11-13)26-28(22,23)24/h9-11H,2-8,12H2,1H3,(H,17,18)(H2,19,20,21)(H2,22,23,24)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.23E+4	n/a	2.49E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig					Assay Description For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...				ACS Chem Biol 10: 2884-90 (2015) Article DOI: 10.1021/acschembio.5b00817 BindingDB Entry DOI: 10.7270/Q2P55M8G
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM165192 (4-((8-Methylnonanamido)methyl)-1,2-phenylene bis(d...) Show SMILES CC(C)CCCCCCC(=O)NCc1ccc(OP(O)(O)=O)c(OP(O)(O)=O)c1 Show InChI InChI=1S/C17H29NO9P2/c1-13(2)7-5-3-4-6-8-17(19)18-12-14-9-10-15(26-28(20,21)22)16(11-14)27-29(23,24)25/h9-11,13H,3-8,12H2,1-2H3,(H,18,19)(H2,20,21,22)(H2,23,24,25)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	1.30E+4	n/a	2.64E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig					Assay Description For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...				ACS Chem Biol 10: 2884-90 (2015) Article DOI: 10.1021/acschembio.5b00817 BindingDB Entry DOI: 10.7270/Q2P55M8G
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM165191 (2-Methoxy-4-(nonanamidomethyl)phenyl dihydrogen ph...) Show SMILES CCCCCCCCC(=O)NCc1ccc(OP(O)(O)=O)c(OC)c1 Show InChI InChI=1S/C17H28NO6P/c1-3-4-5-6-7-8-9-17(19)18-13-14-10-11-15(16(12-14)23-2)24-25(20,21)22/h10-12H,3-9,13H2,1-2H3,(H,18,19)(H2,20,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	4.90E+4	n/a	9.80E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig					Assay Description For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...				ACS Chem Biol 10: 2884-90 (2015) Article DOI: 10.1021/acschembio.5b00817 BindingDB Entry DOI: 10.7270/Q2P55M8G
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM165190 (2-Methoxy-4-((8-methylnonanamido)methyl)phenyl dih...) Show SMILES COc1cc(CNC(=O)CCCCCCC(C)C)ccc1OP(O)(O)=O Show InChI InChI=1S/C18H30NO6P/c1-14(2)8-6-4-5-7-9-18(20)19-13-15-10-11-16(17(12-15)24-3)25-26(21,22)23/h10-12,14H,4-9,13H2,1-3H3,(H,19,20)(H2,21,22,23)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	7.50E+4	n/a	1.52E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Leipzig					Assay Description For competition-based fluorescence polarization assays, the ability of the test compounds to displace fluorophore-labeled peptides from their respect...				ACS Chem Biol 10: 2884-90 (2015) Article DOI: 10.1021/acschembio.5b00817 BindingDB Entry DOI: 10.7270/Q2P55M8G
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50335201 (5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...) Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of Stat5 phosphorylation in human SET2 cells after 1 hr by Western blotting				J Med Chem 54: 262-76 (2011) Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM569234 (US11427563, Compound 101 | US11427563, Compound 16...) Show SMILES Cc1cncc2ccc(NC(=O)[C@@H]3CC3c3ccc(cc3)S(=O)(=O)Nc3cccnc3)cc12 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DJ5JVK
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50335201 (5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...) Show SMILES C[C@H](Nc1ncc(Cl)c(Nc2cc(C)n[nH]2)n1)c1ncc(F)cn1 |r| Show InChI InChI=1S/C14H14ClFN8/c1-7-3-11(24-23-7)21-13-10(15)6-19-14(22-13)20-8(2)12-17-4-9(16)5-18-12/h3-6,8H,1-2H3,(H3,19,20,21,22,23,24)/t8-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	41	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca R&D Curated by ChEMBL					Assay Description Inhibition of Stat5 phosphorylation in human HEL cells after 1 hr by Western blotting				J Med Chem 54: 262-76 (2011) Article DOI: 10.1021/jm1011319 BindingDB Entry DOI: 10.7270/Q2M32WRM
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM569237 (US11427563, Compound 104 | US11427563, Compound 28) Show SMILES Clc1cncc2ccc(NC(=O)[C@@H]3CC3c3ccc(cc3)S(=O)(=O)Nc3cccnc3)cc12 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	57	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DJ5JVK
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM569273 (US11427563, Compound 14 | US11427563, Compound 157...) Show SMILES FC(F)(F)c1cncc2ccc(NC(=O)[C@@H]3CC3c3ccc(cc3)S(=O)(=O)Nc3ccccn3)cc12 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DJ5JVK
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50295809 (12,13-(2,3-Cis-dihyroxy-1,4-butyl)-6,7,12,13-tetra...) Show SMILES O[C@@H]1Cn2c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n(C[C@@H]1O)c4c23 |r| Show InChI InChI=1S/C24H19N3O3/c28-17-10-26-15-7-3-1-5-12(15)19-14-9-25-24(30)21(14)20-13-6-2-4-8-16(13)27(11-18(17)29)23(20)22(19)26/h1-8,17-18,28-29H,9-11H2,(H,25,30)/t17-,18+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	689	n/a	n/a	n/a	n/a	n/a	n/a
Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202 Curated by ChEMBL					Assay Description Inhibition of STAT5 phosphorylation in IL2-stimulated healthy human T cells by western blotting				Bioorg Med Chem Lett 19: 3333-8 (2009) Article DOI: 10.1016/j.bmcl.2009.04.039 BindingDB Entry DOI: 10.7270/Q2ZK5GQ8
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM569235 (US11427563, Compound 10 | US11427563, Compound 102...) Show SMILES Cc1cncc2ccc(NC(=O)[C@@H]3CC3c3ccc(cc3)S(=O)(=O)Nc3cnccn3)cc12 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description All compounds were initially prepared as 10 mM stocks in anhydrous dimethylsulfoxide (DMSO). A 20 μl aliquot of the 10 mM solutions was transfer...				Citation and Details BindingDB Entry DOI: 10.7270/Q2DJ5JVK
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50240455 (CHEMBL1253351) Show SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)c1ccc(NC(=O)c2cc(NC(=O)Nc3cc(cc(c3)C(=O)Nc3ccc(cc3S([O-])(=O)=O)S([O-])(=O)=O)C(=O)Nc3ccc(cc3S([O-])(=O)=O)S([O-])(=O)=O)cc(c2)C(=O)Nc2ccc(cc2S([O-])(=O)=O)S([O-])(=O)=O)c(c1)S([O-])(=O)=O Show InChI InChI=1S/C41H32N6O29S8/c48-37(44-29-5-1-25(77(53,54)55)15-33(29)81(65,66)67)19-9-20(38(49)45-30-6-2-26(78(56,57)58)16-34(30)82(68,69)70)12-23(11-19)42-41(52)43-24-13-21(39(50)46-31-7-3-27(79(59,60)61)17-35(31)83(71,72)73)10-22(14-24)40(51)47-32-8-4-28(80(62,63)64)18-36(32)84(74,75)76/h1-18H,(H,44,48)(H,45,49)(H,46,50)(H,47,51)(H2,42,43,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)/p-8	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Inhibition of 5-carboxyfluorescein-GpYLVLDKW-OH binding to C-terminal 6x-His-tagged and an N-terminal maltose-binding protein-tagged STAT5A SH2 domai...				Bioorg Med Chem Lett 27: 3349-3352 (2017) Article DOI: 10.1016/j.bmcl.2017.06.012 BindingDB Entry DOI: 10.7270/Q2W66P7F
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267892 (CHEMBL4088092) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc3cc(ccc3c2)C(=O)Nc2ccccc2)cc1OP(O)(O)=O Show InChI InChI=1S/C26H24N2O11P2/c29-25(27-15-17-6-11-23(38-40(31,32)33)24(12-17)39-41(34,35)36)16-37-22-10-9-18-13-20(8-7-19(18)14-22)26(30)28-21-4-2-1-3-5-21/h1-14H,15-16H2,(H,27,29)(H,28,30)(H2,31,32,33)(H2,34,35,36)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.97E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from C-terminal His6-tagged/N-terminal maltose-binding protein-tagged STAT5A SH2 domain (unknown...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267888 (CHEMBL4104462) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc3cc(ccc3c2)C(=O)Nc2ccc(F)cc2)cc1OP(O)(O)=O Show InChI InChI=1S/C26H23FN2O11P2/c27-20-5-7-21(8-6-20)29-26(31)19-3-2-18-13-22(9-4-17(18)12-19)38-15-25(30)28-14-16-1-10-23(39-41(32,33)34)24(11-16)40-42(35,36)37/h1-13H,14-15H2,(H,28,30)(H,29,31)(H2,32,33,34)(H2,35,36,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267878 (CHEMBL4104019) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc3cc(ccc3c2)C(=O)Nc2cccc(Cl)c2)cc1OP(O)(O)=O Show InChI InChI=1S/C26H23ClN2O11P2/c27-20-2-1-3-21(13-20)29-26(31)19-6-5-18-12-22(8-7-17(18)11-19)38-15-25(30)28-14-16-4-9-23(39-41(32,33)34)24(10-16)40-42(35,36)37/h1-13H,14-15H2,(H,28,30)(H,29,31)(H2,32,33,34)(H2,35,36,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	7.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267887 (CHEMBL4077592) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc(cc2)C(=O)Nc2ccc(Cl)cc2)cc1OP(O)(O)=O Show InChI InChI=1S/C22H21ClN2O11P2/c23-16-4-6-17(7-5-16)25-22(27)15-2-8-18(9-3-15)34-13-21(26)24-12-14-1-10-19(35-37(28,29)30)20(11-14)36-38(31,32)33/h1-11H,12-13H2,(H,24,26)(H,25,27)(H2,28,29,30)(H2,31,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267890 (CHEMBL4085646) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc3cc(ccc3c2)C(=O)Nc2ccc(Br)cc2)cc1OP(O)(O)=O Show InChI InChI=1S/C26H23BrN2O11P2/c27-20-5-7-21(8-6-20)29-26(31)19-3-2-18-13-22(9-4-17(18)12-19)38-15-25(30)28-14-16-1-10-23(39-41(32,33)34)24(11-16)40-42(35,36)37/h1-13H,14-15H2,(H,28,30)(H,29,31)(H2,32,33,34)(H2,35,36,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267886 (CHEMBL4093849) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc(cc2)C(=O)Nc2ccc(F)cc2)cc1OP(O)(O)=O Show InChI InChI=1S/C22H21FN2O11P2/c23-16-4-6-17(7-5-16)25-22(27)15-2-8-18(9-3-15)34-13-21(26)24-12-14-1-10-19(35-37(28,29)30)20(11-14)36-38(31,32)33/h1-11H,12-13H2,(H,24,26)(H,25,27)(H2,28,29,30)(H2,31,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267877 (CHEMBL4103576) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc3cc(ccc3c2)C(=O)Nc2cccc(F)c2)cc1OP(O)(O)=O Show InChI InChI=1S/C26H23FN2O11P2/c27-20-2-1-3-21(13-20)29-26(31)19-6-5-18-12-22(8-7-17(18)11-19)38-15-25(30)28-14-16-4-9-23(39-41(32,33)34)24(10-16)40-42(35,36)37/h1-13H,14-15H2,(H,28,30)(H,29,31)(H2,32,33,34)(H2,35,36,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267876 (CHEMBL4080740) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc(cc2)C(=O)Nc2ccc(Br)cc2)cc1OP(O)(O)=O Show InChI InChI=1S/C22H21BrN2O11P2/c23-16-4-6-17(7-5-16)25-22(27)15-2-8-18(9-3-15)34-13-21(26)24-12-14-1-10-19(35-37(28,29)30)20(11-14)36-38(31,32)33/h1-11H,12-13H2,(H,24,26)(H,25,27)(H2,28,29,30)(H2,31,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50118228 (5,7-Disulfo-4-(3-{3-[3-(4,6,8-trisulfo-naphthalen-...) Show SMILES [O-]S(=O)(=O)c1cc(c2c(NC(=O)c3cccc(NC(=O)Nc4cccc(c4)C(=O)Nc4ccc(c5cc(cc(c45)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c3)ccc(c2c1)S([O-])(=O)=O)S([O-])(=O)=O Show InChI InChI=1S/C35H26N4O21S6/c40-33(38-25-7-9-27(63(49,50)51)23-13-21(61(43,44)45)15-29(31(23)25)65(55,56)57)17-3-1-5-19(11-17)36-35(42)37-20-6-2-4-18(12-20)34(41)39-26-8-10-28(64(52,53)54)24-14-22(62(46,47)48)16-30(32(24)26)66(58,59)60/h1-16H,(H,38,40)(H,39,41)(H2,36,37,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)/p-6	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Inhibition of 5-carboxyfluorescein-GpYLVLDKW-OH binding to C-terminal 6x-His-tagged and an N-terminal maltose-binding protein-tagged STAT5A SH2 domai...				Bioorg Med Chem Lett 27: 3349-3352 (2017) Article DOI: 10.1016/j.bmcl.2017.06.012 BindingDB Entry DOI: 10.7270/Q2W66P7F
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267889 (CHEMBL4080219) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc3cc(ccc3c2)C(=O)Nc2ccc(Cl)cc2)cc1OP(O)(O)=O Show InChI InChI=1S/C26H23ClN2O11P2/c27-20-5-7-21(8-6-20)29-26(31)19-3-2-18-13-22(9-4-17(18)12-19)38-15-25(30)28-14-16-1-10-23(39-41(32,33)34)24(11-16)40-42(35,36)37/h1-13H,14-15H2,(H,28,30)(H,29,31)(H2,32,33,34)(H2,35,36,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267862 (CHEMBL4075745) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc(cc2)C(=O)Nc2cccc(Cl)c2)cc1OP(O)(O)=O Show InChI InChI=1S/C22H21ClN2O11P2/c23-16-2-1-3-17(11-16)25-22(27)15-5-7-18(8-6-15)34-13-21(26)24-12-14-4-9-19(35-37(28,29)30)20(10-14)36-38(31,32)33/h1-11H,12-13H2,(H,24,26)(H,25,27)(H2,28,29,30)(H2,31,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50000029 (4-Methyl-8-{4-methyl-3-[3-(3-{3-[2-methyl-5-(4,6,8...) Show SMILES Cc1ccc(cc1NC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c3cc(cc(c23)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O)c1)C(=O)Nc1ccc(c2cc(cc(c12)S([O-])(=O)=O)S([O-])(=O)=O)S([O-])(=O)=O Show InChI InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)/p-6	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Inhibition of 5-carboxyfluorescein-GpYLVLDKW-OH binding to C-terminal 6x-His-tagged and an N-terminal maltose-binding protein-tagged STAT5A SH2 domai...				Bioorg Med Chem Lett 27: 3349-3352 (2017) Article DOI: 10.1016/j.bmcl.2017.06.012 BindingDB Entry DOI: 10.7270/Q2W66P7F
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267885 (CHEMBL4066274) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc(cc2)C(=O)Nc2ccccc2)cc1OP(O)(O)=O Show InChI InChI=1S/C22H22N2O11P2/c25-21(14-33-18-9-7-16(8-10-18)22(26)24-17-4-2-1-3-5-17)23-13-15-6-11-19(34-36(27,28)29)20(12-15)35-37(30,31)32/h1-12H,13-14H2,(H,23,25)(H,24,26)(H2,27,28,29)(H2,30,31,32)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267891 (CHEMBL4076474) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc(cc2)C(=O)Nc2cccc(Br)c2)cc1OP(O)(O)=O Show InChI InChI=1S/C22H21BrN2O11P2/c23-16-2-1-3-17(11-16)25-22(27)15-5-7-18(8-6-15)34-13-21(26)24-12-14-4-9-19(35-37(28,29)30)20(10-14)36-38(31,32)33/h1-11H,12-13H2,(H,24,26)(H,25,27)(H2,28,29,30)(H2,31,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.05E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267884 (CHEMBL4086096) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc3cc(ccc3c2)C(=O)Nc2cccc(Br)c2)cc1OP(O)(O)=O Show InChI InChI=1S/C26H23BrN2O11P2/c27-20-2-1-3-21(13-20)29-26(31)19-6-5-18-12-22(8-7-17(18)11-19)38-15-25(30)28-14-16-4-9-23(39-41(32,33)34)24(10-16)40-42(35,36)37/h1-13H,14-15H2,(H,28,30)(H,29,31)(H2,32,33,34)(H2,35,36,37)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50267875 (CHEMBL4062751) Show SMILES OP(O)(=O)Oc1ccc(CNC(=O)COc2ccc(cc2)C(=O)Nc2cccc(F)c2)cc1OP(O)(O)=O Show InChI InChI=1S/C22H21FN2O11P2/c23-16-2-1-3-17(11-16)25-22(27)15-5-7-18(8-6-15)34-13-21(26)24-12-14-4-9-19(35-37(28,29)30)20(10-14)36-38(31,32)33/h1-11H,12-13H2,(H,24,26)(H,25,27)(H2,28,29,30)(H2,31,32,33)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.19E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute of Organic Chemistry, Leipzig University, Johannisallee 29, 04103 Leipzig, Germany. Curated by ChEMBL					Assay Description Displacement of 5-carboxyfluorescein-GY(PO3H2)LVLDKW from STAT5A SH2 domain (unknown origin) pretreated for 1 hr followed by fluorescent tracer addit...				Bioorg Med Chem 25: 3871-3882 (2017) Article DOI: 10.1016/j.bmc.2017.05.039 BindingDB Entry DOI: 10.7270/Q26Q20RB
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	CHEMBL5271424 Show SMILES CO[C@H]1CC[C@@H](CC1)C(=O)OCC1=C[C@H]2[C@@H](Cc3c[nH]c4cccc2c34)N(C)C1 |wU:14.14,5.8,wD:15.29,2.1,t:13,(23.49,-4.75,;21.85,-4.19,;19.9,-5.32,;18.56,-4.52,;17.21,-5.27,;17.18,-6.81,;18.51,-7.61,;19.87,-6.88,;15.84,-7.57,;15.82,-9.11,;14.51,-6.76,;13.15,-7.51,;13.14,-9.08,;11.79,-9.83,;11.77,-11.37,;13.11,-12.16,;13.11,-13.7,;11.77,-14.45,;11.76,-15.99,;9.11,-15.96,;9.12,-14.42,;7.8,-13.67,;7.8,-12.13,;9.12,-11.37,;10.45,-12.13,;10.45,-13.67,;14.46,-11.4,;15.79,-12.19,;14.48,-9.86,)| Show InChI InChI=1S/C24H30N2O3/c1-26-13-15(14-29-24(27)16-6-8-18(28-2)9-7-16)10-20-19-4-3-5-21-23(19)17(12-25-21)11-22(20)26/h3-5,10,12,16,18,20,22,25H,6-9,11,13-14H2,1-2H3/t16-,18-,20-,22-/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL CHEMBL PC cid PC sid UniChem Similars		n/a	n/a	5.08E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay at 50 uM				Citation and Details
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50557878 (CHEMBL4776801) Show SMILES [H][C@]12CC[C@H](N1C(=O)[C@H](CN(CC2)C(=O)CCCCCC#Cc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O)NC(=O)c1cc2cc(ccc2[nH]1)C(=O)P(O)(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c1ccccc1)c1ccccc1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	>10	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Binding affinity to human recombinant STAT5A assessed as dissociation constant incubated for 15 mins by biolayer interferometry				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00155 BindingDB Entry DOI: 10.7270/Q20R9T2F
					More data for this Ligand-Target Pair
Signal transducer and activator of transcription 5A (Homo sapiens (Human))	BDBM50446146 (CHEMBL3108909) Show SMILES CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(cc1)C(O)=O)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F Show InChI InChI=1S/C29H27F5N2O5S/c1-35(42(40,41)28-26(33)24(31)23(30)25(32)27(28)34)16-22(37)36(21-13-11-20(12-14-21)29(38)39)15-17-7-9-19(10-8-17)18-5-3-2-4-6-18/h7-14,18H,2-6,15-16H2,1H3,(H,38,39)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	464	n/a	n/a	n/a	n/a	n/a
University of Toronto at Mississauga Curated by ChEMBL					Assay Description Binding affinity to His-tagged STAT5 (unknown origin) by SPR spectroscopic analysis				ACS Med Chem Lett 4: 1102-7 (2013) Article DOI: 10.1021/ml4003138 BindingDB Entry DOI: 10.7270/Q2D2202P
					More data for this Ligand-Target Pair