Compile Data Set for Download or QSAR

Found 99 hits Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3 [D835Y]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 Show InChI InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	n/a	n/a	0.00200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM50300690 (1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1 Show InChI InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB US Patent	n/a	n/a	0.00200	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair				3D Structure (crystal)
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM50377170 (CHEMBL256570 | US11254667, Compound I-2 | US115422...) Show SMILES Clc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1 Show InChI InChI=1S/C17H18ClN5/c18-12-4-5-17-20-10-15(23(17)11-12)14-2-1-3-16(22-14)21-13-6-8-19-9-7-13/h1-5,10-11,13,19H,6-9H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM139540 (US10189849, staurosporine | US10307427, Staurospor...) Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM50377170 (CHEMBL256570 | US11254667, Compound I-2 | US115422...) Show SMILES Clc1ccc2ncc(-c3cccc(NC4CCNCC4)n3)n2c1 Show InChI InChI=1S/C17H18ClN5/c18-12-4-5-17-20-10-15(23(17)11-12)14-2-1-3-16(22-14)21-13-6-8-19-9-7-13/h1-5,10-11,13,19H,6-9H2,(H,21,22)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.00900	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM139540 (US10189849, staurosporine | US10307427, Staurospor...) Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 |r| Show InChI InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<0.508	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM538618 (NCGC 00262327 | US11254667, Compound I-20 | US1154...) Show SMILES COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cn[nH]c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.508	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM538658 (NCGC 00249373 | US11254667, Compound I-17 | US1154...) Show SMILES Clc1ccc2ncc(-c3cccc(NC4CCCNC4)n3)n2c1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.508	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM538621 (NCGC 00371481 | US11254667, Compound I-24 | US1154...) Show SMILES Cn1cc(cn1)-c1cn2c(cnc2cc1CO)-c1cccc(NC2CCNC2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.508	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM538619 (NCGC 00371479 | US11254667, Compound I-22 | US1154...) Show SMILES COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cccnc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.508	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 8-10: Compounds were tested in 10-dose IC50 mode with 3-fold serial dilution starting at 10 uM, and are relative to DMSO, the negative control....				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM538621 (NCGC 00371481 | US11254667, Compound I-24 | US1154...) Show SMILES Cn1cc(cn1)-c1cn2c(cnc2cc1CO)-c1cccc(NC2CCNC2)n1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.508	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM538619 (NCGC 00371479 | US11254667, Compound I-22 | US1154...) Show SMILES COc1cc2ncc(-c3cccc(NC4CCNC4)n3)n2cc1-c1cccnc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<0.508	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Table 3 and 4: The HotSpot kinase profiling and screening assays were carried out using the method of Anastassiadis et al., Nat. Biotechnol. (2011) V...				Citation and Details BindingDB Entry DOI: 10.7270/Q2154MW8
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397414 (US9987278, Compound Reference 24) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)NC(=O)\C=C\CN(C)C)c1 |r| Show InChI InChI=1S/C30H39N9O3/c1-5-14-32-27-25(20-34-30(38-27)33-17-13-22-11-15-31-16-12-22)29(42)37-24-9-6-8-23(19-24)36-28(41)21(2)35-26(40)10-7-18-39(3)4/h6-12,15-16,19-21H,5,13-14,17-18H2,1-4H3,(H,35,40)(H,36,41)(H,37,42)(H2,32,33,34,38)/b10-7+/t21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397416 (US9987278, Compound Reference 26) Show SMILES CCCNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C(=O)NC1CCCC(C1)NC(=O)CN(C)C(=O)\C=C\CN(C)C Show InChI InChI=1S/C30H43N9O4/c1-5-15-32-28-24(18-33-30(37-28)36-21-13-11-20(12-14-21)27(31)42)29(43)35-23-9-6-8-22(17-23)34-25(40)19-39(4)26(41)10-7-16-38(2)3/h7,10-14,18,22-23H,5-6,8-9,15-17,19H2,1-4H3,(H2,31,42)(H,34,40)(H,35,43)(H2,32,33,36,37)/b10-7+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397417 (US9987278, Compound Reference 27) Show SMILES CCCNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1 |r| Show InChI InChI=1S/C31H39N9O4/c1-6-16-33-28-25(19-34-31(38-28)37-22-14-12-21(13-15-22)27(32)42)30(44)36-24-10-7-9-23(18-24)35-29(43)20(2)40(5)26(41)11-8-17-39(3)4/h7-15,18-20H,6,16-17H2,1-5H3,(H2,32,42)(H,35,43)(H,36,44)(H2,33,34,37,38)/b11-8+/t20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397419 (US9987278, Compound Reference 29) Show SMILES CCCNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C#Cc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1 |r| Show InChI InChI=1S/C32H38N8O3/c1-6-18-34-30-25(21-35-32(38-30)37-26-16-14-24(15-17-26)29(33)42)13-12-23-9-7-10-27(20-23)36-31(43)22(2)40(5)28(41)11-8-19-39(3)4/h7-11,14-17,20-22H,6,18-19H2,1-5H3,(H2,33,42)(H,36,43)(H2,34,35,37,38)/b11-8+/t22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397420 (US9987278, Compound Reference 30) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1 |r| Show InChI InChI=1S/C31H41N9O3/c1-6-15-33-28-26(21-35-31(38-28)34-18-14-23-12-16-32-17-13-23)30(43)37-25-10-7-9-24(20-25)36-29(42)22(2)40(5)27(41)11-8-19-39(3)4/h7-13,16-17,20-22H,6,14-15,18-19H2,1-5H3,(H,36,42)(H,37,43)(H2,33,34,35,38)/b11-8+/t22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397422 (US9987278, Compound Reference 32) Show SMILES CCCNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN2CC(O)C2)c1 |r| Show InChI InChI=1S/C32H39N9O5/c1-4-14-34-29-26(17-35-32(39-29)38-22-12-10-21(11-13-22)28(33)44)31(46)37-24-8-5-7-23(16-24)36-30(45)20(2)40(3)27(43)9-6-15-41-18-25(42)19-41/h5-13,16-17,20,25,42H,4,14-15,18-19H2,1-3H3,(H2,33,44)(H,36,45)(H,37,46)(H2,34,35,38,39)/b9-6+/t20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397425 (US9987278, Compound Reference 35) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C#Cc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1 |r| Show InChI InChI=1S/C32H40N8O2/c1-6-17-34-30-27(23-36-32(38-30)35-20-16-25-14-18-33-19-15-25)13-12-26-9-7-10-28(22-26)37-31(42)24(2)40(5)29(41)11-8-21-39(3)4/h7-11,14-15,18-19,22-24H,6,16-17,20-21H2,1-5H3,(H,37,42)(H2,34,35,36,38)/b11-8+/t24-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397428 (US9987278, Compound Reference 38) Show SMILES CCCNc1nc(Nc2ccc(cc2)C#N)ncc1C#CCCCNC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C |r| Show InChI InChI=1S/C29H38N8O2/c1-6-17-31-27-24(21-33-29(35-27)34-25-15-13-23(20-30)14-16-25)11-8-7-9-18-32-28(39)22(2)37(5)26(38)12-10-19-36(3)4/h10,12-16,21-22H,6-7,9,17-19H2,1-5H3,(H,32,39)(H2,31,33,34,35)/b12-10+/t22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid PDB UniChem	PDB US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair				3D Structure (crystal)
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397429 (US9987278, Compound Reference 39) Show SMILES CCCNc1nc(Nc2cccc(F)c2)ncc1C#C[C@@H]1C[C@@H](C1)NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C |r,wU:20.21,22.26,27.30,(8.95,3.69,;7.61,2.92,;7.61,1.38,;6.28,.61,;6.28,-.93,;7.61,-1.7,;7.61,-3.24,;8.95,-4.01,;10.28,-3.24,;10.28,-1.7,;11.61,-.93,;12.95,-1.7,;12.95,-3.24,;14.28,-4.01,;11.61,-4.01,;6.28,-4.01,;4.94,-3.24,;4.94,-1.7,;3.61,-.93,;2.28,-.16,;.94,.61,;.54,2.1,;-.94,1.7,;-.54,.21,;-2.28,2.47,;-3.61,1.7,;-3.61,.16,;-4.94,2.47,;-4.94,4.01,;-6.28,1.7,;-6.28,.16,;-7.61,2.47,;-7.61,4.01,;-8.95,1.7,;-10.28,2.47,;-11.61,1.7,;-12.95,2.47,;-14.28,1.7,;-12.95,4.01,)| Show InChI InChI=1S/C29H38FN7O2/c1-6-14-31-27-22(19-32-29(35-27)34-24-10-7-9-23(30)18-24)13-12-21-16-25(17-21)33-28(39)20(2)37(5)26(38)11-8-15-36(3)4/h7-11,18-21,25H,6,14-17H2,1-5H3,(H,33,39)(H2,31,32,34,35)/b11-8+/t20-,21-,25+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397430 (US9987278, Compound Reference 40) Show SMILES C[C@H](N(C)C(=O)\C=C\CN(C)C)C(=O)N[C@H]1C[C@H](C1)C#Cc1cnc(Nc2ccc(F)cc2)nc1NC1CC1 |r,wU:17.19,15.14,1.0,(-4.94,4.01,;-4.94,2.47,;-6.28,1.7,;-6.28,.16,;-7.61,2.47,;-7.61,4.01,;-8.95,1.7,;-10.28,2.47,;-11.61,1.7,;-12.95,2.47,;-14.28,1.7,;-12.95,4.01,;-3.61,1.7,;-3.61,.16,;-2.28,2.47,;-.94,1.7,;.54,2.1,;.94,.61,;-.54,.21,;2.28,-.16,;3.61,-.93,;4.94,-1.7,;4.94,-3.24,;6.28,-4.01,;7.61,-3.24,;8.95,-4.01,;10.28,-3.24,;11.61,-4.01,;12.95,-3.24,;12.95,-1.7,;14.28,-.93,;11.61,-.93,;10.28,-1.7,;7.61,-1.7,;6.28,-.93,;6.28,.61,;7.61,1.38,;9.15,1.38,;8.38,2.71,)| Show InChI InChI=1S/C29H36FN7O2/c1-19(37(4)26(38)6-5-15-36(2)3)28(39)33-25-16-20(17-25)7-8-21-18-31-29(35-27(21)32-23-13-14-23)34-24-11-9-22(30)10-12-24/h5-6,9-12,18-20,23,25H,13-17H2,1-4H3,(H,33,39)(H2,31,32,34,35)/b6-5+/t19-,20-,25+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397431 (US9987278, Compound Reference 41) Show SMILES CNc1nc(Nc2ccc(F)cc2)ncc1C#C[C@@H]1C[C@@H](C1)NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C |r,wU:18.19,20.24,25.28,(7.61,1.38,;6.28,.61,;6.28,-.93,;7.61,-1.7,;7.61,-3.24,;8.95,-4.01,;10.28,-3.24,;11.61,-4.01,;12.95,-3.24,;12.95,-1.7,;14.28,-.93,;11.61,-.93,;10.28,-1.7,;6.28,-4.01,;4.94,-3.24,;4.94,-1.7,;3.61,-.93,;2.28,-.16,;.94,.61,;.54,2.1,;-.94,1.7,;-.54,.21,;-2.28,2.47,;-3.61,1.7,;-3.61,.16,;-4.94,2.47,;-4.94,4.01,;-6.28,1.7,;-6.28,.16,;-7.61,2.47,;-7.61,4.01,;-8.95,1.7,;-10.28,2.47,;-11.61,1.7,;-12.95,2.47,;-14.28,1.7,;-12.95,4.01,)| Show InChI InChI=1S/C27H34FN7O2/c1-18(35(5)24(36)7-6-14-34(3)4)26(37)31-23-15-19(16-23)8-9-20-17-30-27(33-25(20)29-2)32-22-12-10-21(28)11-13-22/h6-7,10-13,17-19,23H,14-16H2,1-5H3,(H,31,37)(H2,29,30,32,33)/b7-6+/t18-,19-,23+/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397426 (US9987278, Compound Reference 36) Show SMILES C[C@H](N(C)C(=O)\C=C\CN(C)C)C(=O)Nc1cccc(c1)C#Cc1cnc(NCCc2ccncc2)nc1N1CCOCC1 |r| Show InChI InChI=1S/C33H40N8O3/c1-25(40(4)30(42)9-6-18-39(2)3)32(43)37-29-8-5-7-27(23-29)10-11-28-24-36-33(35-17-14-26-12-15-34-16-13-26)38-31(28)41-19-21-44-22-20-41/h5-9,12-13,15-16,23-25H,14,17-22H2,1-4H3,(H,37,43)(H,35,36,38)/b9-6+/t25-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397412 (US9987278, Compound Reference 22) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1ccc(C)c(NC(=O)CNC(=O)\C=C\CN(C)C)c1 Show InChI InChI=1S/C30H39N9O3/c1-5-13-32-28-24(19-35-30(38-28)33-16-12-22-10-14-31-15-11-22)29(42)36-23-9-8-21(2)25(18-23)37-27(41)20-34-26(40)7-6-17-39(3)4/h6-11,14-15,18-19H,5,12-13,16-17,20H2,1-4H3,(H,34,40)(H,36,42)(H,37,41)(H2,32,33,35,38)/b7-6+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397415 (US9987278, Compound Reference 25) Show SMILES CCCNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C(=O)NCCCNC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C |r| Show InChI InChI=1S/C28H41N9O4/c1-6-14-30-25-22(18-33-28(35-25)34-21-12-10-20(11-13-21)24(29)39)27(41)32-16-8-15-31-26(40)19(2)37(5)23(38)9-7-17-36(3)4/h7,9-13,18-19H,6,8,14-17H2,1-5H3,(H2,29,39)(H,31,40)(H,32,41)(H2,30,33,34,35)/b9-7+/t19-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397418 (US9987278, Compound Reference 28) Show SMILES CCCNc1nc(Nc2ccc3cnccc3c2)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1 |r| Show InChI InChI=1S/C33H39N9O3/c1-6-15-35-30-28(21-36-33(40-30)39-27-13-12-24-20-34-16-14-23(24)18-27)32(45)38-26-10-7-9-25(19-26)37-31(44)22(2)42(5)29(43)11-8-17-41(3)4/h7-14,16,18-22H,6,15,17H2,1-5H3,(H,37,44)(H,38,45)(H2,35,36,39,40)/b11-8+/t22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397424 (US9987278, Compound Reference 34) Show SMILES CCCNc1nc(Nc2cccc(F)c2)ncc1C#CCCCNC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C |r| Show InChI InChI=1S/C28H38FN7O2/c1-6-16-30-26-22(20-32-28(34-26)33-24-14-10-13-23(29)19-24)12-8-7-9-17-31-27(38)21(2)36(5)25(37)15-11-18-35(3)4/h10-11,13-15,19-21H,6-7,9,16-18H2,1-5H3,(H,31,38)(H2,30,32,33,34)/b15-11+/t21-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397427 (US9987278, Compound Reference 37) Show SMILES CCCN(C)c1nc(NCCc2ccncc2)ncc1C#Cc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1 |r| Show InChI InChI=1S/C33H42N8O2/c1-7-21-40(5)31-28(24-36-33(38-31)35-20-17-26-15-18-34-19-16-26)14-13-27-10-8-11-29(23-27)37-32(43)25(2)41(6)30(42)12-9-22-39(3)4/h8-12,15-16,18-19,23-25H,7,17,20-22H2,1-6H3,(H,37,43)(H,35,36,38)/b12-9+/t25-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397413 (US9987278, Compound Reference 23) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCCNC(=O)CNC(=O)\C=C\CN(C)C Show InChI InChI=1S/C26H39N9O3/c1-4-11-29-24-21(18-33-26(34-24)31-16-10-20-8-14-27-15-9-20)25(38)30-13-6-12-28-23(37)19-32-22(36)7-5-17-35(2)3/h5,7-9,14-15,18H,4,6,10-13,16-17,19H2,1-3H3,(H,28,37)(H,30,38)(H,32,36)(H2,29,31,33,34)/b7-5+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397411 (US9987278, Compound Reference 21) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)\C=C\CN2CC(C)NC(C)C2)c1 Show InChI InChI=1S/C33H44N10O3/c1-4-13-35-31-28(19-38-33(42-31)36-16-12-25-10-14-34-15-11-25)32(46)41-27-8-5-7-26(18-27)40-30(45)20-37-29(44)9-6-17-43-21-23(2)39-24(3)22-43/h5-11,14-15,18-19,23-24,39H,4,12-13,16-17,20-22H2,1-3H3,(H,37,44)(H,40,45)(H,41,46)(H2,35,36,38,42)/b9-6+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397410 (US9987278, Compound Reference 20) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCC(CC)NC(=O)CN(C)C(=O)\C=C\CN(C)C Show InChI InChI=1S/C29H45N9O3/c1-6-14-31-27-24(20-34-29(36-27)33-17-12-22-10-15-30-16-11-22)28(41)32-18-13-23(7-2)35-25(39)21-38(5)26(40)9-8-19-37(3)4/h8-11,15-16,20,23H,6-7,12-14,17-19,21H2,1-5H3,(H,32,41)(H,35,39)(H2,31,33,34,36)/b9-8+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397409 (US9987278, Compound Reference 19) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCC(CC)NC(=O)CN(C)C(=O)C=C Show InChI InChI=1S/C26H38N8O3/c1-5-12-28-24-21(17-31-26(33-24)30-15-10-19-8-13-27-14-9-19)25(37)29-16-11-20(6-2)32-22(35)18-34(4)23(36)7-3/h7-9,13-14,17,20H,3,5-6,10-12,15-16,18H2,1-2,4H3,(H,29,37)(H,32,35)(H2,28,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397408 (US9987278, Compound Reference 18) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCC(CC)NC(=O)CNC(=O)\C=C\CN(C)C Show InChI InChI=1S/C28H43N9O3/c1-5-13-30-26-23(19-34-28(36-26)32-16-11-21-9-14-29-15-10-21)27(40)31-17-12-22(6-2)35-25(39)20-33-24(38)8-7-18-37(3)4/h7-10,14-15,19,22H,5-6,11-13,16-18,20H2,1-4H3,(H,31,40)(H,33,38)(H,35,39)(H2,30,32,34,36)/b8-7+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397407 (US9987278, Compound Reference 17) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCC(CC)NC(=O)CNC(=O)C=C Show InChI InChI=1S/C25H36N8O3/c1-4-11-27-23-20(16-31-25(33-23)29-14-9-18-7-12-26-13-8-18)24(36)28-15-10-19(5-2)32-22(35)17-30-21(34)6-3/h6-8,12-13,16,19H,3-5,9-11,14-15,17H2,1-2H3,(H,28,36)(H,30,34)(H,32,35)(H2,27,29,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397406 (US9987278, Compound Reference 16) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)NC(=O)C=C)c1 |r| Show InChI InChI=1S/C27H32N8O3/c1-4-12-29-24-22(17-31-27(35-24)30-15-11-19-9-13-28-14-10-19)26(38)34-21-8-6-7-20(16-21)33-25(37)18(3)32-23(36)5-2/h5-10,13-14,16-18H,2,4,11-12,15H2,1,3H3,(H,32,36)(H,33,37)(H,34,38)(H2,29,30,31,35)/t18-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397404 (US9987278, Compound Reference 14) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)\C=C\CN2CCN(CCO)CC2)c1 Show InChI InChI=1S/C33H44N10O4/c1-2-11-35-31-28(23-38-33(41-31)36-14-10-25-8-12-34-13-9-25)32(47)40-27-6-3-5-26(22-27)39-30(46)24-37-29(45)7-4-15-42-16-18-43(19-17-42)20-21-44/h3-9,12-13,22-23,44H,2,10-11,14-21,24H2,1H3,(H,37,45)(H,39,46)(H,40,47)(H2,35,36,38,41)/b7-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397400 (US9987278, Compound Reference 10) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CN(C)C(=O)C=C)c1 Show InChI InChI=1S/C27H32N8O3/c1-4-12-29-25-22(17-31-27(34-25)30-15-11-19-9-13-28-14-10-19)26(38)33-21-8-6-7-20(16-21)32-23(36)18-35(3)24(37)5-2/h5-10,13-14,16-17H,2,4,11-12,15,18H2,1,3H3,(H,32,36)(H,33,38)(H2,29,30,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397399 (US9987278, Compound Reference 9) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)C(C)(C)NC(=O)C=C)c1 Show InChI InChI=1S/C28H34N8O3/c1-5-13-30-24-22(18-32-27(35-24)31-16-12-19-10-14-29-15-11-19)25(38)33-20-8-7-9-21(17-20)34-26(39)28(3,4)36-23(37)6-2/h6-11,14-15,17-18H,2,5,12-13,16H2,1,3-4H3,(H,33,38)(H,34,39)(H,36,37)(H2,30,31,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397397 (US9987278, Compound Reference 7) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCCNC(=O)CNC(=O)C=C Show InChI InChI=1S/C23H32N8O3/c1-3-9-26-21-18(15-30-23(31-21)28-14-8-17-6-12-24-13-7-17)22(34)27-11-5-10-25-20(33)16-29-19(32)4-2/h4,6-7,12-13,15H,2-3,5,8-11,14,16H2,1H3,(H,25,33)(H,27,34)(H,29,32)(H2,26,28,30,31)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397395 (US9987278, Compound Reference 5) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)\C=C\CN(C)C)c1 Show InChI InChI=1S/C29H37N9O3/c1-4-13-31-27-24(19-34-29(37-27)32-16-12-21-10-14-30-15-11-21)28(41)36-23-8-5-7-22(18-23)35-26(40)20-33-25(39)9-6-17-38(2)3/h5-11,14-15,18-19H,4,12-13,16-17,20H2,1-3H3,(H,33,39)(H,35,40)(H,36,41)(H2,31,32,34,37)/b9-6+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397280 (US9987278, Compound Reference 2) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)C=C)c1 Show InChI InChI=1S/C26H30N8O3/c1-3-11-28-24-21(16-31-26(34-24)29-14-10-18-8-12-27-13-9-18)25(37)33-20-7-5-6-19(15-20)32-23(36)17-30-22(35)4-2/h4-9,12-13,15-16H,2-3,10-11,14,17H2,1H3,(H,30,35)(H,32,36)(H,33,37)(H2,28,29,31,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397423 (US9987278, Compound Reference 33) Show SMILES CCCNc1nc(Nc2cccc(c2)C#N)ncc1C#CCCCNC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C |r| Show InChI InChI=1S/C29H38N8O2/c1-6-16-31-27-24(21-33-29(35-27)34-25-14-10-12-23(19-25)20-30)13-8-7-9-17-32-28(39)22(2)37(5)26(38)15-11-18-36(3)4/h10-12,14-15,19,21-22H,6-7,9,16-18H2,1-5H3,(H,32,39)(H2,31,33,34,35)/b15-11+/t22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397405 (US9987278, Compound Reference 15) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NCCNC(=O)C=C)c1 Show InChI InChI=1S/C26H32N8O2/c1-3-11-30-24-22(18-32-26(34-24)31-14-10-19-8-12-27-13-9-19)25(36)33-21-7-5-6-20(17-21)28-15-16-29-23(35)4-2/h4-9,12-13,17-18,28H,2-3,10-11,14-16H2,1H3,(H,29,35)(H,33,36)(H2,30,31,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397403 (US9987278, Compound Reference 13) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)\C=C\CN2CCOCC2)c1 Show InChI InChI=1S/C31H39N9O4/c1-2-11-33-29-26(21-36-31(39-29)34-14-10-23-8-12-32-13-9-23)30(43)38-25-6-3-5-24(20-25)37-28(42)22-35-27(41)7-4-15-40-16-18-44-19-17-40/h3-9,12-13,20-21H,2,10-11,14-19,22H2,1H3,(H,35,41)(H,37,42)(H,38,43)(H2,33,34,36,39)/b7-4+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397402 (US9987278, Compound Reference 12) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)\C=C\CN2CCN(C)CC2)c1 Show InChI InChI=1S/C32H42N10O3/c1-3-12-34-30-27(22-37-32(40-30)35-15-11-24-9-13-33-14-10-24)31(45)39-26-7-4-6-25(21-26)38-29(44)23-36-28(43)8-5-16-42-19-17-41(2)18-20-42/h4-10,13-14,21-22H,3,11-12,15-20,23H2,1-2H3,(H,36,43)(H,38,44)(H,39,45)(H2,34,35,37,40)/b8-5+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397401 (US9987278, Compound Reference 11) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(c1)N(C)C(=O)CNC(=O)C=C Show InChI InChI=1S/C27H32N8O3/c1-4-12-29-25-22(17-32-27(34-25)30-15-11-19-9-13-28-14-10-19)26(38)33-20-7-6-8-21(16-20)35(3)24(37)18-31-23(36)5-2/h5-10,13-14,16-17H,2,4,11-12,15,18H2,1,3H3,(H,31,36)(H,33,38)(H2,29,30,32,34)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397421 (US9987278, Compound Reference 31) Show SMILES CCCNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C#Cc1cccc(NCCNC(=O)\C=C\CN(C)C)c1 Show InChI InChI=1S/C30H36N8O2/c1-4-16-34-29-24(21-35-30(37-29)36-25-14-12-23(13-15-25)28(31)40)11-10-22-7-5-8-26(20-22)32-17-18-33-27(39)9-6-19-38(2)3/h5-9,12-15,20-21,32H,4,16-19H2,1-3H3,(H2,31,40)(H,33,39)(H2,34,35,36,37)/b9-6+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397396 (US9987278, Compound Reference 6) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(OCCNC(=O)C=C)c1 Show InChI InChI=1S/C26H31N7O3/c1-3-11-29-24-22(18-31-26(33-24)30-14-10-19-8-12-27-13-9-19)25(35)32-20-6-5-7-21(17-20)36-16-15-28-23(34)4-2/h4-9,12-13,17-18H,2-3,10-11,14-16H2,1H3,(H,28,34)(H,32,35)(H2,29,30,31,33)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 [D835Y] (Homo sapiens (Human))	BDBM397394 (US9987278, Compound Reference 4) Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cc(Cl)cc(NC(=O)CNC(=O)C=C)c1 Show InChI InChI=1S/C26H29ClN8O3/c1-3-8-29-24-21(15-32-26(35-24)30-11-7-17-5-9-28-10-6-17)25(38)34-20-13-18(27)12-19(14-20)33-23(37)16-31-22(36)4-2/h4-6,9-10,12-15H,2-3,7-8,11,16H2,1H3,(H,31,36)(H,33,37)(H,34,38)(H2,29,30,32,35)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	5.5	n/a	n/a	n/a	n/a	n/a	n/a
BioCryst Pharmaceuticals					Assay Description Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...				Bioorg Med Chem 17: 3934-58 (2009) BindingDB Entry DOI: 10.7270/Q2J38VZJ
					More data for this Ligand-Target Pair

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