Found 9 hits Enz. Inhib. hit(s) with Target = 'Tyrosine-protein phosphatase non-receptor type 3' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Tyrosine-protein phosphatase non-receptor type 3
(Homo sapiens (Human)) | BDBM50054344
(CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...)Show SMILES Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccsc2)c1 Show InChI InChI=1S/C28H20IN3O5S/c1-32-22-13-23(33)21(28(36)37)12-20(22)24(29)25(32)16-3-2-4-19(11-16)31-27(35)26(34)30-18-7-5-15(6-8-18)17-9-10-38-14-17/h2-14,33H,1H3,(H,30,34)(H,31,35)(H,36,37) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description For selectivity studies, the PTPs, including LYP, mPTPA, SHP1-D1C, PTP1B, LMPTP, VHR, Laforin and PTPα-D1D2 were expressed and purified from E. ... |
US Patent US9522881 (2016)
BindingDB Entry DOI: 10.7270/Q2DN4402 |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 3
(Homo sapiens (Human)) | BDBM50054344
(CHEMBL3319356 | US9522881, 11a-1 L97M74 | US984453...)Show SMILES Cn1c(c(I)c2cc(C(O)=O)c(O)cc12)-c1cccc(NC(=O)C(=O)Nc2ccc(cc2)-c2ccsc2)c1 Show InChI InChI=1S/C28H20IN3O5S/c1-32-22-13-23(33)21(28(36)37)12-20(22)24(29)25(32)16-3-2-4-19(11-16)31-27(35)26(34)30-18-7-5-15(6-8-18)17-9-10-38-14-17/h2-14,33H,1H3,(H,30,34)(H,31,35)(H,36,37) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of PTPH1 (unknown origin) |
J Med Chem 57: 6594-609 (2014)
Article DOI: 10.1021/jm5006176 BindingDB Entry DOI: 10.7270/Q24X59FM |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 3
(Homo sapiens (Human)) | BDBM50436358
(CHEMBL2396718)Show SMILES CCCNC(=O)COc1ccc(cc1)-c1oc2cc(O)c(cc2c1C#Cc1cccc(Cl)c1)C(O)=O Show InChI InChI=1S/C28H22ClNO6/c1-2-12-30-26(32)16-35-20-9-7-18(8-10-20)27-21(11-6-17-4-3-5-19(29)13-17)22-14-23(28(33)34)24(31)15-25(22)36-27/h3-5,7-10,13-15,31H,2,12,16H2,1H3,(H,30,32)(H,33,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of recombinant PTPH1 (unknown origin) using pNPP as substrate by spectrophotometric analysis |
J Med Chem 56: 4990-5008 (2013)
Article DOI: 10.1021/jm400248c BindingDB Entry DOI: 10.7270/Q2N017XW |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 3
(Homo sapiens (Human)) | BDBM231167
(US9340574, 7)Show SMILES COc1cc(CC(=O)NCC(NC(=O)C(CCCNC(=O)c2cccc(I)c2)NC(=O)C(Cc2ccc(cc2)C(F)(F)P(O)(O)=O)NC(=O)c2ccc(C)c(Br)c2)C(N)=O)ccc1O Show InChI InChI=1S/C42H45BrF2IN6O11P/c1-23-8-12-27(21-30(23)43)39(57)51-32(17-24-9-13-28(14-10-24)42(44,45)64(60,61)62)41(59)50-31(7-4-16-48-38(56)26-5-3-6-29(46)20-26)40(58)52-33(37(47)55)22-49-36(54)19-25-11-15-34(53)35(18-25)63-2/h3,5-6,8-15,18,20-21,31-33,53H,4,7,16-17,19,22H2,1-2H3,(H2,47,55)(H,48,56)(H,49,54)(H,50,59)(H,51,57)(H,52,58)(H2,60,61,62) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University Research and Technology Corporation
US Patent
| Assay Description PTP activity was assayed using p-nitrophenyl phosphate (pNPP) as a substrate in 3,3-dimethylglutarate buffer (50 mM 3,3-dimethylglutarate, pH 7.0, 1 ... |
US Patent US9340574 (2016)
BindingDB Entry DOI: 10.7270/Q2NV9H4J |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 3
(Homo sapiens (Human)) | BDBM50607111
(CHEMBL5218807) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
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MCE PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 3
(Homo sapiens (Human)) | BDBM50436357
(CHEMBL2396719)Show SMILES OC(=O)c1cc2c(C#Cc3cccc(Cl)c3)c(oc2cc1O)-c1ccc(OCC(=O)NC2CC2)cc1 Show InChI InChI=1S/C28H20ClNO6/c29-18-3-1-2-16(12-18)4-11-21-22-13-23(28(33)34)24(31)14-25(22)36-27(21)17-5-9-20(10-6-17)35-15-26(32)30-19-7-8-19/h1-3,5-6,9-10,12-14,19,31H,7-8,15H2,(H,30,32)(H,33,34) | PDB
UniProtKB/SwissProt
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CHEMBL MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Indiana University School of Medicine
Curated by ChEMBL
| Assay Description Inhibition of recombinant PTPH1 (unknown origin) using pNPP as substrate by spectrophotometric analysis |
J Med Chem 56: 4990-5008 (2013)
Article DOI: 10.1021/jm400248c BindingDB Entry DOI: 10.7270/Q2N017XW |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 3
(Homo sapiens (Human)) | BDBM50087856
(CHEMBL3426913)Show SMILES CCCCC(Oc1cc(O)c(cc1C#Cc1ccccc1OC(F)(F)F)C(O)=O)C(=O)NC1CCCCC1 Show InChI InChI=1S/C28H30F3NO6/c1-2-3-12-24(26(34)32-20-10-5-4-6-11-20)37-25-17-22(33)21(27(35)36)16-19(25)15-14-18-9-7-8-13-23(18)38-28(29,30)31/h7-9,13,16-17,20,24,33H,2-6,10-12H2,1H3,(H,32,34)(H,35,36) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.39E+4 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Indiana University
Curated by ChEMBL
| Assay Description Inhibition of PTPH1 (unknown origin) using pNPP as substrate at pH 7 at 25 degC by spectrophotometric analysis |
Bioorg Med Chem 23: 2798-809 (2015)
Article DOI: 10.1016/j.bmc.2015.03.066 BindingDB Entry DOI: 10.7270/Q2VD7168 |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 3
(Homo sapiens (Human)) | BDBM50607110
(CHEMBL5219519) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |
Tyrosine-protein phosphatase non-receptor type 3
(Homo sapiens (Human)) | BDBM50558488
(CHEMBL4794972)Show SMILES Cc1c(Br)cc(NC(=O)C(c2ccccc2)S(O)(=O)=O)cc1Br | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c01143 BindingDB Entry DOI: 10.7270/Q2BK1HGF |
More data for this Ligand-Target Pair | |