BindingDB PrimarySearch

Found 2 hits Enz. Inhib. hit(s) with Target = 'Synaptic vesicular amine transporter [V132A]'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Synaptic vesicular amine transporter [V132A] (Rattus norvegicus (Rat))	BDBM50017712 ((-)-reserpine \| (3beta,16beta,17alpha,18beta,20alp...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	>50	n/a	n/a	n/a	n/a	8.5	n/a
Hebrew University of Jerusalem					Assay Description The uptake assay was performed in reaction buffer containing 140 mM K2-tartrate, 10 mM Tricine, 10 mM Tris, and 5 mM MgCl2, pH 8.5. Liposomes (1 _...				J Biol Chem 288: 32160-71 (2013) Article DOI: 10.1074/jbc.M113.502971 BindingDB Entry DOI: 10.7270/Q20P0XVW
Hebrew University of Jerusalem					More data for this Ligand-Target Pair				3D Structure (crystal)
Synaptic vesicular amine transporter [V132A] (Rattus norvegicus (Rat))	BDBM50017701 (3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-...) Show SMILES COc1cc2CCN3CC(CC(C)C)C(=O)CC3c2cc1OC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	63.4	n/a	n/a	n/a	7.5	25
Hebrew University of Jerusalem					Assay Description Liposomes (1-2 ul) were added to 200 ul of reaction buffer containing 150 mM NaCl, 15 mM Tris-HCl, pH 7.5, and increasing concentrations of [3H]TBZOH...				J Biol Chem 288: 32160-71 (2013) Article DOI: 10.1074/jbc.M113.502971 BindingDB Entry DOI: 10.7270/Q20P0XVW
Hebrew University of Jerusalem					More data for this Ligand-Target Pair				3D Structure (crystal)