Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM50463483 (CHEMBL4245242) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc Curated by ChEMBL | Assay Description Inhibition of p38gamma (unknown origin) | Bioorg Med Chem Lett 28: 2622-2626 (2018) Article DOI: 10.1016/j.bmcl.2018.06.040 BindingDB Entry DOI: 10.7270/Q2ZC85HX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM50463479 (CHEMBL4249925) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem | Article PubMed | >2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Vertex Pharmaceuticals Inc Curated by ChEMBL | Assay Description Inhibition of p38gamma (unknown origin) | Bioorg Med Chem Lett 28: 2622-2626 (2018) Article DOI: 10.1016/j.bmcl.2018.06.040 BindingDB Entry DOI: 10.7270/Q2ZC85HX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM50314776 (CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 3.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc. Curated by ChEMBL | Assay Description Inhibition of p38gamma | J Med Chem 53: 2973-85 (2010) Article DOI: 10.1021/jm100095x BindingDB Entry DOI: 10.7270/Q2FX79MD | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM50224883 (7-chloro-3-oxo-8-[(thiazol-5-ylmethyl)-amino]-11,1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | >7.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of P38 gamma | Bioorg Med Chem Lett 17: 6593-601 (2007) Article DOI: 10.1016/j.bmcl.2007.09.063 BindingDB Entry DOI: 10.7270/Q2X067WT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM342101 (3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent | Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio... | US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM342110 (3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent | Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio... | US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM50605761 (CHEMBL5197888) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00115 BindingDB Entry DOI: 10.7270/Q2B280DT | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM342102 (1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent | Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio... | US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM342107 (3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent | Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio... | US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM334348 (1-(4-((2-((3-(2,5,8,11,14,17,20-Heptaoxadocosan-22...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9732063 (2017) BindingDB Entry DOI: 10.7270/Q2PV6NGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM342111 (3-Ethynyl-5-((4-((4-(3-(3-isopropyl-1-methyl-1H-py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent | Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio... | US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM50605756 (CHEMBL5184542) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00115 BindingDB Entry DOI: 10.7270/Q2B280DT | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142613 (US8933228, 29) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM342108 (3-((4-((4-(3-(3-(tert-Butyl)-1-ethyl-1H-pyrazol-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent | Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio... | US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142622 (US8933228, 13) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142626 (US8933228, 18) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142601 (US8933228, 3) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 24 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM334336 (1-(4-((2-((3-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9732063 (2017) BindingDB Entry DOI: 10.7270/Q2PV6NGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM334325 (1-(3-Isopropyl-1-(P-tolyl)-1H-pyrazol-5-yl)-3-(4-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9732063 (2017) BindingDB Entry DOI: 10.7270/Q2PV6NGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM334319 (3-(4-((4-(3-(3-(tert-Butyl)-1-(6-methoxypyridin-3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9732063 (2017) BindingDB Entry DOI: 10.7270/Q2PV6NGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142610 (US8933228, 26) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM13533 (1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Ansaris Curated by ChEMBL | Assay Description Inhibition of P38gamma | Bioorg Med Chem Lett 21: 7155-65 (2011) Article DOI: 10.1016/j.bmcl.2011.09.078 BindingDB Entry DOI: 10.7270/Q2NC61NH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM334345 (1-(4-((2-((3-(2,5,8,11-Tetraoxatridecan-13-yloxy)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9732063 (2017) BindingDB Entry DOI: 10.7270/Q2PV6NGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM334346 (1-(4-((2-((3-(2,5,8,11,14-Pentaoxahexadecan-16-ylo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9732063 (2017) BindingDB Entry DOI: 10.7270/Q2PV6NGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142627 (US8933228, 19) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM342103 (1-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5-yl)-3-(4-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent | Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio... | US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142614 (US8933228, 30) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142597 (US8933228, Ref 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Sygnature Discovery Limited Curated by ChEMBL | Assay Description Inhibitory concentration required for in vitro binding affinity to Nicotinic acetylcholine receptor alpha3-beta2 expressed on cell line sf 9 by using... | J Med Chem 59: 1727-46 (2016) Article DOI: 10.1021/acs.jmedchem.5b01029 BindingDB Entry DOI: 10.7270/Q2319XRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142629 (US8933228, 21) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142603 (US8933228, 5) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142628 (US8933228, 20) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142624 (US8933228, 16) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142619 (US8933228, 10) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142615 (US8933228, 31) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM334327 (3-(4-((4-(3-(3-Isopropyl-1-(p-tolyl)-1H-pyrazol-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9732063 (2017) BindingDB Entry DOI: 10.7270/Q2PV6NGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142609 (US8933228, 22 | US8933228, 25) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM334367 (1-(4-((2-((3-(2,5,8,11,14,17,20-Heptaoxadocosan-22...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9732063 (2017) BindingDB Entry DOI: 10.7270/Q2PV6NGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM50156163 (CHEMBL3780832) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 55 | n/a | n/a | n/a | n/a | n/a | n/a |
Sygnature Discovery Limited Curated by ChEMBL | Assay Description Inhibitory concentration required for in vitro binding affinity to Nicotinic acetylcholine receptor alpha3-beta2 expressed on cell line Sf 9 by using... | J Med Chem 59: 1727-46 (2016) Article DOI: 10.1021/acs.jmedchem.5b01029 BindingDB Entry DOI: 10.7270/Q2319XRB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM334329 (1-(3-Isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 65 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9732063 (2017) BindingDB Entry DOI: 10.7270/Q2PV6NGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM342109 (3-((4-((4-(3-(3-(tert-Butyl)-1-methyl-1H-pyrazol-5...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 66 | n/a | n/a | n/a | n/a | n/a | n/a |
TOPIVERT PHARMA LIMITED; RESPIVERT LIMITED US Patent | Assay Description p38 MAPKγ: The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashio... | US Patent US9771353 (2017) BindingDB Entry DOI: 10.7270/Q2HQ4219 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142600 (US8933228, 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 67 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142604 (US8933228, 6) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142599 (US8933228, 1) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142617 (US8933228, 33) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 74 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 78.7 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human p38gamma using MBP as substrate by [gamma-33P]-ATP assay | Citation and Details Article DOI: 10.1016/j.bmc.2018.02.022 BindingDB Entry DOI: 10.7270/Q2DJ5KB8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM334318 (S,S-Dimethyl-N-(4-((4-((4-(3-(3-(tert-butyl)-1-(6-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9732063 (2017) BindingDB Entry DOI: 10.7270/Q2PV6NGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142616 (US8933228, 32) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 89 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM334378 (1-(3-(tert-Butyl)-1-(P-tolyl)-1H-pyrazol-5-yl)-3-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 95 | n/a | n/a | n/a | n/a | n/a | n/a |
RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED US Patent | Assay Description The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen), are evaluated in a similar fashion to that descri... | US Patent US9732063 (2017) BindingDB Entry DOI: 10.7270/Q2PV6NGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142606 (US8933228, 8) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mitogen-activated protein kinase 12 (Homo sapiens (Human)) | BDBM142605 (US8933228, 7) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Respivert, Ltd. US Patent | Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi... | US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW | |||||||||||
More data for this Ligand-Target Pair |
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