Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Adenosylhomocysteine nucleosidase (Streptococcus pneumoniae) | BDBM22113 ((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 24 | -43.1 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Industrial Research Limited | Assay Description Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293... | J Med Chem 51: 948-56 (2008) Article DOI: 10.1021/jm701265n BindingDB Entry DOI: 10.7270/Q2QC01T3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Streptococcus pneumoniae) | BDBM22112 (7-({3-[(methylsulfanyl)methyl]azetidin-1-yl}methyl...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 84 | -40.0 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Industrial Research Limited | Assay Description Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293... | J Med Chem 51: 948-56 (2008) Article DOI: 10.1021/jm701265n BindingDB Entry DOI: 10.7270/Q2QC01T3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Streptococcus pneumoniae) | BDBM22110 (Azetidine based compound, 43 | [1-({4-amino-5H-pyr...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | 150 | -38.6 | n/a | n/a | n/a | n/a | n/a | 7.0 | 22 |
Industrial Research Limited | Assay Description Enzyme activity was monitored by absorbance change in the xanthine oxidase coupled assay, which measures the formation of 2,8-dihydroxyadenine at 293... | J Med Chem 51: 948-56 (2008) Article DOI: 10.1021/jm701265n BindingDB Entry DOI: 10.7270/Q2QC01T3 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Streptococcus pneumoniae) | BDBM36435 ((3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthi...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 10 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Streptococcus pneumoniae) | BDBM36495 (CHEMBL554642 | ImmA-Bn) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 210 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Streptococcus pneumoniae) | BDBM36496 (CHEMBL552894 | ImmA-pClPh) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 190 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Helicobacter pylori) | BDBM36498 (DADMe-ImmA-p-ClPh) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 0.570 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Adenosylhomocysteine nucleosidase (Streptococcus pneumoniae) | BDBM36497 (CHEMBL191436 | DADMe-ImmA-Bn) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 2.40 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Helicobacter pylori) | BDBM50170093 (2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-di...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.20 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Helicobacter pylori) | BDBM22113 ((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 0.571 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Adenosylhomocysteine nucleosidase (Helicobacter pylori) | BDBM36494 (CHEMBL554965 | ImmA-Et) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 3.40 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Helicobacter pylori) | BDBM36435 ((3R,4S)-1-[(9-Deaza-adenin-9-yl)methyl]-4-ethylthi...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.515 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Helicobacter pylori) | BDBM36495 (CHEMBL554642 | ImmA-Bn) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 200 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Helicobacter pylori) | BDBM36497 (CHEMBL191436 | DADMe-ImmA-Bn) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 200 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Helicobacter pylori) | BDBM36496 (CHEMBL552894 | ImmA-pClPh) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 40 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Streptococcus pneumoniae) | BDBM36494 (CHEMBL554965 | ImmA-Et) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 40 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Streptococcus pneumoniae) | BDBM22113 ((3R,4S)-1-({4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-y...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | Purchase DrugBank MCE MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 24 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Streptococcus pneumoniae) | BDBM50170093 (2-(4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-3,4-di...) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adenosylhomocysteine nucleosidase (Streptococcus pneumoniae) | BDBM36498 (DADMe-ImmA-p-ClPh) | PDB MMDB KEGG UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | n/a | 0.360 | n/a | n/a | n/a | 7.5 | 25 |
Albert Einstein College of Medicine | Assay Description Enzyme activity assay using various bacterial species of 5'-Methylthioadenosine nucleosidases (MTANs) excepted for MTAP, for human MTAP. | ACS Chem Biol 2: 725-34 (2007) Article DOI: 10.1021/cb700166z BindingDB Entry DOI: 10.7270/Q2QF8R7W | |||||||||||
More data for this Ligand-Target Pair |