Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Presenilin-2 (Homo sapiens (Human)) | BDBM50393452 (CHEMBL2159511) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 production | ACS Med Chem Lett 3: 892-896 (2012) Article DOI: 10.1021/ml300044f BindingDB Entry DOI: 10.7270/Q2WD41PQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-2 (Homo sapiens (Human)) | BDBM50393453 (CHEMBL2159510) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 production | ACS Med Chem Lett 3: 892-896 (2012) Article DOI: 10.1021/ml300044f BindingDB Entry DOI: 10.7270/Q2WD41PQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-2 (Homo sapiens (Human)) | BDBM50393454 (CHEMBL2159509) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 production | ACS Med Chem Lett 3: 892-896 (2012) Article DOI: 10.1021/ml300044f BindingDB Entry DOI: 10.7270/Q2WD41PQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-2 (Homo sapiens (Human)) | BDBM50393454 (CHEMBL2159509) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 production | ACS Med Chem Lett 3: 892-896 (2012) Article DOI: 10.1021/ml300044f BindingDB Entry DOI: 10.7270/Q2WD41PQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-2 (Homo sapiens (Human)) | BDBM50393457 (CHEMBL2159689) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 production | ACS Med Chem Lett 3: 892-896 (2012) Article DOI: 10.1021/ml300044f BindingDB Entry DOI: 10.7270/Q2WD41PQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-2 (Homo sapiens (Human)) | BDBM50393451 (CHEMBL2159687) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 production | ACS Med Chem Lett 3: 892-896 (2012) Article DOI: 10.1021/ml300044f BindingDB Entry DOI: 10.7270/Q2WD41PQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-2 (Homo sapiens (Human)) | BDBM50393455 (CHEMBL2159691) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 production | ACS Med Chem Lett 3: 892-896 (2012) Article DOI: 10.1021/ml300044f BindingDB Entry DOI: 10.7270/Q2WD41PQ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Presenilin-2 (Homo sapiens (Human)) | BDBM50393456 (CHEMBL2159690) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Inhibition of PS2 gamma-secretase expressed in HEK cells harboring Awe-Lon gene assessed as reduction of amyloid beta-42 production | ACS Med Chem Lett 3: 892-896 (2012) Article DOI: 10.1021/ml300044f BindingDB Entry DOI: 10.7270/Q2WD41PQ | |||||||||||
More data for this Ligand-Target Pair |