Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM404301 (US10017501, Compound 1020-289) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249309 (US10017501, Compound 1020-114 | US9458145, 1020-11...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249314 (US10017501, Compound 1020-298 | US9458145, 1020-29...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249312 (US10017501, Compound 1020-257 | US9458145, 1020-25...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249311 (US10017501, Compound 1020-239 | US9458145, 1020-23...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM50539804 (CHEMBL4640025 | US11840533, Compound 71) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM50539805 (CHEMBL4644032 | US11840533, Compound 72) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM50539801 (CHEMBL4648912 | US11840533, Compound 70) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | <10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249306 (US10017501, Compound 1020-104 | US9458145, 1020-10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | 11.7 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249305 (US10017501, Compound 1020-103 | US9458145, 1020-10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 12.4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249308 (US10017501, Compound 1020-113 | US9458145, 1020-11...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 12.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249307 (US10017501, Compound 1020-112 | US9458145, 1020-11...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 13.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM179460 (US9675697, Cpd. No. 17) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 16 | -44.5 | 197 | n/a | n/a | n/a | n/a | 7.5 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th... | US Patent US9675697 (2017) BindingDB Entry DOI: 10.7270/Q2CC0XV6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249310 (US10017501, Compound 1020-224 | US9458145, 1020-22...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 20.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM50092323 (CHEMBL3581656 | US9675697, Cpd. No. 21) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 38 | -42.4 | 310 | n/a | n/a | n/a | n/a | 7.5 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th... | US Patent US9675697 (2017) BindingDB Entry DOI: 10.7270/Q2CC0XV6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM179457 (US9675697, Cpd. No. 3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 83 | -40.4 | 514 | n/a | n/a | n/a | n/a | 7.5 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th... | US Patent US9675697 (2017) BindingDB Entry DOI: 10.7270/Q2CC0XV6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM640356 (N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- p...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | <100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM640357 (N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- p...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | <100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM640358 (N-(1-(4-fluorobenzyl)-6-(7- hydroxy-1-methyl-1H- p...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | <100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a | |
TBA | Citation and Details | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM50092318 (CHEMBL3581657 | US9675697, Cpd. No. 2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | 114 | -39.6 | 608 | n/a | n/a | n/a | n/a | 7.5 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th... | US Patent US9675697 (2017) BindingDB Entry DOI: 10.7270/Q2CC0XV6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM179458 (US9675697, Cpd. No. 4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 232 | -37.9 | 873 | n/a | n/a | n/a | n/a | 7.5 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th... | US Patent US9675697 (2017) BindingDB Entry DOI: 10.7270/Q2CC0XV6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM179476 (US9675697, Cpd. No. 34) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 775 | -34.9 | 3.67E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th... | US Patent US9675697 (2017) BindingDB Entry DOI: 10.7270/Q2CC0XV6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM50092339 (CHEMBL3581648 | US9675697, RX-7) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | 850 | -34.6 | 2.90E+3 | n/a | n/a | n/a | n/a | 7.5 | 25 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN US Patent | Assay Description The FAM labeled fluorescent probe (BRD-1F) was synthesized based on a known small-molecule BET bromodomain inhibitor. Kd values of BRD-1F to these th... | US Patent US9675697 (2017) BindingDB Entry DOI: 10.7270/Q2CC0XV6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM223491 (US10407441, Compound JQ6 | US10925881, Name (S)-JQ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.240 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc. US Patent | Assay Description All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ... | US Patent US10407441 (2019) BindingDB Entry DOI: 10.7270/Q2RJ4MV4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM223492 (US10407441, Compound JQ8 | US10925881, Name (S)-JQ...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.427 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc. US Patent | Assay Description All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ... | US Patent US10407441 (2019) BindingDB Entry DOI: 10.7270/Q2RJ4MV4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM223493 (US10407441, Compound JQ13 | US10925881, Name (S)-J...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 0.584 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc. US Patent | Assay Description All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ... | US Patent US10407441 (2019) BindingDB Entry DOI: 10.7270/Q2RJ4MV4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM259884 (US10308662, Compound 125 | US9505780, 125) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.87 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249313 (US9458145, 1020-289) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249309 (US10017501, Compound 1020-114 | US9458145, 1020-11...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249314 (US10017501, Compound 1020-298 | US9458145, 1020-29...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249312 (US10017501, Compound 1020-257 | US9458145, 1020-25...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.60 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249311 (US10017501, Compound 1020-239 | US9458145, 1020-23...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM223495 (US10407441, Compound JQ35 | US9320741, JQ35) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 6.13 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc. US Patent | Assay Description All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ... | US Patent US10407441 (2019) BindingDB Entry DOI: 10.7270/Q2RJ4MV4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249306 (US10017501, Compound 1020-104 | US9458145, 1020-10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase PC cid PC sid UniChem | US Patent | n/a | n/a | 11.7 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249305 (US10017501, Compound 1020-103 | US9458145, 1020-10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12.4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249308 (US10017501, Compound 1020-113 | US9458145, 1020-11...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 12.8 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249307 (US10017501, Compound 1020-112 | US9458145, 1020-11...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 13.5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM50365262 ((+)-JQ1 | (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE MMDB PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc. US Patent | Assay Description All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ... | US Patent US10407441 (2019) BindingDB Entry DOI: 10.7270/Q2RJ4MV4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249310 (US10017501, Compound 1020-224 | US9458145, 1020-22...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 20.2 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description The labeled ligand specifically binds BRD4-1 and BRD4-2 and can be displaced by a small molecule inhibitor that shares a similar or overlapping bindi... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM223494 (US10407441, Compound JQ33 | US9320741, JQ33) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 29.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Dana-Farber Cancer Institute, Inc. US Patent | Assay Description All reagents were diluted in 50 mM HEPES, 100 mM NaCl, 0.1% BSA, pH 7.4 supplemented with 0.05% CHAPS and allowed to equilibrate to room temperature ... | US Patent US10407441 (2019) BindingDB Entry DOI: 10.7270/Q2RJ4MV4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM259897 (US9505780, JQ-1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 39.1 | n/a | n/a | n/a | n/a | n/a | n/a |
SignalRx Pharmaceuticals, Inc. US Patent | Assay Description Several TP Scaffold compounds were tested for inhibition activity against isoforms of PI3K (alpha, beta, gamma, and delta isoforms) and the bromodoma... | US Patent US9505780 (2016) BindingDB Entry DOI: 10.7270/Q22B8WZ1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249283 (US10017501, Compound 1020-57 | US9458145, 1020-57) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 54.4 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249283 (US10017501, Compound 1020-57 | US9458145, 1020-57) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 54.4 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249287 (US10017501, Compound 1020-77 | US9458145, 1020-77) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 64.8 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249287 (US10017501, Compound 1020-77 | US9458145, 1020-77) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 64.8 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249279 (US10017501, Compound 1020-28 | US9458145, 1020-28) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 65.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249279 (US10017501, Compound 1020-28 | US9458145, 1020-28) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 65.5 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249284 (US10017501, Compound 1020-72 | US9458145, 1020-72) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 69.1 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Gilead Sciences, Inc. US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US9458145 (2016) BindingDB Entry DOI: 10.7270/Q26Q1W53 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249284 (US10017501, Compound 1020-72 | US9458145, 1020-72) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 69.1 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bromodomain-containing protein 4 [368-440] (Homo sapiens (Human)) | BDBM249276 (US10017501, Compound 1020-12 | US9458145, 1020-12) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 69.2 | n/a | n/a | n/a | n/a | n/a | n/a |
Gilead Sciences Inc US Patent | Assay Description Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores... | US Patent US10017501 (2018) BindingDB Entry DOI: 10.7270/Q2CV4M3Z | |||||||||||
More data for this Ligand-Target Pair |
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