Found 36 hits Enz. Inhib. hit(s) with Target = 'Voltage-dependent L-type calcium channel subunit alpha-1F' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50499290
(CHEMBL3734797)Show SMILES Cc1noc(n1)[C@H]1C[C@@H]1C(=O)NCc1ccc(-c2cccc(OC(F)(F)F)c2)c2CCN(Cc12)C(=O)NC(C)(C)C |r| Show InChI InChI=1S/C29H32F3N5O4/c1-16-34-26(41-36-16)23-13-22(23)25(38)33-14-18-8-9-20(17-6-5-7-19(12-17)40-29(30,31)32)21-10-11-37(15-24(18)21)27(39)35-28(2,3)4/h5-9,12,22-23H,10-11,13-15H2,1-4H3,(H,33,38)(H,35,39)/t22-,23-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co., Inc.
Curated by ChEMBL
| Assay Description Inhibition of voltage-gated calcium channel (unknown origin) |
J Med Chem 58: 9345-53 (2015)
Article DOI: 10.1021/acs.jmedchem.5b01345 BindingDB Entry DOI: 10.7270/Q28W3H9F |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Mus musculus) | BDBM50101817
(Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CH...)Show SMILES COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC |c:4,9| Show InChI InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Brussels
Curated by ChEMBL
| Assay Description Antagonist activity at voltage-dependent L-type calcium channel in mouse neurobalstoma-rat glioma NG 108-15 hybrid cells assessed as inhibition of KC... |
J Nat Prod 56: 1007-15 (1993)
Article DOI: 10.1021/np50097a004 BindingDB Entry DOI: 10.7270/Q2ZG6W1M |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50461592
(CHEMBL4228929)Show SMILES Cc1ccc2n(Cc3ccccc3[N+]([O-])=O)cc(CN3CCCCC3)c2c1 Show InChI InChI=1S/C22H25N3O2/c1-17-9-10-22-20(13-17)19(14-23-11-5-2-6-12-23)16-24(22)15-18-7-3-4-8-21(18)25(26)27/h3-4,7-10,13,16H,2,5-6,11-12,14-15H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Aut£noma de Madrid
Curated by ChEMBL
| Assay Description Inhibition of KCl-induced cytosolic voltage gated calcium channel opening in human SH-SY5Y cells by Fluo-4 AM dye based fluorescence assay |
Bioorg Med Chem 26: 2551-2560 (2018)
Article DOI: 10.1016/j.bmc.2018.04.019 BindingDB Entry DOI: 10.7270/Q24Q7XM0 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50461590
(CHEMBL4226021)Show InChI InChI=1S/C22H25ClN2/c1-17-8-9-22-21(12-17)19(15-24-10-3-2-4-11-24)16-25(22)14-18-6-5-7-20(23)13-18/h5-9,12-13,16H,2-4,10-11,14-15H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Aut£noma de Madrid
Curated by ChEMBL
| Assay Description Inhibition of KCl-induced cytosolic voltage gated calcium channel opening in human SH-SY5Y cells by Fluo-4 AM dye based fluorescence assay |
Bioorg Med Chem 26: 2551-2560 (2018)
Article DOI: 10.1016/j.bmc.2018.04.019 BindingDB Entry DOI: 10.7270/Q24Q7XM0 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50461591
(CHEMBL4228209)Show InChI InChI=1S/C22H25ClN2/c1-17-5-10-22-21(13-17)19(15-24-11-3-2-4-12-24)16-25(22)14-18-6-8-20(23)9-7-18/h5-10,13,16H,2-4,11-12,14-15H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Aut£noma de Madrid
Curated by ChEMBL
| Assay Description Inhibition of KCl-induced cytosolic voltage gated calcium channel opening in human SH-SY5Y cells by Fluo-4 AM dye based fluorescence assay |
Bioorg Med Chem 26: 2551-2560 (2018)
Article DOI: 10.1016/j.bmc.2018.04.019 BindingDB Entry DOI: 10.7270/Q24Q7XM0 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50461594
(CHEMBL4224773)Show SMILES Cc1ccc2n(Cc3cccc(c3)[N+]([O-])=O)cc(CN3CCCCC3)c2c1 Show InChI InChI=1S/C22H25N3O2/c1-17-8-9-22-21(12-17)19(15-23-10-3-2-4-11-23)16-24(22)14-18-6-5-7-20(13-18)25(26)27/h5-9,12-13,16H,2-4,10-11,14-15H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Aut£noma de Madrid
Curated by ChEMBL
| Assay Description Inhibition of KCl-induced cytosolic voltage gated calcium channel opening in human SH-SY5Y cells by Fluo-4 AM dye based fluorescence assay |
Bioorg Med Chem 26: 2551-2560 (2018)
Article DOI: 10.1016/j.bmc.2018.04.019 BindingDB Entry DOI: 10.7270/Q24Q7XM0 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50461593
(CHEMBL4226275)Show InChI InChI=1S/C22H26N2/c1-18-10-11-22-21(14-18)20(16-23-12-6-3-7-13-23)17-24(22)15-19-8-4-2-5-9-19/h2,4-5,8-11,14,17H,3,6-7,12-13,15-16H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Aut£noma de Madrid
Curated by ChEMBL
| Assay Description Inhibition of KCl-induced cytosolic voltage gated calcium channel opening in human SH-SY5Y cells by Fluo-4 AM dye based fluorescence assay |
Bioorg Med Chem 26: 2551-2560 (2018)
Article DOI: 10.1016/j.bmc.2018.04.019 BindingDB Entry DOI: 10.7270/Q24Q7XM0 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50461588
(CHEMBL4226864)Show InChI InChI=1S/C23H28N2/c1-18-6-9-20(10-7-18)15-25-17-21(16-24-12-4-3-5-13-24)22-14-19(2)8-11-23(22)25/h6-11,14,17H,3-5,12-13,15-16H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Aut£noma de Madrid
Curated by ChEMBL
| Assay Description Inhibition of KCl-induced cytosolic voltage gated calcium channel opening in human SH-SY5Y cells by Fluo-4 AM dye based fluorescence assay |
Bioorg Med Chem 26: 2551-2560 (2018)
Article DOI: 10.1016/j.bmc.2018.04.019 BindingDB Entry DOI: 10.7270/Q24Q7XM0 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50461589
(CHEMBL4225271)Show InChI InChI=1S/C22H25FN2/c1-17-5-10-22-21(13-17)19(15-24-11-3-2-4-12-24)16-25(22)14-18-6-8-20(23)9-7-18/h5-10,13,16H,2-4,11-12,14-15H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universidad Aut£noma de Madrid
Curated by ChEMBL
| Assay Description Inhibition of KCl-induced cytosolic voltage gated calcium channel opening in human SH-SY5Y cells by Fluo-4 AM dye based fluorescence assay |
Bioorg Med Chem 26: 2551-2560 (2018)
Article DOI: 10.1016/j.bmc.2018.04.019 BindingDB Entry DOI: 10.7270/Q24Q7XM0 |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50529710
(CHEMBL4449273)Show SMILES CCCCCCCNC(=O)C12C3C(C(c4ccccc14)c1ccccc21)C(=O)NC3=O |TLB:18:19:25.20:12.11,24:25:19.14:12.11,26:12:19.14:25.20| Show InChI InChI=1S/C26H28N2O3/c1-2-3-4-5-10-15-27-25(31)26-18-13-8-6-11-16(18)20(17-12-7-9-14-19(17)26)21-22(26)24(30)28-23(21)29/h6-9,11-14,20-22H,2-5,10,15H2,1H3,(H,27,31)(H,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
| Assay Description Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-... |
Eur J Med Chem 163: 394-402 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.003 BindingDB Entry DOI: 10.7270/Q26W9FHZ |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50486498
(CHEMBL252580)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCCc3c(N)c2c1-c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C25H29N3O4/c1-5-32-25(29)20-14(2)27-24-22(23(26)16-9-7-6-8-10-17(16)28-24)21(20)15-11-12-18(30-3)19(13-15)31-4/h11-13H,5-10H2,1-4H3,(H2,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50540101
(CHEMBL4643402)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCCc3c(N)c2c1-c1cccc(OC)c1 Show InChI InChI=1S/C24H27N3O3/c1-4-30-24(28)19-14(2)26-23-21(20(19)15-9-8-10-16(13-15)29-3)22(25)17-11-6-5-7-12-18(17)27-23/h8-10,13H,4-7,11-12H2,1-3H3,(H2,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50529710
(CHEMBL4449273)Show SMILES CCCCCCCNC(=O)C12C3C(C(c4ccccc14)c1ccccc21)C(=O)NC3=O |TLB:18:19:25.20:12.11,24:25:19.14:12.11,26:12:19.14:25.20| Show InChI InChI=1S/C26H28N2O3/c1-2-3-4-5-10-15-27-25(31)26-18-13-8-6-11-16(18)20(17-12-7-9-14-19(17)26)21-22(26)24(30)28-23(21)29/h6-9,11-14,20-22H,2-5,10,15H2,1H3,(H,27,31)(H,28,29,30) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
| Assay Description Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-... |
Eur J Med Chem 163: 394-402 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.003 BindingDB Entry DOI: 10.7270/Q26W9FHZ |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50486479
(CHEMBL252781)Show SMILES CC(C)OC(=O)c1c(C)nc2nc3CCCCc3c(N)c2c1-c1ccccc1 Show InChI InChI=1S/C23H25N3O2/c1-13(2)28-23(27)18-14(3)25-22-20(19(18)15-9-5-4-6-10-15)21(24)16-11-7-8-12-17(16)26-22/h4-6,9-10,13H,7-8,11-12H2,1-3H3,(H2,24,25,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50486480
(CHEMBL2234542)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCCCc3c(N)c2c1-c1ccccc1 Show InChI InChI=1S/C24H27N3O2/c1-3-29-24(28)19-15(2)26-23-21(20(19)16-11-7-6-8-12-16)22(25)17-13-9-4-5-10-14-18(17)27-23/h6-8,11-12H,3-5,9-10,13-14H2,1-2H3,(H2,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50529711
(CHEMBL514508)Show SMILES Clc1cccc2C3C4C(C(c5ccccc35)c12)C(=O)NC4=O |TLB:20:7:16.5:10.15,17:8:16.5:10.15,1:16:10.15:8.7,11:10:16.5:8.7,THB:4:5:10.15:8.7,14:15:16.5:8.7| Show InChI InChI=1S/C18H12ClNO2/c19-11-7-3-6-10-12-8-4-1-2-5-9(8)14(13(10)11)16-15(12)17(21)20-18(16)22/h1-7,12,14-16H,(H,20,21,22) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
| Assay Description Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-... |
Eur J Med Chem 163: 394-402 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.003 BindingDB Entry DOI: 10.7270/Q26W9FHZ |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50529711
(CHEMBL514508)Show SMILES Clc1cccc2C3C4C(C(c5ccccc35)c12)C(=O)NC4=O |TLB:20:7:16.5:10.15,17:8:16.5:10.15,1:16:10.15:8.7,11:10:16.5:8.7,THB:4:5:10.15:8.7,14:15:16.5:8.7| Show InChI InChI=1S/C18H12ClNO2/c19-11-7-3-6-10-12-8-4-1-2-5-9(8)14(13(10)11)16-15(12)17(21)20-18(16)22/h1-7,12,14-16H,(H,20,21,22) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
| Assay Description Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-... |
Eur J Med Chem 163: 394-402 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.003 BindingDB Entry DOI: 10.7270/Q26W9FHZ |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50540100
(CHEMBL4637869)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCCc3c(N)c2c1-c1ccc(cc1)[N+]([O-])=O Show InChI InChI=1S/C23H24N4O4/c1-3-31-23(28)18-13(2)25-22-20(19(18)14-9-11-15(12-10-14)27(29)30)21(24)16-7-5-4-6-8-17(16)26-22/h9-12H,3-8H2,1-2H3,(H2,24,25,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50101971
(BAY-E-9736 | CHEBI:7575 | Nimodipine | Nimotop)Show SMILES COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C |c:7,12| Show InChI InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3 | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
DrugBank MCE KEGG PC cid PC sid PDB UniChem
| DrugBank Article PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
| Assay Description Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-... |
Eur J Med Chem 163: 394-402 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.003 BindingDB Entry DOI: 10.7270/Q26W9FHZ |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50101971
(BAY-E-9736 | CHEBI:7575 | Nimodipine | Nimotop)Show SMILES COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C |c:7,12| Show InChI InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3 | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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DrugBank MCE KEGG PC cid PC sid PDB UniChem
| DrugBank Article PubMed
| n/a | n/a | 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
| Assay Description Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-... |
Eur J Med Chem 163: 394-402 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.003 BindingDB Entry DOI: 10.7270/Q26W9FHZ |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50486484
(CHEMBL399040)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCc3c(N)c2c1-c1cccc(OC)c1 Show InChI InChI=1S/C23H25N3O3/c1-4-29-23(27)18-13(2)25-22-20(19(18)14-8-7-9-15(12-14)28-3)21(24)16-10-5-6-11-17(16)26-22/h7-9,12H,4-6,10-11H2,1-3H3,(H2,24,25,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50293136
(4-Chloro-17-Azapentacycle[6.6.5.0(2,7).0(9,14).0(1...)Show SMILES Clc1ccc2C3C4C(C(c5ccccc35)c2c1)C(=O)NC4=O |TLB:20:6:15.4:9.14,17:7:15.4:9.14,16:15:9.14:7.6,10:9:15.4:7.6,THB:3:4:9.14:7.6,13:14:15.4:7.6| Show InChI InChI=1S/C18H12ClNO2/c19-8-5-6-11-12(7-8)14-10-4-2-1-3-9(10)13(11)15-16(14)18(22)20-17(15)21/h1-7,13-16H,(H,20,21,22) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
| Assay Description Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-... |
Eur J Med Chem 163: 394-402 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.003 BindingDB Entry DOI: 10.7270/Q26W9FHZ |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50529709
(CHEMBL4590632)Show SMILES ClC12C3C(C(=O)NC3=O)C(Cl)(c3ccccc13)c1ccccc21 |TLB:15:16:22.17:3.2,21:22:16.11:3.2,4:3:16.11:22.17| Show InChI InChI=1S/C18H11Cl2NO2/c19-17-9-5-1-2-6-10(9)18(20,12-8-4-3-7-11(12)17)14-13(17)15(22)21-16(14)23/h1-8,13-14H,(H,21,22,23) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
| Assay Description Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-... |
Eur J Med Chem 163: 394-402 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.003 BindingDB Entry DOI: 10.7270/Q26W9FHZ |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50293136
(4-Chloro-17-Azapentacycle[6.6.5.0(2,7).0(9,14).0(1...)Show SMILES Clc1ccc2C3C4C(C(c5ccccc35)c2c1)C(=O)NC4=O |TLB:20:6:15.4:9.14,17:7:15.4:9.14,16:15:9.14:7.6,10:9:15.4:7.6,THB:3:4:9.14:7.6,13:14:15.4:7.6| Show InChI InChI=1S/C18H12ClNO2/c19-8-5-6-11-12(7-8)14-10-4-2-1-3-9(10)13(11)15-16(14)18(22)20-17(15)21/h1-7,13-16H,(H,20,21,22) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
| Assay Description Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-... |
Eur J Med Chem 163: 394-402 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.003 BindingDB Entry DOI: 10.7270/Q26W9FHZ |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50529709
(CHEMBL4590632)Show SMILES ClC12C3C(C(=O)NC3=O)C(Cl)(c3ccccc13)c1ccccc21 |TLB:15:16:22.17:3.2,21:22:16.11:3.2,4:3:16.11:22.17| Show InChI InChI=1S/C18H11Cl2NO2/c19-17-9-5-1-2-6-10(9)18(20,12-8-4-3-7-11(12)17)14-13(17)15(22)21-16(14)23/h1-8,13-14H,(H,21,22,23) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Alma Mater Studiorum-University of Bologna
Curated by ChEMBL
| Assay Description Inhibition of K+-induced voltage gated calcium channel opening in human SH-SY5Y cells assessed as decrease in Ca2+ level after 10 mins by Fluo-4 dye-... |
Eur J Med Chem 163: 394-402 (2019)
Article DOI: 10.1016/j.ejmech.2018.12.003 BindingDB Entry DOI: 10.7270/Q26W9FHZ |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50486442
(CHEMBL252578)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCCc3c(N)c2c1-c1ccc(F)cc1 Show InChI InChI=1S/C23H24FN3O2/c1-3-29-23(28)18-13(2)26-22-20(19(18)14-9-11-15(24)12-10-14)21(25)16-7-5-4-6-8-17(16)27-22/h9-12H,3-8H2,1-2H3,(H2,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM8961
(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)Show InChI InChI=1S/C13H14N2/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1,3,5,7H,2,4,6,8H2,(H2,14,15) | PDB
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UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50486502
(CHEMBL2234539)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCCc3c(N)c2c1-c1ccccc1OC |(24.57,-8.62,;25.9,-7.85,;27.24,-8.61,;28.57,-7.84,;28.57,-6.3,;29.9,-8.61,;29.9,-10.15,;28.57,-10.92,;31.23,-10.92,;32.57,-10.15,;33.9,-10.92,;35.23,-10.14,;36.46,-11.11,;37.99,-10.75,;38.65,-9.33,;37.97,-7.92,;36.44,-7.59,;35.22,-8.58,;33.88,-7.83,;33.88,-6.29,;32.57,-8.61,;31.23,-7.84,;31.23,-6.3,;32.57,-5.53,;32.56,-4,;31.23,-3.23,;29.89,-4.01,;29.9,-5.54,;28.36,-5.53,;27.59,-4.2,)| Show InChI InChI=1S/C24H27N3O3/c1-4-30-24(28)19-14(2)26-23-21(20(19)16-11-8-9-13-18(16)29-3)22(25)15-10-6-5-7-12-17(15)27-23/h8-9,11,13H,4-7,10,12H2,1-3H3,(H2,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50486504
(CHEMBL400675)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCc3c(N)c2c1-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C22H22N4O4/c1-3-30-22(27)17-12(2)24-21-19(20(23)15-9-4-5-10-16(15)25-21)18(17)13-7-6-8-14(11-13)26(28)29/h6-8,11H,3-5,9-10H2,1-2H3,(H2,23,24,25) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50241350
(5-Amino-2-methyl-4-phenyl-6,7,8,9-tetrahydro-benzo...)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCc3c(N)c2c1-c1ccccc1 Show InChI InChI=1S/C22H23N3O2/c1-3-27-22(26)17-13(2)24-21-19(18(17)14-9-5-4-6-10-14)20(23)15-11-7-8-12-16(15)25-21/h4-6,9-10H,3,7-8,11-12H2,1-2H3,(H2,23,24,25) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50486497
(CHEMBL2234543)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCCCc3c(N)c2c1-c1ccc(OC)cc1 Show InChI InChI=1S/C25H29N3O3/c1-4-31-25(29)20-15(2)27-24-22(21(20)16-11-13-17(30-3)14-12-16)23(26)18-9-7-5-6-8-10-19(18)28-24/h11-14H,4-10H2,1-3H3,(H2,26,27,28) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50486486
(CHEMBL2234538)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCCc3c(N)c2c1-c1ccc(C)cc1 Show InChI InChI=1S/C24H27N3O2/c1-4-29-24(28)19-15(3)26-23-21(20(19)16-12-10-14(2)11-13-16)22(25)17-8-6-5-7-9-18(17)27-23/h10-13H,4-9H2,1-3H3,(H2,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50486483
(CHEMBL252379)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCc3c(N)c2c1-c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C24H27N3O4/c1-5-31-24(28)19-13(2)26-23-21(22(25)15-8-6-7-9-16(15)27-23)20(19)14-10-11-17(29-3)18(12-14)30-4/h10-12H,5-9H2,1-4H3,(H2,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50486482
(CHEMBL2234540)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCCc3c(N)c2c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C23H24ClN3O2/c1-3-29-23(28)18-13(2)26-22-20(19(18)14-9-11-15(24)12-10-14)21(25)16-7-5-4-6-8-17(16)27-22/h9-12H,3-8H2,1-2H3,(H2,25,26,27) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50486445
(CHEMBL252579)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCc3c(N)c2c1-c1ccc(Cl)cc1 Show InChI InChI=1S/C22H22ClN3O2/c1-3-28-22(27)17-12(2)25-21-19(18(17)13-8-10-14(23)11-9-13)20(24)15-6-4-5-7-16(15)26-21/h8-11H,3-7H2,1-2H3,(H2,24,25,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |
Voltage-dependent L-type calcium channel subunit alpha-1F
(Homo sapiens (Human)) | BDBM50401248
(CHEMBL252380)Show SMILES CCOC(=O)c1c(C)nc2nc3CCCCc3c(N)c2c1-c1ccc(F)cc1 Show InChI InChI=1S/C22H22FN3O2/c1-3-28-22(27)17-12(2)25-21-19(18(17)13-8-10-14(23)11-9-13)20(24)15-6-4-5-7-16(15)26-21/h8-11H,3-7H2,1-2H3,(H2,24,25,26) | PDB
KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hospital Universitario de la Princesa
Curated by ChEMBL
| Assay Description Inhibition of VGCC (unknown origin) |
Eur J Med Chem 166: 381-389 (2019)
Article DOI: 10.1016/j.ejmech.2019.02.005 BindingDB Entry DOI: 10.7270/Q23N26XF |
More data for this Ligand-Target Pair | |