Compile Data Set for Download or QSAR

Found 171 hits Enz. Inhib. hit(s) with Target = 'CREB-binding protein/Histone acetyltransferase p300'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200375 (CHEMBL3902514) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1ccccc1)nn2CC1CC1 Show InChI InChI=1S/C24H26N4O/c1-17(29)27-13-12-23-22(16-27)24(26-28(23)15-18-10-11-18)25-21-9-5-8-20(14-21)19-6-3-2-4-7-19/h2-9,14,18H,10-13,15-16H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200377 (CHEMBL3962542 | US9763922, Example 64) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1ccncc1)nn2CC1CC1 Show InChI InChI=1S/C23H25N5O/c1-16(29)27-12-9-22-21(15-27)23(26-28(22)14-17-5-6-17)25-20-4-2-3-19(13-20)18-7-10-24-11-8-18/h2-4,7-8,10-11,13,17H,5-6,9,12,14-15H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200428 (CHEMBL3917504 | US9763922, Example 89) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cnn(C)c1)nn2CC1CC1 Show InChI InChI=1S/C22H26N6O/c1-15(29)27-10-9-21-20(14-27)22(25-28(21)12-16-3-4-16)24-19-7-5-17(6-8-19)18-11-23-26(2)13-18/h5-8,11,13,16H,3-4,9-10,12,14H2,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200376 (CHEMBL3896323) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cnn(C)c1)nn2[C@@H]1CCOC1 |r| Show InChI InChI=1S/C22H26N6O2/c1-15(29)27-9-7-21-20(13-27)22(25-28(21)19-8-10-30-14-19)24-18-5-3-16(4-6-18)17-11-23-26(2)12-17/h3-6,11-12,19H,7-10,13-14H2,1-2H3,(H,24,25)/t19-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200429 (CHEMBL3981511 | US9763922, Example 67) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cnn(C)c1)nn2CC1CC1 Show InChI InChI=1S/C22H26N6O/c1-15(29)27-9-8-21-20(14-27)22(25-28(21)12-16-6-7-16)24-19-5-3-4-17(10-19)18-11-23-26(2)13-18/h3-5,10-11,13,16H,6-9,12,14H2,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50286461 (CHEMBL4166626) Show SMILES CNC(=O)Nc1ccc2c(CC[C@@]22OC(=O)N(CC(=O)N(Cc3ccccc3)[C@@H](C)C3CC3)C2=O)c1 |r| Show InChI InChI=1S/C27H30N4O5/c1-17(19-8-9-19)30(15-18-6-4-3-5-7-18)23(32)16-31-24(33)27(36-26(31)35)13-12-20-14-21(10-11-22(20)27)29-25(34)28-2/h3-7,10-11,14,17,19H,8-9,12-13,15-16H2,1-2H3,(H2,28,29,34)/t17-,27+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie, Inc. Curated by ChEMBL					Assay Description Inhibition of p300/CBP (unknown origin) using biotinylated synthetic Histone H4 Peptide as substrate pretreated for 30 mins followed by substrate add...				ACS Med Chem Lett 9: 28-33 (2018) Article DOI: 10.1021/acsmedchemlett.7b00395 BindingDB Entry DOI: 10.7270/Q2HQ42FP
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200459 (CHEMBL3920459 | US9763922, Example 71) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cnoc1)nn2CC1CC1 Show InChI InChI=1S/C21H23N5O2/c1-14(27)25-8-7-20-19(12-25)21(24-26(20)11-15-5-6-15)23-18-4-2-3-16(9-18)17-10-22-28-13-17/h2-4,9-10,13,15H,5-8,11-12H2,1H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200430 (CHEMBL3893541 | US9763922, Example 63) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cccnc1)nn2CC1CC1 Show InChI InChI=1S/C23H25N5O/c1-16(29)27-11-9-22-21(15-27)23(26-28(22)14-17-7-8-17)25-20-6-2-4-18(12-20)19-5-3-10-24-13-19/h2-6,10,12-13,17H,7-9,11,14-15H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200431 (CHEMBL3889679 | US9763922, Example 218) Show SMILES CC(C)NC(=O)c1cccc(Nc2nn(CC3CC3)c3CCN(Cc23)C(C)=O)c1 Show InChI InChI=1S/C22H29N5O2/c1-14(2)23-22(29)17-5-4-6-18(11-17)24-21-19-13-26(15(3)28)10-9-20(19)27(25-21)12-16-7-8-16/h4-6,11,14,16H,7-10,12-13H2,1-3H3,(H,23,29)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair				3D Structure (crystal)
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200427 (CHEMBL3924330 | US9763922, Example 179) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cnn(C)c1)nn2[C@H]1CCOC1 |r| Show InChI InChI=1S/C22H26N6O2/c1-15(29)27-9-7-21-20(13-27)22(25-28(21)19-8-10-30-14-19)24-18-5-3-16(4-6-18)17-11-23-26(2)12-17/h3-6,11-12,19H,7-10,13-14H2,1-2H3,(H,24,25)/t19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200425 (CHEMBL3934488) Show SMILES CCCNC(=O)c1cccc(Nc2nn(CC3CC3)c3CCN(Cc23)C(C)=O)c1 Show InChI InChI=1S/C22H29N5O2/c1-3-10-23-22(29)17-5-4-6-18(12-17)24-21-19-14-26(15(2)28)11-9-20(19)27(25-21)13-16-7-8-16/h4-6,12,16H,3,7-11,13-14H2,1-2H3,(H,23,29)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200390 (CHEMBL3892467 | US9763922, Example 70) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cn[nH]c1)nn2CC1CC1 Show InChI InChI=1S/C21H24N6O/c1-14(28)26-8-7-20-19(13-26)21(25-27(20)12-15-5-6-15)24-18-4-2-3-16(9-18)17-10-22-23-11-17/h2-4,9-11,15H,5-8,12-13H2,1H3,(H,22,23)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200383 (CHEMBL3938408 | US9763922, Example 73) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1ccnn1C)nn2CC1CC1 Show InChI InChI=1S/C22H26N6O/c1-15(29)27-11-9-21-19(14-27)22(25-28(21)13-16-6-7-16)24-18-5-3-4-17(12-18)20-8-10-23-26(20)2/h3-5,8,10,12,16H,6-7,9,11,13-14H2,1-2H3,(H,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200423 (CHEMBL3911524) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cc[nH]n1)nn2CC1CC1 Show InChI InChI=1S/C21H24N6O/c1-14(28)26-10-8-20-18(13-26)21(25-27(20)12-15-5-6-15)23-17-4-2-3-16(11-17)19-7-9-22-24-19/h2-4,7,9,11,15H,5-6,8,10,12-13H2,1H3,(H,22,24)(H,23,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200397 (CHEMBL3973515 | US9763922, Example 79) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1ccccn1)nn2CC1CC1 Show InChI InChI=1S/C23H25N5O/c1-16(29)27-12-10-22-20(15-27)23(26-28(22)14-17-8-9-17)25-19-6-4-5-18(13-19)21-7-2-3-11-24-21/h2-7,11,13,17H,8-10,12,14-15H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50286424 (CHEMBL4170186) Show SMILES CNC(=O)Nc1ccc2c(CC[C@@]22OC(=O)N(CC(=O)N(Cc3ccccc3)[C@H](C3CC3)C(F)(F)F)C2=O)c1 |r| Show InChI InChI=1S/C27H27F3N4O5/c1-31-24(37)32-19-9-10-20-18(13-19)11-12-26(20)23(36)34(25(38)39-26)15-21(35)33(14-16-5-3-2-4-6-16)22(17-7-8-17)27(28,29)30/h2-6,9-10,13,17,22H,7-8,11-12,14-15H2,1H3,(H2,31,32,37)/t22-,26-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie, Inc. Curated by ChEMBL					Assay Description Inhibition of p300/CBP (unknown origin) using biotinylated synthetic Histone H4 Peptide as substrate pretreated for 30 mins followed by substrate add...				ACS Med Chem Lett 9: 28-33 (2018) Article DOI: 10.1021/acsmedchemlett.7b00395 BindingDB Entry DOI: 10.7270/Q2HQ42FP
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200424 (CHEMBL3915331) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cnn(C)c1)nn2C1COC1 Show InChI InChI=1S/C21H24N6O2/c1-14(28)26-8-7-20-19(11-26)21(24-27(20)18-12-29-13-18)23-17-5-3-15(4-6-17)16-9-22-25(2)10-16/h3-6,9-10,18H,7-8,11-13H2,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200378 (CHEMBL3906525) Show SMILES CCNC(=O)c1cccc(Nc2nn(CC3CC3)c3CCN(Cc23)C(C)=O)c1 Show InChI InChI=1S/C21H27N5O2/c1-3-22-21(28)16-5-4-6-17(11-16)23-20-18-13-25(14(2)27)10-9-19(18)26(24-20)12-15-7-8-15/h4-6,11,15H,3,7-10,12-13H2,1-2H3,(H,22,28)(H,23,24)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200421 (CHEMBL3985118 | US9763922, Example 173) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1ccc(cc1)-c1cnn(C)c1)nn2C Show InChI InChI=1S/C19H22N6O/c1-13(26)25-9-8-18-17(12-25)19(22-24(18)3)21-16-6-4-14(5-7-16)15-10-20-23(2)11-15/h4-7,10-11H,8-9,12H2,1-3H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50286424 (CHEMBL4170186) Show SMILES CNC(=O)Nc1ccc2c(CC[C@@]22OC(=O)N(CC(=O)N(Cc3ccccc3)[C@H](C3CC3)C(F)(F)F)C2=O)c1 |r| Show InChI InChI=1S/C27H27F3N4O5/c1-31-24(37)32-19-9-10-20-18(13-19)11-12-26(20)23(36)34(25(38)39-26)15-21(35)33(14-16-5-3-2-4-6-16)22(17-7-8-17)27(28,29)30/h2-6,9-10,13,17,22H,7-8,11-12,14-15H2,1H3,(H2,31,32,37)/t22-,26-/m1/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie, Inc. Curated by ChEMBL					Assay Description Inhibition of p300/CBP in human PC3 cells assessed as reduction in acetylated H3K27 levels after 3 hrs by fluorescence assay				ACS Med Chem Lett 9: 28-33 (2018) Article DOI: 10.1021/acsmedchemlett.7b00395 BindingDB Entry DOI: 10.7270/Q2HQ42FP
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50286461 (CHEMBL4166626) Show SMILES CNC(=O)Nc1ccc2c(CC[C@@]22OC(=O)N(CC(=O)N(Cc3ccccc3)[C@@H](C)C3CC3)C2=O)c1 |r| Show InChI InChI=1S/C27H30N4O5/c1-17(19-8-9-19)30(15-18-6-4-3-5-7-18)23(32)16-31-24(33)27(36-26(31)35)13-12-20-14-21(10-11-22(20)27)29-25(34)28-2/h3-7,10-11,14,17,19H,8-9,12-13,15-16H2,1-2H3,(H2,28,29,34)/t17-,27+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	47	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie, Inc. Curated by ChEMBL					Assay Description Inhibition of p300/CBP in human PC3 cells assessed as reduction in acetylated H3K27 levels after 3 hrs by fluorescence assay				ACS Med Chem Lett 9: 28-33 (2018) Article DOI: 10.1021/acsmedchemlett.7b00395 BindingDB Entry DOI: 10.7270/Q2HQ42FP
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200379 (CHEMBL3962757 | US9763922, Example 201) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2CC1CC1 Show InChI InChI=1S/C19H24N4O/c1-13-4-3-5-16(10-13)20-19-17-12-22(14(2)24)9-8-18(17)23(21-19)11-15-6-7-15/h3-5,10,15H,6-9,11-12H2,1-2H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50286423 (CHEMBL4174931) Show SMILES CNC(=O)Nc1ccc2c(CC[C@@]22OC(=O)N(CC(=O)N(Cc3ccccc3)[C@@H](C)C(F)(F)F)C2=O)c1 |r| Show InChI InChI=1S/C25H25F3N4O5/c1-15(25(26,27)28)31(13-16-6-4-3-5-7-16)20(33)14-32-21(34)24(37-23(32)36)11-10-17-12-18(8-9-19(17)24)30-22(35)29-2/h3-9,12,15H,10-11,13-14H2,1-2H3,(H2,29,30,35)/t15-,24+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie, Inc. Curated by ChEMBL					Assay Description Inhibition of p300/CBP (unknown origin) using biotinylated synthetic Histone H4 Peptide as substrate pretreated for 30 mins followed by substrate add...				ACS Med Chem Lett 9: 28-33 (2018) Article DOI: 10.1021/acsmedchemlett.7b00395 BindingDB Entry DOI: 10.7270/Q2HQ42FP
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200455 (CHEMBL3915504 | US9763922, Example 219) Show SMILES CNC(=O)c1cccc(Nc2nn(CC3CC3)c3CCN(Cc23)C(C)=O)c1 Show InChI InChI=1S/C20H25N5O2/c1-13(26)24-9-8-18-17(12-24)19(23-25(18)11-14-6-7-14)22-16-5-3-4-15(10-16)20(27)21-2/h3-5,10,14H,6-9,11-12H2,1-2H3,(H,21,27)(H,22,23)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200426 (CHEMBL3980755) Show SMILES CCCn1nc(Nc2cccc(C)c2)c2CN(CCc12)C(C)=O Show InChI InChI=1S/C18H24N4O/c1-4-9-22-17-8-10-21(14(3)23)12-16(17)18(20-22)19-15-7-5-6-13(2)11-15/h5-7,11H,4,8-10,12H2,1-3H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200398 (CHEMBL3910675 | US9763922, Example 199) Show SMILES CCn1nc(Nc2cccc(C)c2)c2CN(CCc12)C(C)=O Show InChI InChI=1S/C17H22N4O/c1-4-21-16-8-9-20(13(3)22)11-15(16)17(19-21)18-14-7-5-6-12(2)10-14/h5-7,10H,4,8-9,11H2,1-3H3,(H,18,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200389 (CHEMBL3936675 | US9763922, Example 195) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2Cc1ccccn1 Show InChI InChI=1S/C21H23N5O/c1-15-6-5-8-17(12-15)23-21-19-14-25(16(2)27)11-9-20(19)26(24-21)13-18-7-3-4-10-22-18/h3-8,10,12H,9,11,13-14H2,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200381 (CHEMBL3898753) Show SMILES CC(=O)N1CCc2[nH]nc(Nc3cccc(c3)C(F)(F)F)c2C1 Show InChI InChI=1S/C15H15F3N4O/c1-9(23)22-6-5-13-12(8-22)14(21-20-13)19-11-4-2-3-10(7-11)15(16,17)18/h2-4,7H,5-6,8H2,1H3,(H2,19,20,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50524837 (CHEMBL4441544) Show SMILES O=C1N(CCc2ccccc2)C(=S)S\C1=C/c1ccc(o1)-c1ccc(cc1)C#N Show InChI InChI=1S/C23H16N2O2S2/c24-15-17-6-8-18(9-7-17)20-11-10-19(27-20)14-21-22(26)25(23(28)29-21)13-12-16-4-2-1-3-5-16/h1-11,14H,12-13H2/b21-14-	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibition of GST-tagged p300 (unknown origin)/CBP (unknown origin) protein-protein interaction				J Med Chem 62: 5725-5749 (2019) Article DOI: 10.1021/acs.jmedchem.8b01596 BindingDB Entry DOI: 10.7270/Q2QF8X9V
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50286423 (CHEMBL4174931) Show SMILES CNC(=O)Nc1ccc2c(CC[C@@]22OC(=O)N(CC(=O)N(Cc3ccccc3)[C@@H](C)C(F)(F)F)C2=O)c1 |r| Show InChI InChI=1S/C25H25F3N4O5/c1-15(25(26,27)28)31(13-16-6-4-3-5-7-16)20(33)14-32-21(34)24(37-23(32)36)11-10-17-12-18(8-9-19(17)24)30-22(35)29-2/h3-9,12,15H,10-11,13-14H2,1-2H3,(H2,29,30,35)/t15-,24+/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	101	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie, Inc. Curated by ChEMBL					Assay Description Inhibition of p300/CBP in human PC3 cells assessed as reduction in acetylated H3K27 levels after 3 hrs by fluorescence assay				ACS Med Chem Lett 9: 28-33 (2018) Article DOI: 10.1021/acsmedchemlett.7b00395 BindingDB Entry DOI: 10.7270/Q2HQ42FP
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200440 (CHEMBL3907779) Show SMILES COC(=O)c1cccc(Nc2n[nH]c3CCN(Cc23)C(C)=O)c1 Show InChI InChI=1S/C16H18N4O3/c1-10(21)20-7-6-14-13(9-20)15(19-18-14)17-12-5-3-4-11(8-12)16(22)23-2/h3-5,8H,6-7,9H2,1-2H3,(H2,17,18,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50286465 (CHEMBL4177251) Show SMILES CNC(=O)Nc1ccc2c(CC[C@]22OC(=O)N(CC(=O)N(Cc3ccccc3)[C@@H](C)C3CC3)C2=O)c1 |r| Show InChI InChI=1S/C27H30N4O5/c1-17(19-8-9-19)30(15-18-6-4-3-5-7-18)23(32)16-31-24(33)27(36-26(31)35)13-12-20-14-21(10-11-22(20)27)29-25(34)28-2/h3-7,10-11,14,17,19H,8-9,12-13,15-16H2,1-2H3,(H2,28,29,34)/t17-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	121	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie, Inc. Curated by ChEMBL					Assay Description Inhibition of p300/CBP (unknown origin) using biotinylated synthetic Histone H4 Peptide as substrate pretreated for 30 mins followed by substrate add...				ACS Med Chem Lett 9: 28-33 (2018) Article DOI: 10.1021/acsmedchemlett.7b00395 BindingDB Entry DOI: 10.7270/Q2HQ42FP
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200435 (CHEMBL3897524 | US9763922, Example 203) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2Cc1ccccc1 Show InChI InChI=1S/C22H24N4O/c1-16-7-6-10-19(13-16)23-22-20-15-25(17(2)27)12-11-21(20)26(24-22)14-18-8-4-3-5-9-18/h3-10,13H,11-12,14-15H2,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200453 (CHEMBL3926801) Show SMILES COC(=O)c1ccc(Nc2n[nH]c3CCN(Cc23)C(C)=O)cc1 Show InChI InChI=1S/C16H18N4O3/c1-10(21)20-8-7-14-13(9-20)15(19-18-14)17-12-5-3-11(4-6-12)16(22)23-2/h3-6H,7-9H2,1-2H3,(H2,17,18,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200434 (CHEMBL3986361 | US9763922, Example 196) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2Cc1cccnc1 Show InChI InChI=1S/C21H23N5O/c1-15-5-3-7-18(11-15)23-21-19-14-25(16(2)27)10-8-20(19)26(24-21)13-17-6-4-9-22-12-17/h3-7,9,11-12H,8,10,13-14H2,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200444 (CHEMBL3900573 | US9763922, Example 217) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2C1CC1 Show InChI InChI=1S/C18H22N4O/c1-12-4-3-5-14(10-12)19-18-16-11-21(13(2)23)9-8-17(16)22(20-18)15-6-7-15/h3-5,10,15H,6-9,11H2,1-2H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200438 (CHEMBL3891644) Show SMILES CC(=O)N1CCc2[nH]nc(Nc3cccc(OC(F)F)c3)c2C1 Show InChI InChI=1S/C15H16F2N4O2/c1-9(22)21-6-5-13-12(8-21)14(20-19-13)18-10-3-2-4-11(7-10)23-15(16)17/h2-4,7,15H,5-6,8H2,1H3,(H2,18,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50286459 (CHEMBL4163183) Show SMILES CNC(=O)Nc1ccc2c(CC[C@]22NC(=O)N(CC(=O)N(Cc3ccccc3)[C@@H](C)C3CC3)C2=O)c1 |r| Show InChI InChI=1S/C27H31N5O4/c1-17(19-8-9-19)31(15-18-6-4-3-5-7-18)23(33)16-32-24(34)27(30-26(32)36)13-12-20-14-21(10-11-22(20)27)29-25(35)28-2/h3-7,10-11,14,17,19H,8-9,12-13,15-16H2,1-2H3,(H,30,36)(H2,28,29,35)/t17-,27-/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie, Inc. Curated by ChEMBL					Assay Description Inhibition of p300/CBP (unknown origin) using biotinylated synthetic Histone H4 Peptide as substrate pretreated for 30 mins followed by substrate add...				ACS Med Chem Lett 9: 28-33 (2018) Article DOI: 10.1021/acsmedchemlett.7b00395 BindingDB Entry DOI: 10.7270/Q2HQ42FP
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200386 (CHEMBL3909879) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2CCC1CC1 Show InChI InChI=1S/C20H26N4O/c1-14-4-3-5-17(12-14)21-20-18-13-23(15(2)25)10-9-19(18)24(22-20)11-8-16-6-7-16/h3-5,12,16H,6-11,13H2,1-2H3,(H,21,22)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200422 (CHEMBL3963381) Show SMILES CCc1cccc(Nc2n[nH]c3CCN(Cc23)C(C)=O)c1 Show InChI InChI=1S/C16H20N4O/c1-3-12-5-4-6-13(9-12)17-16-14-10-20(11(2)21)8-7-15(14)18-19-16/h4-6,9H,3,7-8,10H2,1-2H3,(H2,17,18,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200433 (CHEMBL3916599 | US9763922, Example 202) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2Cc1ccncc1 Show InChI InChI=1S/C21H23N5O/c1-15-4-3-5-18(12-15)23-21-19-14-25(16(2)27)11-8-20(19)26(24-21)13-17-6-9-22-10-7-17/h3-7,9-10,12H,8,11,13-14H2,1-2H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200387 (CHEMBL3972721 | US9763922, Example 198) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2C Show InChI InChI=1S/C16H20N4O/c1-11-5-4-6-13(9-11)17-16-14-10-20(12(2)21)8-7-15(14)19(3)18-16/h4-6,9H,7-8,10H2,1-3H3,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200391 (CHEMBL3928531 | US9763922, Example 214) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2CCC#N Show InChI InChI=1S/C18H21N5O/c1-13-5-3-6-15(11-13)20-18-16-12-22(14(2)24)10-7-17(16)23(21-18)9-4-8-19/h3,5-6,11H,4,7,9-10,12H2,1-2H3,(H,20,21)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200454 (CHEMBL3919629 | US9763922, Example 188) Show SMILES COCCn1nc(Nc2cccc(C)c2)c2CN(CCc12)C(C)=O Show InChI InChI=1S/C18H24N4O2/c1-13-5-4-6-15(11-13)19-18-16-12-21(14(2)23)8-7-17(16)22(20-18)9-10-24-3/h4-6,11H,7-10,12H2,1-3H3,(H,19,20)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	230	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50286469 (CHEMBL4173894) Show SMILES CNC(=O)Nc1ccc2c(CCC22NC(=O)N(CC(=O)N(Cc3ccccc3)[C@@H](C)C3CC3)C2=O)c1 |r| Show InChI InChI=1S/C27H31N5O4/c1-17(19-8-9-19)31(15-18-6-4-3-5-7-18)23(33)16-32-24(34)27(30-26(32)36)13-12-20-14-21(10-11-22(20)27)29-25(35)28-2/h3-7,10-11,14,17,19H,8-9,12-13,15-16H2,1-2H3,(H,30,36)(H2,28,29,35)/t17-,27?/m0/s1	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	n/a	n/a
AbbVie, Inc. Curated by ChEMBL					Assay Description Inhibition of p300/CBP (unknown origin) using biotinylated synthetic Histone H4 Peptide as substrate pretreated for 30 mins followed by substrate add...				ACS Med Chem Lett 9: 28-33 (2018) Article DOI: 10.1021/acsmedchemlett.7b00395 BindingDB Entry DOI: 10.7270/Q2HQ42FP
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200458 (CHEMBL3935734) Show SMILES CCc1ccc(Nc2n[nH]c3CCN(Cc23)C(C)=O)cc1 Show InChI InChI=1S/C16H20N4O/c1-3-12-4-6-13(7-5-12)17-16-14-10-20(11(2)21)9-8-15(14)18-19-16/h4-7H,3,8-10H2,1-2H3,(H2,17,18,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200377 (CHEMBL3962542 | US9763922, Example 64) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1ccncc1)nn2CC1CC1 Show InChI InChI=1S/C23H25N5O/c1-16(29)27-12-9-22-21(15-27)23(26-28(22)14-17-5-6-17)25-20-4-2-3-19(13-20)18-7-10-24-11-8-18/h2-4,7-8,10-11,13,17H,5-6,9,12,14-15H2,1H3,(H,25,26)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of Halo-tagged histone H3.3 binding to CBP/EP300 (unknown origin) expressed in HEK293 cells measured after overnight incubation by lucifer...				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200456 (CHEMBL3899464) Show SMILES CC(=O)N1CCc2[nH]nc(Nc3ccc(C)cc3)c2C1 Show InChI InChI=1S/C15H18N4O/c1-10-3-5-12(6-4-10)16-15-13-9-19(11(2)20)8-7-14(13)17-18-15/h3-6H,7-9H2,1-2H3,(H2,16,17,18)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200452 (CHEMBL3891576 | US9763922, Example 204) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2CCO Show InChI InChI=1S/C17H22N4O2/c1-12-4-3-5-14(10-12)18-17-15-11-20(13(2)23)7-6-16(15)21(19-17)8-9-22/h3-5,10,22H,6-9,11H2,1-2H3,(H,18,19)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assay				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair
CREB-binding protein/Histone acetyltransferase p300 (Homo sapiens (Human))	BDBM50200390 (CHEMBL3892467 | US9763922, Example 70) Show SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(c1)-c1cn[nH]c1)nn2CC1CC1 Show InChI InChI=1S/C21H24N6O/c1-14(28)26-8-7-20-19(13-26)21(25-27(20)12-15-5-6-15)24-18-4-2-3-16(9-18)17-10-22-23-11-17/h2-4,9-11,15H,5-8,12-13H2,1H3,(H,22,23)(H,24,25)	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	330	n/a	n/a	n/a	n/a	n/a	n/a
Genentech Curated by ChEMBL					Assay Description Inhibition of Halo-tagged histone H3.3 binding to CBP/EP300 (unknown origin) expressed in HEK293 cells measured after overnight incubation by lucifer...				J Med Chem 59: 10549-10563 (2016) Article DOI: 10.1021/acs.jmedchem.6b01022 BindingDB Entry DOI: 10.7270/Q27083DF
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 171 total )  |  Next  |  Last  >>

Jump to: