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Compile Data Set for Download or QSAR

Found 868 hits Enz. Inhib. hit(s) with Target = 'D(1B) dopamine receptor'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50184428
PNG
(4-Chloro-3-hydroxy-7-methyl-5,6,7,8,9,14-hexahydro...)
Show SMILES CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1
Show InChI InChI=1S/C18H20ClNO/c1-20-10-8-13-4-2-3-5-14(13)12-15-6-7-17(21)18(19)16(15)9-11-20/h2-7,21H,8-12H2,1H3
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 0.0530n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay

J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50184428
PNG
(4-Chloro-3-hydroxy-7-methyl-5,6,7,8,9,14-hexahydro...)
Show SMILES CN1CCc2ccccc2Cc2ccc(O)c(Cl)c2CC1
Show InChI InChI=1S/C18H20ClNO/c1-20-10-8-13-4-2-3-5-14(13)12-15-6-7-17(21)18(19)16(15)9-11-20/h2-7,21H,8-12H2,1H3
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 0.0570n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity to D5 dopamine receptor by radioligand binding assay

J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(RAT)		BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1 |r|
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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 0.110n/an/an/an/an/an/an/an/a



Duke University

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 88: 7491-5 (1991)


Article DOI: 10.1073/pnas.88.17.7491
BindingDB Entry DOI: 10.7270/Q2DB80B9
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human)-RAT)		BDBM50164588
PNG
(1-[1-(2-Chloro-phenyl)-cyclopropyl]-6-fluoro-2-met...)
Show SMILES CN1CCc2cc(F)c(O)cc2C1C1(CC1)c1ccccc1Cl
Show InChI InChI=1S/C19H19ClFNO/c1-22-9-6-12-10-16(21)17(23)11-13(12)18(22)19(7-8-19)14-4-2-3-5-15(14)20/h2-5,10-11,18,23H,6-9H2,1H3
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 0.180n/an/an/an/an/an/an/an/a



Universit£ G. D'Annunzio

Curated by ChEMBL


Assay Description
Inhibitory constant for Dopamine receptor D1-like

J Med Chem 48: 2646-54 (2005)


Article DOI: 10.1021/jm040889k
BindingDB Entry DOI: 10.7270/Q2QR4XW2
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50201337
PNG
(11-methoxy-7,14-dimethyl-6,7,8,9,14,15-hexahydro-5...)
Show SMILES COc1ccc2n(C)c3Cc4ccccc4CCN(C)CCc3c2c1
Show InChI InChI=1S/C22H26N2O/c1-23-12-10-16-6-4-5-7-17(16)14-22-19(11-13-23)20-15-18(25-3)8-9-21(20)24(22)2/h4-9,15H,10-14H2,1-3H3
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 0.230n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells

Bioorg Med Chem Lett 17: 1399-402 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.093
BindingDB Entry DOI: 10.7270/Q24T6J1G
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1 |r|
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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 0.300n/an/an/an/an/an/an/an/a



City University of New York

Curated by ChEMBL


Assay Description
Antagonist activity at dopamine D5 receptor (unknown origin)

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127305
BindingDB Entry DOI: 10.7270/Q2377D85
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1 |r|
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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 0.300n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Nature 350: 614-9 (1991)


Article DOI: 10.1038/350614a0
BindingDB Entry DOI: 10.7270/Q2NV9GQR
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50547397
PNG
(LU-31-130 | Lu 31-130 | Zicronapine)
Show SMILES CN1CCN(CC1(C)C)[C@@H]1C[C@H](c2ccc(Cl)cc12)c1ccccc1 |r|
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 0.370n/an/an/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128879
BindingDB Entry DOI: 10.7270/Q2P27346
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50201338
PNG
(7-methyl-6,7,8,9,14,15-hexahydro-5H-indolo[3,2-f][...)
Show SMILES CN1CCc2c(Cc3ccccc3CC1)[nH]c1ccc(O)cc21
Show InChI InChI=1S/C20H22N2O/c1-22-10-8-14-4-2-3-5-15(14)12-20-17(9-11-22)18-13-16(23)6-7-19(18)21-20/h2-7,13,21,23H,8-12H2,1H3
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 0.390n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells

Bioorg Med Chem Lett 17: 1399-402 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.093
BindingDB Entry DOI: 10.7270/Q24T6J1G
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50010301
PNG
(8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-be...)
Show SMILES CN1CCc2cc(Br)c(O)cc2C(C1)c1ccccc1
Show InChI InChI=1S/C17H18BrNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3
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 0.400n/an/an/an/an/an/an/an/a



University of Toronto

Curated by PDSP Ki Database




Nature 350: 614-9 (1991)


Article DOI: 10.1038/350614a0
BindingDB Entry DOI: 10.7270/Q2NV9GQR
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(RAT)		BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1 |r|
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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 0.470n/an/an/an/an/an/an/an/a



University of North Carolina

Curated by PDSP Ki Database




Neuropsychopharmacology 20: 612-27 (1999)


Article DOI: 10.1016/S0893-133X(98)00099-2
BindingDB Entry DOI: 10.7270/Q2ZP44NW
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50004822
PNG
((R)-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine...)
Show SMILES Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
Show InChI InChI=1S/C16H17NO2/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11/h1-5,8-9,14,17-19H,6-7,10H2/t14-/m1/s1
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 0.5n/an/an/an/an/an/an/an/a



City University of New York

Curated by ChEMBL


Assay Description
Agonist activity at dopamine D5 receptor (unknown origin)

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127305
BindingDB Entry DOI: 10.7270/Q2377D85
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50184439
PNG
(3,11-Dihydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibe...)
Show SMILES CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1
Show InChI InChI=1S/C18H21NO2/c1-19-8-6-15-11-17(20)4-2-13(15)10-14-3-5-18(21)12-16(14)7-9-19/h2-5,11-12,20-21H,6-10H2,1H3
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 0.540n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay

J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50151041
PNG
(12-Methyl-9-oxa-12-aza-tricyclo[13.4.0.0*3,8*]nona...)
Show SMILES CN1CCOc2cc(O)ccc2Cc2ccccc2CC1
Show InChI InChI=1S/C18H21NO2/c1-19-9-8-14-4-2-3-5-15(14)12-16-6-7-17(20)13-18(16)21-11-10-19/h2-7,13,20H,8-12H2,1H3
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 0.570n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant dopamine receptor D5

J Med Chem 47: 4155-8 (2004)


Article DOI: 10.1021/jm049720x
BindingDB Entry DOI: 10.7270/Q2WQ0379
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50196234
PNG
(8-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g]...)
Show SMILES CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1
Show InChI InChI=1S/C21H24N2/c1-23-13-6-9-16-7-2-3-8-17(16)15-21-19(12-14-23)18-10-4-5-11-20(18)22-21/h2-5,7-8,10-11,22H,6,9,12-15H2,1H3
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 0.610n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human D5 dopamine receptor expressed in HEK293 cells

J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50592735
PNG
(CHEMBL5201983)
Show SMILES [2H]c1c([2H])c([2H])c([C@@H]2C[C@@H](N3CCNC(C)(C)C3)c3cc(Cl)ccc23)c([2H])c1[2H] |r|
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 0.670n/an/an/an/an/an/an/an/a


TBA



Citation and Details

Article DOI: 10.1016/j.bmcl.2022.128879
BindingDB Entry DOI: 10.7270/Q2P27346
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM86269
PNG
(MCL-209)
Show SMILES Cc1cccc(c1)C1CNCCc2c(Cl)c(O)c(O)cc12
Show InChI InChI=1S/C17H18ClNO2/c1-10-3-2-4-11(7-10)14-9-19-6-5-12-13(14)8-15(20)17(21)16(12)18/h2-4,7-8,14,19-21H,5-6,9H2,1H3
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 0.880n/an/an/an/an/an/an/an/a



Harvard University

Curated by PDSP Ki Database




Eur J Pharmacol 474: 137-40 (2003)


Article DOI: 10.1016/s0014-2999(03)02008-9
BindingDB Entry DOI: 10.7270/Q2DN43MQ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50184440
PNG
(1-Chloro-2-hydroxy-7-methyl-5,6,7,8,9,14-hexahydro...)
Show SMILES CN1CCc2ccccc2Cc2c(CC1)ccc(O)c2Cl
Show InChI InChI=1S/C18H20ClNO/c1-20-10-8-13-4-2-3-5-15(13)12-16-14(9-11-20)6-7-17(21)18(16)19/h2-7,21H,8-12H2,1H3
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 0.980n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity to D5 dopamine receptor by radioligand binding assay

J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(RAT)		BDBM86180
PNG
(CAS_87075-17-0 | NSC_5018 | SCH 23390 | SCH23390 |...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2C(C1)c1ccccc1
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3
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 1n/an/an/an/an/an/an/an/a



Purdue University

Curated by PDSP Ki Database




Bioorg Med Chem 11: 1451-64 (2003)


Article DOI: 10.1016/S0968-0896(02)00561-8
BindingDB Entry DOI: 10.7270/Q2CV4G90
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50306317
PNG
((R)-N-(4-(7-chloro-8-hydroxy-3-methyl-2,3,4,5-tetr...)
Show SMILES CN(Cc1ccc(cc1)[C@H]1CN(C)CCc2cc(Cl)c(O)cc12)S(=O)(=O)c1ccccc1 |r|
Show InChI InChI=1S/C25H27ClN2O3S/c1-27-13-12-20-14-24(26)25(29)15-22(20)23(17-27)19-10-8-18(9-11-19)16-28(2)32(30,31)21-6-4-3-5-7-21/h3-11,14-15,23,29H,12-13,16-17H2,1-2H3/t23-/m1/s1
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 1.20n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to dopamine D5 receptor

Bioorg Med Chem Lett 20: 836-40 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.100
BindingDB Entry DOI: 10.7270/Q23N23HT
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50184438
PNG
(2,4-dichloro-3-hydroxy-7-methyl-5,6,7,8,9,14-hexah...)
Show SMILES CN1CCc2ccccc2Cc2cc(Cl)c(O)c(Cl)c2CC1
Show InChI InChI=1S/C18H19Cl2NO/c1-21-8-6-12-4-2-3-5-13(12)10-14-11-16(19)18(22)17(20)15(14)7-9-21/h2-5,11,22H,6-10H2,1H3
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 1.20n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay

J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50306435
PNG
((6aS,13bS)-11-chloro-7-methyl-6,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c(O)cccc21 |r|
Show InChI InChI=1S/C19H20ClNO2/c1-21-8-7-11-9-15(20)18(23)10-14(11)19-13-3-2-4-17(22)12(13)5-6-16(19)21/h2-4,9-10,16,19,22-23H,5-8H2,1H3/t16-,19+/m0/s1
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 1.40n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting

Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50180913
PNG
(11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(...)
Show SMILES CN1CCc2ccccc2Cc2ccc(O)cc2CC1
Show InChI InChI=1S/C18H21NO/c1-19-10-8-14-4-2-3-5-15(14)12-16-6-7-18(20)13-17(16)9-11-19/h2-7,13,20H,8-12H2,1H3
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 1.5n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23390 from human dopamine D5 receptor expressed in HEK293 cells

J Med Chem 50: 4528-33 (2007)


Article DOI: 10.1021/jm070388+
BindingDB Entry DOI: 10.7270/Q2S46RPG
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50180913
PNG
(11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(...)
Show SMILES CN1CCc2ccccc2Cc2ccc(O)cc2CC1
Show InChI InChI=1S/C18H21NO/c1-19-10-8-14-4-2-3-5-15(14)12-16-6-7-18(20)13-17(16)9-11-19/h2-7,13,20H,8-12H2,1H3
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 1.5n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity to human cloned dopamine D5 receptor expressed in HEK 293 cells

Bioorg Med Chem Lett 17: 1399-402 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.093
BindingDB Entry DOI: 10.7270/Q24T6J1G
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50180913
PNG
(11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(...)
Show SMILES CN1CCc2ccccc2Cc2ccc(O)cc2CC1
Show InChI InChI=1S/C18H21NO/c1-19-10-8-14-4-2-3-5-15(14)12-16-6-7-18(20)13-17(16)9-11-19/h2-7,13,20H,8-12H2,1H3
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 1.5n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universit£t Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH23390 from human dopamine D5 receptor expressed in CHO cells by scintillation counting

Bioorg Med Chem 17: 6898-907 (2009)


Article DOI: 10.1016/j.bmc.2009.08.028
BindingDB Entry DOI: 10.7270/Q2SB46P5
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50180913
PNG
(11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(...)
Show SMILES CN1CCc2ccccc2Cc2ccc(O)cc2CC1
Show InChI InChI=1S/C18H21NO/c1-19-10-8-14-4-2-3-5-15(14)12-16-6-7-18(20)13-17(16)9-11-19/h2-7,13,20H,8-12H2,1H3
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 1.5n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity to D5 dopamine receptor by radioligand binding assay

J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50180913
PNG
(11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(...)
Show SMILES CN1CCc2ccccc2Cc2ccc(O)cc2CC1
Show InChI InChI=1S/C18H21NO/c1-19-10-8-14-4-2-3-5-15(14)12-16-6-7-18(20)13-17(16)9-11-19/h2-7,13,20H,8-12H2,1H3
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 1.5n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by radioligand binding assay

J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM86278
PNG
(MCL-202)
Show SMILES CN1CCc2c(Cl)c(O)c(O)cc2[C@@H](C1)c1cccc(C)c1 |r|
Show InChI InChI=1S/C18H20ClNO2/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3/t15-/m0/s1
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 1.53n/an/an/an/an/an/an/an/a



Harvard University

Curated by PDSP Ki Database




Eur J Pharmacol 474: 137-40 (2003)


Article DOI: 10.1016/s0014-2999(03)02008-9
BindingDB Entry DOI: 10.7270/Q2DN43MQ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50184440
PNG
(1-Chloro-2-hydroxy-7-methyl-5,6,7,8,9,14-hexahydro...)
Show SMILES CN1CCc2ccccc2Cc2c(CC1)ccc(O)c2Cl
Show InChI InChI=1S/C18H20ClNO/c1-20-10-8-13-4-2-3-5-15(13)12-16-14(9-11-20)6-7-17(21)18(16)19/h2-7,21H,8-12H2,1H3
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 1.60n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay

J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50184439
PNG
(3,11-Dihydroxy-7-methyl-5,6,7,8,9,14-hexahydrodibe...)
Show SMILES CN1CCc2cc(O)ccc2Cc2ccc(O)cc2CC1
Show InChI InChI=1S/C18H21NO2/c1-19-8-6-15-11-17(20)4-2-13(15)10-14-3-5-18(21)12-16(14)7-9-19/h2-5,11-12,20-21H,6-10H2,1H3
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 1.68n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity to D5 dopamine receptor by radioligand binding assay

J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50180913
PNG
(11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(...)
Show SMILES CN1CCc2ccccc2Cc2ccc(O)cc2CC1
Show InChI InChI=1S/C18H21NO/c1-19-10-8-14-4-2-3-5-15(14)12-16-6-7-18(20)13-17(16)9-11-19/h2-7,13,20H,8-12H2,1H3
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 1.69n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay

J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50180913
PNG
(11-methyl-11-aza-tricyclo[12.4.0.0.3,8]octadeca-1(...)
Show SMILES CN1CCc2ccccc2Cc2ccc(O)cc2CC1
Show InChI InChI=1S/C18H21NO/c1-19-10-8-14-4-2-3-5-15(14)12-16-6-7-18(20)13-17(16)9-11-19/h2-7,13,20H,8-12H2,1H3
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 1.69n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay

J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50010301
PNG
(8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-be...)
Show SMILES CN1CCc2cc(Br)c(O)cc2C(C1)c1ccccc1
Show InChI InChI=1S/C17H18BrNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3
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 1.80n/an/an/an/an/an/an/an/a


TBA

Assay Description
Displacement of [3H]SCH23390 from dopamine D5 receptor (unknown origin)

Citation and Details

Article DOI: 10.1016/j.bmcl.2021.128047
BindingDB Entry DOI: 10.7270/Q2CJ8J8S
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50151049
PNG
(6-Methoxy-12-methyl-9-oxa-12-aza-tricyclo[13.4.0.0...)
Show SMILES COc1ccc2Cc3ccccc3CCN(C)CCOc2c1
Show InChI InChI=1S/C19H23NO2/c1-20-10-9-15-5-3-4-6-16(15)13-17-7-8-18(21-2)14-19(17)22-12-11-20/h3-8,14H,9-13H2,1-2H3
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 1.80n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Binding affinity for human recombinant dopamine receptor D5

J Med Chem 47: 4155-8 (2004)


Article DOI: 10.1021/jm049720x
BindingDB Entry DOI: 10.7270/Q2WQ0379
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50306451
PNG
((6aS,13bS)-11-chloro-7-methyl-4-(thiophen-2-yl)-6,...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c2cccc1-c1cccs1 |r|
Show InChI InChI=1S/C23H22ClNOS/c1-25-10-9-14-12-19(24)21(26)13-18(14)23-17-5-2-4-16(22-6-3-11-27-22)15(17)7-8-20(23)25/h2-6,11-13,20,23,26H,7-10H2,1H3/t20-,23+/m0/s1
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 1.90n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting

Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM86280
PNG
(MCL-216)
Show SMILES Cc1ccccc1C1CNCCc2c(Br)c(O)c(O)cc12
Show InChI InChI=1S/C17H18BrNO2/c1-10-4-2-3-5-11(10)14-9-19-7-6-12-13(14)8-15(20)17(21)16(12)18/h2-5,8,14,19-21H,6-7,9H2,1H3
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 1.95n/an/an/an/an/an/an/an/a



Harvard University

Curated by PDSP Ki Database




Eur J Pharmacol 474: 137-40 (2003)


Article DOI: 10.1016/s0014-2999(03)02008-9
BindingDB Entry DOI: 10.7270/Q2DN43MQ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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 2n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to dopamine D5 receptor

Bioorg Med Chem Lett 20: 836-40 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.100
BindingDB Entry DOI: 10.7270/Q23N23HT
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(RAT)		BDBM81490
PNG
(CAS_60197-32-2 | CIS PIFLUTIXOL | NSC_68714 | Pifl...)
Show SMILES OCCC1CCN(CCC=C2c3ccc(F)cc3Sc3ccc(cc23)C(F)(F)F)CC1 |w:9.8|
Show InChI InChI=1S/C24H25F4NOS/c25-18-4-5-20-19(2-1-10-29-11-7-16(8-12-29)9-13-30)21-14-17(24(26,27)28)3-6-22(21)31-23(20)15-18/h2-6,14-16,30H,1,7-13H2
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 2n/an/an/an/an/an/an/an/a



Duke University

Curated by PDSP Ki Database




Proc Natl Acad Sci U S A 88: 7491-5 (1991)


Article DOI: 10.1073/pnas.88.17.7491
BindingDB Entry DOI: 10.7270/Q2DB80B9
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50004823
PNG
((6aS,13bR)-11-Chloro-7-methyl-5,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1ccccc21
Show InChI InChI=1S/C19H20ClNO/c1-21-9-8-13-10-16(20)18(22)11-15(13)19-14-5-3-2-4-12(14)6-7-17(19)21/h2-5,10-11,17,19,22H,6-9H2,1H3/t17-,19+/m0/s1
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 2n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting

Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50306441
PNG
(11-chloro-12-hydroxy-7-methyl-6,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c(\C=N\Oc3ccccc3)cccc21 |r|
Show InChI InChI=1S/C26H25ClN2O2/c1-29-13-12-17-14-23(27)25(30)15-22(17)26-21-9-5-6-18(20(21)10-11-24(26)29)16-28-31-19-7-3-2-4-8-19/h2-9,14-16,24,26,30H,10-13H2,1H3/b28-16+/t24-,26+/m0/s1
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 2.10n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting

Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50010301
PNG
(8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-be...)
Show SMILES CN1CCc2cc(Br)c(O)cc2C(C1)c1ccccc1
Show InChI InChI=1S/C17H18BrNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3
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 2.30n/an/an/an/an/an/an/an/a



City University of New York

Curated by ChEMBL


Assay Description
Binding affinity to human D5 receptor

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.127053
BindingDB Entry DOI: 10.7270/Q2H135KF
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50370693
PNG
(CHEMBL1202298)
Show SMILES CN1CCc2ccccc2Cc2cc(O)c(O)cc2CC1
Show InChI InChI=1S/C18H21NO2/c1-19-8-6-13-4-2-3-5-14(13)10-16-12-18(21)17(20)11-15(16)7-9-19/h2-5,11-12,20-21H,6-10H2,1H3
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 2.32n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay

J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM86276
PNG
(CAS_0 | MCL-207 | NSC_0)
Show SMILES CN1CCc2c(Cl)c(O)c(O)cc2C(C1)c1ccccc1C
Show InChI InChI=1S/C18H20ClNO2/c1-11-5-3-4-6-12(11)15-10-20(2)8-7-13-14(15)9-16(21)18(22)17(13)19/h3-6,9,15,21-22H,7-8,10H2,1-2H3
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 2.32n/an/an/an/an/an/an/an/a



Harvard University

Curated by PDSP Ki Database




Eur J Pharmacol 474: 137-40 (2003)


Article DOI: 10.1016/s0014-2999(03)02008-9
BindingDB Entry DOI: 10.7270/Q2DN43MQ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM86275
PNG
(MCL-203)
Show SMILES CN1CCc2c(Br)c(O)c(O)cc2[C@@H](C1)c1cccc(C)c1 |r|
Show InChI InChI=1S/C18H20BrNO2/c1-11-4-3-5-12(8-11)15-10-20(2)7-6-13-14(15)9-16(21)18(22)17(13)19/h3-5,8-9,15,21-22H,6-7,10H2,1-2H3/t15-/m0/s1
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 2.47n/an/an/an/an/an/an/an/a



Harvard University

Curated by PDSP Ki Database




Eur J Pharmacol 474: 137-40 (2003)


Article DOI: 10.1016/s0014-2999(03)02008-9
BindingDB Entry DOI: 10.7270/Q2DN43MQ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50306440
PNG
(11-chloro-12-hydroxy-7-methyl-6,6a,7,8,9,13b-hexah...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H]2[C@@H]1CCc1c(\C=N\OCc3ccccc3)cccc21 |r|
Show InChI InChI=1S/C27H27ClN2O2/c1-30-13-12-19-14-24(28)26(31)15-23(19)27-22-9-5-8-20(21(22)10-11-25(27)30)16-29-32-17-18-6-3-2-4-7-18/h2-9,14-16,25,27,31H,10-13,17H2,1H3/b29-16+/t25-,27+/m0/s1
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 2.5n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Displacement of radioligand from dopamine D5 receptor expressed in mouse LTK cells by scintillation counting

Bioorg Med Chem Lett 20: 832-5 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.094
BindingDB Entry DOI: 10.7270/Q2FX79JH
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50313917
PNG
(6-Methyl-5,6,7,8,13,15-hexahydro-4H-indolo[4,3a,3-...)
Show SMILES CN1CCc2ccccc2Cc2c[nH]c3cccc(CC1)c23
Show InChI InChI=1S/C20H22N2/c1-22-11-9-15-5-2-3-6-17(15)13-18-14-21-19-8-4-7-16(10-12-22)20(18)19/h2-8,14,21H,9-13H2,1H3
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 2.5n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universit£t Jena

Curated by ChEMBL


Assay Description
Displacement of [3H]radioligand from human recombinant dopamine D5 receptor expressed in HEK293 cells by microplate scintillation counting

J Med Chem 53: 2646-50 (2010)


Article DOI: 10.1021/jm901291r
BindingDB Entry DOI: 10.7270/Q2SJ1KRJ
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM82247
PNG
(8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-b...)
Show SMILES CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c1ccccc1 |r|
Show InChI InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3/t15-/m1/s1
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 2.80n/an/an/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to dopamine D5 receptor

Bioorg Med Chem Lett 20: 836-40 (2010)


Article DOI: 10.1016/j.bmcl.2009.12.100
BindingDB Entry DOI: 10.7270/Q23N23HT
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50196234
PNG
(8-methyl-5,6,7,8,9,10,15,16-octahydroindolo[3,2-g]...)
Show SMILES CN1CCCc2ccccc2Cc2[nH]c3ccccc3c2CC1
Show InChI InChI=1S/C21H24N2/c1-23-13-6-9-16-7-2-3-8-17(16)15-21-19(12-14-23)18-10-4-5-11-20(18)22-21/h2-5,7-8,10-11,22H,6,9,12-15H2,1H3
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 2.80n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Activity at human D5 dopamine receptor expressed in HEK293 cells by calcium fluorescence assay

J Med Chem 49: 6408-11 (2006)


Article DOI: 10.1021/jm060213k
BindingDB Entry DOI: 10.7270/Q2GT5MTB
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50180925
PNG
(11-methyl-11-aza-tricyclo[12.4.0.03,8]octadeca-1(1...)
Show SMILES CN1CCc2ccccc2Cc2ccccc2CC1
Show InChI InChI=1S/C18H21N/c1-19-12-10-15-6-2-4-8-17(15)14-18-9-5-3-7-16(18)11-13-19/h2-9H,10-14H2,1H3
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 3.09n/an/an/an/an/an/an/an/a



University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of binding to human D5 receptor expressed in HEK 293 cells by functional calcium assay

J Med Chem 49: 760-9 (2006)


Article DOI: 10.1021/jm050846j
BindingDB Entry DOI: 10.7270/Q22R3SF9
More data for this
Ligand-Target Pair
D(1B) dopamine receptor


(Homo sapiens (Human))		BDBM50184431
PNG
(3-Chloro-2-hydroxy-7-methyl-5,6,7,8,9,14-hexahydro...)
Show SMILES CN1CCc2ccccc2Cc2cc(O)c(Cl)cc2CC1
Show InChI InChI=1S/C18H20ClNO/c1-20-8-6-13-4-2-3-5-14(13)10-16-12-18(21)17(19)11-15(16)7-9-20/h2-5,11-12,21H,6-10H2,1H3
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 3.10n/an/an/an/an/an/an/an/a



Friedrich-Schiller-Universität Jena

Curated by ChEMBL


Assay Description
Inhibition of D5 dopamine receptor in HEK 293 cells by intracellular calcium assay

J Med Chem 49: 2110-6 (2006)


Article DOI: 10.1021/jm051237e
BindingDB Entry DOI: 10.7270/Q2ZW1KHD
More data for this
Ligand-Target Pair
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