Compile Data Set for Download or QSAR

Found 12 hits Enz. Inhib. hit(s) with Target = 'DNA polymerase alpha subunit B'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
DNA polymerase alpha subunit B (Bos taurus (bovine))	BDBM21688 (1-cyclopropyl-7-[4-(4-{4-[(3-ethyl-4-methylphenyl)...) Show SMILES CCc1cc(Nc2cc(=O)n(CCCCN3CCN(CC3C)c3c(F)cc4c(c3F)n(cc(C(O)=O)c4=O)C3CC3)c(=O)[nH]2)ccc1C Show InChI InChI=1S/C35H40F2N6O5/c1-4-22-15-23(8-7-20(22)2)38-28-17-29(44)42(35(48)39-28)12-6-5-11-40-13-14-41(18-21(40)3)32-27(36)16-25-31(30(32)37)43(24-9-10-24)19-26(33(25)45)34(46)47/h7-8,15-17,19,21,24,38H,4-6,9-14,18H2,1-3H3,(H,39,48)(H,46,47)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>4.82E+5	>-19.7	n/a	n/a	n/a	n/a	n/a	7.5	37
Microbiotix					Assay Description Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...				Antimicrob Agents Chemother 51: 119-27 (2007) Article DOI: 10.1128/AAC.01311-05 BindingDB Entry DOI: 10.7270/Q2988599
					More data for this Ligand-Target Pair
DNA polymerase alpha subunit B (Bos taurus (bovine))	BDBM21686 (3-(4-hydroxybutyl)-6-(3-ethyl-4-methylanilino)urac...) Show SMILES CCc1cc(Nc2cc(=O)n(CCCCO)c(=O)[nH]2)ccc1C Show InChI InChI=1S/C17H23N3O3/c1-3-13-10-14(7-6-12(13)2)18-15-11-16(22)20(17(23)19-15)8-4-5-9-21/h6-7,10-11,18,21H,3-5,8-9H2,1-2H3,(H,19,23)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	>1.01E+6	>-17.8	n/a	n/a	n/a	n/a	n/a	7.5	37
Microbiotix					Assay Description Reaction velocities were determined at each dGTP concentration and used to create double reciprocal plots of velocity versus dGTP concentration. The ...				Antimicrob Agents Chemother 51: 119-27 (2007) Article DOI: 10.1128/AAC.01311-05 BindingDB Entry DOI: 10.7270/Q2988599
					More data for this Ligand-Target Pair
DNA polymerase alpha subunit B (Bos taurus (bovine))	BDBM33388 (dehydroaltenusin derivative, 16) Show SMILES CCCCCCCCCCCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1 |c:28| Show InChI InChI=1S/C26H34O6/c1-3-4-5-6-7-8-9-10-11-12-13-31-18-14-19-20-16-21(27)23(29)17-26(20,2)32-25(30)24(19)22(28)15-18/h14-16,28H,3-13,17H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	7.5	37
Kyoto Prefectural University					Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...				Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK
					More data for this Ligand-Target Pair
DNA polymerase alpha subunit B (Bos taurus (bovine))	BDBM33387 (dehydroaltenusin derivative, 15) Show SMILES CCCCCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1 |c:22| Show InChI InChI=1S/C20H22O6/c1-3-4-5-6-7-25-12-8-13-14-10-15(21)17(23)11-20(14,2)26-19(24)18(13)16(22)9-12/h8-10,22H,3-7,11H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	7.5	37
Kyoto Prefectural University					Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...				Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK
					More data for this Ligand-Target Pair
DNA polymerase alpha subunit B (Bos taurus (bovine))	BDBM33386 (dehydroaltenusin derivative, 14) Show SMILES CCCOc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1 |c:19| Show InChI InChI=1S/C17H16O6/c1-3-4-22-9-5-10-11-7-12(18)14(20)8-17(11,2)23-16(21)15(10)13(19)6-9/h5-7,19H,3-4,8H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	180	n/a	n/a	n/a	n/a	7.5	37
Kyoto Prefectural University					Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...				Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK
					More data for this Ligand-Target Pair
DNA polymerase alpha subunit B (Bos taurus (bovine))	BDBM33389 (dehydroaltenusin derivative, 20) Show SMILES CC12CC(=O)C(=O)C=C1c1cccc(O)c1C(=O)O2 |c:7| Show InChI InChI=1S/C14H10O5/c1-14-6-11(17)10(16)5-8(14)7-3-2-4-9(15)12(7)13(18)19-14/h2-5,15H,6H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	240	n/a	n/a	n/a	n/a	7.5	37
Kyoto Prefectural University					Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...				Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK
					More data for this Ligand-Target Pair
DNA polymerase alpha subunit B (Bos taurus (bovine))	BDBM33384 (dehydroaltenusin) Show SMILES COc1cc(O)c2C(=O)OC3(C)CC(=O)C(=O)C=C3c2c1 |c:17| Show InChI InChI=1S/C15H12O6/c1-15-6-12(18)10(16)5-9(15)8-3-7(20-2)4-11(17)13(8)14(19)21-15/h3-5,17H,6H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	680	n/a	n/a	n/a	n/a	7.5	37
Kyoto Prefectural University					Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...				Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK
					More data for this Ligand-Target Pair
DNA polymerase alpha subunit B (Bos taurus (bovine))	BDBM33385 (desmethyldehydroaltenusin, 2) Show SMILES CC12CC(=O)C(=O)C=C1c1cc(O)cc(O)c1C(=O)O2 |c:7| Show InChI InChI=1S/C14H10O6/c1-14-5-11(18)9(16)4-8(14)7-2-6(15)3-10(17)12(7)13(19)20-14/h2-4,15,17H,5H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	890	n/a	n/a	n/a	n/a	7.5	37
Kyoto Prefectural University					Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...				Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK
					More data for this Ligand-Target Pair
DNA polymerase alpha subunit B (Bos taurus (bovine))	BDBM33393 (dehydroaltenusin derivative, 32) Show SMILES CC12OC(=O)c3c(O)cccc3C1=CC(=O)C=C2 |c:14,18| Show InChI InChI=1S/C14H10O4/c1-14-6-5-8(15)7-10(14)9-3-2-4-11(16)12(9)13(17)18-14/h2-7,16H,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.5	37
Kyoto Prefectural University					Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...				Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK
					More data for this Ligand-Target Pair
DNA polymerase alpha subunit B (Bos taurus (bovine))	BDBM33390 (dehydroaltenusin derivative, 25) Show SMILES COc1cc(O)c2c(c1)c1cc(OCc3ccccc3)c(OCc3ccccc3)cc1oc2=O Show InChI InChI=1S/C28H22O6/c1-31-20-12-22-21-14-25(32-16-18-8-4-2-5-9-18)26(33-17-19-10-6-3-7-11-19)15-24(21)34-28(30)27(22)23(29)13-20/h2-15,29H,16-17H2,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.5	37
Kyoto Prefectural University					Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...				Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK
					More data for this Ligand-Target Pair
DNA polymerase alpha subunit B (Bos taurus (bovine))	BDBM33391 (dehydroaltenusin derivative, 26) Show SMILES COc1cc(O)c2c(c1)c1cc(O)c(O)cc1oc2=O Show InChI InChI=1S/C14H10O6/c1-19-6-2-8-7-4-9(15)10(16)5-12(7)20-14(18)13(8)11(17)3-6/h2-5,15-17H,1H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.5	37
Kyoto Prefectural University					Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...				Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK
					More data for this Ligand-Target Pair
DNA polymerase alpha subunit B (Bos taurus (bovine))	BDBM33392 (dehydroaltenusin derivative, 31) Show SMILES COc1cc(O)c2C(=O)OC3(C)C=CC(=O)C=C3c2c1 |c:12,16| Show InChI InChI=1S/C15H12O5/c1-15-4-3-8(16)5-11(15)10-6-9(19-2)7-12(17)13(10)14(18)20-15/h3-7,17H,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	7.5	37
Kyoto Prefectural University					Assay Description For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...				Bioorg Med Chem 17: 7227-38 (2009) Article DOI: 10.1016/j.bmc.2009.08.051 BindingDB Entry DOI: 10.7270/Q2348HQK
					More data for this Ligand-Target Pair