Compile Data Set for Download or QSAR

Found 6 hits Enz. Inhib. hit(s) with Target = 'Dihydropyrimidine dehydrogenase [NADP(+)]'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydropyrimidine dehydrogenase [NADP(+)] (Homo sapiens (Human))	BDBM50124202 (5-Ethynyl-1H-pyrimidine-2,4-dione | CHEMBL355200) Show SMILES O=c1[nH]cc(C#C)c(=O)[nH]1 Show InChI InChI=1S/C6H4N2O2/c1-2-4-3-7-6(10)8-5(4)9/h1,3H,(H2,7,8,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Nippon Roche Research Center Curated by ChEMBL					Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD)				Bioorg Med Chem Lett 13: 867-72 (2003) BindingDB Entry DOI: 10.7270/Q21V5DBW
					More data for this Ligand-Target Pair				3D Structure (crystal)
Dihydropyrimidine dehydrogenase [NADP(+)] (Homo sapiens (Human))	BDBM50124200 (5-((E)-Styryl)-1H-pyrimidine-2,4-dione | CHEMBL352...) Show SMILES O=c1[nH]cc(C=Cc2ccccc2)c(=O)[nH]1 |w:6.6| Show InChI InChI=1S/C12H10N2O2/c15-11-10(8-13-12(16)14-11)7-6-9-4-2-1-3-5-9/h1-8H,(H2,13,14,15,16)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Nippon Roche Research Center Curated by ChEMBL					Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD)				Bioorg Med Chem Lett 13: 867-72 (2003) BindingDB Entry DOI: 10.7270/Q21V5DBW
					More data for this Ligand-Target Pair
Dihydropyrimidine dehydrogenase [NADP(+)] (Homo sapiens (Human))	BDBM50124204 (5-Vinyl-1H-pyrimidine-2,4-dione | CHEMBL170188) Show SMILES C=Cc1c[nH]c(=O)[nH]c1=O Show InChI InChI=1S/C6H6N2O2/c1-2-4-3-7-6(10)8-5(4)9/h2-3H,1H2,(H2,7,8,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	89	n/a	n/a	n/a	n/a	n/a	n/a
Nippon Roche Research Center Curated by ChEMBL					Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD)				Bioorg Med Chem Lett 13: 867-72 (2003) BindingDB Entry DOI: 10.7270/Q21V5DBW
					More data for this Ligand-Target Pair
Dihydropyrimidine dehydrogenase [NADP(+)] (Homo sapiens (Human))	BDBM50124201 (5-(3-Benzyloxy-benzyl)-1H-pyrimidine-2,4-dione | C...) Show SMILES O=c1[nH]cc(Cc2cccc(OCc3ccccc3)c2)c(=O)[nH]1 Show InChI InChI=1S/C18H16N2O3/c21-17-15(11-19-18(22)20-17)9-14-7-4-8-16(10-14)23-12-13-5-2-1-3-6-13/h1-8,10-11H,9,12H2,(H2,19,20,21,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
Nippon Roche Research Center Curated by ChEMBL					Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD)				Bioorg Med Chem Lett 13: 867-72 (2003) BindingDB Entry DOI: 10.7270/Q21V5DBW
					More data for this Ligand-Target Pair
Dihydropyrimidine dehydrogenase [NADP(+)] (Homo sapiens (Human))	BDBM50124205 (2,4-Dioxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonit...) Show SMILES O=c1[nH]cc(C#N)c(=O)[nH]1 Show InChI InChI=1S/C5H3N3O2/c6-1-3-2-7-5(10)8-4(3)9/h2H,(H2,7,8,9,10)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Nippon Roche Research Center Curated by ChEMBL					Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD)				Bioorg Med Chem Lett 13: 867-72 (2003) BindingDB Entry DOI: 10.7270/Q21V5DBW
					More data for this Ligand-Target Pair
Dihydropyrimidine dehydrogenase [NADP(+)] (Homo sapiens (Human))	BDBM50124203 (5-IODOURACIL | 5-Iodo-1H-pyrimidine-2,4-dione | CH...) Show SMILES Ic1c[nH]c(=O)[nH]c1=O Show InChI InChI=1S/C4H3IN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents	MMDB PDB PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Nippon Roche Research Center Curated by ChEMBL					Assay Description Inhibitory activity of the compound against dihydropyrimidine dehydrogenase (DPD)				Bioorg Med Chem Lett 13: 867-72 (2003) BindingDB Entry DOI: 10.7270/Q21V5DBW
					More data for this Ligand-Target Pair				3D Structure (crystal)