Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Epidermal growth factor receptor [G719S] (Homo sapiens (Human)) | BDBM5447 (CHEMBL939 | GEFITINIB | Iressa | N-(3-Chloro-4-flu...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Synovo GmbH US Patent | Assay Description FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 μl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the fol... | US Patent US9416123 (2016) BindingDB Entry DOI: 10.7270/Q2V123PP | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Epidermal growth factor receptor [G719S] (Homo sapiens (Human)) | BDBM50379214 (CHEMBL2011291 | US9416123, 6) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Synovo GmbH US Patent | Assay Description FlashPlates from Perkin Elmer (Boston, Mass., USA) with a 50 μl reaction volume are used. The reaction cocktail was pipetted in 4 steps in the fol... | US Patent US9416123 (2016) BindingDB Entry DOI: 10.7270/Q2V123PP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Epidermal growth factor receptor [G719S] (Homo sapiens (Human)) | BDBM373711 (US10246444, Example 40) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital | Assay Description KINOMEscan is based on a competition binding assay that quantitatively measures the ability of a compound to compete with an immobilized, active-site... | J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2NC63HJ | |||||||||||
More data for this Ligand-Target Pair |